dbPTM

MARK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MARK3_HUMAN
UniProt AC	P27448
Protein Name	MAP/microtubule affinity-regulating kinase 3
Gene Name	MARK3
Organism	Homo sapiens (Human).
Sequence Length	753
Subcellular Localization	Cell membrane Peripheral membrane protein . Cell projection, dendrite . Cytoplasm .
Protein Description	Serine/threonine-protein kinase. [PubMed: 23666762 Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU]
Protein Sequence	MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTRTPLPT ------CCCCCCCCC	26.96	23401153
3	Phosphorylation	-----MSTRTPLPTV -----CCCCCCCCCC	36.94	23186163
5	Phosphorylation	---MSTRTPLPTVNE ---CCCCCCCCCCCC	29.30	22617229
42	Phosphorylation	SGARCRNSIASCADE CCCHHHHCHHHHCCC	10.53	23927012
45	Phosphorylation	RCRNSIASCADEQPH HHHHCHHHHCCCCCC	14.25	23927012
56	Phosphorylation	EQPHIGNYRLLKTIG CCCCCCCEEHHHHHC	9.45	22496350
61	Phosphorylation	GNYRLLKTIGKGNFA CCEEHHHHHCCCCCH	34.63	22617229
90	Phosphorylation	AIKIIDKTQLNPTSL HEEECCCCCCCHHHH	34.24	20068231
95	Phosphorylation	DKTQLNPTSLQKLFR CCCCCCHHHHHHHHH	40.78	-
96	Phosphorylation	KTQLNPTSLQKLFRE CCCCCHHHHHHHHHH	30.02	-
157	Phosphorylation	MKEKEARSKFRQIVS CCHHHHHHHHHHHHH	43.10	24702127
180	Ubiquitination	RIVHRDLKAENLLLD CCCCCCCHHHHHEEC	58.92	22053931
204	Phosphorylation	FGFSNEFTVGGKLDT CCCCCCEEECCCHHH	16.44	26074081
211	Phosphorylation	TVGGKLDTFCGSPPY EECCCHHHCCCCCCC	31.12	14976552
215	Phosphorylation	KLDTFCGSPPYAAPE CHHHCCCCCCCCCHH	24.71	14976552
215	Ubiquitination	KLDTFCGSPPYAAPE CHHHCCCCCCCCCHH	24.71	21890473
218	Phosphorylation	TFCGSPPYAAPELFQ HCCCCCCCCCHHHHC	20.84	23898821
234	Phosphorylation	KKYDGPEVDVWSLGV CCCCCCCCCHHHHHH	8.94	17192257
238	Phosphorylation	GPEVDVWSLGVILYT CCCCCHHHHHHHHHH	18.33	14976552
277	Phosphorylation	YRIPFYMSTDCENLL CCCCEEECCCHHHHH	15.09	21082442
278	Phosphorylation	RIPFYMSTDCENLLK CCCEEECCCHHHHHH	28.30	21082442
294	Acetylation	FLVLNPIKRGTLEQI HHHCCCCCCCCHHHH	46.13	25953088
294	Ubiquitination	FLVLNPIKRGTLEQI HHHCCCCCCCCHHHH	46.13	2189047
294 (in isoform 3)	Ubiquitination	-	46.13	21890473
294 (in isoform 4)	Ubiquitination	-	46.13	21890473
294 (in isoform 5)	Ubiquitination	-	46.13	21890473
294 (in isoform 6)	Ubiquitination	-	46.13	21890473
297	Phosphorylation	LNPIKRGTLEQIMKD CCCCCCCCHHHHHHH	31.02	21082442
317	Ubiquitination	GHEEDELKPFVEPEL CCCCCCCCCCCCCCC	34.07	-
317 (in isoform 2)	Ubiquitination	-	34.07	21890473
317 (in isoform 7)	Ubiquitination	-	34.07	21890473
321	Phosphorylation	DELKPFVEPELDISD CCCCCCCCCCCCCCC	33.18	18691976
330	Ubiquitination	ELDISDQKRIDIMVG CCCCCCCHHHEEEEC	57.20	-
331	Phosphorylation	LDISDQKRIDIMVGM CCCCCCHHHEEEECC	26.61	24719451
339	Phosphorylation	IDIMVGMGYSQEEIQ HEEEECCCCCHHHHH	17.01	18691976
340	Phosphorylation	DIMVGMGYSQEEIQE EEEECCCCCHHHHHH	9.78	17192257
340	Phosphorylation	DIMVGMGYSQEEIQE EEEECCCCCHHHHHH	9.78	19664995
341	Phosphorylation	IMVGMGYSQEEIQES EEECCCCCHHHHHHH	25.95	22817900
353 (in isoform 7)	Ubiquitination	-	53.97	-
354	Phosphorylation	ESLSKMKYDEITATY HHHHCCCHHHHHHHH	18.47	29496907
361	Phosphorylation	YDEITATYLLLGRKS HHHHHHHHHHHCCCC	7.90	29496907
368	Phosphorylation	YLLLGRKSSELDASD HHHHCCCCCCCCCCC	27.90	23403867
369	Phosphorylation	LLLGRKSSELDASDS HHHCCCCCCCCCCCC	45.26	30108239
374	Phosphorylation	KSSELDASDSSSSSN CCCCCCCCCCCCCCC	37.38	22617229
376	Phosphorylation	SELDASDSSSSSNLS CCCCCCCCCCCCCCE	29.62	30278072
377	Phosphorylation	ELDASDSSSSSNLSL CCCCCCCCCCCCCEE	38.95	30278072
378	Phosphorylation	LDASDSSSSSNLSLA CCCCCCCCCCCCEEC	41.56	30278072
379	Phosphorylation	DASDSSSSSNLSLAK CCCCCCCCCCCEECE	25.78	25159151
380	Phosphorylation	ASDSSSSSNLSLAKV CCCCCCCCCCEECEE	43.68	27732954
380	Phosphorylation	ASDSSSSSNLSLAKV CCCCCCCCCCEECEE	43.68	25159151
380 (in isoform 6)	Phosphorylation	-	43.68	27732954
381	Phosphorylation	SDSSSSSNLSLAKVR CCCCCCCCCEECEEC	35.28	27732954
381 (in isoform 6)	Phosphorylation	-	35.28	27732954
383	Phosphorylation	SSSSSNLSLAKVRPS CCCCCCCEECEECCC	30.45	25159151
384	Phosphorylation	SSSSNLSLAKVRPSS CCCCCCEECEECCCC	6.36	18691976
384	Phosphorylation	SSSSNLSLAKVRPSS CCCCCCEECEECCCC	6.36	18691976
384 (in isoform 6)	Phosphorylation	-	6.36	25849741
390	Phosphorylation	SLAKVRPSSDLNNST EECEECCCCCCCCCC	26.39	23401153
391	Phosphorylation	LAKVRPSSDLNNSTG ECEECCCCCCCCCCC	49.12	23927012
394	Phosphorylation	VRPSSDLNNSTGQSP ECCCCCCCCCCCCCC	45.45	24719451
396	Phosphorylation	PSSDLNNSTGQSPHH CCCCCCCCCCCCCCC	32.61	29255136
397	Phosphorylation	SSDLNNSTGQSPHHK CCCCCCCCCCCCCCC	41.17	29255136
400	Phosphorylation	LNNSTGQSPHHKVQR CCCCCCCCCCCCHHH	27.78	18691976
400	Phosphorylation	LNNSTGQSPHHKVQR CCCCCCCCCCCCHHH	27.78	23401153
402	Phosphorylation	NSTGQSPHHKVQRSV CCCCCCCCCCHHHCC	38.35	18691976
403	Phosphorylation	STGQSPHHKVQRSVS CCCCCCCCCHHHCCC	35.05	17192257
403 (in isoform 7)	Phosphorylation	-	35.05	27732954
404 (in isoform 7)	Phosphorylation	-	36.71	27732954
407 (in isoform 7)	Phosphorylation	-	37.46	25849741
410	Phosphorylation	HKVQRSVSSSQKQRR CCHHHCCCHHHHHHH	6.49	24719451
418	Phosphorylation	SSQKQRRYSDHAGPA HHHHHHHHCCCCCCC	22.19	18691976
418	Phosphorylation	SSQKQRRYSDHAGPA HHHHHHHHCCCCCCC	22.19	23927012
419	Phosphorylation	SQKQRRYSDHAGPAI HHHHHHHCCCCCCCC	22.55	17192257
419	Phosphorylation	SQKQRRYSDHAGPAI HHHHHHHCCCCCCCC	22.55	23927012
428	Phosphorylation	HAGPAIPSVVAYPKR CCCCCCCCEEECCCC	24.10	23927012
432	Phosphorylation	AIPSVVAYPKRSQTS CCCCEEECCCCCCCC	9.55	23927012
436	Phosphorylation	VVAYPKRSQTSTADS EEECCCCCCCCCCCC	43.89	29978859
438	Phosphorylation	AYPKRSQTSTADSDL ECCCCCCCCCCCCCC	29.32	29978859
439	Phosphorylation	YPKRSQTSTADSDLK CCCCCCCCCCCCCCC	17.60	25849741
440	Phosphorylation	PKRSQTSTADSDLKE CCCCCCCCCCCCCCC	37.56	27282143
442	Phosphorylation	RSQTSTADSDLKEDG CCCCCCCCCCCCCCC	42.65	17192257
443	Phosphorylation	SQTSTADSDLKEDGI CCCCCCCCCCCCCCC	42.24	25849741
451	Phosphorylation	DLKEDGISSRKSSGS CCCCCCCCCCCCCCC	29.62	23312004
452	Phosphorylation	LKEDGISSRKSSGSA CCCCCCCCCCCCCCC	41.63	23882029
455	Phosphorylation	DGISSRKSSGSAVGG CCCCCCCCCCCCCCC	38.53	17192257
456	Phosphorylation	GISSRKSSGSAVGGK CCCCCCCCCCCCCCC	39.54	26657352
458	Phosphorylation	SSRKSSGSAVGGKGI CCCCCCCCCCCCCCC	23.02	26657352
469	Phosphorylation	GKGIAPASPMLGNAS CCCCCCCCCCCCCCC	15.13	19664994
476	Phosphorylation	SPMLGNASNPNKADI CCCCCCCCCCCCCCC	57.74	22167270
489	Phosphorylation	DIPERKKSSTVPSSN CCCCCCCCCCCCCCC	33.99	28857561
490	Phosphorylation	IPERKKSSTVPSSNT CCCCCCCCCCCCCCC	42.16	28857561
491	Phosphorylation	PERKKSSTVPSSNTA CCCCCCCCCCCCCCC	43.45	27273156
492	Phosphorylation	ERKKSSTVPSSNTAS CCCCCCCCCCCCCCC	4.71	17192257
494	Phosphorylation	KKSSTVPSSNTASGG CCCCCCCCCCCCCCC	31.70	18691976
495	Phosphorylation	KSSTVPSSNTASGGM CCCCCCCCCCCCCCC	31.93	27732954
497	Phosphorylation	STVPSSNTASGGMTR CCCCCCCCCCCCCCC	24.93	23186163
499	Phosphorylation	VPSSNTASGGMTRRN CCCCCCCCCCCCCCC	33.56	25159151
502	Sulfoxidation	SNTASGGMTRRNTYV CCCCCCCCCCCCEEE	2.76	21406390
503	Phosphorylation	NTASGGMTRRNTYVC CCCCCCCCCCCEEEC	29.74	24667141
507	Phosphorylation	GGMTRRNTYVCSERT CCCCCCCEEECCCCC	18.60	23401153
508	Phosphorylation	GMTRRNTYVCSERTT CCCCCCEEECCCCCC	11.74	20007894
511	Phosphorylation	RRNTYVCSERTTADR CCCEEECCCCCCCCC	21.77	23403867
514	Phosphorylation	TYVCSERTTADRHSV EEECCCCCCCCCCCH	23.45	23312004
515	Phosphorylation	YVCSERTTADRHSVI EECCCCCCCCCCCHH	32.55	23312004
520	Phosphorylation	RTTADRHSVIQNGKE CCCCCCCCHHHCCCC	23.08	29396449
520 (in isoform 3)	Phosphorylation	-	23.08	18220336
529	Phosphorylation	IQNGKENSTIPDQRT HHCCCCCCCCCCCCC	28.89	28450419
530	Phosphorylation	QNGKENSTIPDQRTP HCCCCCCCCCCCCCC	48.38	28450419
536	Phosphorylation	STIPDQRTPVASTHS CCCCCCCCCCCCCCC	19.24	29255136
540	Phosphorylation	DQRTPVASTHSISSA CCCCCCCCCCCCCCC	27.21	22617229
541	Phosphorylation	QRTPVASTHSISSAA CCCCCCCCCCCCCCC	15.20	23401153
543	Phosphorylation	TPVASTHSISSAATP CCCCCCCCCCCCCCC	25.01	22617229
545	Phosphorylation	VASTHSISSAATPDR CCCCCCCCCCCCCCC	19.55	27762562
545	Phosphorylation	VASTHSISSAATPDR CCCCCCCCCCCCCCC	19.55	22167270
545 (in isoform 8)	Phosphorylation	-	19.55	27762562
546	Phosphorylation	ASTHSISSAATPDRI CCCCCCCCCCCCCCE	21.91	22167270
549	Phosphorylation	HSISSAATPDRIRFP CCCCCCCCCCCEECC	25.99	22167270
563	Phosphorylation	PRGTASRSTFHGQPR CCCCCCCCCCCCCCC	32.69	23403867
564	Phosphorylation	RGTASRSTFHGQPRE CCCCCCCCCCCCCCC	20.67	28348404
566	Phosphorylation	TASRSTFHGQPRERR CCCCCCCCCCCCCCC	33.78	18220336
568	Phosphorylation	SRSTFHGQPRERRTA CCCCCCCCCCCCCCC	25.88	18220336
572	Phosphorylation	FHGQPRERRTATYNG CCCCCCCCCCCEECC	42.39	18220336
574	Phosphorylation	GQPRERRTATYNGPP CCCCCCCCCEECCCC	29.58	21945579
576	Phosphorylation	PRERRTATYNGPPAS CCCCCCCEECCCCCC	19.53	21945579
577	Phosphorylation	RERRTATYNGPPASP CCCCCCEECCCCCCC	18.69	21945579
583	Phosphorylation	TYNGPPASPSLSHEA EECCCCCCCCCCCCC	22.31	21945579
585	Phosphorylation	NGPPASPSLSHEATP CCCCCCCCCCCCCCC	39.75	25849741
585	Phosphorylation	NGPPASPSLSHEATP CCCCCCCCCCCCCCC	39.75	21945579
585 (in isoform 6)	Phosphorylation	-	39.75	25849741
587	Phosphorylation	PPASPSLSHEATPLS CCCCCCCCCCCCCHH	24.50	21945579
590	Phosphorylation	SPSLSHEATPLSQTR CCCCCCCCCCHHHCC	14.75	29116813
590 (in isoform 6)	Phosphorylation	-	14.75	29116813
591	Phosphorylation	PSLSHEATPLSQTRS CCCCCCCCCHHHCCC	23.06	21945579
594	Phosphorylation	SHEATPLSQTRSRGS CCCCCCHHHCCCCCC	30.61	21945579
596	Phosphorylation	EATPLSQTRSRGSTN CCCCHHHCCCCCCCC	27.51	21945579
598	Phosphorylation	TPLSQTRSRGSTNLF CCHHHCCCCCCCCHH	44.36	22617229
599	Phosphorylation	PLSQTRSRGSTNLFS CHHHCCCCCCCCHHH	39.53	25849741
599	Methylation	PLSQTRSRGSTNLFS CHHHCCCCCCCCHHH	39.53	58858443
599	Phosphorylation	PLSQTRSRGSTNLFS CHHHCCCCCCCCHHH	39.53	25849741
599 (in isoform 6)	Phosphorylation	-	39.53	25849741
601	Phosphorylation	SQTRSRGSTNLFSKL HHCCCCCCCCHHHHH	17.01	22617229
601 (in isoform 3)	Phosphorylation	-	17.01	25849741
602	Phosphorylation	QTRSRGSTNLFSKLT HCCCCCCCCHHHHHH	38.47	22115753
603	Phosphorylation	TRSRGSTNLFSKLTS CCCCCCCCHHHHHHH	40.56	28634120
603	Phosphorylation	TRSRGSTNLFSKLTS CCCCCCCCHHHHHHH	40.56	18691976
603 (in isoform 6)	Phosphorylation	-	40.56	28634120
606	Phosphorylation	RGSTNLFSKLTSKLT CCCCCHHHHHHHHHH	29.89	27794612
606 (in isoform 3)	Phosphorylation	-	29.89	29116813
608	Phosphorylation	STNLFSKLTSKLTRR CCCHHHHHHHHHHHH	6.74	18669648
610	Phosphorylation	NLFSKLTSKLTRRNM CHHHHHHHHHHHHCC	35.78	18669648
611	Acetylation	LFSKLTSKLTRRNMS HHHHHHHHHHHHCCC	48.95	25953088
614	Phosphorylation	KLTSKLTRRNMSFRF HHHHHHHHHCCCHHH	38.11	18220336
615 (in isoform 3)	Phosphorylation	-	37.66	25849741
618	Phosphorylation	KLTRRNMSFRFIKRL HHHHHCCCHHHHHCC	19.47	29514088
619 (in isoform 3)	Phosphorylation	-	5.27	28634120
624	Phosphorylation	MSFRFIKRLPTEYER CCHHHHHCCCCHHHH	40.87	17192257
624 (in isoform 2)	Phosphorylation	-	40.87	25849741
627	Phosphorylation	RFIKRLPTEYERNGR HHHHCCCCHHHHCCC	56.65	26437602
629 (in isoform 2)	Phosphorylation	-	23.75	29116813
629 (in isoform 4)	Phosphorylation	-	23.75	25056879
635	Phosphorylation	EYERNGRYEGSSRNV HHHHCCCCCCCCCCC	26.49	26437602
638	Phosphorylation	RNGRYEGSSRNVSAE HCCCCCCCCCCCCHH	17.74	19369195
638 (in isoform 2)	Phosphorylation	-	17.74	25849741
639	Phosphorylation	NGRYEGSSRNVSAEQ CCCCCCCCCCCCHHH	38.44	27794612
642 (in isoform 2)	Phosphorylation	-	5.80	28634120
643	Phosphorylation	EGSSRNVSAEQKDEN CCCCCCCCHHHCCCC	29.63	14976552
647	Ubiquitination	RNVSAEQKDENKEAK CCCCHHHCCCCCCCC	59.52	21890473
657	Phosphorylation	NKEAKPRSLRFTWSM CCCCCCCCEEEEEEC	32.21	20860994
663	Phosphorylation	RSLRFTWSMKTTSSM CCEEEEEECEECCCC	13.82	-
666	Phosphorylation	RFTWSMKTTSSMDPG EEEEECEECCCCCHH	24.22	19369195
667	Phosphorylation	FTWSMKTTSSMDPGD EEEECEECCCCCHHH	17.18	28348404
668	Phosphorylation	TWSMKTTSSMDPGDM EEECEECCCCCHHHH	28.97	27251275
669	Phosphorylation	WSMKTTSSMDPGDMM EECEECCCCCHHHHH	25.72	25307156
681	Ubiquitination	DMMREIRKVLDANNC HHHHHHHHHHHHCCC	53.46	22053931
690	Phosphorylation	LDANNCDYEQRERFL HHHCCCCHHHHHCEE	19.03	26074081
701 (in isoform 6)	Ubiquitination	-	4.41	21890473
717 (in isoform 3)	Ubiquitination	-	3.17	21890473
724	Phosphorylation	VCKLPRLSLNGVRFK HHCCCCEEECCEEEE	22.52	27067055
732 (in isoform 4)	Ubiquitination	-	26.12	21890473
734	Phosphorylation	GVRFKRISGTSIAFK CEEEEECCCCHHHHH	39.80	29514088
736	Phosphorylation	RFKRISGTSIAFKNI EEEECCCCHHHHHHH	15.35	29514088
737	Phosphorylation	FKRISGTSIAFKNIA EEECCCCHHHHHHHH	18.55	29514088
740 (in isoform 2)	Ubiquitination	-	6.24	21890473
741	Ubiquitination	SGTSIAFKNIASKIA CCCHHHHHHHHHHHH	38.12	-
741 (in isoform 5)	Ubiquitination	-	38.12	21890473
745	Phosphorylation	IAFKNIASKIANELK HHHHHHHHHHHHHHC	22.31	-
748 (in isoform 7)	Ubiquitination	-	13.74	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
90	T	Phosphorylation	Kinase	PIM1	P11309	PSP
95	T	Phosphorylation	Kinase	PIM1	P11309	PSP
96	S	Phosphorylation	Kinase	PIM1	P11309	PSP
211	T	Phosphorylation	Kinase	STK11	Q15831	GPS
215	S	Phosphorylation	Kinase	STK11	Q15831	GPS
234	T	Phosphorylation	Kinase	STK11	Q15831	PhosphoELM
507	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
564	T	Phosphorylation	Kinase	PRKCI	P41743	GPS
564	T	Phosphorylation	Kinase	PKCZ	Q05513	PSP
598	S	Phosphorylation	Kinase	MARK3	P27448-3	GPS
601	S	Phosphorylation	Kinase	MARK3	P27448-3	GPS
602	T	Phosphorylation	Kinase	MARK3	P27448-3	GPS
606	S	Phosphorylation	Kinase	MARK3	P27448-3	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
211	T	Phosphorylation	14976552
Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
564	T	Phosphorylation	15084291
Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MARK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGRF1_HUMAN	RASGRF1	physical	9543386
VATL_HUMAN	ATP6V0C	physical	16169070
SCG1_HUMAN	CHGB	physical	16169070
SAAL1_HUMAN	SAAL1	physical	16169070
MPPB_HUMAN	PMPCB	physical	16169070
PLPL2_HUMAN	PNPLA2	physical	16169070
VPS11_HUMAN	VPS11	physical	16169070
TTHY_HUMAN	TTR	physical	16169070
HDAC7_HUMAN	HDAC7	physical	16980613
MTAP2_HUMAN	MAP2	physical	12879020
1433Z_HUMAN	YWHAZ	physical	16968750
1433E_HUMAN	YWHAE	physical	16968750
MPIP3_HUMAN	CDC25C	physical	16968750
PKP2_HUMAN	PKP2	physical	12941695
MPIP3_HUMAN	CDC25C	physical	9543386
KSR1_HUMAN	KSR1	physical	11741534
PIM1_HUMAN	PIM1	physical	15319445
MARK3_HUMAN	MARK3	physical	15319445
MPIP3_HUMAN	CDC25C	physical	15319445
TCEA2_HUMAN	TCEA2	physical	16169070
TAU_HUMAN	MAPT	physical	23666762
CRTC2_MOUSE	Crtc2	physical	18626018
CAZA1_HUMAN	CAPZA1	physical	25852190
CAPZB_HUMAN	CAPZB	physical	25852190
CNBP_HUMAN	CNBP	physical	25852190
DLG5_HUMAN	DLG5	physical	25852190
HNRDL_HUMAN	HNRNPDL	physical	25852190
MTCL1_HUMAN	MTCL1	physical	25852190
THOC4_HUMAN	ALYREF	physical	25852190
1433Z_HUMAN	YWHAZ	physical	25852190
MARK3_HUMAN	MARK3	physical	18082144

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MARK3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-3; SER-42;THR-61; THR-211; TYR-340; SER-341; SER-374; SER-376; SER-377; SER-378;SER-379; SER-380; SER-383; THR-397; SER-400; TYR-418; SER-419;SER-436; THR-438; SER-456; SER-469; SER-494; SER-499; SER-540;THR-541; SER-543; SER-545; SER-583; SER-585; SER-587; SER-598;SER-601; SER-639 AND SER-643, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-469; SER-583AND SER-585, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61; SER-380; SER-383;SER-400; SER-419; SER-455; SER-469; SER-476; THR-536; THR-549;SER-583; SER-587; SER-598 AND SER-643, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540; SER-543; THR-549AND THR-591, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-211; SER-419; SER-469AND SER-601, AND MASS SPECTROMETRY.	17192257 [Abstract]
"LKB1 is a master kinase that activates 13 kinases of the AMPKsubfamily, including MARK/PAR-1."; Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A.,Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G.,Alessi D.R.; EMBO J. 23:833-843(2004). Cited for: ENZYME REGULATION, PHOSPHORYLATION AT THR-211, AND MUTAGENESIS OFTHR-211.	14976552 [Abstract]

show

show