dbPTM

SYGP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYGP1_HUMAN
UniProt AC	Q96PV0
Protein Name	Ras/Rap GTPase-activating protein SynGAP
Gene Name	SYNGAP1
Organism	Homo sapiens (Human).
Sequence Length	1343
Subcellular Localization
Protein Description	Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)..
Protein Sequence	MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 3)	Phosphorylation	-	18.76	22210691
12	Phosphorylation	RASIHRGSIPAMSYA CHHHCCCCCCCHHCC	25.92	25332170
18 (in isoform 3)	Phosphorylation	-	12.76	22210691
34	Phosphorylation	PSMHRTQYVHSPYDR CCCCCCCCCCCCCCC	10.26	-
39	Phosphorylation	TQYVHSPYDRPGWNP CCCCCCCCCCCCCCC	27.83	27196784
87	Phosphorylation	KLLRRTVSVPVEGRP HHHHEEEECCCCCCC	21.79	27732954
117	Phosphorylation	VPGGKQYSMEGAPAA CCCCCCCCCCCCCCC	14.09	-
145	Acetylation	KSSIKRTKSQPKLDR HHHHHHHCCCCCCCC	51.64	7307403
146	Phosphorylation	SSIKRTKSQPKLDRT HHHHHHCCCCCCCCC	51.61	28857561
178	Methylation	ARLMQSFKESHSHES HHHHHHHHHCCCCCC	64.65	115980273
204	Phosphorylation	ELNLDEDSIIKPVHS HCCCCCCCCCHHHHH	24.94	24719451
291	Phosphorylation	LCLDDMLYARTTSKP EEHHHHHHCCCCCCC	6.34	-
359	Phosphorylation	TLAGRHFTEQWYPVT HHCCCCCCCCEEEEE	22.57	22210691
363	Phosphorylation	RHFTEQWYPVTLPTG CCCCCCEEEEEECCC	6.37	22210691
366	Phosphorylation	TEQWYPVTLPTGSGG CCCEEEEEECCCCCC	23.63	24076635
369	Phosphorylation	WYPVTLPTGSGGSGG EEEEEECCCCCCCCC	47.28	22210691
371	Phosphorylation	PVTLPTGSGGSGGMG EEEECCCCCCCCCCC	42.32	22210691
374	Phosphorylation	LPTGSGGSGGMGSGG ECCCCCCCCCCCCCC	35.38	24076635
379	Phosphorylation	GGSGGMGSGGGGGSG CCCCCCCCCCCCCCC	25.93	-
385	Phosphorylation	GSGGGGGSGGGSGGK CCCCCCCCCCCCCCC	37.22	-
423	Phosphorylation	LYKEFAEYVTNHYRM HHHHHHHHHHHHHHH	14.78	24114839
425	Phosphorylation	KEFAEYVTNHYRMLC HHHHHHHHHHHHHHH	18.51	24114839
428	Phosphorylation	AEYVTNHYRMLCAVL HHHHHHHHHHHHHHH	10.37	24114839
449	Phosphorylation	KGKEEVASALVHILQ CCHHHHHHHHHHHHH	27.58	-
466	Phosphorylation	GKAKDFLSDMAMSEV CCHHHHHHHHHHHHH	25.90	21082442
637	Phosphorylation	IQNLANFSKFTSKED HHHHHCHHHCCCHHH	27.02	28258704
640	Phosphorylation	LANFSKFTSKEDFLG HHCHHHCCCHHHHHH	42.50	28258704
641	Phosphorylation	ANFSKFTSKEDFLGF HCHHHCCCHHHHHHH	36.86	28258704
682	Phosphorylation	NSSSFEGYIDLGREL CCCCCCCCHHHHHHH	5.53	-
723	Phosphorylation	RLLNDISTALRNPNI HHHHHHHHHHHCCCC	30.00	24114839
752	Phosphorylation	PVVLRGPSAEMQGYM CEEEECCCHHHHHHH	39.42	-
758	Phosphorylation	PSAEMQGYMMRDLNS CCHHHHHHHHCCCCC	3.20	23663014
766	Phosphorylation	MMRDLNSSIDLQSFM HHCCCCCCCCHHHHH	21.03	14970204
771	Phosphorylation	NSSIDLQSFMARGLN CCCCCHHHHHHHCCC	25.04	14970204
779	Phosphorylation	FMARGLNSSMDMARL HHHHCCCCCCCHHCC	31.89	14970204
780	Phosphorylation	MARGLNSSMDMARLP HHHCCCCCCCHHCCC	20.09	14970204
788	Phosphorylation	MDMARLPSPTKEKPP CCHHCCCCCCCCCCC	50.20	28060719
809	O-linked_Glycosylation	GKDLFYVSRPPLARS CCCCEEECCCCCCCC	27.91	28657654
816	Phosphorylation	SRPPLARSSPAYCTS CCCCCCCCCCCCCCC	34.76	24076635
817	Phosphorylation	RPPLARSSPAYCTSS CCCCCCCCCCCCCCC	14.16	24076635
820	Phosphorylation	LARSSPAYCTSSSDI CCCCCCCCCCCCCCC	10.31	24076635
822	Phosphorylation	RSSPAYCTSSSDITE CCCCCCCCCCCCCCC	20.97	24076635
823	Phosphorylation	SSPAYCTSSSDITEP CCCCCCCCCCCCCCH	25.04	24076635
824	Phosphorylation	SPAYCTSSSDITEPE CCCCCCCCCCCCCHH	17.55	24076635
825	Phosphorylation	PAYCTSSSDITEPEQ CCCCCCCCCCCCHHH	32.57	24076635
828	Phosphorylation	CTSSSDITEPEQKML CCCCCCCCCHHHHHH	50.94	-
836	Phosphorylation	EPEQKMLSVNKSVSM CHHHHHHHCCCCEEE	21.83	-
840	Phosphorylation	KMLSVNKSVSMLDLQ HHHHCCCCEEEEECC	17.77	19060867
842	Phosphorylation	LSVNKSVSMLDLQGD HHCCCCEEEEECCCC	22.25	19060867
857	Phosphorylation	GPGGRLNSSSVSNLA CCCCCCCCCHHCHHH	28.69	22210691
876	Phosphorylation	LLHSSQASLTAALGL HHHHCHHHHHHHHCC	20.72	22210691
892	O-linked_Glycosylation	PAPAGRLSQGSGSSI CCCCCCCCCCCCCCC	31.00	28657654
892	Phosphorylation	PAPAGRLSQGSGSSI CCCCCCCCCCCCCCC	31.00	-
895	Phosphorylation	AGRLSQGSGSSITAA CCCCCCCCCCCCCHH	28.06	19060867
898	Phosphorylation	LSQGSGSSITAAGMR CCCCCCCCCCHHHHC	27.73	-
900	O-linked_Glycosylation	QGSGSSITAAGMRLS CCCCCCCCHHHHCHH	16.65	28657654
907	Phosphorylation	TAAGMRLSQMGVTTD CHHHHCHHHCCCCCC	14.04	-
912	O-linked_Glycosylation	RLSQMGVTTDGVPAQ CHHHCCCCCCCCCHH	17.28	28657654
912	Phosphorylation	RLSQMGVTTDGVPAQ CHHHCCCCCCCCCHH	17.28	-
913	Phosphorylation	LSQMGVTTDGVPAQQ HHHCCCCCCCCCHHH	28.49	-
982	Phosphorylation	TFAPFHGYSKSEDLS CCCCCCCCCCCCCCC	12.35	27196784
985	Phosphorylation	PFHGYSKSEDLSSGV CCCCCCCCCCCCCCC	30.33	-
1073	Phosphorylation	PPLQRGKSQQLTVSA CCCCCCCCCEEEEEE	26.44	15358237
1077	Phosphorylation	RGKSQQLTVSAAQKP CCCCCEEEEEECCCC	14.21	15358237
1079	Phosphorylation	KSQQLTVSAAQKPRP CCCEEEEEECCCCCC	16.80	14970204
1094	Phosphorylation	SSGNLLQSPEPSYGP CCCCCCCCCCCCCCC	31.06	29759185
1114	Phosphorylation	QSLSKEGSIGGSGGS CCCCCCCCCCCCCCC	21.10	25307156
1118	Phosphorylation	KEGSIGGSGGSGGGG CCCCCCCCCCCCCCC	34.46	25307156
1121	Phosphorylation	SIGGSGGSGGGGGGG CCCCCCCCCCCCCCC	37.48	23403867
1132	Phosphorylation	GGGGLKPSITKQHSQ CCCCCCCCCCCCCCC	41.10	23403867
1138	Phosphorylation	PSITKQHSQTPSTLN CCCCCCCCCCCCCCC	33.00	14970204
1151	Phosphorylation	LNPTMPASERTVAWV CCCCCCCCHHHEEHH	23.03	-
1165	Phosphorylation	VSNMPHLSADIESAH HHCCCCCCCCHHHHH	22.36	24076635
1183	Phosphorylation	EEYKLKEYSKSMDES HHHHHHHHHHHCCHH	21.58	29449344
1184	Phosphorylation	EYKLKEYSKSMDESR HHHHHHHHHHCCHHH	21.24	29449344
1186	Phosphorylation	KLKEYSKSMDESRLD HHHHHHHHCCHHHHH	26.06	29449344
1190	Phosphorylation	YSKSMDESRLDRVKE HHHHCCHHHHHHHHH	33.60	29449344
1204	Phosphorylation	EYEEEIHSLKERLHM HHHHHHHHHHHHHHH	46.96	25332170
1206	Ubiquitination	EEEIHSLKERLHMSN HHHHHHHHHHHHHCH	43.75	-
1261	Phosphorylation	EKDSQIKSIIGRLML HHHHHHHHHHHHHHH	22.52	-
1267 (in isoform 2)	Phosphorylation	-	3.67	18691976
1310	O-linked_Glycosylation	GPTNPRVTLAPPWNG CCCCCCCEECCCCCC	20.62	28657654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
385	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
449	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
466	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
836	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
840	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
842	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
895	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYGP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYGP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DLG4_HUMAN	DLG4	physical	9581761
DLG3_HUMAN	DLG3	physical	9581761

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612621	Mental retardation, autosomal dominant 5 (MRD5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYGP1_HUMAN

Related Literatures of Post-Translational Modification