dbPTM

CIZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CIZ1_HUMAN
UniProt AC	Q9ULV3
Protein Name	Cip1-interacting zinc finger protein
Gene Name	CIZ1
Organism	Homo sapiens (Human).
Sequence Length	898
Subcellular Localization	Nucleus.
Protein Description	May regulate the subcellular localization of CIP/WAF1..
Protein Sequence	MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVQPQAHSQPPRQVQLQLQKQVQTQTYPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPGVWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQALQFFCYICKASCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSQQQQQQL -----CCCHHHHHHH	26.27	20068231
45	Phosphorylation	LQQLLQQSPPQAPLP HHHHHHCCCCCCCCC	26.11	20068231
56	Phosphorylation	APLPMAVSRGLPPQQ CCCCCHHHCCCCCCC	15.87	20068231
83	Phosphorylation	SASLLNGSMLQRALL CHHHCCHHHHHHHHH	18.42	-
125	Phosphorylation	TLGNLRGYGMASPGL CCCCCCCCCCCCCCC	9.41	22199227
129	Phosphorylation	LRGYGMASPGLAAPS CCCCCCCCCCCCCCC	15.60	22199227
136	Phosphorylation	SPGLAAPSLTPPQLA CCCCCCCCCCCCCCC	39.90	22210691
138	Phosphorylation	GLAAPSLTPPQLATP CCCCCCCCCCCCCCC	36.94	22199227
144	Phosphorylation	LTPPQLATPNLQQFF CCCCCCCCCCHHHHC	22.69	27251275
159	Phosphorylation	PQATRQSLLGPPPVG CHHHHHHHHCCCCCC	4.92	27251275
166	Phosphorylation	LLGPPPVGVPMNPSQ HHCCCCCCCCCCHHH	24.47	27251275
173 (in isoform 2)	Phosphorylation	-	32.29	22210691
180 (in isoform 2)	Phosphorylation	-	47.05	22210691
186 (in isoform 2)	Phosphorylation	-	32.42	22210691
187	Phosphorylation	NPQKQARTSSSTTPN CHHHCCCCCCCCCCC	35.66	27251275
188	Phosphorylation	PQKQARTSSSTTPNR HHHCCCCCCCCCCCC	19.42	30631047
189	Phosphorylation	QKQARTSSSTTPNRK HHCCCCCCCCCCCCC	30.96	27251275
190	Phosphorylation	KQARTSSSTTPNRKD HCCCCCCCCCCCCCC	35.75	28102081
191	Phosphorylation	QARTSSSTTPNRKDS CCCCCCCCCCCCCCC	48.50	28102081
192	Phosphorylation	ARTSSSTTPNRKDSS CCCCCCCCCCCCCCC	22.10	28102081
198	Phosphorylation	TTPNRKDSSSQTMPV CCCCCCCCCCCCCCC	34.62	29255136
199	Phosphorylation	TPNRKDSSSQTMPVE CCCCCCCCCCCCCCC	36.28	23401153
200	Phosphorylation	PNRKDSSSQTMPVED CCCCCCCCCCCCCCC	33.35	29255136
202	Phosphorylation	RKDSSSQTMPVEDKS CCCCCCCCCCCCCCC	25.95	29255136
209	Phosphorylation	TMPVEDKSDPPEGSE CCCCCCCCCCCCCCH	68.61	23917254
221	Phosphorylation	GSEEAAEPRMDTPED CCHHHCCCCCCCCCC	31.97	27251275
225	Phosphorylation	AAEPRMDTPEDQDLP HCCCCCCCCCCCCCC	21.16	27499020
244	Phosphorylation	DIAKEKRTPAPEPEP HHHHCCCCCCCCCCC	34.57	23401153
255	Phosphorylation	EPEPCEASELPAKRL CCCCCCHHHCCHHHC	19.85	23403867
260	Acetylation	EASELPAKRLRSSEE CHHHCCHHHCCCCCC	50.45	25953088
264	Phosphorylation	LPAKRLRSSEEPTEK CCHHHCCCCCCCCCC	46.85	30108239
265	Phosphorylation	PAKRLRSSEEPTEKE CHHHCCCCCCCCCCC	39.27	30108239
269	Phosphorylation	LRSSEEPTEKEPPGQ CCCCCCCCCCCCCCC	64.07	30108239
271	Acetylation	SSEEPTEKEPPGQLQ CCCCCCCCCCCCCCE	77.37	26051181
274	Phosphorylation	EPTEKEPPGQLQVKA CCCCCCCCCCCEEEE	44.23	27251275
280	Sumoylation	PPGQLQVKAQPQARM CCCCCEEEECCCCCC	28.48	28112733
293	Phosphorylation	RMTVPKQTQTPDLLP CCCCCCCCCCCCCCH	40.30	25850435
295	Phosphorylation	TVPKQTQTPDLLPEA CCCCCCCCCCCCHHH	23.35	26657352
325	Phosphorylation	VQAQVQSQTQPRIPS EEHHHHCCCCCCCCC	27.36	27251275
332	Phosphorylation	QTQPRIPSTDTQVQP CCCCCCCCCCCCCCH	36.22	30266825
333	Phosphorylation	TQPRIPSTDTQVQPK CCCCCCCCCCCCCHH	37.40	30266825
335	Phosphorylation	PRIPSTDTQVQPKLQ CCCCCCCCCCCHHHH	30.63	30266825
340	Acetylation	TDTQVQPKLQKQAQT CCCCCCHHHHHHHHC	46.59	26051181
340	Sumoylation	TDTQVQPKLQKQAQT CCCCCCHHHHHHHHC	46.59	28112733
347	Phosphorylation	KLQKQAQTQTSPEHL HHHHHHHCCCCHHHH	36.51	27794612
349	Phosphorylation	QKQAQTQTSPEHLVL HHHHHCCCCHHHHHH	50.03	30266825
350	Phosphorylation	KQAQTQTSPEHLVLQ HHHHCCCCHHHHHHH	20.62	23401153
363	Phosphorylation	LQQKQVQPQLQQEAE HHHHHHHHHHHHHCC	37.68	27251275
380	Phosphorylation	KQVQPQVQPQAHSQG HCCCCCCCCCCCCCC	21.09	27251275
401	Sumoylation	QQEAEPLKQVQPQVQ HHHCCHHHHCCCCCC	60.17	28112733
504	Phosphorylation	AGGGMEKTLPEPVGT CCCCCCCCCCCCCCC	33.95	27251275
511	Phosphorylation	TLPEPVGTQVSMEEI CCCCCCCCCCCHHHH	26.49	26657352
514	Phosphorylation	EPVGTQVSMEEIQNE CCCCCCCCHHHHHCC	15.62	30108239
522	Phosphorylation	MEEIQNESACGLDVG HHHHHCCCCCCCCHH	36.09	30576142
544	Phosphorylation	EMPGVWGAGGSLKVT CCCCCCCCCCCEEEE	11.94	27251275
547	Phosphorylation	GVWGAGGSLKVTILQ CCCCCCCCEEEEEEE	24.89	23917254
549	Sumoylation	WGAGGSLKVTILQSS CCCCCCEEEEEEECC	38.74	28112733
558	Phosphorylation	TILQSSDSRAFSTVP EEEECCCCCCCEECC	27.70	26074081
562	Phosphorylation	SSDSRAFSTVPLTPV CCCCCCCEECCCCCC	27.75	29978859
563	Phosphorylation	SDSRAFSTVPLTPVP CCCCCCEECCCCCCC	21.49	20068231
567	Phosphorylation	AFSTVPLTPVPRPSD CCEECCCCCCCCCCC	19.03	25159151
573	Phosphorylation	LTPVPRPSDSVSSTP CCCCCCCCCCCCCCC	43.74	30576142
575	Phosphorylation	PVPRPSDSVSSTPAA CCCCCCCCCCCCCCC	28.39	26462736
577	Phosphorylation	PRPSDSVSSTPAATS CCCCCCCCCCCCCCC	32.23	30108239
578	Phosphorylation	RPSDSVSSTPAATST CCCCCCCCCCCCCCC	35.93	21712546
579	Phosphorylation	PSDSVSSTPAATSTP CCCCCCCCCCCCCCC	14.94	25159151
583	Phosphorylation	VSSTPAATSTPSKQA CCCCCCCCCCCCHHH	34.93	25159151
584	Phosphorylation	SSTPAATSTPSKQAL CCCCCCCCCCCHHHH	33.33	25159151
585	Phosphorylation	STPAATSTPSKQALQ CCCCCCCCCCHHHHH	27.51	25159151
587	Phosphorylation	PAATSTPSKQALQFF CCCCCCCCHHHHHHH	37.17	21712546
588	Sumoylation	AATSTPSKQALQFFC CCCCCCCHHHHHHHH	40.57	28112733
597	Phosphorylation	ALQFFCYICKASCSS HHHHHHHHHHHHCCC	1.72	27251275
605	Phosphorylation	CKASCSSQQEFQDHM HHHHCCCHHHHHHHC	30.45	27251275
614	Phosphorylation	EFQDHMSEPQHQQRL HHHHHCCCHHHHHHH	41.21	27251275
628	Phosphorylation	LGEIQHMSQACLLSL HHHHHHHHHHHHHHC	16.70	29978859
634	Phosphorylation	MSQACLLSLLPVPRD HHHHHHHHCCCCCHH	18.21	23186163
645	Phosphorylation	VPRDVLETEDEEPPP CCHHHHCCCCCCCCC	44.57	30576142
680	Sumoylation	TQDHKIAKQSLRPFC HCCHHHHHHHHHHHH	43.84	28112733
682	Phosphorylation	DHKIAKQSLRPFCTV CHHHHHHHHHHHHHH	26.16	28555341
693	Phosphorylation	FCTVCNRYFKTPRKF HHHHHHHHCCCHHHH	8.74	-
696	Phosphorylation	VCNRYFKTPRKFVEH HHHHHCCCHHHHHHH	20.58	24719451
705	Sumoylation	RKFVEHVKSQGHKDK HHHHHHHHHCCCHHH	38.68	-
705	Sumoylation	RKFVEHVKSQGHKDK HHHHHHHHHCCCHHH	38.68	28112733
705	Ubiquitination	RKFVEHVKSQGHKDK HHHHHHHHHCCCHHH	38.68	-
717	Sumoylation	KDKAKELKSLEKEIA HHHHHHHHHHHHHHC	54.83	-
717	Sumoylation	KDKAKELKSLEKEIA HHHHHHHHHHHHHHC	54.83	-
750	Ubiquitination	DEEEEEDDEDEEEIE CCCCCCCCCCHHHHH	69.40	21890473
768	Phosphorylation	ELCKQVRSRDISREE HHHHHHHCCCCCHHH	35.13	23186163
772	Phosphorylation	QVRSRDISREEWKGS HHHCCCCCHHHHCCC	37.62	23186163
774	Ubiquitination	RSRDISREEWKGSET HCCCCCHHHHCCCCC	62.51	21890473
774	Ubiquitination	RSRDISREEWKGSET HCCCCCHHHHCCCCC	62.51	21890473
779	Phosphorylation	SREEWKGSETYSPNT CHHHHCCCCCCCCCH	24.04	27732954
781	Phosphorylation	EEWKGSETYSPNTAY HHHCCCCCCCCCHHH	30.88	27732954
782	Phosphorylation	EWKGSETYSPNTAYG HHCCCCCCCCCHHHC	20.34	27732954
783	Phosphorylation	WKGSETYSPNTAYGV HCCCCCCCCCHHHCC	21.06	27732954
786	Phosphorylation	SETYSPNTAYGVDFL CCCCCCCHHHCCCCH	25.33	28464451
788	Phosphorylation	TYSPNTAYGVDFLVP CCCCCHHHCCCCHHH	18.68	27732954
799	Phosphorylation	FLVPVMGYICRICHK CHHHHHHHHHHHHHH	4.44	22817900
801 (in isoform 2)	Ubiquitination	-	1.48	21890473
817	Phosphorylation	SNSGAQLSHCKSLGH CCCCCCHHHCHHHCC	18.11	28555341
821	Phosphorylation	AQLSHCKSLGHFENL CCHHHCHHHCCHHHH	45.00	25159151
830	Ubiquitination	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	2189047
830	Ubiquitination	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	21890473
830	Ubiquitination	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	21890473
830	Ubiquitination	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	21890473
830	Ubiquitination	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	21890473
830	Sumoylation	GHFENLQKYKAAKNP CCHHHHHHHHHHCCC	52.46	28112733
830 (in isoform 1)	Ubiquitination	-	52.46	21890473
835	Ubiquitination	LQKYKAAKNPSPTTR HHHHHHHCCCCCCCC	74.40	-
838	Phosphorylation	YKAAKNPSPTTRPVS HHHHCCCCCCCCCCH	44.25	23401153
840	Phosphorylation	AAKNPSPTTRPVSRR HHCCCCCCCCCCHHH	39.51	30266825
841	Phosphorylation	AKNPSPTTRPVSRRC HCCCCCCCCCCHHHH	36.04	27794612
842	Phosphorylation	KNPSPTTRPVSRRCA CCCCCCCCCCHHHHH	31.91	27251275
845	Phosphorylation	SPTTRPVSRRCAINA CCCCCCCHHHHHHHH	19.38	22496350
861	Phosphorylation	NALTALFTSSGRPPS HHHHHHHHCCCCCCC	23.88	23403867
862	Phosphorylation	ALTALFTSSGRPPSQ HHHHHHHCCCCCCCC	24.38	23403867
863	Phosphorylation	LTALFTSSGRPPSQP HHHHHHCCCCCCCCC	35.45	23403867
868	Phosphorylation	TSSGRPPSQPNTQDK HCCCCCCCCCCCCCC	62.04	17525332
872	Phosphorylation	RPPSQPNTQDKTPSK CCCCCCCCCCCCCCC	44.84	23403867
876	Phosphorylation	QPNTQDKTPSKVTAR CCCCCCCCCCCCCCC	40.87	26055452
877	Phosphorylation	PNTQDKTPSKVTARP CCCCCCCCCCCCCCC	37.58	27251275
878	Phosphorylation	NTQDKTPSKVTARPS CCCCCCCCCCCCCCC	45.01	30576142
879	Sumoylation	TQDKTPSKVTARPSQ CCCCCCCCCCCCCCC	44.82	28112733
885	Phosphorylation	SKVTARPSQPPLPRR CCCCCCCCCCCCCCC	50.17	28555341
894	Phosphorylation	PPLPRRSTRLKT--- CCCCCCCCCCCC---	37.90	27251275
924	Phosphorylation	--------------------------------- ---------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CIZ1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CIZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CIZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CDN1A_HUMAN	CDKN1A	physical	10529385

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CIZ1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-868, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-567, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-244, AND MASSSPECTROMETRY.	17081983 [Abstract]