PERI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PERI_HUMAN
• UniProt AC: P41219
• Protein Name: Peripherin
• Gene Name: PRPH
• Organism: Homo sapiens (Human).
• Sequence Length: 470
• Protein Description: Class-III neuronal intermediate filament protein..
• Protein Sequence: MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSELDKSSAHSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSHHPSGLRAGFS --CCCCCCCCCCCCC	46.21	27732954
13	Phosphorylation	SGLRAGFSSTSYRRT CCCCCCCCCCCCCCC	31.61	27732954
14	Phosphorylation	GLRAGFSSTSYRRTF CCCCCCCCCCCCCCC	21.07	27732954
15	Phosphorylation	LRAGFSSTSYRRTFG CCCCCCCCCCCCCCC	28.69	27732954
16	Phosphorylation	RAGFSSTSYRRTFGP CCCCCCCCCCCCCCC	20.70	27732954
17	Nitrated tyrosine	AGFSSTSYRRTFGPP CCCCCCCCCCCCCCC	12.28	-
17	Phosphorylation	AGFSSTSYRRTFGPP CCCCCCCCCCCCCCC	12.28	27732954
17	Nitration	AGFSSTSYRRTFGPP CCCCCCCCCCCCCCC	12.28	-
26	Phosphorylation	RTFGPPPSLSPGAFS CCCCCCCCCCCCCCC	47.45	27732954
28	Phosphorylation	FGPPPSLSPGAFSYS CCCCCCCCCCCCCCC	26.14	26657352
33	Phosphorylation	SLSPGAFSYSSSSRF CCCCCCCCCCCCCCC	24.46	27732954
34	Phosphorylation	LSPGAFSYSSSSRFS CCCCCCCCCCCCCCC	13.20	27732954
35	Phosphorylation	SPGAFSYSSSSRFSS CCCCCCCCCCCCCCC	23.65	27732954
36	Phosphorylation	PGAFSYSSSSRFSSS CCCCCCCCCCCCCCC	24.89	27732954
37	Phosphorylation	GAFSYSSSSRFSSSR CCCCCCCCCCCCCCC	21.42	27732954
38	Phosphorylation	AFSYSSSSRFSSSRL CCCCCCCCCCCCCCC	39.01	27732954
41	Phosphorylation	YSSSSRFSSSRLLGS CCCCCCCCCCCCCCC	26.71	-
43	Phosphorylation	SSSRFSSSRLLGSAS CCCCCCCCCCCCCCC	26.25	-
48	Phosphorylation	SSSRLLGSASPSSSV CCCCCCCCCCCCCCC	26.08	21406692
50	Phosphorylation	SRLLGSASPSSSVRL CCCCCCCCCCCCCCC	27.32	21406692
52	Phosphorylation	LLGSASPSSSVRLGS CCCCCCCCCCCCCCC	32.52	21406692
53	Phosphorylation	LGSASPSSSVRLGSF CCCCCCCCCCCCCCC	35.92	21406692
53 (in isoform 2)	Phosphorylation	-	35.92	21406692
54	Phosphorylation	GSASPSSSVRLGSFR CCCCCCCCCCCCCCC	18.65	21406692
59	Phosphorylation	SSSVRLGSFRSPRAG CCCCCCCCCCCCCCC	23.29	24670416
62	Phosphorylation	VRLGSFRSPRAGAGA CCCCCCCCCCCCCCH	19.41	24670416
75	Phosphorylation	GALLRLPSERLDFSM CHHCCCCHHHCCCHH	39.68	25884760
81	Phosphorylation	PSERLDFSMAEALNQ CHHHCCCHHHHHHCH	19.42	27732954
93	O-linked_Glycosylation	LNQEFLATRSNEKQE HCHHHHHCCCCHHHH	36.46	29351928
98	"N6,N6-dimethyllysine"	LATRSNEKQELQELN HHCCCCHHHHHHHHH	54.01	-
98	Methylation	LATRSNEKQELQELN HHCCCCHHHHHHHHH	54.01	23644510
114	Succinylation	RFANFIEKVRFLEQQ HHHHHHHHHHHHHHH	33.62	-
114	Acetylation	RFANFIEKVRFLEQQ HHHHHHHHHHHHHHH	33.62	-
187	Phosphorylation	KQRLEEETRKREDAE HHHHHHHHHHHHHHC	44.78	28060719
217	Acetylation	SRLELERKIESLMDE HHHHHHHHHHHHHHH	41.26	-
220	Phosphorylation	ELERKIESLMDEIEF HHHHHHHHHHHHHHH	32.25	27732954
229	Acetylation	MDEIEFLKKLHEEEL HHHHHHHHHHCHHHH	59.62	19608861
287	Phosphorylation	LQEAEEWYKSKYADL HHHHHHHHHHHCCCH	14.52	25884760
288 (in isoform 2)	Ubiquitination	-	41.36	21906983
288 (in isoform 1)	Ubiquitination	-	41.36	21906983
288	Ubiquitination	QEAEEWYKSKYADLS HHHHHHHHHHCCCHH	41.36	21890473
288	Acetylation	QEAEEWYKSKYADLS HHHHHHHHHHCCCHH	41.36	22631355
289	Phosphorylation	EAEEWYKSKYADLSD HHHHHHHHHCCCHHH	18.40	28857561
290	Ubiquitination	AEEWYKSKYADLSDA HHHHHHHHCCCHHHH	40.06	-
290	Succinylation	AEEWYKSKYADLSDA HHHHHHHHCCCHHHH	40.06	-
290	Acetylation	AEEWYKSKYADLSDA HHHHHHHHCCCHHHH	40.06	-
295	Phosphorylation	KSKYADLSDAANRNH HHHCCCHHHHHHHHH	26.25	-
321	Phosphorylation	ESRRQIQSLTCEVDG HHHHHHHHHHHHHCC	27.55	-
369	Acetylation	EEELRQLKEEMARHL HHHHHHHHHHHHHHH	43.20	-
379	Nitration	MARHLREYQELLNVK HHHHHHHHHHHHCHH	10.80	-
379	Nitrated tyrosine	MARHLREYQELLNVK HHHHHHHHHHHHCHH	10.80	-
387	Sulfoxidation	QELLNVKMALDIEIA HHHHCHHHHHHHHHH	3.79	28183972
396	Phosphorylation	LDIEIATYRKLLEGE HHHHHHHHHHHHCCC	9.20	18083107
398 (in isoform 1)	Ubiquitination	-	47.19	21906983
398 (in isoform 2)	Ubiquitination	-	47.19	21906983
398	Acetylation	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	8664467
398	Sumoylation	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	-
398	Ubiquitination	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	2190698
398	Sumoylation	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	-
405	Phosphorylation	KLLEGEESRISVPVH HHHCCCCCCCCCCHH	30.52	21815630
408	Phosphorylation	EGEESRISVPVHSFA CCCCCCCCCCHHHEE	21.18	23312004
413	Phosphorylation	RISVPVHSFASLNIK CCCCCHHHEEECCCC	23.81	23403867
416	Phosphorylation	VPVHSFASLNIKTTV CCHHHEEECCCCCCC	21.68	27732954
421	Phosphorylation	FASLNIKTTVPEVEP EEECCCCCCCCCCCC	29.27	27732954
422	Phosphorylation	ASLNIKTTVPEVEPP EECCCCCCCCCCCCC	29.12	27732954
432	Phosphorylation	EVEPPQDSHSRKTVL CCCCCCCCCCCCEEE	20.36	27732954
434	Phosphorylation	EPPQDSHSRKTVLIK CCCCCCCCCCEEEEE	39.15	27732954
441	Acetylation	SRKTVLIKTIETRNG CCCEEEEEEEECCCC	39.01	-
441	Succinylation	SRKTVLIKTIETRNG CCCEEEEEEEECCCC	39.01	-
442	Phosphorylation	RKTVLIKTIETRNGE CCEEEEEEEECCCCE	19.63	22817900
465	Phosphorylation	QRSELDKSSAHSY-- HHHHHCCHHCCCC--	32.21	27732954
466	Phosphorylation	RSELDKSSAHSY--- HHHHCCHHCCCC---	35.42	27732954
469	Phosphorylation	LDKSSAHSY------ HCCHHCCCC------	32.05	27732954
470	Phosphorylation	DKSSAHSY------- CCHHCCCC-------	16.83	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PERI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PERI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PERI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	23718855

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.