MYL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYL3_HUMAN
• UniProt AC: P08590
• Protein Name: Myosin light chain 3 {ECO:0000305}
• Gene Name: MYL3 {ECO:0000312|HGNC:HGNC:7584}
• Organism: Homo sapiens (Human).
• Sequence Length: 195
• Protein Description: Regulatory light chain of myosin. Does not bind calcium..
• Protein Sequence: MAPKKPEPKKDDAKAAPKAAPAPAPPPEPERPKEVEFDASKIKIEFTPEQIEEFKEAFMLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPKKPEPK ------CCCCCCCCC	25.31	3979397
47	Phosphorylation	SKIKIEFTPEQIEEF HHCEEEECHHHHHHH	17.08	22673903
72	Phosphorylation	PKCEMKITYGQCGDV CCCEEEEEECCHHHH	18.97	-
73	Phosphorylation	KCEMKITYGQCGDVL CCEEEEEECCHHHHH	14.52	26437602
73	Nitration	KCEMKITYGQCGDVL CCEEEEEECCHHHHH	14.52	-
88	Phosphorylation	RALGQNPTQAEVLRV HHCCCCCCHHHHHHH	48.22	26437602
106	Phosphorylation	PRQEELNTKMMDFET CCHHHHHHHCCCHHH	32.70	26437602
113	Phosphorylation	TKMMDFETFLPMLQH HHCCCHHHHHHHHHH	30.39	22673903
123	Acetylation	PMLQHISKNKDTGTY HHHHHHHCCCCCCCH	68.37	30590591
125	Acetylation	LQHISKNKDTGTYED HHHHHCCCCCCCHHH	61.47	30590585
127	Phosphorylation	HISKNKDTGTYEDFV HHHCCCCCCCHHHHH	32.79	26437602
129	Phosphorylation	SKNKDTGTYEDFVEG HCCCCCCCHHHHHHH	26.32	22673903
130	Phosphorylation	KNKDTGTYEDFVEGL CCCCCCCHHHHHHHE	18.17	-
130	Nitration	KNKDTGTYEDFVEGL CCCCCCCHHHHHHHE	18.17	-
142	Ubiquitination	EGLRVFDKEGNGTVM HHEEEEEECCCCEEE	56.93	21890473
142	Ubiquitination	EGLRVFDKEGNGTVM HHEEEEEECCCCEEE	56.93	21890473
142	Acetylation	EGLRVFDKEGNGTVM HHEEEEEECCCCEEE	56.93	55169717
147	Phosphorylation	FDKEGNGTVMGAELR EEECCCCEEEHHHHH	16.00	26437602
159	Phosphorylation	ELRHVLATLGERLTE HHHHHHHHHHHHCCH	31.00	26437602
165	Phosphorylation	ATLGERLTEDEVEKL HHHHHHCCHHHHHHH	47.84	26437602
179	Phosphorylation	LMAGQEDSNGCINYE HHCCCCCCCCCCCHH	34.08	19764811
185	Phosphorylation	DSNGCINYEAFVKHI CCCCCCCHHHHHHHH	6.68	22673903
185	Nitration	DSNGCINYEAFVKHI CCCCCCCHHHHHHHH	6.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYH10_HUMAN	MYH10	physical	28514442
MY18A_HUMAN	MYO18A	physical	28514442
IQGA1_HUMAN	IQGAP1	physical	28514442
MYH14_HUMAN	MYH14	physical	28514442
MYH9_HUMAN	MYH9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608751: Cardiomyopathy, familial hypertrophic 8 (CMH8)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.