CAVN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAVN3_HUMAN
• UniProt AC: Q969G5
• Protein Name: Caveolae-associated protein 3 {ECO:0000312|HGNC:HGNC:9400}
• Gene Name: CAVIN3 {ECO:0000312|HGNC:HGNC:9400}
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm . Membrane, caveola . Cytoplasm, cytosol . Localizes in the caveolae in a caveolin-dependent manner.
• Protein Description: Regulates the traffic and/or budding of caveolae. [PubMed: 19262564 Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity]
• Protein Sequence: MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRESALERGPV ----CCHHHHHCCCC		17081983
31	Ubiquitination	TVVTLLEKLASMLET HHHHHHHHHHHHHHH		-
34	Phosphorylation	TLLEKLASMLETLRE HHHHHHHHHHHHHHH		21406692
35	Sulfoxidation	LLEKLASMLETLRER HHHHHHHHHHHHHHH		30846556
38	Phosphorylation	KLASMLETLRERQGG HHHHHHHHHHHHHCH		21406692
56	Phosphorylation	RQGGLAGSVRRIQSG HHCCCHHHHHHHHHH		28102081
62	Phosphorylation	GSVRRIQSGLGALSR HHHHHHHHHHCHHHC		28355574
68	Phosphorylation	QSGLGALSRSHDTTS HHHHCHHHCCCCCCH		21406692
70	Phosphorylation	GLGALSRSHDTTSNT HHCHHHCCCCCCHHH		28857561
73	Phosphorylation	ALSRSHDTTSNTLAQ HHHCCCCCCHHHHHH		23186163
74	Phosphorylation	LSRSHDTTSNTLAQL HHCCCCCCHHHHHHH		21712546
75	Phosphorylation	SRSHDTTSNTLAQLL HCCCCCCHHHHHHHH		23186163
84	Ubiquitination	TLAQLLAKAERVSSH HHHHHHHHHHHHHHH		21906983
121	Acetylation	GLLVARGKLHVLLFK CEEEECCEEEEEEEE		26051181
121	Malonylation	GLLVARGKLHVLLFK CEEEECCEEEEEEEE		26320211
128	Sumoylation	KLHVLLFKEEGEVPA EEEEEEEECCCCCCH		28112733
136	Phosphorylation	EEGEVPASAFQKAPE CCCCCCHHHHHCCCC		-
151	Phosphorylation	PLGPADQSELGPEQL CCCCCCHHHHCHHHH		23927012
165	Phosphorylation	LEAEVGESSDEEPVE HHHHCCCCCCCCCHH		29255136
166	Phosphorylation	EAEVGESSDEEPVES HHHCCCCCCCCCHHH		29255136
173	Phosphorylation	SDEEPVESRAQRLRR CCCCCHHHHHHHHHH		23927012
185	Ubiquitination	LRRTGLQKVQSLRRA HHHHHHHHHHHHHHH		21906983
188	Phosphorylation	TGLQKVQSLRRALSG HHHHHHHHHHHHHCC		20068231
194	Phosphorylation	QSLRRALSGRKGPAA HHHHHHHCCCCCCCC		26699800
197	Ubiquitination	RRALSGRKGPAAPPP HHHHCCCCCCCCCCC		29967540
205	Phosphorylation	GPAAPPPTPVKPPRL CCCCCCCCCCCCCCC		29255136
208	Ubiquitination	APPPTPVKPPRLGPG CCCCCCCCCCCCCCC		29967540
217	Phosphorylation	PRLGPGRSAEAQPEA CCCCCCCCCCCCCCC		28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAVN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAVN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAVN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPTN1_HUMAN	SPTAN1	physical	22939629
RL21_HUMAN	RPL21	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
SYSM_HUMAN	SARS2	physical	22939629
SFXN1_HUMAN	SFXN1	physical	22939629
TCPB_HUMAN	CCT2	physical	22939629
RM49_HUMAN	MRPL49	physical	22939629
PTBP3_HUMAN	PTBP3	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
PYC_HUMAN	PC	physical	22939629
SSRD_HUMAN	SSR4	physical	22939629
SPTB2_HUMAN	SPTBN1	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
MR1L1_HUMAN	MRFAP1L1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.