PPA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPA5_HUMAN
• UniProt AC: P13686
• Protein Name: Tartrate-resistant acid phosphatase type 5
• Gene Name: ACP5
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Subcellular Localization: Lysosome.
• Protein Description: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias..
• Protein Sequence: MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	VPNAPFHTAREMANA CCCCCHHHHHHHHCH	27.99	29083192
116	N-linked_Glycosylation	GNHDHLGNVSAQIAY CCCCCCCCHHHHHHH	30.81	15993892
147	N-linked_Glycosylation	HFKIPQTNVSVAIFM EEECCCCCCEEEEEE	20.86	UniProtKB CARBOHYD
222	Ubiquitination	GPTHCLVKQLRPLLA CCCCCHHHHHHHHHH	30.57	-
278	Phosphorylation	QRKVPNGYLRFHYGT CCCCCCCEEEEEECC	11.01	8278711
283	Phosphorylation	NGYLRFHYGTEDSLG CCEEEEEECCCCCCC	24.03	8278721
306	Phosphorylation	SKEMTVTYIEASGKS CCEEEEEEEEECCCC	7.76	22210691
313	Phosphorylation	YIEASGKSLFKTRLP EEEECCCCHHHCCCC	42.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S35F6_HUMAN	SLC35F6	physical	16169070
GRP78_HUMAN	HSPA5	physical	26186194
KLH15_HUMAN	KLHL15	physical	26186194
CIZ1_HUMAN	CIZ1	physical	26186194
PPA5_HUMAN	ACP5	physical	27432908
CALR_HUMAN	CALR	physical	27432908
SEP15_HUMAN	SEP15	physical	27432908
UGGG1_HUMAN	UGGT1	physical	27432908
CLGN_HUMAN	CLGN	physical	27432908
COA7_HUMAN	COA7	physical	27432908
OS9_HUMAN	OS9	physical	27432908
PDIA3_HUMAN	PDIA3	physical	27432908
CALX_HUMAN	CANX	physical	27432908
SE1L1_HUMAN	SEL1L	physical	27432908
PDIA1_HUMAN	P4HB	physical	27432908
CAB45_HUMAN	SDF4	physical	27432908
GANAB_HUMAN	GANAB	physical	27432908
NGLY1_HUMAN	NGLY1	physical	27432908
CIZ1_HUMAN	CIZ1	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607944: Spondyloenchondrodysplasia with immune dysregulation (SPENCDI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Crystal structures of recombinant human purple acid phosphatase withand without an inhibitory conformation of the repression loop.";
Straeter N., Jasper B., Scholte M., Krebs B., Duff A.P., Langley D.B.,Han R., Averill B.A., Freeman H.C., Guss J.M.;
J. Mol. Biol. 351:233-246(2005).
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 22-325 IN COMPLEX WITH IRONIONS, AND GLYCOSYLATION AT ASN-116.
PubMed: 15993892