dbPTM

PALLD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PALLD_HUMAN
UniProt AC	Q8WX93
Protein Name	Palladin
Gene Name	PALLD
Organism	Homo sapiens (Human).
Sequence Length	1383
Subcellular Localization	Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, ruffle . Cell projection, podosome . Cell projection, lamellipodium . Cell projection, axon . Cell projection, growth cone . Localize
Protein Description	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci..
Protein Sequence	MSGTSSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFKAAKPRNRSPNGESSSPDSGYLSPKNQPSALLSASASQSPMEDQGEMEREVKSPGARHCYQDNQDLAVPHNRKSHPQPHSALHFPAAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNNDHFQHFPPPPPILETSSLELASKKPSEIQQVNNPELGLSRAALQMQFNAAERETNGVHPSRGVNGLINGKANSNKSLPTPAVLLSPTKEPPPLLAKPKLDPLKLQQLQNQIRLEQEAGARQPPPAPRSAPPSPPFPPPPAFPELAACTPPASPEPMSALASRSAPAMQSSGSFNYARPKQFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPRQFGRAPVPPFAQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAAFPVPDVFPLPPPPPPLPSPGQASHCSSPATRFGHSQTPAAFLSALLPSQPPPAAVNALGLPKGVTPAGFPKKASRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQEYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVESEDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGTSSHES ------CCCCCCHHH	63.18	27732954
4	Phosphorylation	----MSGTSSHESFY ----CCCCCCHHHHH	36.03	27732954
5	Phosphorylation	---MSGTSSHESFYD ---CCCCCCHHHHHH	32.97	23401153
6	Phosphorylation	--MSGTSSHESFYDS --CCCCCCHHHHHHH	30.98	27732954
8 (in isoform 4)	Phosphorylation	-	44.48	27251275
9	Phosphorylation	SGTSSHESFYDSLSD CCCCCHHHHHHHHHH	24.55	27732954
11	Phosphorylation	TSSHESFYDSLSDMQ CCCHHHHHHHHHHHH	17.57	27732954
13	Phosphorylation	SHESFYDSLSDMQEE CHHHHHHHHHHHHHH	20.56	27732954
14 (in isoform 4)	Phosphorylation	-	4.62	24719451
15	Phosphorylation	ESFYDSLSDMQEESK HHHHHHHHHHHHHHC	34.68	27732954
15 (in isoform 4)	Phosphorylation	-	34.68	27251275
17 (in isoform 4)	Phosphorylation	-	4.92	27251275
21	Phosphorylation	LSDMQEESKNTDFFP HHHHHHHHCCCCCCC	30.38	27732954
24	Phosphorylation	MQEESKNTDFFPGLS HHHHHCCCCCCCHHH	37.61	24043423
31	Phosphorylation	TDFFPGLSAFLSQEE CCCCCHHHHHCCHHH	23.92	29523821
35	Phosphorylation	PGLSAFLSQEEINKS CHHHHHCCHHHHHHH	29.14	27050516
36 (in isoform 4)	Phosphorylation	-	55.26	27251275
40 (in isoform 4)	Phosphorylation	-	31.01	27251275
43 (in isoform 4)	Phosphorylation	-	7.17	24719451
44 (in isoform 4)	Phosphorylation	-	45.43	24719451
47 (in isoform 4)	Phosphorylation	-	35.54	27251275
48 (in isoform 4)	Phosphorylation	-	25.41	27251275
52 (in isoform 4)	Phosphorylation	-	40.67	24719451
53	Phosphorylation	ARRAIADSETEDFDS HHHHHHCCCCCCCCC	37.08	20363803
55	Phosphorylation	RAIADSETEDFDSEK HHHHCCCCCCCCCHH	44.82	20363803
55 (in isoform 4)	Phosphorylation	-	44.82	24719451
60	Phosphorylation	SETEDFDSEKEISQI CCCCCCCCHHHHHHH	51.03	23322592
71	Phosphorylation	ISQIFSTSPASLCEH HHHHHHCCHHHHCCC	19.78	28985074
99	Phosphorylation	RRPQDNRSTPVQPLA CCCCCCCCCCCHHHC	43.23	24719451
99 (in isoform 2)	Phosphorylation	-	43.23	24719451
100	Phosphorylation	RPQDNRSTPVQPLAE CCCCCCCCCCHHHCH	25.00	26437602
110	Phosphorylation	QPLAEKQTKSISSPV HHHCHHHCCCCCCCH	37.51	24719451
110 (in isoform 2)	Phosphorylation	-	37.51	24719451
112	Phosphorylation	LAEKQTKSISSPVSK HCHHHCCCCCCCHHH	30.96	22496350
112 (in isoform 2)	Phosphorylation	-	30.96	-
114	Phosphorylation	EKQTKSISSPVSKRK HHHCCCCCCCHHHCC	35.36	30266825
114 (in isoform 2)	Phosphorylation	-	35.36	24719451
115	Phosphorylation	KQTKSISSPVSKRKP HHCCCCCCCHHHCCC	27.87	30266825
115 (in isoform 2)	Phosphorylation	-	27.87	-
118	Phosphorylation	KSISSPVSKRKPAMS CCCCCCHHHCCCCCC	30.08	30266825
118 (in isoform 2)	Phosphorylation	-	30.08	24719451
125	Phosphorylation	SKRKPAMSPLLTRPS HHCCCCCCHHHCCHH	17.95	28152594
125 (in isoform 2)	Phosphorylation	-	17.95	-
129	Phosphorylation	PAMSPLLTRPSYIRS CCCCHHHCCHHHHHH	48.49	27174698
132	Phosphorylation	SPLLTRPSYIRSLRK CHHHCCHHHHHHHHH	29.87	28152594
132 (in isoform 2)	Phosphorylation	-	29.87	-
133	Phosphorylation	PLLTRPSYIRSLRKA HHHCCHHHHHHHHHH	11.75	20068231
136	Phosphorylation	TRPSYIRSLRKAEKR CCHHHHHHHHHHHHC	23.98	20068231
136 (in isoform 2)	Phosphorylation	-	23.98	-
147	Phosphorylation	AEKRGAKTPSTNVKP HHHCCCCCCCCCCCC	23.18	26657352
166	Phosphorylation	QRKGGPQSQLCDKAA CCCCCCHHHHHHHHH	28.40	29083192
166 (in isoform 4)	Phosphorylation	-	28.40	24719451
180	Phosphorylation	ANLIEELTSIFKAAK HHHHHHHHHHHHHCC	24.05	29083192
181	Phosphorylation	NLIEELTSIFKAAKP HHHHHHHHHHHHCCC	38.36	24719451
182 (in isoform 4)	Phosphorylation	-	3.28	24719451
190 (in isoform 4)	Ubiquitination	-	58.26	21906983
192	Phosphorylation	AAKPRNRSPNGESSS HCCCCCCCCCCCCCC	26.68	28387310
197	Phosphorylation	NRSPNGESSSPDSGY CCCCCCCCCCCCCCC	37.20	20860994
198	Phosphorylation	RSPNGESSSPDSGYL CCCCCCCCCCCCCCC	41.40	20860994
199	Phosphorylation	SPNGESSSPDSGYLS CCCCCCCCCCCCCCC	41.84	20860994
202	Phosphorylation	GESSSPDSGYLSPKN CCCCCCCCCCCCCCC	32.49	20860994
204	Phosphorylation	SSSPDSGYLSPKNQP CCCCCCCCCCCCCCC	14.14	20860994
206	Phosphorylation	SPDSGYLSPKNQPSA CCCCCCCCCCCCCCH	25.91	20860994
222	Phosphorylation	LSASASQSPMEDQGE HHCCCCCCCCCCCCC	24.58	28985074
230 (in isoform 4)	Phosphorylation	-	8.22	24719451
236	Phosphorylation	EMEREVKSPGARHCY CHHHHCCCCCCCHHC	33.47	28985074
259 (in isoform 4)	Phosphorylation	-	57.39	24719451
259 (in isoform 8)	Phosphorylation	-	57.39	24719451
287 (in isoform 8)	Phosphorylation	-	31.77	25056879
356	Phosphorylation	PSGSDTTSAEVFIEG CCCCCCCEEEEEEEC	25.23	-
390	Phosphorylation	MPQAQKKTTSVSLTI CCCCCCCEEEEEEEE	31.19	24732914
390 (in isoform 4)	Phosphorylation	-	31.19	24719451
391	Phosphorylation	PQAQKKTTSVSLTIG CCCCCCEEEEEEEEC	35.69	24732914
392	O-linked_Glycosylation	QAQKKTTSVSLTIGS CCCCCEEEEEEEECC	18.23	23301498
392	Phosphorylation	QAQKKTTSVSLTIGS CCCCCEEEEEEEECC	18.23	28152594
393 (in isoform 4)	Phosphorylation	-	5.23	24719451
394	Phosphorylation	QKKTTSVSLTIGSSS CCCEEEEEEEECCCC	21.40	28152594
396	Phosphorylation	KTTSVSLTIGSSSPK CEEEEEEEECCCCCC	18.78	28152594
399	Phosphorylation	SVSLTIGSSSPKTGV EEEEEECCCCCCCCC	24.64	30266825
400	Phosphorylation	VSLTIGSSSPKTGVT EEEEECCCCCCCCCE	45.51	30266825
401	Phosphorylation	SLTIGSSSPKTGVTT EEEECCCCCCCCCEE	31.92	30266825
401 (in isoform 2)	Phosphorylation	-	31.92	-
401 (in isoform 9)	Phosphorylation	-	31.92	27251275
405 (in isoform 4)	Phosphorylation	-	22.39	24719451
407 (in isoform 4)	Phosphorylation	-	15.47	24719451
410 (in isoform 4)	Phosphorylation	-	3.82	24719451
415	Phosphorylation	TAVIQPLSVPVQQVH EEEEEECCCCCEECC	30.93	22210691
423	Phosphorylation	VPVQQVHSPTSYLCR CCCEECCCCCCEEEC	30.89	26657352
423 (in isoform 2)	Phosphorylation	-	30.89	-
423 (in isoform 9)	Phosphorylation	-	30.89	27251275
425	Phosphorylation	VQQVHSPTSYLCRPD CEECCCCCCEEECCC	32.77	23898821
452 (in isoform 4)	Phosphorylation	-	4.72	24719451
468 (in isoform 4)	Phosphorylation	-	32.72	24719451
479	Phosphorylation	VQWFRQGSEIQDSPD EEEEECCCCCCCCCC	24.16	26133373
479 (in isoform 9)	Phosphorylation	-	24.16	27251275
484	Phosphorylation	QGSEIQDSPDFRILQ CCCCCCCCCCCCCCC	15.25	21815630
519 (in isoform 3)	Ubiquitination	-	5.73	21906983
582	Phosphorylation	ELASKKPSEIQQVNN HHHCCCCHHHCCCCC	57.10	20068231
595	Phosphorylation	NNPELGLSRAALQMQ CCHHHCHHHHHHHHH	20.34	20068231
615 (in isoform 4)	Phosphorylation	-	24.26	24719451
632	Phosphorylation	GKANSNKSLPTPAVL CCCCCCCCCCCCEEE	43.78	25159151
635	Phosphorylation	NSNKSLPTPAVLLSP CCCCCCCCCEEEECC	29.22	30183078
635 (in isoform 9)	Phosphorylation	-	29.22	27251275
641	Phosphorylation	PTPAVLLSPTKEPPP CCCEEEECCCCCCCC	26.77	22167270
641 (in isoform 2)	Phosphorylation	-	26.77	-
641 (in isoform 4)	Phosphorylation	-	26.77	24719451
641 (in isoform 9)	Phosphorylation	-	26.77	27251275
643	Phosphorylation	PAVLLSPTKEPPPLL CEEEECCCCCCCCCC	44.67	22167270
643 (in isoform 2)	Phosphorylation	-	44.67	-
659	Acetylation	KPKLDPLKLQQLQNQ CCCCCHHHHHHHHHH	50.03	26051181
659	Ubiquitination	KPKLDPLKLQQLQNQ CCCCCHHHHHHHHHH	50.03	-
669	Phosphorylation	QLQNQIRLEQEAGAR HHHHHHHHHHHHCCC	9.47	19664994
669 (in isoform 2)	Phosphorylation	-	9.47	25056879
669 (in isoform 5)	Phosphorylation	-	9.47	25056879
669 (in isoform 9)	Phosphorylation	-	9.47	25056879
676	Phosphorylation	LEQEAGARQPPPAPR HHHHHCCCCCCCCCC	48.93	18452278
676 (in isoform 2)	Phosphorylation	-	48.93	-
677 (in isoform 2)	Ubiquitination	-	55.08	21906983
677 (in isoform 5)	Ubiquitination	-	55.08	21906983
684	Phosphorylation	QPPPAPRSAPPSPPF CCCCCCCCCCCCCCC	44.03	30278072
688	Phosphorylation	APRSAPPSPPFPPPP CCCCCCCCCCCCCCC	44.11	30278072
704	Phosphorylation	FPELAACTPPASPEP CHHHHCCCCCCCCCC	27.81	26657352
708	Phosphorylation	AACTPPASPEPMSAL HCCCCCCCCCCHHHH	35.25	29116813
713	Phosphorylation	PASPEPMSALASRSA CCCCCCHHHHHHCCC	30.74	20068231
717	Phosphorylation	EPMSALASRSAPAMQ CCHHHHHHCCCCCHH	27.84	20068231
717 (in isoform 2)	Phosphorylation	-	27.84	27251275
719	Phosphorylation	MSALASRSAPAMQSS HHHHHHCCCCCHHCC	35.79	21945579
720 (in isoform 8)	Phosphorylation	-	8.51	27251275
721 (in isoform 8)	Phosphorylation	-	29.52	27251275
725	Phosphorylation	RSAPAMQSSGSFNYA CCCCCHHCCCCCCCC	24.47	21945579
726	Phosphorylation	SAPAMQSSGSFNYAR CCCCHHCCCCCCCCC	22.89	21945579
727 (in isoform 8)	Phosphorylation	-	41.31	27251275
728	Phosphorylation	PAMQSSGSFNYARPK CCHHCCCCCCCCCHH	16.56	21945579
730 (in isoform 2)	Phosphorylation	-	31.11	-
731	Phosphorylation	QSSGSFNYARPKQFI HCCCCCCCCCHHHEE	11.28	21945579
735 (in isoform 2)	Phosphorylation	-	52.89	-
746 (in isoform 8)	Phosphorylation	-	26.75	27251275
747	Phosphorylation	AQNLGPASGHGTPAS EECCCCCCCCCCCCC	34.16	23927012
751	Phosphorylation	GPASGHGTPASSPSS CCCCCCCCCCCCCCC	15.26	23927012
754	Phosphorylation	SGHGTPASSPSSSSL CCCCCCCCCCCCCCC	43.94	23927012
755	Phosphorylation	GHGTPASSPSSSSLP CCCCCCCCCCCCCCC	30.79	23927012
755 (in isoform 2)	Phosphorylation	-	30.79	-
757	Phosphorylation	GTPASSPSSSSLPSP CCCCCCCCCCCCCCC	44.81	23927012
758	Phosphorylation	TPASSPSSSSLPSPM CCCCCCCCCCCCCCC	27.59	23927012
759	Phosphorylation	PASSPSSSSLPSPMS CCCCCCCCCCCCCCC	39.99	23927012
760	Phosphorylation	ASSPSSSSLPSPMSP CCCCCCCCCCCCCCC	46.37	23927012
760 (in isoform 2)	Phosphorylation	-	46.37	-
763	Phosphorylation	PSSSSLPSPMSPTPR CCCCCCCCCCCCCHH	38.23	23927012
763 (in isoform 8)	Phosphorylation	-	38.23	27251275
763 (in isoform 9)	Phosphorylation	-	38.23	27251275
766	Phosphorylation	SSLPSPMSPTPRQFG CCCCCCCCCCHHHCC	29.07	23927012
766 (in isoform 2)	Phosphorylation	-	29.07	-
768	Phosphorylation	LPSPMSPTPRQFGRA CCCCCCCCHHHCCCC	24.64	23927012
770	Methylation	SPMSPTPRQFGRAPV CCCCCCHHHCCCCCC	47.11	115486391
772	Phosphorylation	MSPTPRQFGRAPVPP CCCCHHHCCCCCCCC	8.26	17081983
772 (in isoform 9)	Phosphorylation	-	8.26	27251275
774 (in isoform 8)	Phosphorylation	-	36.69	27251275
777	Phosphorylation	RQFGRAPVPPFAQPF HHCCCCCCCCCCCCC	10.31	20068231
777 (in isoform 9)	Phosphorylation	-	10.31	27251275
783	Phosphorylation	PVPPFAQPFGAEPEA CCCCCCCCCCCCCCC	26.64	20068231
794	Phosphorylation	EPEAPWGSSSPSPPP CCCCCCCCCCCCCCC	24.63	20068231
795	Phosphorylation	PEAPWGSSSPSPPPP CCCCCCCCCCCCCCC	42.18	26657352
796	Phosphorylation	EAPWGSSSPSPPPPP CCCCCCCCCCCCCCC	30.97	20068231
798	Phosphorylation	PWGSSSPSPPPPPPP CCCCCCCCCCCCCCC	52.57	20068231
808	Phosphorylation	PPPPPVFSPTAAFPV CCCCCCCCCCCCCCC	22.90	20068231
810	Phosphorylation	PPPVFSPTAAFPVPD CCCCCCCCCCCCCCC	29.44	20068231
830	Phosphorylation	PPPPPLPSPGQASHC CCCCCCCCCCCCCCC	49.71	20068231
835	Phosphorylation	LPSPGQASHCSSPAT CCCCCCCCCCCCCCH	19.69	20068231
838	Phosphorylation	PGQASHCSSPATRFG CCCCCCCCCCCHHCC	33.65	20068231
839	Phosphorylation	GQASHCSSPATRFGH CCCCCCCCCCHHCCC	24.77	20068231
842	Phosphorylation	SHCSSPATRFGHSQT CCCCCCCHHCCCCCC	29.89	20068231
877	Phosphorylation	LGLPKGVTPAGFPKK CCCCCCCCCCCCCCC	18.98	30266825
877 (in isoform 2)	Phosphorylation	-	18.98	-
880 (in isoform 2)	Phosphorylation	-	40.36	-
882 (in isoform 2)	Phosphorylation	-	36.00	-
886	Phosphorylation	AGFPKKASRTARIAS CCCCCCCCCCEECCC	38.76	29514088
888	Phosphorylation	FPKKASRTARIASDE CCCCCCCCEECCCHH	20.14	29514088
892 (in isoform 2)	Phosphorylation	-	12.84	-
893	Phosphorylation	SRTARIASDEEIQGT CCCEECCCHHHHCCC	43.09	19664994
894	Phosphorylation	RTARIASDEEIQGTK CCEECCCHHHHCCCH	48.83	19651622
894 (in isoform 2)	Phosphorylation	-	48.83	-
894 (in isoform 9)	Phosphorylation	-	48.83	27251275
897	Phosphorylation	RIASDEEIQGTKDAV ECCCHHHHCCCHHHH	4.27	20068231
897 (in isoform 2)	Phosphorylation	-	4.27	-
897 (in isoform 9)	Phosphorylation	-	4.27	27251275
899	Phosphorylation	ASDEEIQGTKDAVIQ CCHHHHCCCHHHHHH	40.15	17081983
899 (in isoform 9)	Phosphorylation	-	40.15	27251275
900	Phosphorylation	SDEEIQGTKDAVIQD CHHHHCCCHHHHHHH	14.91	23927012
901	Ubiquitination	DEEIQGTKDAVIQDL HHHHCCCHHHHHHHH	50.98	2190698
901 (in isoform 1)	Ubiquitination	-	50.98	21906983
909	Phosphorylation	DAVIQDLERKLRFKE HHHHHHHHHHHHCHH	56.94	20166139
909 (in isoform 9)	Phosphorylation	-	56.94	27251275
911	Phosphorylation	VIQDLERKLRFKEDL HHHHHHHHHHCHHHH	34.34	20166139
911 (in isoform 9)	Phosphorylation	-	34.34	27251275
914	Phosphorylation	DLERKLRFKEDLLNN HHHHHHHCHHHHHHC	17.19	20166139
914 (in isoform 9)	Phosphorylation	-	17.19	27251275
915	2-Hydroxyisobutyrylation	LERKLRFKEDLLNNG HHHHHHCHHHHHHCC	43.83	-
915	Ubiquitination	LERKLRFKEDLLNNG HHHHHHCHHHHHHCC	43.83	-
941	Phosphorylation	RRLLGADSATVFNIQ HHHHCCCCCEEEECC	25.88	20068231
943	Phosphorylation	LLGADSATVFNIQEP HHCCCCCEEEECCCC	29.58	24173317
954	Phosphorylation	IQEPEEETANQEYKV CCCCCHHHCCCCEEC	33.90	20068231
956 (in isoform 9)	Phosphorylation	-	42.51	27251275
959	Phosphorylation	EETANQEYKVSSCEQ HHHCCCCEECCHHHH	13.61	20068231
962	Phosphorylation	ANQEYKVSSCEQRLI CCCCEECCHHHHHHH	25.72	21712546
963	Phosphorylation	NQEYKVSSCEQRLIS CCCEECCHHHHHHHH	25.35	21712546
964	S-nitrosocysteine	QEYKVSSCEQRLISE CCEECCHHHHHHHHH	3.93	-
964	S-nitrosylation	QEYKVSSCEQRLISE CCEECCHHHHHHHHH	3.93	22178444
970	Phosphorylation	SCEQRLISEIEYRLE HHHHHHHHHHHHHHH	36.79	28857561
972 (in isoform 9)	Phosphorylation	-	4.50	27251275
974	Phosphorylation	RLISEIEYRLERSPV HHHHHHHHHHHCCCC	26.59	-
979	Phosphorylation	IEYRLERSPVDESGD HHHHHHCCCCCCCCC	21.65	25159151
984	Phosphorylation	ERSPVDESGDEVQYG HCCCCCCCCCCCEEC	47.26	23927012
990	Phosphorylation	ESGDEVQYGDVPVEN CCCCCCEECCCCCCC	22.07	23927012
1019	Phosphorylation	IFEGMPVTFTCRVAG ECCCCEEEEEEEECC	13.83	20068231
1019 (in isoform 2)	Phosphorylation	-	13.83	-
1029	Acetylation	CRVAGNPKPKIYWFK EEECCCCCCEEEEEE	64.04	19811959
1031	Acetylation	VAGNPKPKIYWFKDG ECCCCCCEEEEEECC	55.33	19811969
1036	Phosphorylation	KPKIYWFKDGKQISP CCEEEEEECCCEECC	51.96	20068231
1039	Acetylation	IYWFKDGKQISPKSD EEEEECCCEECCCCC	55.37	19811979
1044	Malonylation	DGKQISPKSDHYTIQ CCCEECCCCCCEEEE	62.82	26320211
1044	Ubiquitination	DGKQISPKSDHYTIQ CCCEECCCCCCEEEE	62.82	-
1048	Phosphorylation	ISPKSDHYTIQRDLD ECCCCCCEEEEECCC	15.55	28796482
1049	Phosphorylation	SPKSDHYTIQRDLDG CCCCCCEEEEECCCC	13.76	28796482
1073	Phosphorylation	TLDDDGNYTIMAANP EECCCCCEEEEEECC	11.81	27642862
1091	Sulfoxidation	ISCTGRLMVQAVNQR EEECCHHHHHHHHHC	1.70	21406390
1096 (in isoform 2)	Phosphorylation	-	28.93	22210691
1098	Methylation	MVQAVNQRGRSPRSP HHHHHHHCCCCCCCC	36.97	54557891
1101	Phosphorylation	AVNQRGRSPRSPSGH HHHHCCCCCCCCCCC	27.73	22167270
1102 (in isoform 2)	Phosphorylation	-	39.13	22210691
1104	Phosphorylation	QRGRSPRSPSGHPHV HCCCCCCCCCCCCCC	27.14	22167270
1104 (in isoform 2)	Phosphorylation	-	27.14	22210691
1106	Phosphorylation	GRSPRSPSGHPHVRR CCCCCCCCCCCCCCC	51.48	30266825
1113 (in isoform 9)	Phosphorylation	-	29.87	22210691
1116	Phosphorylation	PHVRRPRSRSRDSGD CCCCCCCCCCCCCCC	36.97	22167270
1118	Phosphorylation	VRRPRSRSRDSGDEN CCCCCCCCCCCCCCC	41.51	22167270
1119 (in isoform 9)	Phosphorylation	-	40.79	22210691
1121	Phosphorylation	PRSRSRDSGDENEPI CCCCCCCCCCCCCCH	47.21	29255136
1121 (in isoform 9)	Phosphorylation	-	47.21	22210691
1150	Acetylation	DLTVQEGKLCRMDCK CEEECCCCEEECEEE	43.60	26051181
1159	Phosphorylation	CRMDCKVSGLPTPDL EECEEEECCCCCCCC	21.80	22199227
1163	Phosphorylation	CKVSGLPTPDLSWQL EEECCCCCCCCCEEE	34.18	26657352
1167	Phosphorylation	GLPTPDLSWQLDGKP CCCCCCCCEEECCEE	21.84	27080861
1179	Phosphorylation	GKPVRPDSAHKMLVR CEECCCCCHHHHHHH	34.65	26657352
1199	O-linked_Glycosylation	SLIIEPVTSRDAGIY EEEEECCCCCCCCEE	28.85	23301498
1206	Phosphorylation	TSRDAGIYTCIATNR CCCCCCEEEEEECCC	8.47	27642862
1232	Acetylation	VAAKEAHKPPVFIEK HHHHHHHCCCEEEEH	59.05	26051181
1232	Malonylation	VAAKEAHKPPVFIEK HHHHHHHCCCEEEEH	59.05	32601280
1243	Phosphorylation	FIEKLQNTGVADGYP EEEHHHCCCCCCCCC	21.77	28152594
1249	Phosphorylation	NTGVADGYPVRLECR CCCCCCCCCEEEEEE	10.09	27273156
1269	2-Hydroxyisobutyrylation	PPQIFWKKENESLTH CCCEEEECCCCCCCC	57.26	-
1326	Phosphorylation	CTARLDVYTQWHQQS EEEEEEHHHHHHHHC	7.90	28152594
1327	Phosphorylation	TARLDVYTQWHQQSQ EEEEEHHHHHHHHCC	25.65	28152594
1333	Phosphorylation	YTQWHQQSQSTKPKK HHHHHHHCCCCCCCC	21.38	17525332
1335	Phosphorylation	QWHQQSQSTKPKKVR HHHHHCCCCCCCCCC	43.58	26356563
1336	Phosphorylation	WHQQSQSTKPKKVRP HHHHCCCCCCCCCCC	43.67	26356563
1337	Acetylation	HQQSQSTKPKKVRPS HHHCCCCCCCCCCCC	61.15	26051181
1346	Phosphorylation	KKVRPSASRYAALSD CCCCCCHHHHHHHHH	30.11	27642862
1348	Phosphorylation	VRPSASRYAALSDQG CCCCHHHHHHHHHCC	8.17	28796482
1352	Phosphorylation	ASRYAALSDQGLDIK HHHHHHHHHCCCCCE	24.14	25159151
1369	Phosphorylation	FQPEANPSHLTLNTA CCCCCCHHCEEEEEE	30.82	27251275
1380	Phosphorylation	LNTALVESEDL---- EEEEEEECCCC----	29.00	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
641	S	Phosphorylation	Kinase	CDK1	P06493	PSP
688	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
688	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
766	S	Phosphorylation	Kinase	CDK1	P06493	PSP
808	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
808	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1118	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1118	S	Phosphorylation		20471940
Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PALLD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRBS2_HUMAN	SORBS2	physical	16125169
ACTN1_HUMAN	ACTN1	physical	16125169
SYSC_HUMAN	SARS	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
606856	Pancreatic cancer 1 (PNCA1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PALLD_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The actin-bundling protein palladin is an Akt1-specific substratethat regulates breast cancer cell migration."; Chin Y.R., Toker A.; Mol. Cell 38:333-344(2010). Cited for: PHOSPHORYLATION AT SER-1118.	20471940 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; THR-877; SER-893;SER-979; SER-984; SER-1116; SER-1118 AND SER-1121, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893, AND MASSSPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1333, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893, AND MASSSPECTROMETRY.	17287340 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; THR-877 ANDSER-893, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979; SER-893; SER-1116;SER-1118 AND SER-1121, AND MASS SPECTROMETRY.	17081983 [Abstract]

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