| UniProt ID | IGBP1_HUMAN | |
|---|---|---|
| UniProt AC | P78318 | |
| Protein Name | Immunoglobulin-binding protein 1 | |
| Gene Name | IGBP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 339 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.. | |
| Protein Sequence | MAAEDELQLPRLPELFETGRQLLDEVEVATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLDLFSRNEDLEEIASTDLKYLLVPAFQGALTMKQVNPSKRLDHLQRAREHFINYLTQCHCYHVAEFELPKTMNNSAENHTANSSMAYPSLVAMASQRQAKIQRYKQKKELEHRLSAMKSAVESGQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERDSSREASTSNSSRQERPPVKPFILTRNMAQAKVFGAGYPSLPTMTVSDWYEQHRKYGALPDQGIAKAAPEEFRKAAQQQEEQEEKEEEDDEQTLHRAREWDDWKDTHPRGYGNRQNMG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAEDELQL ------CCHHHHCCC | 21.40 | 22814378 | |
| 41 | Acetylation | GSRIVQEKVFKGLDL CCHHHHHHHHHCHHH | 35.56 | 27452117 | |
| 41 | Ubiquitination | GSRIVQEKVFKGLDL CCHHHHHHHHHCHHH | 35.56 | 23000965 | |
| 44 | Ubiquitination | IVQEKVFKGLDLLEK HHHHHHHHCHHHHHH | 62.64 | 23000965 | |
| 55 | Sulfoxidation | LLEKAAEMLSQLDLF HHHHHHHHHHHHCCC | 3.60 | 30846556 | |
| 77 | Ubiquitination | EIASTDLKYLLVPAF HHHHCCHHHHHHHHH | 36.34 | 32015554 | |
| 91 | Ubiquitination | FQGALTMKQVNPSKR HCCCCHHHCCCHHHH | 45.95 | - | |
| 96 | Phosphorylation | TMKQVNPSKRLDHLQ HHHCCCHHHHHHHHH | 25.79 | 24719451 | |
| 129 | Phosphorylation | AEFELPKTMNNSAEN EEECCCCCCCCCCCC | 24.16 | 25278378 | |
| 133 | Phosphorylation | LPKTMNNSAENHTAN CCCCCCCCCCCCCCC | 31.77 | 25278378 | |
| 138 | Phosphorylation | NNSAENHTANSSMAY CCCCCCCCCCCCCHH | 38.83 | 25278378 | |
| 141 | Phosphorylation | AENHTANSSMAYPSL CCCCCCCCCCHHHHH | 21.01 | 25278378 | |
| 142 | Phosphorylation | ENHTANSSMAYPSLV CCCCCCCCCHHHHHH | 13.77 | 21945579 | |
| 145 | Phosphorylation | TANSSMAYPSLVAMA CCCCCCHHHHHHHHH | 5.68 | 21945579 | |
| 147 | Phosphorylation | NSSMAYPSLVAMASQ CCCCHHHHHHHHHHH | 23.85 | 21945579 | |
| 153 | Phosphorylation | PSLVAMASQRQAKIQ HHHHHHHHHHHHHHH | 16.89 | 20068231 | |
| 165 | Ubiquitination | KIQRYKQKKELEHRL HHHHHHHHHHHHHHH | 44.02 | 24816145 | |
| 173 | Phosphorylation | KELEHRLSAMKSAVE HHHHHHHHHHHHHHH | 26.69 | 29514088 | |
| 176 | Ubiquitination | EHRLSAMKSAVESGQ HHHHHHHHHHHHHCC | 34.67 | 21906983 | |
| 177 | Phosphorylation | HRLSAMKSAVESGQA HHHHHHHHHHHHCCC | 25.18 | 22964224 | |
| 181 | Phosphorylation | AMKSAVESGQADDER HHHHHHHHCCCCHHH | 29.61 | - | |
| 184 | Ubiquitination | SAVESGQADDERVRE HHHHHCCCCHHHHHH | 29.73 | 33845483 | |
| 195 | Ubiquitination | RVREYYLLHLQRWID HHHHHHHHHHHHHHC | 1.88 | 32015554 | |
| 224 | Phosphorylation | ILRERDSSREASTSN HHHHHHCCCCCCCCC | 38.13 | 30576142 | |
| 225 | Methylation | LRERDSSREASTSNS HHHHHCCCCCCCCCC | 47.67 | 24379803 | |
| 225 | Dimethylation | LRERDSSREASTSNS HHHHHCCCCCCCCCC | 47.67 | - | |
| 228 | Phosphorylation | RDSSREASTSNSSRQ HHCCCCCCCCCCCCC | 27.84 | 30576142 | |
| 230 | Phosphorylation | SSREASTSNSSRQER CCCCCCCCCCCCCCC | 32.02 | 30576142 | |
| 241 | Ubiquitination | RQERPPVKPFILTRN CCCCCCCCCEEEECC | 39.73 | 23000965 | |
| 241 | Acetylation | RQERPPVKPFILTRN CCCCCCCCCEEEECC | 39.73 | 19608861 | |
| 246 | Phosphorylation | PVKPFILTRNMAQAK CCCCEEEECCCHHHH | 18.38 | 27251275 | |
| 253 | Ubiquitination | TRNMAQAKVFGAGYP ECCCHHHHHHCCCCC | 26.47 | 21906983 | |
| 259 | Phosphorylation | AKVFGAGYPSLPTMT HHHHCCCCCCCCCCC | 6.79 | 27251275 | |
| 261 | Phosphorylation | VFGAGYPSLPTMTVS HHCCCCCCCCCCCHH | 38.20 | 27251275 | |
| 264 | Phosphorylation | AGYPSLPTMTVSDWY CCCCCCCCCCHHHHH | 30.66 | 29978859 | |
| 266 | Phosphorylation | YPSLPTMTVSDWYEQ CCCCCCCCHHHHHHH | 21.24 | 29978859 | |
| 268 | Phosphorylation | SLPTMTVSDWYEQHR CCCCCCHHHHHHHHH | 17.17 | 29978859 | |
| 271 | Phosphorylation | TMTVSDWYEQHRKYG CCCHHHHHHHHHHHC | 15.65 | 28796482 | |
| 276 | Ubiquitination | DWYEQHRKYGALPDQ HHHHHHHHHCCCCCC | 46.00 | 33845483 | |
| 277 | Phosphorylation | WYEQHRKYGALPDQG HHHHHHHHCCCCCCH | 13.95 | 25394399 | |
| 287 | Acetylation | LPDQGIAKAAPEEFR CCCCHHHHHCHHHHH | 43.06 | 25953088 | |
| 287 | Ubiquitination | LPDQGIAKAAPEEFR CCCCHHHHHCHHHHH | 43.06 | 21906983 | |
| 295 | Ubiquitination | AAPEEFRKAAQQQEE HCHHHHHHHHHHHHH | 54.09 | 22817900 | |
| 306 | Ubiquitination | QQEEQEEKEEEDDEQ HHHHHHHHHHHHHHH | 70.45 | 24816145 | |
| 325 | Ubiquitination | AREWDDWKDTHPRGY HHHHHCCCCCCCCCC | 60.80 | 29967540 | |
| 330 | Methylation | DWKDTHPRGYGNRQN CCCCCCCCCCCCCCC | 43.28 | 115480179 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IGBP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IGBP1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 300472 | Mental retardation, X-linked, syndromic, 28 (MRXS28) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-241, AND MASS SPECTROMETRY. | |
