MEA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEA1_HUMAN
• UniProt AC: Q16626
• Protein Name: Male-enhanced antigen 1
• Gene Name: MEA1
• Organism: Homo sapiens (Human).
• Sequence Length: 185
• Protein Description: May play an important role in spermatogenesis and/or testis development..
• Protein Sequence: MGPERHLSGAPARMATVVLGGDTMGPERIFPNQTEELGHQGPSEGTGDWSSEEPEEEQEETGSGPAGYSYQPLNQDPEQEEVELAPVGDGDVVADIQDRIQALGLHLPDPPLESEDEDEEGATALNNHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQASPAWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGPERHLSGAPARMA CCCCCCCCCCCCCEE	27.12	24719451
50	Phosphorylation	SEGTGDWSSEEPEEE CCCCCCCCCCCCHHH	32.39	26074081
51	Phosphorylation	EGTGDWSSEEPEEEQ CCCCCCCCCCCHHHH	41.55	26074081
68	Phosphorylation	TGSGPAGYSYQPLNQ HCCCCCCCCCCCCCC	13.30	-
69	Phosphorylation	GSGPAGYSYQPLNQD CCCCCCCCCCCCCCC	19.17	-
70	Phosphorylation	SGPAGYSYQPLNQDP CCCCCCCCCCCCCCC	12.98	-
101	Phosphorylation	ADIQDRIQALGLHLP CCHHHHHHHHCCCCC	31.28	18669648
114	Phosphorylation	LPDPPLESEDEDEEG CCCCCCCCCCCCHHH	59.01	30175587
123	Phosphorylation	DEDEEGATALNNHSS CCCHHHCCHHHCCCC	42.40	28464451
129	Phosphorylation	ATALNNHSSIPMDPE CCHHHCCCCCCCCHH	31.89	30576142
130	Phosphorylation	TALNNHSSIPMDPEH CHHHCCCCCCCCHHH	24.14	28464451
173	Ubiquitination	QWEDVVQKALQARQA HHHHHHHHHHHHHHH	39.18	21890473
181	Phosphorylation	ALQARQASPAWK--- HHHHHHHCCCCC---	13.55	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NU153_HUMAN	NUP153	physical	22939629
RAD21_HUMAN	RAD21	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND SER-181, ANDMASS SPECTROMETRY.
PubMed: 18691976