DECR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DECR2_HUMAN
• UniProt AC: Q9NUI1
• Protein Name: Peroxisomal 2,4-dienoyl-CoA reductase
• Gene Name: DECR2
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Peroxisome.
• Protein Description: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid..
• Protein Sequence: MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQPPPDVE ------CCCCCCCCC	30.50	22814378
29	Ubiquitination	CPDLLRDKVAFITGG CHHHHCCCEEEEECC	29.09	-
29	2-Hydroxyisobutyrylation	CPDLLRDKVAFITGG CHHHHCCCEEEEECC	29.09	-
38	Phosphorylation	AFITGGGSGIGFRIA EEEECCCCCHHHHHH	30.43	22210691
59	Phosphorylation	GCHTVIASRSLPRVL CCEEEEECCCHHHHH	15.98	20068231
61	Phosphorylation	HTVIASRSLPRVLTA EEEEECCCHHHHHHH	39.98	20068231
67	Phosphorylation	RSLPRVLTAARKLAG CCHHHHHHHHHHHCC	18.53	-
94	Sulfoxidation	VRAPPAVMAAVDQAL CCCCHHHHHHHHHHH	1.84	21406390
138	Phosphorylation	KTVMDIDTSGTFNVS CEEEEECCCCCCCHH	29.41	20068231
139	Phosphorylation	TVMDIDTSGTFNVSR EEEEECCCCCCCHHH	31.89	20068231
141	Phosphorylation	MDIDTSGTFNVSRVL EEECCCCCCCHHHHH	16.29	20068231
145	Phosphorylation	TSGTFNVSRVLYEKF CCCCCCHHHHHHHHH	20.13	20068231
151	2-Hydroxyisobutyrylation	VSRVLYEKFFRDHGG HHHHHHHHHHHHCCC	35.92	-
151	Acetylation	VSRVLYEKFFRDHGG HHHHHHHHHHHHCCC	35.92	19608861
226	Phosphorylation	RLGGPQASLSTKVTA HHCCCCCCCCCCCCC	20.01	23312004
228	Phosphorylation	GGPQASLSTKVTASP CCCCCCCCCCCCCHH	24.56	20068231
229	Phosphorylation	GPQASLSTKVTASPL CCCCCCCCCCCCHHH	34.52	20068231
230	Malonylation	PQASLSTKVTASPLQ CCCCCCCCCCCHHHH	33.92	26320211
230	Acetylation	PQASLSTKVTASPLQ CCCCCCCCCCCHHHH	33.92	25953088
232	Phosphorylation	ASLSTKVTASPLQRL CCCCCCCCCHHHHHC	23.99	-
234	Phosphorylation	LSTKVTASPLQRLGN CCCCCCCHHHHHCCC	19.44	20068231
287	Phosphorylation	KGLPDFASFSAKL-- CCCCCHHHHHCCC--	21.52	30266825
289	Phosphorylation	LPDFASFSAKL---- CCCHHHHHCCC----	23.23	30266825
291	Acetylation	DFASFSAKL------ CHHHHHCCC------	54.23	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DECR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DECR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DECR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
EP300_HUMAN	EP300	physical	21988832
SESD1_HUMAN	SESTD1	physical	26186194
SESD1_HUMAN	SESTD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-151 AND LYS-291, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-61, AND MASSSPECTROMETRY.
PubMed: 17081983