SEP15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEP15_HUMAN
• UniProt AC: O60613
• Protein Name: Selenoprotein F {ECO:0000303|PubMed:27645994}
• Gene Name: SELENOF {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:17705}
• Organism: Homo sapiens (Human).
• Sequence Length: 165
• Subcellular Localization: Endoplasmic reticulum lumen . The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
• Protein Description: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity)..
• Protein Sequence: MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVAMAAGPSGCLV --CCCCCCCCCCCCH	41.02	21406692
80	Ubiquitination	CCQEEAQFETKKLYA CCHHHHHHHHCHHHH	33.32	-
81	Ubiquitination	CQEEAQFETKKLYAG CHHHHHHHHCHHHHH	54.90	-
83	Ubiquitination	EEAQFETKKLYAGAI HHHHHHHCHHHHHHH	16.33	21963094
83	2-Hydroxyisobutyrylation	EEAQFETKKLYAGAI HHHHHHHCHHHHHHH	16.33	-
84	Ubiquitination	EAQFETKKLYAGAIL HHHHHHCHHHHHHHH	16.04	22817900
119	Ubiquitination	KPKLFRGLQIKYVRG CCCCCCCEEEEEEEC	25.40	-
120	Phosphorylation	PKLFRGLQIKYVRGS CCCCCCEEEEEEECC	9.30	28152594
122	Methylation	LFRGLQIKYVRGSDP CCCCEEEEEEECCCC	35.49	-
124	Phosphorylation	RGLQIKYVRGSDPVL CCEEEEEEECCCCCH	28.33	28152594
142	Phosphorylation	DDNGNIAEELSILKW CCCCCHHHHHHHHCC	29.20	24719451
148	Phosphorylation	AEELSILKWNTDSVE HHHHHHHCCCCHHHH	28.65	24719451
150	Phosphorylation	ELSILKWNTDSVEEF HHHHHCCCCHHHHHH	29.41	28355574
153	Phosphorylation	ILKWNTDSVEEFLSE HHCCCCHHHHHHHHH	50.13	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEP15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEP15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEP15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAMBI_HUMAN	BAMBI	physical	21900206
XRCC6_HUMAN	XRCC6	physical	21900206

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.