SYSM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYSM_HUMAN
• UniProt AC: Q9NP81
• Protein Name: Serine--tRNA ligase, mitochondrial
• Gene Name: SARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)..
• Protein Sequence: MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDIERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRALLANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVGDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASMARRLWP ----CHHHHHHHHHH	11.93	28509920
14	Phosphorylation	RRLWPLLTRRGFRPR HHHHHHHHCCCCCCC	26.46	28509920
52	Phosphorylation	YEYAREGYSALPQLD HHHHHHCCCCCCCCC	5.99	28152594
53	Phosphorylation	EYAREGYSALPQLDI HHHHHCCCCCCCCCH	33.90	28152594
110	Acetylation	IRSLEEEKAAVTEAV HHHHHHHHHHHHHHH	44.95	23954790
110	Succinylation	IRSLEEEKAAVTEAV HHHHHHHHHHHHHHH	44.95	23954790
110	Malonylation	IRSLEEEKAAVTEAV HHHHHHHHHHHHHHH	44.95	26320211
126	Phosphorylation	ALLANQDSGEVQQDP HHHHCCCCCCCCCCC	27.39	29507054
134	Acetylation	GEVQQDPKYQGLRAR CCCCCCCCHHHHHHH	59.50	23236377
134	Ubiquitination	GEVQQDPKYQGLRAR CCCCCCCCHHHHHHH	59.50	29967540
134	2-Hydroxyisobutyrylation	GEVQQDPKYQGLRAR CCCCCCCCHHHHHHH	59.50	-
135	Phosphorylation	EVQQDPKYQGLRARG CCCCCCCHHHHHHHH	17.13	29083192
147	Malonylation	ARGREIRKELVHLYP HHHHHHHHHHHHHCC	62.15	26320211
184	O-linked_Glycosylation	DVPVGDESQARVLHM CCCCCCHHHHEEEEE	33.60	23301498
195	Acetylation	VLHMVGDKPVFSFQP EEEEECCCCCEEECC	36.83	25953088
195	Malonylation	VLHMVGDKPVFSFQP EEEEECCCCCEEECC	36.83	26320211
195	Succinylation	VLHMVGDKPVFSFQP EEEEECCCCCEEECC	36.83	-
195	Ubiquitination	VLHMVGDKPVFSFQP EEEEECCCCCEEECC	36.83	21890473
195	Succinylation	VLHMVGDKPVFSFQP EEEEECCCCCEEECC	36.83	-
197	Ubiquitination	HMVGDKPVFSFQPRG EEECCCCCEEECCCC	8.48	21890473
197	Ubiquitination	HMVGDKPVFSFQPRG EEECCCCCEEECCCC	8.48	21890473
211	Malonylation	GHLEIGEKLDIIRQK CCCCHHHHHHHHHHH	46.37	26320211
211	Acetylation	GHLEIGEKLDIIRQK CCCCHHHHHHHHHHH	46.37	25953088
221	Phosphorylation	IIRQKRLSHVSGHRS HHHHHCHHCCCCCHH	26.35	23312004
224	Phosphorylation	QKRLSHVSGHRSYYL HHCHHCCCCCHHHCH	24.37	23312004
256	Phosphorylation	KLLRRGFTPMTVPDL HHHHCCCCCCCHHHH	18.25	21406692
259	Phosphorylation	RRGFTPMTVPDLLRG HCCCCCCCHHHHHCC	30.04	21406692
325	Phosphorylation	LPVRMVCSSTCYRAE CCCEEEEECEEEEEE	19.78	25219547
326	Phosphorylation	PVRMVCSSTCYRAET CCEEEEECEEEEEEC	19.85	25219547
327	Phosphorylation	VRMVCSSTCYRAETN CEEEEECEEEEEECC	9.39	25219547
329	Phosphorylation	MVCSSTCYRAETNTG EEEECEEEEEECCCC	16.97	25219547
343	Phosphorylation	GQEPRGLYRVHHFTK CCCCCCEEEEEEEEE	17.26	-
401	Phosphorylation	QELGLPAYRKFDIEA HHCCCCCHHCCCEEE	16.64	30576142
500	Phosphorylation	PTHVPLQYIGPNQPR CCCCCCCCCCCCCCC	18.61	-
518	Phosphorylation	LPGQPAVS------- CCCCCCCC-------	36.29	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYSM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYSM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYSM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYHM_HUMAN	HARS2	physical	26344197
SBDS_HUMAN	SBDS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613845: Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome (HUPRAS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-110, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-52, AND MASSSPECTROMETRY.
PubMed: 18083107