CCD61_HUMAN - dbPTM
CCD61_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCD61_HUMAN
UniProt AC Q9Y6R9
Protein Name Coiled-coil domain-containing protein 61
Gene Name CCDC61
Organism Homo sapiens (Human).
Sequence Length 512
Subcellular Localization
Protein Description
Protein Sequence MDQPAGLQVDYVFRGVEHAVRVMVSGQVLELEVEDRMTADQWRGEFDAGFIEDLTHKTGNFKQFNIFCHMLESALTQSSESVTLDLLTYTDLESLRNRKMGGRPGSLAPRSAQLNSKRYLILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELGRLQGLDGQNTRDTRENEIWHLREQVSRLASEKRELEAQLGRSREEALAGRAARQEAEALRGLVRGLELELRQERGLGHRVAGRRGQDCRRLAKELEEAKASERSLRARLKTLTSELALYKRGRRTPPVQPPPTREDRASSSRERSASRGRGAARSSSRESGRGSRGRGRPARPSPSPTGGRALRFDPTAFVKAKERKQREIQMKQQQRNRLGSGGSGDGPSVSWSRQTQPPAALTGRGDAPNRSRNRSSSVDSFRSRCSSASSCSDLEDFSESLSRGGHRRRGKPPSPTPWSGSNMKSPPVERSHHQKSLANSGGWVPIKEYSSEHQAADMAEIDARLKALQEYMNRLDMRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDQPAGLQ
-------CCCCCCCC		11.0222814378
57UbiquitinationFIEDLTHKTGNFKQF
HHHHHHHCCCCCHHH		53.55-
73PhosphorylationIFCHMLESALTQSSE
HHHHHHHHHHHCCCC		25.3122210691
76PhosphorylationHMLESALTQSSESVT
HHHHHHHHCCCCCEE		26.5622210691
89PhosphorylationVTLDLLTYTDLESLR
EEEEEEEHHCHHHHH		9.75-
94PhosphorylationLTYTDLESLRNRKMG
EEHHCHHHHHCCCCC		39.6722210691
98MethylationDLESLRNRKMGGRPG
CHHHHHCCCCCCCCC		24.73-
99UbiquitinationLESLRNRKMGGRPGS
HHHHHCCCCCCCCCC		45.50-
103MethylationRNRKMGGRPGSLAPR
HCCCCCCCCCCCCCC		27.03-
106PhosphorylationKMGGRPGSLAPRSAQ
CCCCCCCCCCCCCHH		24.8424719451
154O-linked_GlycosylationVLQGIIRSLKEELGR
HHHHHHHHHHHHHHH		33.1330379171
156UbiquitinationQGIIRSLKEELGRLQ
HHHHHHHHHHHHHHC		50.84-
170PhosphorylationQGLDGQNTRDTRENE
CCCCCCCCCCCHHHH		23.2623312004
193 (in isoform 2)Phosphorylation-50.0829507054
196 (in isoform 2)Phosphorylation-29.6229507054
253UbiquitinationQDCRRLAKELEEAKA
HHHHHHHHHHHHHHH		68.38-
261PhosphorylationELEEAKASERSLRAR
HHHHHHHHHHHHHHH		32.6026657352
264PhosphorylationEAKASERSLRARLKT
HHHHHHHHHHHHHHH		20.3926657352
270UbiquitinationRSLRARLKTLTSELA
HHHHHHHHHHHHHHH		35.62-
273PhosphorylationRARLKTLTSELALYK
HHHHHHHHHHHHHHH		25.9528348404
274PhosphorylationARLKTLTSELALYKR
HHHHHHHHHHHHHHC		33.4527251275
279PhosphorylationLTSELALYKRGRRTP
HHHHHHHHHCCCCCC		7.9523917254
285PhosphorylationLYKRGRRTPPVQPPP
HHHCCCCCCCCCCCC		25.6029255136
293PhosphorylationPPVQPPPTREDRASS
CCCCCCCCCCHHHCC		34.3630576142
299PhosphorylationPTREDRASSSRERSA
CCCCHHHCCHHHHHH		38.1529052541
300O-linked_GlycosylationTREDRASSSRERSAS
CCCHHHCCHHHHHHH		57.5130379171
300PhosphorylationTREDRASSSRERSAS
CCCHHHCCHHHHHHH		57.5129052541
301PhosphorylationREDRASSSRERSASR
CCHHHCCHHHHHHHH		27.2929052541
305PhosphorylationASSSRERSASRGRGA
HCCHHHHHHHHCCCC		5.5929052541
307PhosphorylationSSRERSASRGRGAAR
CHHHHHHHHCCCCCC		15.9729052541
314UbiquitinationSRGRGAARSSSRESG
HHCCCCCCCCCCCCC		47.49-
334PhosphorylationRGRPARPSPSPTGGR
CCCCCCCCCCCCCCC		22.4723401153
335PhosphorylationGRPARPSPSPTGGRA
CCCCCCCCCCCCCCC		44.5721406692
336PhosphorylationRPARPSPSPTGGRAL
CCCCCCCCCCCCCCC		32.2723401153
338PhosphorylationARPSPSPTGGRALRF
CCCCCCCCCCCCCCC		36.9229255136
343PhosphorylationSPTGGRALRFDPTAF
CCCCCCCCCCCCHHH		34.0221406692
352AcetylationFDPTAFVKAKERKQR
CCCHHHHHHHHHHHH		24.727408297
352UbiquitinationFDPTAFVKAKERKQR
CCCHHHHHHHHHHHH		24.7232015554
354AcetylationPTAFVKAKERKQREI
CHHHHHHHHHHHHHH		23.067408307
357AcetylationFVKAKERKQREIQMK
HHHHHHHHHHHHHHH		21.807408317
364UbiquitinationKQREIQMKQQQRNRL
HHHHHHHHHHHHHCC		57.1729967540
373PhosphorylationQQRNRLGSGGSGDGP
HHHHCCCCCCCCCCC		8.4722167270
376PhosphorylationNRLGSGGSGDGPSVS
HCCCCCCCCCCCCCC		7.7122167270
381PhosphorylationGGSGDGPSVSWSRQT
CCCCCCCCCCCCCCC		28.0322617229
383PhosphorylationSGDGPSVSWSRQTQP
CCCCCCCCCCCCCCC		6.8123403867
385PhosphorylationDGPSVSWSRQTQPPA
CCCCCCCCCCCCCCC		19.8423403867
388PhosphorylationSVSWSRQTQPPAALT
CCCCCCCCCCCCHHC		59.4124043423
395PhosphorylationTQPPAALTGRGDAPN
CCCCCHHCCCCCCCC		30.3717081983
408PhosphorylationPNRSRNRSSSVDSFR
CCCCCCCCCCHHHHH		57.3227794612
409PhosphorylationNRSRNRSSSVDSFRS
CCCCCCCCCHHHHHH		50.3521406692
410PhosphorylationRSRNRSSSVDSFRSR
CCCCCCCCHHHHHHH		48.5327794612
413PhosphorylationNRSSSVDSFRSRCSS
CCCCCHHHHHHHHCC		20.1527794612
416PhosphorylationSSVDSFRSRCSSASS
CCHHHHHHHHCCCCC		28.38-
420PhosphorylationSFRSRCSSASSCSDL
HHHHHHCCCCCCCCH		24.5421406692
423PhosphorylationSRCSSASSCSDLEDF
HHHCCCCCCCCHHHH		12.39-
425PhosphorylationCSSASSCSDLEDFSE
HCCCCCCCCHHHHHH		41.34-
447PhosphorylationRRRGKPPSPTPWSGS
CCCCCCCCCCCCCCC		33.7923401153
449PhosphorylationRGKPPSPTPWSGSNM
CCCCCCCCCCCCCCC		33.9127794612
452PhosphorylationPPSPTPWSGSNMKSP
CCCCCCCCCCCCCCC		39.5827794612
454PhosphorylationSPTPWSGSNMKSPPV
CCCCCCCCCCCCCCC		15.9027794612
458PhosphorylationWSGSNMKSPPVERSH
CCCCCCCCCCCCCCH		25.1123401153
461UbiquitinationSNMKSPPVERSHHQK
CCCCCCCCCCCHHHH		41.31-
468UbiquitinationVERSHHQKSLANSGG
CCCCHHHHHHHCCCC		40.2232015554
469PhosphorylationERSHHQKSLANSGGW
CCCHHHHHHHCCCCC		18.6128450419
473PhosphorylationHQKSLANSGGWVPIK
HHHHHHCCCCCEEHH		38.5925159151
499UbiquitinationAEIDARLKALQEYMN
HHHHHHHHHHHHHHH		29967540
512PhosphorylationMNRLDMRS-------
HHHHHCCC-------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCD61_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCD61_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCD61_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CCD61_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCD61_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-338, ANDMASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-338, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-338, ANDMASS SPECTROMETRY.

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