dbPTM

DLG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLG5_HUMAN
UniProt AC	Q8TDM6
Protein Name	Disks large homolog 5
Gene Name	DLG5
Organism	Homo sapiens (Human).
Sequence Length	1919
Subcellular Localization	Cell junction . Cell membrane Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cytoplasm, cytoskeleton, cilium basal body . Localized at sites of cell-cell contact.
Protein Description	Acts as a regulator of the Hippo signaling pathway. [PubMed: 28087714]
Protein Sequence	MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPACPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9 (in isoform 5)	Phosphorylation	-	2.37	25056879
37	Phosphorylation	LEAAGALSPGERRQL HHHHCCCCHHHHHHH	30.26	25159151
63	2-Hydroxyisobutyrylation	LLKLLLAKERDHFQD HHHHHHHHCCHHHHH	53.93	-
63	Ubiquitination	LLKLLLAKERDHFQD HHHHHHHHCCHHHHH	53.93	-
113	Phosphorylation	SVLSTMPSDSESSSS EEEECCCCCCCCCCC	42.84	22777824
132	Phosphorylation	GTTGKAPSPPPLLTD CCCCCCCCCCCCCCH	55.70	30278072
150	Phosphorylation	NEKVENLSIQLRLMT HHHHHHHHHHHHHHH	21.63	26471730
181	Phosphorylation	TAFDKRPYHRLNPDY CCCCCCCHHHCCCCH	12.01	27259358
188	Phosphorylation	YHRLNPDYERLKIQC HHHCCCCHHHHHHHH	12.28	26356563
192	Ubiquitination	NPDYERLKIQCVRAM CCCHHHHHHHHHHHH	36.63	29967540
200	Phosphorylation	IQCVRAMSDLQSLQN HHHHHHHHHHHHHHH	33.90	24719451
204	Phosphorylation	RAMSDLQSLQNQHTN HHHHHHHHHHHHHCH	38.94	28348404
210	Phosphorylation	QSLQNQHTNALKRCE HHHHHHHCHHHHHHH	16.66	-
214	Ubiquitination	NQHTNALKRCEEVAK HHHCHHHHHHHHHHH	53.22	29967540
264	Phosphorylation	ERNLLQQSWEDMKRL HHHHHHHHHHHHHHH	21.33	28355574
269	Ubiquitination	QQSWEDMKRLHEEDQ HHHHHHHHHHHHHHH	65.22	29967540
277	Ubiquitination	RLHEEDQKEIGDLRA HHHHHHHHHHHHHHH	64.72	29967540
291	Ubiquitination	AQQQQVLKHNGSSEI HHHHHHHHHCCCHHH	35.85	29967540
295	Phosphorylation	QVLKHNGSSEILNKL HHHHHCCCHHHHHHH	30.07	30266825
296	Phosphorylation	VLKHNGSSEILNKLY HHHHCCCHHHHHHHH	30.01	30266825
303	Phosphorylation	SEILNKLYDTAMDKL HHHHHHHHHHHHHHH	16.92	27642862
309	2-Hydroxyisobutyrylation	LYDTAMDKLEVVKKD HHHHHHHHHHHHHHH	33.20	-
327	Ubiquitination	LRKRYSEKVAIHNAD HHHHHHHCHHHHHCC	30.90	29967540
350	Ubiquitination	EENQRLLKQTEMLTQ HHHHHHHHHHHHHHH	60.82	29967540
365 (in isoform 3)	Ubiquitination	-	3.92	21890473
372	Phosphorylation	LQHQCALSLRRFEAI HHHHHHHHHHHHHHH	10.99	24719451
429	Phosphorylation	REERDAVYSEYKLIM HHHHHHHHHHHHHHH	9.48	28796482
430	Phosphorylation	EERDAVYSEYKLIMS HHHHHHHHHHHHHHC	28.05	28796482
432	Phosphorylation	RDAVYSEYKLIMSER HHHHHHHHHHHHCHH	12.73	28796482
448	Ubiquitination	QVISELDKLQTEVEL HHHHHHHHHHHHHHH	55.93	29967540
459	Ubiquitination	EVELAESKLKSSTSE HHHHHHHHHCCCHHH	51.98	32015554
462	O-linked_Glycosylation	LAESKLKSSTSEKKA HHHHHHCCCHHHHHH	49.65	30379171
510	Acetylation	KALCQELKEALQEAD HHHHHHHHHHHHHCH	39.94	26051181
510	Ubiquitination	KALCQELKEALQEAD HHHHHHHHHHHHHCH	39.94	21890473
661	Ubiquitination	IFVTKVDKGSIADGR EEEEEECCCCCCCCC	58.51	21890473
704	Ubiquitination	NGEGAINMVVRRRKS CCCCHHHHHHHCCCC	2.11	21890473
706	Ubiquitination	EGAINMVVRRRKSLG CCHHHHHHHCCCCCC	2.47	21890473
706 (in isoform 4)	Ubiquitination	-	2.47	21890473
711	Phosphorylation	MVVRRRKSLGGKVVT HHHHCCCCCCCEEEE	30.36	22617229
718	Phosphorylation	SLGGKVVTPLHINLS CCCCEEEEEEEEECC	24.10	22199227
722	Ubiquitination	KVVTPLHINLSGQKD EEEEEEEEECCCCCC	7.95	21890473
725	Phosphorylation	TPLHINLSGQKDSGI EEEEEECCCCCCCCE	34.39	22199227
726	Ubiquitination	PLHINLSGQKDSGIS EEEEECCCCCCCCEE	41.54	21890473
730	Phosphorylation	NLSGQKDSGISLENG ECCCCCCCCEECCCC	45.09	-
733	Phosphorylation	GQKDSGISLENGVYA CCCCCCEECCCCEEE	32.91	-
747	Phosphorylation	AAAVLPGSPAAKEGS EEEECCCCCCCCCCC	14.93	22199227
757	Ubiquitination	AKEGSLAVGDRIVAI CCCCCCCCCCEEEEE	11.26	21890473
773	Phosphorylation	GIALDNKSLNECESL CEECCCCCHHHHHHH	42.56	28348404
779	Phosphorylation	KSLNECESLLRSCQD CCHHHHHHHHHHHHH	44.34	24719451
791	Phosphorylation	CQDSLTLSLLKVFPQ HHHHHHHHHHHHCCC	26.81	25159151
799	Phosphorylation	LLKVFPQSSSWSGQN HHHHCCCCCCCCCCC	26.95	30624053
800	Phosphorylation	LKVFPQSSSWSGQNI HHHCCCCCCCCCCCH	30.49	30624053
801	Phosphorylation	KVFPQSSSWSGQNIF HHCCCCCCCCCCCHH	30.43	30624053
803	Phosphorylation	FPQSSSWSGQNIFEN CCCCCCCCCCCHHHC	32.23	22199227
812	Ubiquitination	QNIFENIKDSDKMLS CCHHHCCCCHHHCCC	63.86	21890473
814	Phosphorylation	IFENIKDSDKMLSFR HHHCCCCHHHCCCCC	33.84	28102081
816	Ubiquitination	ENIKDSDKMLSFRAH HCCCCHHHCCCCCCC	45.77	21890473
816 (in isoform 1)	Ubiquitination	-	45.77	21890473
819	Phosphorylation	KDSDKMLSFRAHGPE CCHHHCCCCCCCCHH	14.80	24719451
841	Phosphorylation	NLIQHNNSTQTDIFY CCCCCCCCCCCEEEE	27.49	30266825
842	Phosphorylation	LIQHNNSTQTDIFYT CCCCCCCCCCEEEEC	37.30	30266825
844	Phosphorylation	QHNNSTQTDIFYTDR CCCCCCCCEEEECCC	31.02	30266825
848	Phosphorylation	STQTDIFYTDRLEDR CCCCEEEECCCCCCC	14.20	27642862
849	Phosphorylation	TQTDIFYTDRLEDRK CCCEEEECCCCCCCC	12.14	23312004
864	Phosphorylation	EPGPPGGSSSFLHKP CCCCCCCCCCCCCCC	28.82	25849741
865	Phosphorylation	PGPPGGSSSFLHKPF CCCCCCCCCCCCCCC	28.52	25159151
866	Phosphorylation	GPPGGSSSFLHKPFP CCCCCCCCCCCCCCC	33.26	30576142
886	Phosphorylation	VCPQACPSASERSLS ECCCCCCCCCHHHHH	44.29	30576142
888	Phosphorylation	PQACPSASERSLSSF CCCCCCCCHHHHHHH	37.57	28348404
891	Phosphorylation	CPSASERSLSSFRSD CCCCCHHHHHHHCCC	28.66	24719451
893	Phosphorylation	SASERSLSSFRSDAS CCCHHHHHHHCCCCC	28.77	24719451
894	Phosphorylation	ASERSLSSFRSDASG CCHHHHHHHCCCCCC	29.94	30576142
897	Phosphorylation	RSLSSFRSDASGDRG HHHHHHCCCCCCCCC	35.20	22617229
900	Phosphorylation	SSFRSDASGDRGFGL HHHCCCCCCCCCCCE	46.33	22199227
921	Phosphorylation	RPLLPFETEVGPCGV CCCCCCCCCCCCCCC	36.03	20873877
932	Phosphorylation	PCGVGEASLDKADSE CCCCCCHHCCCCCCC	32.57	29507054
938	Phosphorylation	ASLDKADSEGSNSGG HHCCCCCCCCCCCCC	49.03	25159151
941	Phosphorylation	DKADSEGSNSGGTWP CCCCCCCCCCCCCCC	24.62	23927012
943	Phosphorylation	ADSEGSNSGGTWPKA CCCCCCCCCCCCCHH	40.05	30576142
946	Phosphorylation	EGSNSGGTWPKAMLS CCCCCCCCCCHHHHC	41.96	23927012
953	Phosphorylation	TWPKAMLSSTAVPEK CCCHHHHCCCCCCHH	16.74	26852163
954	Phosphorylation	WPKAMLSSTAVPEKL CCHHHHCCCCCCHHH	19.20	26852163
955	Phosphorylation	PKAMLSSTAVPEKLS CHHHHCCCCCCHHHC	28.44	26852163
962	Phosphorylation	TAVPEKLSVYKKPKQ CCCCHHHCCCCCCCC	34.17	30576142
964	Phosphorylation	VPEKLSVYKKPKQRK CCHHHCCCCCCCCCC	15.21	23403867
971	Ubiquitination	YKKPKQRKSIFDPNT CCCCCCCCCCCCCCC	45.47	29967540
972	Phosphorylation	KKPKQRKSIFDPNTF CCCCCCCCCCCCCCC	30.58	25159151
984	Phosphorylation	NTFKRPQTPPKIDYL CCCCCCCCCCCCCEE	44.21	25159151
990	Phosphorylation	QTPPKIDYLLPGPGP CCCCCCCEECCCCCC	17.38	30266825
1000	Phosphorylation	PGPGPAHSPQPSKRA CCCCCCCCCCCCCCC	27.60	22167270
1004	Phosphorylation	PAHSPQPSKRAGPLT CCCCCCCCCCCCCCC	29.53	30266825
1011	Phosphorylation	SKRAGPLTPPKPPRR CCCCCCCCCCCCCCC	40.45	30266825
1019	Phosphorylation	PPKPPRRSDSIKFQH CCCCCCCCCCCCEEE	36.67	23403867
1021	Phosphorylation	KPPRRSDSIKFQHRL CCCCCCCCCCEEEEE	28.99	23927012
1064	Phosphorylation	PGEPMHASPPRKARV CCCCCCCCCCCCCCE	22.28	26471730
1075	Phosphorylation	KARVRIASSYYPEGD CCCEEEEECCCCCCC	19.26	25394399
1076	Phosphorylation	ARVRIASSYYPEGDG CCEEEEECCCCCCCC	21.47	21955146
1077	Phosphorylation	RVRIASSYYPEGDGD CEEEEECCCCCCCCC	22.12	21955146
1078	Phosphorylation	VRIASSYYPEGDGDS EEEEECCCCCCCCCC	9.21	21955146
1085	Phosphorylation	YPEGDGDSSHLPAKK CCCCCCCCCCCCCCC	25.78	23312004
1086	Phosphorylation	PEGDGDSSHLPAKKS CCCCCCCCCCCCCCC	33.51	23312004
1091	Methylation	DSSHLPAKKSCDEDL CCCCCCCCCCCCCCH	43.19	-
1092	Methylation	SSHLPAKKSCDEDLT CCCCCCCCCCCCCHH	59.42	-
1093	Phosphorylation	SHLPAKKSCDEDLTS CCCCCCCCCCCCHHH	26.54	28985074
1115	Phosphorylation	QKRRRPKSAPSFRPK HHCCCCCCCCCCCHH	48.36	30266825
1118	Phosphorylation	RRPKSAPSFRPKLAP CCCCCCCCCCHHCCC	33.34	30266825
1142	Phosphorylation	EQKCVPASGELSPEL HCCCCCCCCCCCHHH	27.08	28450419
1146	Phosphorylation	VPASGELSPELQEWA CCCCCCCCHHHHHCC	16.42	23927012
1155	Phosphorylation	ELQEWAPYSPGHSSR HHHHCCCCCCCCCCC	21.54	28450419
1156	Phosphorylation	LQEWAPYSPGHSSRH HHHCCCCCCCCCCCC	24.28	23927012
1160	Phosphorylation	APYSPGHSSRHSNPP CCCCCCCCCCCCCCC	34.68	28450419
1161	Phosphorylation	PYSPGHSSRHSNPPL CCCCCCCCCCCCCCC	28.47	28450419
1164	Phosphorylation	PGHSSRHSNPPLYPS CCCCCCCCCCCCCCC	50.34	28348404
1171	Phosphorylation	SNPPLYPSRPSVGTV CCCCCCCCCCCCCCC	43.18	24719451
1174	Phosphorylation	PLYPSRPSVGTVPRS CCCCCCCCCCCCCCC	31.88	28555341
1177	Phosphorylation	PSRPSVGTVPRSLTP CCCCCCCCCCCCCCC	25.77	30576142
1181	O-linked_Glycosylation	SVGTVPRSLTPSTTV CCCCCCCCCCCCCCH	30.44	30379171
1181	Phosphorylation	SVGTVPRSLTPSTTV CCCCCCCCCCCCCCH	30.44	23186163
1183	Phosphorylation	GTVPRSLTPSTTVSS CCCCCCCCCCCCHHH	19.21	22199227
1185	Phosphorylation	VPRSLTPSTTVSSIL CCCCCCCCCCHHHHH	31.32	23186163
1186	O-linked_Glycosylation	PRSLTPSTTVSSILR CCCCCCCCCHHHHHC	32.21	30379171
1187	O-linked_Glycosylation	RSLTPSTTVSSILRN CCCCCCCCHHHHHCC	23.80	30379171
1187	Phosphorylation	RSLTPSTTVSSILRN CCCCCCCCHHHHHCC	23.80	28555341
1190	Phosphorylation	TPSTTVSSILRNPIY CCCCCHHHHHCCCEE	22.70	24719451
1197	Phosphorylation	SILRNPIYTVRSHRV HHHCCCEEEECCCCC	10.63	21945579
1198	Phosphorylation	ILRNPIYTVRSHRVG HHCCCEEEECCCCCC	15.34	21945579
1208	Phosphorylation	SHRVGPCSSPPAARD CCCCCCCCCCCHHHC	49.35	30243723
1209	Phosphorylation	HRVGPCSSPPAARDA CCCCCCCCCCHHHCC	41.44	30266825
1224	Phosphorylation	GPQGLHPSVQHQGRL CCCCCCCCCCCCCCE	24.54	26074081
1232	Phosphorylation	VQHQGRLSLDLSHRT CCCCCCEEEECCCCC	20.62	30266825
1236	Phosphorylation	GRLSLDLSHRTCSDY CCEEEECCCCCCCCH	15.58	30576142
1239	Phosphorylation	SLDLSHRTCSDYSEM EEECCCCCCCCHHHH	15.78	30576142
1241	Phosphorylation	DLSHRTCSDYSEMRA ECCCCCCCCHHHHHH	38.68	24719451
1243	Phosphorylation	SHRTCSDYSEMRATH CCCCCCCHHHHHHHC	7.10	26356563
1244	Phosphorylation	HRTCSDYSEMRATHG CCCCCCHHHHHHHCC	29.88	26356563
1247	Ubiquitination	CSDYSEMRATHGSNS CCCHHHHHHHCCCCC	32.08	23000965
1249	Phosphorylation	DYSEMRATHGSNSLP CHHHHHHHCCCCCCC	19.19	23403867
1249	Ubiquitination	DYSEMRATHGSNSLP CHHHHHHHCCCCCCC	19.19	23000965
1252	Phosphorylation	EMRATHGSNSLPSSA HHHHHCCCCCCCCCC	18.68	23927012
1254	Phosphorylation	RATHGSNSLPSSARL HHHCCCCCCCCCCCC	43.27	30278072
1257	Phosphorylation	HGSNSLPSSARLGSS CCCCCCCCCCCCCCC	41.75	29691806
1258	Phosphorylation	GSNSLPSSARLGSSS CCCCCCCCCCCCCCC	18.57	29691806
1263	Phosphorylation	PSSARLGSSSNLQFK CCCCCCCCCCCCEEE	34.87	19664994
1264	Phosphorylation	SSARLGSSSNLQFKA CCCCCCCCCCCEEEE	22.80	30266825
1265	Phosphorylation	SARLGSSSNLQFKAE CCCCCCCCCCEEEEE	43.17	30266825
1278	Phosphorylation	AERIKIPSTPRYPRS EEECCCCCCCCCCCC	55.29	24719451
1279	Phosphorylation	ERIKIPSTPRYPRSV EECCCCCCCCCCCCC	13.36	28857561
1281	Ubiquitination	IKIPSTPRYPRSVVG CCCCCCCCCCCCCCC	54.93	23000965
1282	Phosphorylation	KIPSTPRYPRSVVGS CCCCCCCCCCCCCCC	12.28	21406692
1283	Ubiquitination	IPSTPRYPRSVVGSE CCCCCCCCCCCCCCC	24.29	23000965
1285	Phosphorylation	STPRYPRSVVGSERG CCCCCCCCCCCCCCC	19.36	21406692
1289	Phosphorylation	YPRSVVGSERGSVSH CCCCCCCCCCCCCCC	16.71	21406692
1293	Phosphorylation	VVGSERGSVSHSECS CCCCCCCCCCCCCCC	27.03	22199227
1295	Phosphorylation	GSERGSVSHSECSTP CCCCCCCCCCCCCCC	24.00	22199227
1297	Phosphorylation	ERGSVSHSECSTPPQ CCCCCCCCCCCCCCC	32.56	22199227
1300	Phosphorylation	SVSHSECSTPPQSPL CCCCCCCCCCCCCCC	39.64	22199227
1301	Phosphorylation	VSHSECSTPPQSPLN CCCCCCCCCCCCCCC	51.12	33259812
1305	Phosphorylation	ECSTPPQSPLNIDTL CCCCCCCCCCCCCCC	36.81	22199227
1311	Phosphorylation	QSPLNIDTLSSCSQS CCCCCCCCCCCCCCC	25.41	22199227
1313	Phosphorylation	PLNIDTLSSCSQSQT CCCCCCCCCCCCCCC	31.24	22199227
1314	Phosphorylation	LNIDTLSSCSQSQTS CCCCCCCCCCCCCCC	22.39	27174698
1316	Phosphorylation	IDTLSSCSQSQTSAS CCCCCCCCCCCCCCC	34.51	27174698
1318	Phosphorylation	TLSSCSQSQTSASTL CCCCCCCCCCCCCCC	21.09	27174698
1320	Phosphorylation	SSCSQSQTSASTLPR CCCCCCCCCCCCCCE	31.35	27174698
1321	Phosphorylation	SCSQSQTSASTLPRI CCCCCCCCCCCCCEE	16.76	27174698
1323	Phosphorylation	SQSQTSASTLPRIAV CCCCCCCCCCCEEEC	30.19	27174698
1324	Phosphorylation	QSQTSASTLPRIAVN CCCCCCCCCCEEECC	40.26	24719451
1334	Phosphorylation	RIAVNPASLGERRKD EEECCHHHHCCCCCC	37.86	22199227
1357	Phosphorylation	HVKVQKGSEPLGISI EEECCCCCCCCCEEE	42.97	24719451
1363	Phosphorylation	GSEPLGISIVSGEKG CCCCCCEEEEECCCC	18.35	24719451
1432	Ubiquitination	AQYNPHVHQLSSHSR EECCCCHHHHCCCCC	21.60	23000965
1434	Ubiquitination	YNPHVHQLSSHSRSS CCCCHHHHCCCCCCC	3.24	23000965
1440	Phosphorylation	QLSSHSRSSSHLDPA HHCCCCCCCCCCCCC	38.93	28348404
1441	Phosphorylation	LSSHSRSSSHLDPAG HCCCCCCCCCCCCCC	22.22	28348404
1442	Phosphorylation	SSHSRSSSHLDPAGT CCCCCCCCCCCCCCC	29.34	23927012
1444	Ubiquitination	HSRSSSHLDPAGTHS CCCCCCCCCCCCCCC	10.23	23000965
1449	Phosphorylation	SHLDPAGTHSTLQGS CCCCCCCCCCCCCCC	18.11	28348404
1451	Phosphorylation	LDPAGTHSTLQGSGT CCCCCCCCCCCCCCC	30.56	28348404
1452	Phosphorylation	DPAGTHSTLQGSGTT CCCCCCCCCCCCCCC	18.59	28348404
1456	Phosphorylation	THSTLQGSGTTTPEH CCCCCCCCCCCCCCC	21.72	28348404
1458	Phosphorylation	STLQGSGTTTPEHPS CCCCCCCCCCCCCCC	29.24	28348404
1459	Phosphorylation	TLQGSGTTTPEHPSV CCCCCCCCCCCCCCC	43.83	28348404
1460	Phosphorylation	LQGSGTTTPEHPSVI CCCCCCCCCCCCCCC	26.90	28348404
1465	Phosphorylation	TTTPEHPSVIDPLME CCCCCCCCCCCCCCC	33.34	28348404
1475	Ubiquitination	DPLMEQDEGPSTPPA CCCCCCCCCCCCCCC	73.10	23000965
1477	Ubiquitination	LMEQDEGPSTPPAKQ CCCCCCCCCCCCCCC	32.74	23000965
1478	Phosphorylation	MEQDEGPSTPPAKQS CCCCCCCCCCCCCCC	65.49	23927012
1478	Ubiquitination	MEQDEGPSTPPAKQS CCCCCCCCCCCCCCC	65.49	23000965
1479	Phosphorylation	EQDEGPSTPPAKQSS CCCCCCCCCCCCCCC	36.10	30576142
1479	Ubiquitination	EQDEGPSTPPAKQSS CCCCCCCCCCCCCCC	36.10	23000965
1493	Ubiquitination	SSRIAGDANKKTLEP CCCCCCCCCCCCCCC	28.91	23000965
1495	Ubiquitination	RIAGDANKKTLEPRV CCCCCCCCCCCCCEE	49.18	23000965
1497	Ubiquitination	AGDANKKTLEPRVVF CCCCCCCCCCCEEEE	37.65	23000965
1499	Ubiquitination	DANKKTLEPRVVFIK CCCCCCCCCEEEEEE	35.97	23000965
1528	Ubiquitination	LHGVFVAEVEDDSPA EEEEEEEEECCCCCC	40.93	23000965
1530	Ubiquitination	GVFVAEVEDDSPAKG EEEEEEECCCCCCCC	47.83	23000965
1550	Phosphorylation	PGDLILEYGSLDVRN CCCEEEEECCEECCC	14.47	27732954
1552	Phosphorylation	DLILEYGSLDVRNKT CEEEEECCEECCCCE	22.09	27732954
1559	O-linked_Glycosylation	SLDVRNKTVEEVYVE CEECCCCEEEEEEEE	36.38	30379171
1564	Phosphorylation	NKTVEEVYVEMLKPR CCEEEEEEEEECCCC	8.25	27642862
1583	Ubiquitination	LKVQYRPEEFTKAKG EEEEECHHHHHCCCC	57.66	23000965
1585	Ubiquitination	VQYRPEEFTKAKGLP EEECHHHHHCCCCCC	8.94	23000965
1587	Ubiquitination	YRPEEFTKAKGLPGD ECHHHHHCCCCCCCC	54.12	23000965
1589	Ubiquitination	PEEFTKAKGLPGDSF HHHHHCCCCCCCCHH	63.64	23000965
1595	Phosphorylation	AKGLPGDSFYIRALY CCCCCCCHHHHHHHH	26.34	28152594
1597	Phosphorylation	GLPGDSFYIRALYDR CCCCCHHHHHHHHHH	8.08	28152594
1613	Phosphorylation	ADVEQELSFKKDDIL HHHHHHHCCCCCCEE	33.98	24719451
1629	Ubiquitination	VDDTLPQGTFGSWMA EECCCCCCCCHHHEE	22.52	23000965
1653	Phosphorylation	IQRGQIPSKYVMDQE HHCCCCCCHHHCCHH	37.94	24719451
1655	Phosphorylation	RGQIPSKYVMDQEFS CCCCCCHHHCCHHHH	12.82	23401153
1662	Phosphorylation	YVMDQEFSRRLSMSE HHCCHHHHHHHCHHH	18.75	23401153
1666	Phosphorylation	QEFSRRLSMSEVKDD HHHHHHHCHHHHCCC	20.60	23401153
1668	Phosphorylation	FSRRLSMSEVKDDNS HHHHHCHHHHCCCCH	35.54	23401153
1672	Ubiquitination	LSMSEVKDDNSATKT HCHHHHCCCCHHHHH	66.55	23000965
1674	Ubiquitination	MSEVKDDNSATKTLS HHHHCCCCHHHHHHH	43.61	23000965
1675	Phosphorylation	SEVKDDNSATKTLSA HHHCCCCHHHHHHHH	44.29	28555341
1677	Phosphorylation	VKDDNSATKTLSAAA HCCCCHHHHHHHHHH	25.12	28387310
1678	Ubiquitination	KDDNSATKTLSAAAR CCCCHHHHHHHHHHH	47.38	29967540
1687	Phosphorylation	LSAAARRSFFRRKHK HHHHHHHHHHHHHHC	24.16	24719451
1690	Ubiquitination	AARRSFFRRKHKHKR HHHHHHHHHHHCCCC	44.73	23000965
1694	Ubiquitination	SFFRRKHKHKRSGSK HHHHHHHCCCCCCCC	54.58	23000965
1698	Phosphorylation	RKHKHKRSGSKDGKD HHHCCCCCCCCCCCC	52.82	25849741
1700	Phosphorylation	HKHKRSGSKDGKDLL HCCCCCCCCCCCCCH	28.90	25849741
1713	Phosphorylation	LLALDAFSSDSIPLF CHHHCCCCCCCCCCC	34.65	28348404
1714	Phosphorylation	LALDAFSSDSIPLFE HHHCCCCCCCCCCCC	28.99	28348404
1716	Phosphorylation	LDAFSSDSIPLFEDS HCCCCCCCCCCCCCH	28.22	28348404
1725	Ubiquitination	PLFEDSVSLAYQRVQ CCCCCHHHHHHHHHH	15.96	23000965
1773	Ubiquitination	RCPLEVMKASQQAIE CCCHHHHHHHHHHHH	50.49	29967540
1780	Ubiquitination	KASQQAIERGVKDCL HHHHHHHHHCCCCEE	46.53	23000965
1784	Ubiquitination	QAIERGVKDCLFVDY HHHHHCCCCEEEEEC	45.61	23000965
1795	Phosphorylation	FVDYKRRSGHFDVTT EEECCCCCCCCCEEE	40.42	30266825
1801	Phosphorylation	RSGHFDVTTVASIKE CCCCCCEEEEEHHHH	19.87	30266825
1802	Phosphorylation	SGHFDVTTVASIKEI CCCCCEEEEEHHHHH	17.58	22468782
1805	Phosphorylation	FDVTTVASIKEITEK CCEEEEEHHHHHHHH	29.83	27535140
1867	Ubiquitination	KVTQRHSKEQFEAAQ HHHHHCCHHHHHHHH	49.78	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1115	S	Phosphorylation	Kinase	CDKL5	O76039	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:12902344

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CTNB1_HUMAN	CTNNB1	physical	12657639

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLG5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1263, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-1209, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-984 AND SER-1000, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1011, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1011, AND MASSSPECTROMETRY.	17924679 [Abstract]