NENF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NENF_HUMAN
• UniProt AC: Q9UMX5
• Protein Name: Neudesin
• Gene Name: NENF {ECO:0000312|HGNC:HGNC:30384}
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Secreted, extracellular space.
• Protein Description: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis. [PubMed: 22748190]
• Protein Sequence: MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPVRLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAKELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	GPPVRLFTEEELARY CCCEEEECHHHHHHH	47.26	-
48	O-linked_Glycosylation	GPPVRLFTEEELARY CCCEEEECHHHHHHH	47.26	110760457
65	Phosphorylation	EEEDQPIYLAVKGVV CCCCCCEEEEEECEE	8.69	-
76	Phosphorylation	KGVVFDVTSGKEFYG ECEEEECCCCCEECC	33.34	-
76	O-linked_Glycosylation	KGVVFDVTSGKEFYG ECEEEECCCCCEECC	33.34	55827247
79	Ubiquitination	VFDVTSGKEFYGRGA EEECCCCCEECCCCC	44.40	22817900
79	2-Hydroxyisobutyrylation	VFDVTSGKEFYGRGA EEECCCCCEECCCCC	44.40	-
82	Phosphorylation	VTSGKEFYGRGAPYN CCCCCEECCCCCCCC	13.65	21406692
84	Methylation	SGKEFYGRGAPYNAL CCCEECCCCCCCCCC	27.07	115484815
88	Phosphorylation	FYGRGAPYNALTGKD ECCCCCCCCCCCCCC	16.72	21406692
92	O-linked_Glycosylation	GAPYNALTGKDSTRG CCCCCCCCCCCCCCC	39.51	55827273
92	Phosphorylation	GAPYNALTGKDSTRG CCCCCCCCCCCCCCC	39.51	20068231
96	Phosphorylation	NALTGKDSTRGVAKM CCCCCCCCCCCEEEE	24.40	21406692
96	O-linked_Glycosylation	NALTGKDSTRGVAKM CCCCCCCCCCCEEEE	24.40	10404351
97	Phosphorylation	ALTGKDSTRGVAKMS CCCCCCCCCCEEEEE	41.39	21406692
103	Sulfoxidation	STRGVAKMSLDPADL CCCCEEEEECCHHHC	3.29	21406390
111	Phosphorylation	SLDPADLTHDTTGLT ECCHHHCCCCCCCCC	20.46	-
136	Acetylation	FTKVYKAKYPIVGYT HHHHHHCCCCCCCEE	47.62	19608861
143	O-linked_Glycosylation	KYPIVGYTARRILNE CCCCCCEEHHHHHCC	14.04	55834823

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NENF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NENF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NENF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDIA4_HUMAN	PDIA4	physical	22939629
PERI_HUMAN	PRPH	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM49_HUMAN	MRPL49	physical	22939629
SYSM_HUMAN	SARS2	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
SPT5H_HUMAN	SUPT5H	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
SND1_HUMAN	SND1	physical	22939629
PPT2_HUMAN	PPT2	physical	22939629
SSRD_HUMAN	SSR4	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
TXND5_HUMAN	TXNDC5	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
SPTB2_HUMAN	SPTBN1	physical	22939629
QCR6_HUMAN	UQCRH	physical	22939629
PLAK_HUMAN	JUP	physical	22939629
CAVN3_HUMAN	PRKCDBP	physical	22939629
RL32_HUMAN	RPL32	physical	22939629
PTBP3_HUMAN	PTBP3	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
SPTN1_HUMAN	SPTAN1	physical	22939629
PDIA5_HUMAN	PDIA5	physical	26186194
SELM_HUMAN	SELM	physical	26186194
BLVRB_HUMAN	BLVRB	physical	26186194
PNCB_HUMAN	NAPRT	physical	26344197
SELM_HUMAN	SELM	physical	28514442
BLVRB_HUMAN	BLVRB	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-136, AND MASS SPECTROMETRY.
PubMed: 19608861