BAMBI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAMBI_HUMAN
• UniProt AC: Q13145
• Protein Name: BMP and activin membrane-bound inhibitor homolog
• Gene Name: BAMBI
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Negatively regulates TGF-beta signaling..
• Protein Sequence: MDRHSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSGTTIPTLECCHEDMCNYRGLHDVLSPPRGEASGQGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDRHSSYIFIWL ---CCCCHHHHHHHH	26.23	24043423
6	Phosphorylation	--MDRHSSYIFIWLQ --CCCCHHHHHHHHH	19.00	24043423
7	Phosphorylation	-MDRHSSYIFIWLQL -CCCCHHHHHHHHHH	11.67	24043423
24	Phosphorylation	CAMAVLLTKGEIRCY HHHHHHHHCCCHHHE	32.61	24043423
31	Phosphorylation	TKGEIRCYCDAAHCV HCCCHHHEECHHHHH	5.41	-
40	Phosphorylation	DAAHCVATGYMCKSE CHHHHHHHHCCCHHH	14.40	-
83	Ubiquitination	TTDICQAKQARNHSG CHHHHHHHHHHCCCC	20.72	21963094
87	N-linked_Glycosylation	CQAKQARNHSGTTIP HHHHHHHCCCCCCCC	36.37	UniProtKB CARBOHYD
91	O-linked_Glycosylation	QARNHSGTTIPTLEC HHHCCCCCCCCCHHH	25.27	OGP
114	Phosphorylation	RGLHDVLSPPRGEAS CCCCCCCCCCCCCCC	32.48	24719451
114	O-linked_Glycosylation	RGLHDVLSPPRGEAS CCCCCCCCCCCCCCC	32.48	55832609
132	Phosphorylation	NRYQHDGSRNLITKV CCCCCCCCCCHHHHH	24.85	22468782
143	Phosphorylation	ITKVQELTSSKELWF HHHHHHHHCCHHHHH	30.15	22468782
145	Phosphorylation	KVQELTSSKELWFRA HHHHHHCCHHHHHHH	25.55	22468782
146	Ubiquitination	VQELTSSKELWFRAA HHHHHCCHHHHHHHH	57.50	-
196	Phosphorylation	QMLSRLHYSFHGHHS HHHHHHHHHHCCCCC	20.02	-
210	Ubiquitination	SKKGQVAKLDLECMV CCCCCEEEEEEEEEC	43.61	33845483
231	Sumoylation	NCCLTCDKMRQADLS CCEECCHHHHHHCCC	37.82	-
231	Ubiquitination	NCCLTCDKMRQADLS CCEECCHHHHHHCCC	37.82	33845483
238	Phosphorylation	KMRQADLSNDKILSL HHHHHCCCCCHHHHH	43.46	29514088
241	Sumoylation	QADLSNDKILSLVHW HHCCCCCHHHHHHHH	50.20	-
241	Ubiquitination	QADLSNDKILSLVHW HHCCCCCHHHHHHHH	50.20	21890473
251	Phosphorylation	SLVHWGMYSGHGKLE HHHHHHHCCCCCCEE	13.94	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAMBI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAMBI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAMBI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD7_HUMAN	SMAD7	physical	19758997

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.