REXO5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REXO5_HUMAN
• UniProt AC: Q96IC2
• Protein Name: RNA exonuclease 5 {ECO:0000312|HGNC:HGNC:24661}
• Gene Name: REXO5 {ECO:0000312|HGNC:HGNC:24661}
• Organism: Homo sapiens (Human).
• Sequence Length: 774
• Protein Sequence: MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPEAKKARLSTILFTDNCEVTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVLQGMSQLHFYRFYLEFGCLRKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGPLPSNAKAAINLQDDPIIQKYGSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKCNGSIADNSPLFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKILDYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYVREQGRRFKLKFLAKVILGKDIQCPDRLGHDATEDARTILELARYFLKHGPKKIAELNLEALANHQEIQAAGQEPKNTAEVLQHPNTSVLECLDSVGQKLLFLTRETDAGELPSSRNCQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFKAFSPVLTEEMNKRMRIKWTEISTVYAGPFSKNCNLRALKRLFKSFGPVQSMTFVLETRQPHLCIQYEVLEAAQLAIESLDGILVDGICIKVQRPVTELTLDCDTLVNELEGDSENQGSIYLSGVSETFKEQLLQEPRLFLGLEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNILTGKDWKLKGRHALTPRHLHAWLRGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAWRWSRKIGKLYNSLCPGTLCLILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	QLHFYRFYLEFGCLR HHHHHHHHHHHHHHH		18083107
180	Phosphorylation	DDPIIQKYGSKKVGL CCHHHHHHCCCCCCC		-
182	Phosphorylation	PIIQKYGSKKVGLTR HHHHHHCCCCCCCCE		-
271	Phosphorylation	PENKILDYLTSFSGI CCHHHHHHHHHCCCC		29083192
273	Phosphorylation	NKILDYLTSFSGITK HHHHHHHHHCCCCCH		29083192
274	Phosphorylation	KILDYLTSFSGITKK HHHHHHHHCCCCCHH		29083192
276	Phosphorylation	LDYLTSFSGITKKIL HHHHHHCCCCCHHHH		29083192
279	Phosphorylation	LTSFSGITKKILNPV HHHCCCCCHHHHCCH		29083192
481	Phosphorylation	PFSIVQFSFKAFSPV CCEEEEEEEHHHCHH		24719451
533	Phosphorylation	KSFGPVQSMTFVLET HHHCCCCEEEEEEEC		-
649	Phosphorylation	YCFLKFKSFGSAQQA EEEEEECCCCCHHHH		-
652	Phosphorylation	LKFKSFGSAQQALNI EEECCCCCHHHHHHH		-
661	Phosphorylation	QQALNILTGKDWKLK HHHHHHHHCCCCCCC		-
723	Phosphorylation	KIAAWRWSRKIGKLY HHHHHHHHHHHHHHH		24260401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REXO5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REXO5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REXO5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of REXO5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.