SAAL1_HUMAN - dbPTM
SAAL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAAL1_HUMAN
UniProt AC Q96ER3
Protein Name Protein SAAL1
Gene Name SAAL1
Organism Homo sapiens (Human).
Sequence Length 474
Subcellular Localization Nucleus .
Protein Description Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli..
Protein Sequence MDRNPSPPPPGRDKEEEEEVAGGDCIGSTVYSKHWLFGVLSGLIQIVSPENTKSSSDDEEQLTELDEEMENEICRVWDMSMDEDVALFLQEFNAPDIFMGVLAKSKCPRLREICVGILGNMACFQEICVSISSDKNLGQVLLHCLYDSDPPTLLETSRLLLTCLSQAEVASVWVERIQEHPAIYDSICFIMSSSTNVDLLVKVGEVVDKLFDLDEKLMLEWVRNGAAQPLDQPQEESEEQPVFRLVPCILEAAKQVRSENPEWLDVYMHILQLLTTVDDGIQAIVHCPDTGKDIWNLLFDLVCHEFCQSDDPPIILQEQKTVLASVFSVLSAIYASQTEQEYLKIEKVDLPLIDSLIRVLQNMEQCQKKPENSAESNTEETKRTDLTQDDFHLKILKDILCEFLSNIFQALTKETVAQGVKEGQLSKQKCSSAFQNLLPFYSPVVEDFIKILREVDKALADDLEKNFPSLKVQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MDRNPSPPPPGRD
--CCCCCCCCCCCCC		54.2929255136
28PhosphorylationAGGDCIGSTVYSKHW
CCCCCCCCCHHCHHH		8.5226074081
29PhosphorylationGGDCIGSTVYSKHWL
CCCCCCCCHHCHHHH		20.4626074081
31PhosphorylationDCIGSTVYSKHWLFG
CCCCCCHHCHHHHHH		16.4626074081
32PhosphorylationCIGSTVYSKHWLFGV
CCCCCHHCHHHHHHH		17.4426074081
54PhosphorylationVSPENTKSSSDDEEQ
CCCCCCCCCCCCHHH		32.7923401153
55PhosphorylationSPENTKSSSDDEEQL
CCCCCCCCCCCHHHH		39.0730278072
56PhosphorylationPENTKSSSDDEEQLT
CCCCCCCCCCHHHHH		57.0530278072
63PhosphorylationSDDEEQLTELDEEME
CCCHHHHHHHHHHHH		33.9128287266
202UbiquitinationTNVDLLVKVGEVVDK
CCCEEEHHHHHHHHH		44.48-
209UbiquitinationKVGEVVDKLFDLDEK
HHHHHHHHHCCCCHH		39.1721890473
237PhosphorylationLDQPQEESEEQPVFR
CCCCCCCCCCCCHHH		45.7621815630
254UbiquitinationPCILEAAKQVRSENP
HHHHHHHHHHHHCCH		57.27-
321PhosphorylationIILQEQKTVLASVFS
CHHHHHHHHHHHHHH		22.0523663014
325PhosphorylationEQKTVLASVFSVLSA
HHHHHHHHHHHHHHH		21.3823663014
328PhosphorylationTVLASVFSVLSAIYA
HHHHHHHHHHHHHHC		21.7223663014
331PhosphorylationASVFSVLSAIYASQT
HHHHHHHHHHHCCCC		15.5123663014
334PhosphorylationFSVLSAIYASQTEQE
HHHHHHHHCCCCHHH		10.4223663014
336PhosphorylationVLSAIYASQTEQEYL
HHHHHHCCCCHHHHH		22.2123663014
338PhosphorylationSAIYASQTEQEYLKI
HHHHCCCCHHHHHHH		36.8223663014
342PhosphorylationASQTEQEYLKIEKVD
CCCCHHHHHHHHCCC		17.0023663014
347UbiquitinationQEYLKIEKVDLPLID
HHHHHHHCCCHHHHH		44.51-
355PhosphorylationVDLPLIDSLIRVLQN
CCHHHHHHHHHHHHC		20.7824719451
373PhosphorylationCQKKPENSAESNTEE
HHHCCCCCCCCCCCH		31.5821406692
376PhosphorylationKPENSAESNTEETKR
CCCCCCCCCCCHHHH		49.0921406692
378PhosphorylationENSAESNTEETKRTD
CCCCCCCCCHHHHCC		44.4721406692
381PhosphorylationAESNTEETKRTDLTQ
CCCCCCHHHHCCCCC		21.4221406692
382UbiquitinationESNTEETKRTDLTQD
CCCCCHHHHCCCCCC		57.492190698
384PhosphorylationNTEETKRTDLTQDDF
CCCHHHHCCCCCCHH		36.6028555341
387PhosphorylationETKRTDLTQDDFHLK
HHHHCCCCCCHHHHH		32.5317525332
388PhosphorylationTKRTDLTQDDFHLKI
HHHCCCCCCHHHHHH		56.4217525332
394UbiquitinationTQDDFHLKILKDILC
CCCHHHHHHHHHHHH		37.11-
421UbiquitinationETVAQGVKEGQLSKQ
HHHHHHHHCCCCCHH		64.05-
457UbiquitinationKILREVDKALADDLE
HHHHHHHHHHHHHHH		50.94-
465UbiquitinationALADDLEKNFPSLKV
HHHHHHHHHCCCCCC		71.79-
471UbiquitinationEKNFPSLKVQT----
HHHCCCCCCCC----		36.31-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAAL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAAL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAAL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHRM3_HUMANSHROOM3physical
22939629
USH1C_HUMANUSH1Cphysical
22939629
SYGP1_HUMANSYNGAP1physical
22939629
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAAL1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-387, AND MASSSPECTROMETRY.

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