RGRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGRF1_HUMAN
• UniProt AC: Q13972
• Protein Name: Ras-specific guanine nucleotide-releasing factor 1
• Gene Name: RASGRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 1273
• Protein Description: Promotes the exchange of Ras-bound GDP by GTP..
• Protein Sequence: MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSSRPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKLPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LNDGHVASLGLLARK CCCCCHHHHEEEECC	26.35	-
33	Phosphorylation	KGYLSKRSSDNTKWQ CCCCCCCCCCCCCHH	45.86	25072903
34	Phosphorylation	GYLSKRSSDNTKWQT CCCCCCCCCCCCHHH	38.62	25072903
37	Phosphorylation	SKRSSDNTKWQTKWF CCCCCCCCCHHHHHH	38.35	25072903
78	Phosphorylation	CVCDRAPSPKPALSA EEECCCCCCCCCCCC	44.57	24076635
180	Phosphorylation	RLKAEITSLLKDNER HHHHHHHHHHHCCCC	37.05	24719451
232	Phosphorylation	IIQDYIRSPHADSMR HHHHHHHCCCHHHHH	16.10	30257219
481	Phosphorylation	ITRGRLGSLSLKKEG CCCCCCCCEECCCCC	21.27	23401153
483	Phosphorylation	RGRLGSLSLKKEGER CCCCCCEECCCCCCC	35.86	24719451
496	Phosphorylation	ERQCFLFSKHLIICT CCEEEEEECEEEEEE	22.70	24719451
557	Phosphorylation	IGVEPKDSPPFTVIL ECCCCCCCCCEEEEE	40.37	28509920
577	Phosphorylation	QEKAAWTSDISQCVD CHHHHCCCCHHHHHH	23.42	-
613 (in isoform 3)	Phosphorylation	-	65.39	-
615	Phosphorylation	IKRTREGTREAEMSR HHHHCCCCCHHCCCC	22.15	22210691
621	Phosphorylation	GTREAEMSRSDASLY CCCHHCCCCCHHHHE	21.82	22210691
626	Phosphorylation	EMSRSDASLYCDDVD CCCCCHHHHEECCCC	25.51	-
637	Phosphorylation	DDVDIRFSKTMNSCK CCCCEEEECCCCCCC	19.85	-
709	Phosphorylation	IPARWLRSLELLFAS CCHHHHHHHHHHHHC	24.83	-
730	Phosphorylation	LYGEPPKSPRATRKF EECCCCCCCCCCCCC	25.95	28348404
738	Phosphorylation	PRATRKFSSPPPLSI CCCCCCCCCCCCCCC	44.99	28348404
739	Phosphorylation	RATRKFSSPPPLSIT CCCCCCCCCCCCCCC	44.55	24076635
744	Phosphorylation	FSSPPPLSITKTSSP CCCCCCCCCCCCCCH	33.70	24719451
750	Phosphorylation	LSITKTSSPSRRRKL CCCCCCCCHHHCCCE	31.93	-
752	Phosphorylation	ITKTSSPSRRRKLSL CCCCCCHHHCCCEEE	40.13	-
758	Phosphorylation	PSRRRKLSLNIPIIT HHHCCCEEECCCEEE	5.02	27251275
779	Phosphorylation	LAALSCNSNGYTSMY HHHHCCCCCCCCHHH	8.64	-
782	Phosphorylation	LSCNSNGYTSMYSAM HCCCCCCCCHHHHCC	33.24	-
786	Phosphorylation	SNGYTSMYSAMSPFS CCCCCHHHHCCCCCC	13.77	-
787	Phosphorylation	NGYTSMYSAMSPFSK CCCCHHHHCCCCCCC	2.06	-
800	Phosphorylation	SKATLDTSKLYVSSS CCCCCCCCCEEECHH	44.58	-
818	Phosphorylation	KIPDEGDTTPEKPED CCCCCCCCCCCCCCC	44.97	28348404
819	Phosphorylation	IPDEGDTTPEKPEDP CCCCCCCCCCCCCCH	45.41	28348404
827	Phosphorylation	PEKPEDPSALSKQSS CCCCCCHHHHHHCCC	51.48	25954137
830	Phosphorylation	PEDPSALSKQSSEVS CCCHHHHHHCCCCCC	22.65	25954137
833	Phosphorylation	PSALSKQSSEVSMRE HHHHHHCCCCCCCCC	55.86	28111955
834	Phosphorylation	SALSKQSSEVSMREE HHHHHCCCCCCCCCH	49.14	25954137
837	Phosphorylation	SKQSSEVSMREESDI HHCCCCCCCCCHHHC	43.81	25954137
842	Phosphorylation	EVSMREESDIDQNQS CCCCCCHHHCCCCCC	53.89	30576142
856	Phosphorylation	SDDGDTETSPTKSPT CCCCCCCCCCCCCCC	46.85	30576142
859	Phosphorylation	GDTETSPTKSPTTPK CCCCCCCCCCCCCCC	25.08	30576142
863	Phosphorylation	TSPTKSPTTPKSVKN CCCCCCCCCCCCCCC	29.92	23532336
927	Phosphorylation	KEKYRRMSLASAGFP HHHHHHHHHHHCCCC	18.89	12538592
929	Phosphorylation	KYRRMSLASAGFPPD HHHHHHHHHCCCCCC	20.97	15853814
1023	Phosphorylation	QITLEEITQMAEGVK EEEHHHHHHHHCCCC	55.22	-
1090	Phosphorylation	TKHFNDISNLIASEI CCCHHHHHHHHHHHH	44.76	-
1095	Phosphorylation	DISNLIASEIIRNED HHHHHHHHHHHHCCC	4.66	-
1245	Phosphorylation	IEHQAKVTQYLLDQS HHHHHHHHHHHHHHH	38.96	28111955
1247	Phosphorylation	HQAKVTQYLLDQSFV HHHHHHHHHHHHHHC	15.70	28111955
1252	Phosphorylation	TQYLLDQSFVMDEES HHHHHHHHHCCCHHH	39.21	28111955
1259	Phosphorylation	SFVMDEESLYESSLR HHCCCHHHHHHCCCC	31.24	28111955
1261	Phosphorylation	VMDEESLYESSLRIE CCCHHHHHHCCCCCC	33.92	28111955
1263	Phosphorylation	DEESLYESSLRIEPK CHHHHHHCCCCCCCC	24.04	28111955
1264	Phosphorylation	EESLYESSLRIEPKL HHHHHHCCCCCCCCC	38.86	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
577	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
626	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
779	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
800	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
927	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433B_HUMAN	YWHAB	physical	9543386
MARK3_HUMAN	MARK3	physical	9543386
RU17_HUMAN	SNRNP70	physical	21988832

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.