S10AD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10AD_HUMAN
• UniProt AC: Q99584
• Protein Name: Protein S100-A13
• Gene Name: S100A13
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Subcellular Localization: Cytoplasm. Secreted. Secretion is mediated by exposure to stress and requires copper ions.
• Protein Description: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)..
• Protein Sequence: MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	FARQEGRKDSLSVNE HHHHCCCCCCCCHHH	63.63	33845483
32	Phosphorylation	RQEGRKDSLSVNEFK HHCCCCCCCCHHHHH	26.11	29255136
34	Phosphorylation	EGRKDSLSVNEFKEL CCCCCCCCHHHHHHH	27.18	29255136
51	Ubiquitination	QQLPHLLKDVGSLDE HHHHHHHHHHCCCCH	57.64	29967540
51	Acetylation	QQLPHLLKDVGSLDE HHHHHHHHHHCCCCH	57.64	26051181
55	Phosphorylation	HLLKDVGSLDEKMKS HHHHHHCCCCHHHHC	32.28	21712546
59	Ubiquitination	DVGSLDEKMKSLDVN HHCCCCHHHHCCCCC	51.82	23000965
59	Acetylation	DVGSLDEKMKSLDVN HHCCCCHHHHCCCCC	51.82	27452117
61	Ubiquitination	GSLDEKMKSLDVNQD CCCCHHHHCCCCCCC	59.96	23000965
62	Phosphorylation	SLDEKMKSLDVNQDS CCCHHHHCCCCCCCC	26.72	25159151
69	Phosphorylation	SLDVNQDSELKFNEY CCCCCCCCHHHHHHH	34.76	21712546
85	Acetylation	RLIGELAKEIRKKKD HHHHHHHHHHHHHHC	67.32	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10AD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10AD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10AD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT1_HUMAN	SYT1	physical	9712836
FGF1_HUMAN	FGF1	physical	9712836
FGF1_HUMAN	FGF1	physical	11432880
SYT1_HUMAN	SYT1	physical	11432880
STK4_HUMAN	STK4	physical	22939629
THOC7_HUMAN	THOC7	physical	22939629
S10AD_HUMAN	S100A13	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01025: Amlexanox
• DB00768: Olopatadine