dbPTM

PP2AB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP2AB_HUMAN
UniProt AC	P62714
Protein Name	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Gene Name	PPP2CB
Organism	Homo sapiens (Human).
Sequence Length	309
Subcellular Localization	Cytoplasm . Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole . In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
Protein Description	PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase..
Protein Sequence	MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MDDKAFTKELD ----CCHHHHHHHHH	40.93	-
8	Ubiquitination	MDDKAFTKELDQWVE CCHHHHHHHHHHHHH	50.23	-
21	Ubiquitination	VEQLNECKQLNENQV HHHHHHHHHCCHHHH	52.20	21890473
21	Ubiquitination	VEQLNECKQLNENQV HHHHHHHHHCCHHHH	52.20	21890473
34	Ubiquitination	QVRTLCEKAKEILTK HHHHHHHHHHHHHHC	64.86	-
36	Ubiquitination	RTLCEKAKEILTKES HHHHHHHHHHHHCCC	57.25	21890473
41	Ubiquitination	KAKEILTKESNVQEV HHHHHHHCCCCCCEE	56.55	21890473
41	Acetylation	KAKEILTKESNVQEV HHHHHHHCCCCCCEE	56.55	25953088
41	Ubiquitination	KAKEILTKESNVQEV HHHHHHHCCCCCCEE	56.55	21890473
43	Phosphorylation	KEILTKESNVQEVRC HHHHHCCCCCCEEEC	43.80	26437602
74	Ubiquitination	ELFRIGGKSPDTNYL HHHHCCCCCCCCCEE	54.31	21890473
75	Phosphorylation	LFRIGGKSPDTNYLF HHHCCCCCCCCCEEE	31.14	21712546
78	Phosphorylation	IGGKSPDTNYLFMGD CCCCCCCCCEEECCC	29.19	-
83	Sulfoxidation	PDTNYLFMGDYVDRG CCCCEEECCCCCCCC	3.54	30846556
86	Phosphorylation	NYLFMGDYVDRGYYS CEEECCCCCCCCCEE	9.87	-
124	Phosphorylation	NHESRQITQVYGFYD CCCHHHHHEEEEHHH	12.02	24043423
127	Phosphorylation	SRQITQVYGFYDECL HHHHHEEEEHHHHHH	7.53	28152594
130	Phosphorylation	ITQVYGFYDECLRKY HHEEEEHHHHHHHHH	13.38	28152594
136	Ubiquitination	FYDECLRKYGNANVW HHHHHHHHHCCCCHH	44.56	21890473
136	Acetylation	FYDECLRKYGNANVW HHHHHHHHHCCCCHH	44.56	26051181
195	Sulfoxidation	EVPHEGPMCDLLWSD CCCCCCCCCCEECCC	4.00	30846556
212	Phosphorylation	DRGGWGISPRGAGYT CCCCCCCCCCCCCCC	12.47	26074081
218	Phosphorylation	ISPRGAGYTFGQDIS CCCCCCCCCCCCCHH	9.81	26074081
219	Phosphorylation	SPRGAGYTFGQDISE CCCCCCCCCCCCHHH	22.00	26074081
225	Phosphorylation	YTFGQDISETFNHAN CCCCCCHHHHHHHCC	38.58	26074081
245	Sulfoxidation	SRAHQLVMEGYNWCH HHHHHHHHCCCCCCC	4.49	30846556
248	Phosphorylation	HQLVMEGYNWCHDRN HHHHHCCCCCCCCCC	7.68	24927040
265	Phosphorylation	TIFSAPNYCYRCGNQ EEEECCCCHHHCCCE	6.98	20090780
267	Phosphorylation	FSAPNYCYRCGNQAA EECCCCHHHCCCEEE	9.89	28152594
283	Ubiquitination	MELDDTLKYSFLQFD EECCCCCEEEEEECC	40.72	21890473
284	Phosphorylation	ELDDTLKYSFLQFDP ECCCCCEEEEEECCC	14.04	28796482
285	Phosphorylation	LDDTLKYSFLQFDPA CCCCCEEEEEECCCC	20.21	28796482
295	Methylation	QFDPAPRRGEPHVTR ECCCCCCCCCCCCCC	53.41	-
301	Phosphorylation	RRGEPHVTRRTPDYF CCCCCCCCCCCCCCC	16.05	29214152
304	Phosphorylation	EPHVTRRTPDYFL-- CCCCCCCCCCCCC--	19.74	30266825
307	Phosphorylation	VTRRTPDYFL----- CCCCCCCCCC-----	14.16	28152594
309	Methylation	RRTPDYFL------- CCCCCCCC-------	5.81	8206937

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MPG	P29372	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP2AB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP2AB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAA_HUMAN	PPP2R1A	physical	18782753
STRN_HUMAN	STRN	physical	18782753
STRP1_HUMAN	STRIP1	physical	18782753
STRN4_HUMAN	STRN4	physical	18782753
STRN3_HUMAN	STRN3	physical	18782753
TCPA_HUMAN	TCP1	physical	18782753
TCPB_HUMAN	CCT2	physical	18782753
TCPZ_HUMAN	CCT6A	physical	18782753
CT2NL_HUMAN	CTTNBP2NL	physical	18782753
PHOCN_HUMAN	MOB4	physical	18782753
TCPG_HUMAN	CCT3	physical	18782753
TCPE_HUMAN	CCT5	physical	18782753
IGBP1_HUMAN	IGBP1	physical	18782753
2ABA_HUMAN	PPP2R2A	physical	18782753
TCPQ_HUMAN	CCT8	physical	18782753
TCPH_HUMAN	CCT7	physical	18782753
TCPD_HUMAN	CCT4	physical	18782753
FR1OP_HUMAN	FGFR1OP	physical	18782753
2A5D_HUMAN	PPP2R5D	physical	18782753
CTTB2_HUMAN	CTTNBP2	physical	18782753
ACTBL_HUMAN	ACTBL2	physical	19156129
PR14L_HUMAN	PRR14L	physical	19156129
SGO1_HUMAN	SGOL1	physical	19156129
MLRS_HUMAN	MYLPF	physical	19156129
STRP1_HUMAN	STRIP1	physical	19156129
SIKE1_HUMAN	SIKE1	physical	19156129
2ABA_HUMAN	PPP2R2A	physical	19156129
PRR14_HUMAN	PRR14	physical	19156129
CT2NL_HUMAN	CTTNBP2NL	physical	19156129
PPME1_HUMAN	PPME1	physical	19156129
STRN3_HUMAN	STRN3	physical	19156129
STRN4_HUMAN	STRN4	physical	19156129
PHOCN_HUMAN	MOB4	physical	19156129
ANKL2_HUMAN	ANKLE2	physical	19156129
TCPE_HUMAN	CCT5	physical	19156129
TCPQ_HUMAN	CCT8	physical	19156129
TCPB_HUMAN	CCT2	physical	19156129
TCPD_HUMAN	CCT4	physical	19156129
TCPH_HUMAN	CCT7	physical	19156129
PFD6_HUMAN	PFDN6	physical	19156129
LIPA1_HUMAN	PPFIA1	physical	19156129
SLMAP_HUMAN	SLMAP	physical	19156129
PFD3_HUMAN	VBP1	physical	19156129
TCPG_HUMAN	CCT3	physical	19156129
TCPA_HUMAN	TCP1	physical	19156129
STRN_HUMAN	STRN	physical	19156129
2A5E_HUMAN	PPP2R5E	physical	19156129
2A5D_HUMAN	PPP2R5D	physical	19156129
2A5G_HUMAN	PPP2R5C	physical	19156129
2AAB_HUMAN	PPP2R1B	physical	19156129
2AAA_HUMAN	PPP2R1A	physical	19156129
PFD5_HUMAN	PFDN5	physical	19156129
PFD2_HUMAN	PFDN2	physical	19156129
IGBP1_HUMAN	IGBP1	physical	19156129
TCPZ_HUMAN	CCT6A	physical	19156129
2ABD_HUMAN	PPP2R2D	physical	19156129
MYH10_HUMAN	MYH10	physical	19156129
RED1_HUMAN	ADARB1	physical	19156129
ZN775_HUMAN	ZNF775	physical	21900206
ZFP28_HUMAN	ZFP28	physical	21900206
DOCK7_HUMAN	DOCK7	physical	21900206
CV039_HUMAN	C22orf39	physical	21900206
TC1D2_HUMAN	TCTEX1D2	physical	21900206
RLA1_HUMAN	RPLP1	physical	21900206
PLXA3_HUMAN	PLXNA3	physical	21900206
PPA5_HUMAN	ACP5	physical	21900206
RAF1_HUMAN	RAF1	physical	21988832
TR61B_HUMAN	TRMT61B	physical	21988832
AASD1_HUMAN	AARSD1	physical	22863883
ATG7_HUMAN	ATG7	physical	22863883
NIF3L_HUMAN	NIF3L1	physical	22863883
NSUN2_HUMAN	NSUN2	physical	22863883
TTC1_HUMAN	TTC1	physical	22863883
CE350_HUMAN	CEP350	physical	26186194
STRP2_HUMAN	STRIP2	physical	26186194
STRP1_HUMAN	STRIP1	physical	26186194
PRR14_HUMAN	PRR14	physical	26186194
PR14L_HUMAN	PRR14L	physical	26186194
STRN_HUMAN	STRN	physical	26186194
STRN3_HUMAN	STRN3	physical	26186194
STRN4_HUMAN	STRN4	physical	26186194
CCDC6_HUMAN	CCDC6	physical	26186194
TBCC1_HUMAN	TBCCD1	physical	26186194
SIKE1_HUMAN	SIKE1	physical	26186194
CIA30_HUMAN	NDUFAF1	physical	26186194
FR1OP_HUMAN	FGFR1OP	physical	26186194
PP4R1_HUMAN	PPP4R1	physical	26186194
ANKL2_HUMAN	ANKLE2	physical	26186194
2AAB_HUMAN	PPP2R1B	physical	26186194
2AAA_HUMAN	PPP2R1A	physical	26186194
2A5G_HUMAN	PPP2R5C	physical	26186194
2A5D_HUMAN	PPP2R5D	physical	26186194
2A5A_HUMAN	PPP2R5A	physical	26186194
2A5E_HUMAN	PPP2R5E	physical	26186194
SLMAP_HUMAN	SLMAP	physical	26186194
2ABD_HUMAN	PPP2R2D	physical	26186194
2ABA_HUMAN	PPP2R2A	physical	26186194
PPME1_HUMAN	PPME1	physical	26186194
CT2NL_HUMAN	CTTNBP2NL	physical	26186194
PHOCN_HUMAN	MOB4	physical	26186194
LIPA1_HUMAN	PPFIA1	physical	26186194
HEMH_HUMAN	FECH	physical	26186194
P2R3C_HUMAN	PPP2R3C	physical	26186194
P2R3B_HUMAN	PPP2R3B	physical	26186194
SGO1_HUMAN	SGOL1	physical	26186194
CTTB2_HUMAN	CTTNBP2	physical	26186194
FGOP2_HUMAN	FGFR1OP2	physical	26186194
FOXC1_HUMAN	FOXC1	physical	26186194
ZN444_HUMAN	ZNF444	physical	26186194
HMCS1_HUMAN	HMGCS1	physical	26344197
IGBP1_HUMAN	IGBP1	physical	26344197
PP2AA_HUMAN	PPP2CA	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26344197
2AAB_HUMAN	PPP2R1B	physical	26344197
2A5D_HUMAN	PPP2R5D	physical	26344197
2A5E_HUMAN	PPP2R5E	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
TCPZ_HUMAN	CCT6A	physical	26496610
HEMH_HUMAN	FECH	physical	26496610
IGBP1_HUMAN	IGBP1	physical	26496610
MARK3_HUMAN	MARK3	physical	26496610
2AAA_HUMAN	PPP2R1A	physical	26496610
2AAB_HUMAN	PPP2R1B	physical	26496610
2ABA_HUMAN	PPP2R2A	physical	26496610
2A5D_HUMAN	PPP2R5D	physical	26496610
2A5E_HUMAN	PPP2R5E	physical	26496610
PP4C_HUMAN	PPP4C	physical	26496610
SET_HUMAN	SET	physical	26496610
STRN_HUMAN	STRN	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
SLMAP_HUMAN	SLMAP	physical	26496610
CCDC6_HUMAN	CCDC6	physical	26496610
STK24_HUMAN	STK24	physical	26496610
LIPA1_HUMAN	PPFIA1	physical	26496610
LIPA3_HUMAN	PPFIA3	physical	26496610
MAP7_HUMAN	MAP7	physical	26496610
M4K4_HUMAN	MAP4K4	physical	26496610
CE350_HUMAN	CEP350	physical	26496610
PP4R1_HUMAN	PPP4R1	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
FR1OP_HUMAN	FGFR1OP	physical	26496610
PDC10_HUMAN	PDCD10	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
ANKL2_HUMAN	ANKLE2	physical	26496610
PHOCN_HUMAN	MOB4	physical	26496610
DECR2_HUMAN	DECR2	physical	26496610
FGOP2_HUMAN	FGFR1OP2	physical	26496610
INT6_HUMAN	INTS6	physical	26496610
P2R3B_HUMAN	PPP2R3B	physical	26496610
STRN4_HUMAN	STRN4	physical	26496610
PKN3_HUMAN	PKN3	physical	26496610
STRN3_HUMAN	STRN3	physical	26496610
PKHA5_HUMAN	PLEKHA5	physical	26496610
INT11_HUMAN	CPSF3L	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
INT9_HUMAN	INTS9	physical	26496610
CT2NL_HUMAN	CTTNBP2NL	physical	26496610
INT12_HUMAN	INTS12	physical	26496610
P4R3B_HUMAN	SMEK2	physical	26496610
STRP2_HUMAN	STRIP2	physical	26496610
INT2_HUMAN	INTS2	physical	26496610
SIKE1_HUMAN	SIKE1	physical	26496610
STRP1_HUMAN	STRIP1	physical	26496610
INT4_HUMAN	INTS4	physical	26496610
TM41B_HUMAN	TMEM41B	physical	26496610
CCD61_HUMAN	CCDC61	physical	26496610
INT1_HUMAN	INTS1	physical	26496610
ANKL2_HUMAN	ANKLE2	physical	27880917
ARHG2_HUMAN	ARHGEF2	physical	27880917
CAMP3_HUMAN	CAMSAP3	physical	27880917
CCDC6_HUMAN	CCDC6	physical	27880917
ENSA_HUMAN	ENSA	physical	27880917
F122A_HUMAN	FAM122A	physical	27880917
F122B_HUMAN	FAM122B	physical	27880917
FXL16_HUMAN	FBXL16	physical	27880917
HEMH_HUMAN	FECH	physical	27880917
FOXC1_HUMAN	FOXC1	physical	27880917
IGBP1_HUMAN	IGBP1	physical	27880917
RED_HUMAN	IK	physical	27880917
LIPA1_HUMAN	PPFIA1	physical	27880917
LIPA3_HUMAN	PPFIA3	physical	27880917
PPME1_HUMAN	PPME1	physical	27880917
PP2AA_HUMAN	PPP2CA	physical	27880917
2AAA_HUMAN	PPP2R1A	physical	27880917
2ABA_HUMAN	PPP2R2A	physical	27880917
2ABD_HUMAN	PPP2R2D	physical	27880917
P2R3B_HUMAN	PPP2R3B	physical	27880917
PTPA_HUMAN	PPP2R4	physical	27880917
2A5A_HUMAN	PPP2R5A	physical	27880917
2A5G_HUMAN	PPP2R5C	physical	27880917
2A5D_HUMAN	PPP2R5D	physical	27880917
2A5E_HUMAN	PPP2R5E	physical	27880917
PP4C_HUMAN	PPP4C	physical	27880917
PP4R1_HUMAN	PPP4R1	physical	27880917
TBCD4_HUMAN	TBC1D4	physical	27880917
TIPRL_HUMAN	TIPRL	physical	27880917
TTC33_HUMAN	TTC33	physical	27880917
WDR61_HUMAN	WDR61	physical	27880917
TBCC1_HUMAN	TBCCD1	physical	28514442
2A5D_HUMAN	PPP2R5D	physical	28514442
STRP2_HUMAN	STRIP2	physical	28514442
P2R3C_HUMAN	PPP2R3C	physical	28514442
PRR14_HUMAN	PRR14	physical	28514442
2ABD_HUMAN	PPP2R2D	physical	28514442
CE350_HUMAN	CEP350	physical	28514442
P2R3B_HUMAN	PPP2R3B	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
2A5A_HUMAN	PPP2R5A	physical	28514442
PPME1_HUMAN	PPME1	physical	28514442
ANKL2_HUMAN	ANKLE2	physical	28514442
CT2NL_HUMAN	CTTNBP2NL	physical	28514442
LIPA1_HUMAN	PPFIA1	physical	28514442
STRP1_HUMAN	STRIP1	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
STRN_HUMAN	STRN	physical	28514442
STRN4_HUMAN	STRN4	physical	28514442
STRN3_HUMAN	STRN3	physical	28514442
FGOP2_HUMAN	FGFR1OP2	physical	28514442
2A5G_HUMAN	PPP2R5C	physical	28514442
SIKE1_HUMAN	SIKE1	physical	28514442
PP4R1_HUMAN	PPP4R1	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442
CTTB2_HUMAN	CTTNBP2	physical	28514442
CCDC6_HUMAN	CCDC6	physical	28514442
FR1OP_HUMAN	FGFR1OP	physical	28514442
PHOCN_HUMAN	MOB4	physical	28514442
SGO1_HUMAN	SGOL1	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	28514442
HEMH_HUMAN	FECH	physical	28514442
ZN444_HUMAN	ZNF444	physical	28514442
PR14L_HUMAN	PRR14L	physical	28514442
2ABA_HUMAN	PPP2R2A	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00163	Vitamin E

Regulatory Network of PP2AB_HUMAN

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo."; Favre B., Zolnierowicz S., Turowski P., Hemmings B.A.; J. Biol. Chem. 269:16311-16317(1994). Cited for: METHYLATION AT LEU-309.	8206937 [Abstract]