PAIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAIP2_HUMAN
• UniProt AC: Q9BPZ3
• Protein Name: Polyadenylate-binding protein-interacting protein 2
• Gene Name: PAIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 127
• Subcellular Localization: Cytoplasm .
• Protein Description: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization..
• Protein Sequence: MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKYGNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKDPSRSSTSPS ---CCCCCCCCCCCC	55.73	26074081
7	Phosphorylation	-MKDPSRSSTSPSII -CCCCCCCCCCCCCC	42.16	26074081
8	Phosphorylation	MKDPSRSSTSPSIIN CCCCCCCCCCCCCCC	31.62	26074081
9	Phosphorylation	KDPSRSSTSPSIINE CCCCCCCCCCCCCCC	46.00	26074081
10	Phosphorylation	DPSRSSTSPSIINED CCCCCCCCCCCCCCC	20.71	26074081
12	Phosphorylation	SRSSTSPSIINEDVI CCCCCCCCCCCCCEE	35.55	26074081
24	Phosphorylation	DVIINGHSHEDDNPF CEEECCCCCCCCCCH	29.94	27080861
34	Phosphorylation	DDNPFAEYMWMENEE CCCCHHHHCCHHCHH	7.83	27251275
83	Phosphorylation	PARDLPQTMDQIQDQ EHHHCCHHHHHHHHH	22.30	26074081
97	Phosphorylation	QFNDLVISDGSSLED HHHCEEECCCCCHHH	28.56	26074081
100	Phosphorylation	DLVISDGSSLEDLVV CEEECCCCCHHHHHH	36.42	26074081
101	Phosphorylation	LVISDGSSLEDLVVK EEECCCCCHHHHHHH	41.11	26074081
116	Acetylation	SNLNPNAKEFVPGVK CCCCCCHHHCCCCCC	59.32	26051181
116	Ubiquitination	SNLNPNAKEFVPGVK CCCCCCHHHCCCCCC	59.32	21890473
123	Acetylation	KEFVPGVKYGNI--- HHCCCCCCCCCC---	54.04	23749302
123	Ubiquitination	KEFVPGVKYGNI--- HHCCCCCCCCCC---	54.04	21890473
124	Phosphorylation	EFVPGVKYGNI---- HCCCCCCCCCC----	17.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	UBR5	O95071	PMID:16601676

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	11438674
UBR5_HUMAN	UBR5	physical	16601676
PABP1_HUMAN	PABPC1	physical	16804161
A4_HUMAN	APP	physical	21832049
PABP1_HUMAN	PABPC1	physical	23964095
RL11_HUMAN	RPL11	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.