dbPTM

FOXO3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FOXO3_HUMAN
UniProt AC	O43524
Protein Name	Forkhead box protein O3 {ECO:0000305}
Gene Name	FOXO3 {ECO:0000312\|HGNC:HGNC:3821}
Organism	Homo sapiens (Human).
Sequence Length	673
Subcellular Localization	Cytoplasm, cytosol . Nucleus . Mitochondrion matrix . Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side . Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Tran
Protein Description	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. [PubMed: 10102273]
Protein Sequence	MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAEAPASPAPLSPL -CCCCCCCCCCCCCC	22.12	28355574
12	Phosphorylation	PASPAPLSPLEVELD CCCCCCCCCCEEECC	26.78	28355574
26	Phosphorylation	DPEFEPQSRPRSCTW CCCCCCCCCCCCCCC	55.77	26552605
30	Phosphorylation	EPQSRPRSCTWPLQR CCCCCCCCCCCCCCC	20.69	25159151
32	Phosphorylation	QSRPRSCTWPLQRPE CCCCCCCCCCCCCHH	31.22	17200115
43	Phosphorylation	QRPELQASPAKPSGE CCHHHCCCCCCCCCC	16.66	25159151
46	Methylation	ELQASPAKPSGETAA HHCCCCCCCCCCCCH	43.00	22820736
48	Phosphorylation	QASPAKPSGETAADS CCCCCCCCCCCCHHH	48.86	23927012
51	Phosphorylation	PAKPSGETAADSMIP CCCCCCCCCHHHCCC	30.58	30140170
55	Phosphorylation	SGETAADSMIPEEED CCCCCHHHCCCCCCC	17.55	30140170
75	Phosphorylation	DGGGRAGSAMAIGGG CCCCCCCCEEEECCC	17.56	25850435
85	Phosphorylation	AIGGGGGSGTLGSGL EECCCCCCCCCCCCC	31.70	25850435
87	Phosphorylation	GGGGGSGTLGSGLLL CCCCCCCCCCCCCEE	29.64	27251275
90	Phosphorylation	GGSGTLGSGLLLEDS CCCCCCCCCCEECCC	29.40	27050516
149	Methylation	GGSGQPRKCSSRRNA CCCCCCCCCCCCCCC	45.19	22820736
161	Phosphorylation	RNAWGNLSYADLITR CCCCCCCCHHHHHHH	23.44	-
162	Phosphorylation	NAWGNLSYADLITRA CCCCCCCHHHHHHHH	13.80	27642862
179	Phosphorylation	SSPDKRLTLSQIYEW CCCCCCEEHHHHHHH	28.53	22137581
181	Phosphorylation	PDKRLTLSQIYEWMV CCCCEEHHHHHHHHH	14.86	30622161
184	Phosphorylation	RLTLSQIYEWMVRCV CEEHHHHHHHHHHHH	8.90	-
200	Phosphorylation	YFKDKGDSNSSAGWK HCCCCCCCCCCHHHH	47.48	21406692
202	Phosphorylation	KDKGDSNSSAGWKNS CCCCCCCCCHHHHHH	26.05	21406692
203	Phosphorylation	DKGDSNSSAGWKNSI CCCCCCCCHHHHHHH	34.74	21406692
207	Ubiquitination	SNSSAGWKNSIRHNL CCCCHHHHHHHHHHH	39.64	-
209	Phosphorylation	SSAGWKNSIRHNLSL CCHHHHHHHHHHHHH	19.78	20110348
215	Phosphorylation	NSIRHNLSLHSRFMR HHHHHHHHHHHEEEE	29.38	22817900
228	Phosphorylation	MRVQNEGTGKSSWWI EEEEECCCCCCCEEE	34.95	23403867
230	Methylation	VQNEGTGKSSWWIIN EEECCCCCCCEEEEC	40.95	22820736
231	Phosphorylation	QNEGTGKSSWWIINP EECCCCCCCEEEECC	32.32	22817900
232	Phosphorylation	NEGTGKSSWWIINPD ECCCCCCCEEEECCC	29.89	22817900
242	Acetylation	IINPDGGKSGKAPRR EECCCCCCCCCCCCC	62.66	25953088
242	Ubiquitination	IINPDGGKSGKAPRR EECCCCCCCCCCCCC	62.66	PubMed
243	Phosphorylation	INPDGGKSGKAPRRR ECCCCCCCCCCCCCC	49.12	26434776
245	Acetylation	PDGGKSGKAPRRRAV CCCCCCCCCCCCCEE	63.41	101542399
253	Phosphorylation	APRRRAVSMDNSNKY CCCCCEECCCCCCCH	21.31	27273156
257	Phosphorylation	RAVSMDNSNKYTKSR CEECCCCCCCHHHHH	30.36	20068231
259	Acetylation	VSMDNSNKYTKSRGR ECCCCCCCHHHHHHH	54.86	14976264
259	Ubiquitination	VSMDNSNKYTKSRGR ECCCCCCCHHHHHHH	54.86	PubMed
260	Phosphorylation	SMDNSNKYTKSRGRA CCCCCCCHHHHHHHH	24.53	23927012
262	Methylation	DNSNKYTKSRGRAAK CCCCCHHHHHHHHHH	34.76	22820736
271	Acetylation	RGRAAKKKAALQTAP HHHHHHHHHHHHCCC	37.88	22820736
271	Methylation	RGRAAKKKAALQTAP HHHHHHHHHHHHCCC	37.88	22820736
276	Phosphorylation	KKKAALQTAPESADD HHHHHHHCCCCCCCC	45.06	30266825
280	Phosphorylation	ALQTAPESADDSPSQ HHHCCCCCCCCCHHH	35.62	30266825
284	O-linked_Glycosylation	APESADDSPSQLSKW CCCCCCCCHHHHHCC	27.31	30379171
284	Phosphorylation	APESADDSPSQLSKW CCCCCCCCHHHHHCC	27.31	23927012
286	O-linked_Glycosylation	ESADDSPSQLSKWPG CCCCCCHHHHHCCCC	47.94	30379171
286	Phosphorylation	ESADDSPSQLSKWPG CCCCCCHHHHHCCCC	47.94	30266825
289	Phosphorylation	DDSPSQLSKWPGSPT CCCHHHHHCCCCCCC	25.66	30266825
290	Acetylation	DSPSQLSKWPGSPTS CCHHHHHCCCCCCCC	67.03	14976264
290	Methylation	DSPSQLSKWPGSPTS CCHHHHHCCCCCCCC	67.03	22820736
290	Ubiquitination	DSPSQLSKWPGSPTS CCHHHHHCCCCCCCC	67.03	PubMed
294	Phosphorylation	QLSKWPGSPTSRSSD HHHCCCCCCCCCCHH	22.41	18204439
296	Phosphorylation	SKWPGSPTSRSSDEL HCCCCCCCCCCHHHH	38.17	23927012
297	Phosphorylation	KWPGSPTSRSSDELD CCCCCCCCCCHHHHH	33.28	23927012
299	Phosphorylation	PGSPTSRSSDELDAW CCCCCCCCHHHHHHH	41.74	30266825
300	Phosphorylation	GSPTSRSSDELDAWT CCCCCCCHHHHHHHH	33.71	30266825
307	Phosphorylation	SDELDAWTDFRSRTN HHHHHHHHCHHHHCC	27.29	23927012
311	Phosphorylation	DAWTDFRSRTNSNAS HHHHCHHHHCCCCCC	43.37	23927012
313	Phosphorylation	WTDFRSRTNSNASTV HHCHHHHCCCCCCCC	44.22	27794612
315	Phosphorylation	DFRSRTNSNASTVSG CHHHHCCCCCCCCCC	32.91	27732954
318	Phosphorylation	SRTNSNASTVSGRLS HHCCCCCCCCCCCCC	33.32	21602804
319	Phosphorylation	RTNSNASTVSGRLSP HCCCCCCCCCCCCCC	19.11	27794612
321	Phosphorylation	NSNASTVSGRLSPIM CCCCCCCCCCCCCCC	20.48	21602804
325	Phosphorylation	STVSGRLSPIMASTE CCCCCCCCCCCCCCC	15.83	28348404
330	Phosphorylation	RLSPIMASTELDEVQ CCCCCCCCCCCCCCC	12.68	28348404
331	Phosphorylation	LSPIMASTELDEVQD CCCCCCCCCCCCCCC	30.91	28348404
344	Phosphorylation	QDDDAPLSPMLYSSS CCCCCCCCHHHCCCC	13.75	18204439
348	Phosphorylation	APLSPMLYSSSASLS CCCCHHHCCCCCCCC	10.56	26074081
349	Phosphorylation	PLSPMLYSSSASLSP CCCHHHCCCCCCCCC	17.54	26074081
350	Phosphorylation	LSPMLYSSSASLSPS CCHHHCCCCCCCCCC	19.16	26074081
351	Phosphorylation	SPMLYSSSASLSPSV CHHHCCCCCCCCCCC	18.88	26074081
353	Phosphorylation	MLYSSSASLSPSVSK HHCCCCCCCCCCCCC	31.18	26074081
355	Phosphorylation	YSSSASLSPSVSKPC CCCCCCCCCCCCCCC	16.78	26074081
357	Phosphorylation	SSASLSPSVSKPCTV CCCCCCCCCCCCCEE	35.33	26074081
359	Phosphorylation	ASLSPSVSKPCTVEL CCCCCCCCCCCEEEC	34.91	26074081
363	Phosphorylation	PSVSKPCTVELPRLT CCCCCCCEEECCCCC	26.07	26074081
370	Phosphorylation	TVELPRLTDMAGTMN EEECCCCCCCCCCCC	25.63	26074081
395	Phosphorylation	DDLLDNITLPPSQPS HHHHHHCCCCCCCCC	39.19	-
399	Phosphorylation	DNITLPPSQPSPTGG HHCCCCCCCCCCCCC	53.43	22137581
402	Phosphorylation	TLPPSQPSPTGGLMQ CCCCCCCCCCCCCCC	27.70	28348404
411	O-linked_Glycosylation	TGGLMQRSSSFPYTT CCCCCCCCCCCCCCC	17.28	30379171
411	Phosphorylation	TGGLMQRSSSFPYTT CCCCCCCCCCCCCCC	17.28	27732954
412	Phosphorylation	GGLMQRSSSFPYTTK CCCCCCCCCCCCCCC	37.88	27732954
413	Phosphorylation	GLMQRSSSFPYTTKG CCCCCCCCCCCCCCC	31.33	25159151
416	Phosphorylation	QRSSSFPYTTKGSGL CCCCCCCCCCCCCCC	25.65	28985074
418	O-linked_Glycosylation	SSSFPYTTKGSGLGS CCCCCCCCCCCCCCC	27.80	30379171
419	Methylation	SSFPYTTKGSGLGSP CCCCCCCCCCCCCCC	43.19	22820736
421	Phosphorylation	FPYTTKGSGLGSPTS CCCCCCCCCCCCCCC	32.19	22617229
425	Phosphorylation	TKGSGLGSPTSSFNS CCCCCCCCCCCCCCC	30.01	18204439
427	Phosphorylation	GSGLGSPTSSFNSTV CCCCCCCCCCCCCCC	38.41	22617229
428	Phosphorylation	SGLGSPTSSFNSTVF CCCCCCCCCCCCCCC	35.99	28102081
429	Phosphorylation	GLGSPTSSFNSTVFG CCCCCCCCCCCCCCC	30.81	25106551
432	Phosphorylation	SPTSSFNSTVFGPSS CCCCCCCCCCCCHHH	24.76	28450419
433	Phosphorylation	PTSSFNSTVFGPSSL CCCCCCCCCCCHHHH	22.43	28464451
438	Phosphorylation	NSTVFGPSSLNSLRQ CCCCCCHHHHHHHHC	48.08	28450419
439	Phosphorylation	STVFGPSSLNSLRQS CCCCCHHHHHHHHCC	34.40	28450419
442	Phosphorylation	FGPSSLNSLRQSPMQ CCHHHHHHHHCCCCC	30.17	25106551
446	Phosphorylation	SLNSLRQSPMQTIQE HHHHHHCCCCCHHHH	18.86	25690035
450	Phosphorylation	LRQSPMQTIQENKPA HHCCCCCHHHHCCCC	20.55	25690035
475	O-linked_Glycosylation	QTLQDLLTSDSLSHS CHHHHHHHCCCCCHH	37.47	30379171
476	O-linked_Glycosylation	TLQDLLTSDSLSHSD HHHHHHHCCCCCHHH	25.77	30379171
482	O-linked_Glycosylation	TSDSLSHSDVMMTQS HCCCCCHHHEEECCC	28.64	30379171
551	O-linked_Glycosylation	LGGSRALSNSVSNMG CCHHHHHHHHHHCCC	26.52	30379171
551	Phosphorylation	LGGSRALSNSVSNMG CCHHHHHHHHHHCCC	26.52	28857561
553	Phosphorylation	GSRALSNSVSNMGLS HHHHHHHHHHCCCCC	24.44	28857561
555	Phosphorylation	RALSNSVSNMGLSES HHHHHHHHCCCCCCC	22.41	19060867
564	Phosphorylation	MGLSESSSLGSAKHQ CCCCCCCCHHCCCHH	46.13	28555341
569	Acetylation	SSSLGSAKHQQQSPV CCCHHCCCHHHCCCC	43.58	14976264
569	Ubiquitination	SSSLGSAKHQQQSPV CCCHHCCCHHHCCCC	43.58	PubMed
574	Phosphorylation	SAKHQQQSPVSQSMQ CCCHHHCCCCCHHHH	23.96	27251275
588	Phosphorylation	QTLSDSLSGSSLYST HHHHHHHCCCCCCCC	40.35	22137581
626	Phosphorylation	SLECDMESIIRSELM CEECCHHHHHHHHHC	19.37	22137581
644	Phosphorylation	GLDFNFDSLISTQNV CCCCCHHHHEECCCE	24.38	14702039
666	O-linked_Glycosylation	FTGAKQASSQSWVPG CCCCCCCCCCCCCCC	26.81	30379171
666	Phosphorylation	FTGAKQASSQSWVPG CCCCCCCCCCCCCCC	26.81	27251275
667	Phosphorylation	TGAKQASSQSWVPG- CCCCCCCCCCCCCC-	31.11	27251275
669	Phosphorylation	AKQASSQSWVPG--- CCCCCCCCCCCC---	31.80	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
12	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
12	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
12	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
30	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
30	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
32	T	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM
32	T	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
32	T	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
32	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
32	T	Phosphorylation	Kinase	PIM1	P11309	PSP
32	T	Phosphorylation	Kinase	AKT1	P47196	PSP
32	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
179	T	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
179	T	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
179	T	Phosphorylation	Kinase	PRKAA2	P54646	GPS
179	T	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
209	S	Phosphorylation	Kinase	STK4	Q13043	GPS
209	S	Phosphorylation	Kinase	MST1	P26927	Uniprot
215	S	Phosphorylation	Kinase	STK4	Q13043	GPS
215	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
231	S	Phosphorylation	Kinase	STK4	Q13043	GPS
232	S	Phosphorylation	Kinase	STK4	Q13043	GPS
243	S	Phosphorylation	Kinase	STK4	Q13043	GPS
253	S	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM
253	S	Phosphorylation	Kinase	AKT1	P47196	PSP
253	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
253	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
253	S	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
253	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
253	S	Phosphorylation	Kinase	AKT1	P31750	PSP
253	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
253	S	Phosphorylation	Kinase	PIM1	P11309	PSP
294	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
294	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
294	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
299	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	Uniprot
315	S	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM
315	S	Phosphorylation	Kinase	SGK1	O00141	Uniprot
315	S	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
344	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
344	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
344	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
399	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
399	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
399	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
399	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
413	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
413	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
413	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
413	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
425	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
425	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
425	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
551	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
555	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
555	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
555	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
555	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
555	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
574	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
588	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
588	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
588	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
588	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
626	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
626	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
626	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
626	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
644	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
644	S	Phosphorylation	Kinase	CHUK	O15111	GPS
644	S	Phosphorylation	Kinase	IKBKE	Q14164	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:20625400
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:21841822
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:19321440

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
12	S	Phosphorylation	29445193
In cancer cells, ERK mediated-phosphorylation of Ser-12 is required for mitochondrial translocation of FOXO3 in response to metabolic stress or chemotherapeutic agents.
30	S	Phosphorylation	29445193
In response to metabolic stress, phosphorylated by AMPK on Ser-30 which mediates FOXO3 mitochondrial translocation.
32	T	Phosphorylation	10102273
In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB.
209	S	Oxidation	16751106
Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.
209	S	Phosphorylation	16751106
Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.
253	S	Phosphorylation	10102273
In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB.
271	K	Methylation	22820736
The main methylation site is Lys-271.
299	S	Phosphorylation	23805378
May be dephosphorylated by calcineurin A on Ser-299 which abolishes FOXO3 transcriptional activity (By similarity).
315	S	Phosphorylation	10102273
Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue.
644	S	Phosphorylation	15084260
TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation.
644	S	ubiquitylation	15084260
TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FOXO3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD4_HUMAN	SMAD4	physical	15084259
UBP7_HUMAN	USP7	physical	16964248
1433E_HUMAN	YWHAE	physical	20562859
1433F_HUMAN	YWHAH	physical	20562859
1433B_HUMAN	YWHAB	physical	20562859
PGK1_HUMAN	PGK1	physical	20562859
FKBP4_HUMAN	FKBP4	physical	20562859
CTNB1_HUMAN	CTNNB1	physical	15905404
H2AX_HUMAN	H2AFX	physical	18344987
BRCA1_HUMAN	BRCA1	physical	18344987
RAD17_HUMAN	RAD17	physical	18344987
ATM_HUMAN	ATM	physical	18344987
SIR1_HUMAN	SIRT1	physical	15126506
CBP_HUMAN	CREBBP	physical	15126506
FACD2_HUMAN	FANCD2	physical	20040763
EP300_HUMAN	EP300	physical	19592618
VDR_HUMAN	VDR	physical	20733005
SIR1_HUMAN	SIRT1	physical	20733005
MDM2_HUMAN	MDM2	physical	19321440
SKP2_HUMAN	SKP2	physical	21841822
SMAD3_HUMAN	SMAD3	physical	21532621
SMAD4_HUMAN	SMAD4	physical	21532621
CBP_HUMAN	CREBBP	physical	22474372
FBW1A_HUMAN	BTRC	physical	20625400
MK01_HUMAN	MAPK1	physical	18204439
MDM2_HUMAN	MDM2	physical	18204439
CDT1_HUMAN	CDT1	physical	22451935
SKP2_HUMAN	SKP2	physical	22310285
IKKA_HUMAN	CHUK	physical	15084260
IKKB_HUMAN	IKBKB	physical	15084260
1433B_HUMAN	YWHAB	physical	19940129
SIR1_HUMAN	SIRT1	physical	14976264
EP300_MOUSE	Ep300	physical	11896584
PP2AB_HUMAN	PPP2CB	physical	26280018
PLK1_HUMAN	PLK1	physical	26280018
PTPA_HUMAN	PPP2R4	physical	26280018
2AAA_HUMAN	PPP2R1A	physical	26280018
2AAB_HUMAN	PPP2R1B	physical	26280018
UBP7_HUMAN	USP7	physical	26280018
1433E_HUMAN	YWHAE	physical	26280018
ATGA1_HUMAN	ATG101	physical	23640897
TRRAP_HUMAN	TRRAP	physical	25609649
CBP_HUMAN	CREBBP	physical	25609649
EP300_HUMAN	EP300	physical	25609649
RBL1_HUMAN	RBL1	physical	25609649
CDC27_HUMAN	CDC27	physical	25609649
FOXK1_HUMAN	FOXK1	physical	25609649
RB_HUMAN	RB1	physical	25609649
PNKP_HUMAN	PNKP	physical	25609649
ARHG2_HUMAN	ARHGEF2	physical	25609649
TAF5L_HUMAN	TAF5L	physical	25609649
TERT_HUMAN	TERT	physical	26370108
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FOXO3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The MK5/PRAK kinase and Myc form a negative feedback loop that isdisrupted during colorectal tumorigenesis."; Kress T.R., Cannell I.G., Brenkman A.B., Samans B., Gaestel M.,Roepman P., Burgering B.M., Bushell M., Rosenwald A., Eilers M.; Mol. Cell 41:445-457(2011). Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, AND PHOSPHORYLATION ATSER-215; SER-253; SER-551 AND SER-555.	21329882 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-12 AND SER-280,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-284 ANDSER-286, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280 AND SER-284, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND THR-427, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"The energy sensor AMP-activated protein kinase directly regulates themammalian FOXO3 transcription factor."; Greer E.L., Oskoui P.R., Banko M.R., Maniar J.M., Gygi M.P.,Gygi S.P., Brunet A.; J. Biol. Chem. 282:30107-30119(2007). Cited for: PHOSPHORYLATION AT THR-179; SER-399; SER-413; SER-555; SER-588 ANDSER-626, MUTAGENESIS OF THR-179; SER-399; SER-413; SER-555; SER-588AND SER-626, AND SUBCELLULAR LOCATION.	17711846 [Abstract]
"A conserved MST-FOXO signaling pathway mediates oxidative-stressresponses and extends life span."; Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B.E.,DiBacco S., de la Iglesia N., Gygi S.P., Blackwell T.K., Bonni A.; Cell 125:987-1001(2006). Cited for: FUNCTION, PHOSPHORYLATION AT SER-209, INTERACTION WITH STK4/MST1 ANDYWHAB, SUBCELLULAR LOCATION, AND MUTAGENESIS OF SER-209.	16751106 [Abstract]
"Protein kinase SGK mediates survival signals by phosphorylating theforkhead transcription factor FKHRL1 (FOXO3a)."; Brunet A., Park J., Tran H., Hu L.S., Hemmings B.A., Greenberg M.E.; Mol. Cell. Biol. 21:952-965(2001). Cited for: PHOSPHORYLATION AT SER-315.	11154281 [Abstract]
"Akt promotes cell survival by phosphorylating and inhibiting aForkhead transcription factor."; Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S.,Anderson M.J., Arden K.C., Blenis J., Greenberg M.E.; Cell 96:857-868(1999). Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-32; SER-253 ANDSER-315, AND MUTAGENESIS OF THR-32; SER-253 AND SER-315.	10102273 [Abstract]

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