dbPTM

CNBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CNBP_HUMAN
UniProt AC	P62633
Protein Name	Cellular nucleic acid-binding protein
Gene Name	CNBP
Organism	Homo sapiens (Human).
Sequence Length	177
Subcellular Localization	Cytoplasm. Endoplasmic reticulum.
Protein Description	Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression..
Protein Sequence	MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSNECFKC ------CCCCCCCCC	41.70	22814378
2	Phosphorylation	------MSSNECFKC ------CCCCCCCCC	41.70	27251275
3	Phosphorylation	-----MSSNECFKCG -----CCCCCCCCCC	35.04	24719451
3 (in isoform 6)	Phosphorylation	-	35.04	24719451
8	Methylation	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	83040663
8	Acetylation	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	-
8	Ubiquitination	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	-
8	Succinylation	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	23954790
8	Acetylation	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	23749302
8	Ubiquitination	MSSNECFKCGRSGHW CCCCCCCCCCCCCCC	47.65	-
11	Methylation	NECFKCGRSGHWARE CCCCCCCCCCCCCCC	49.27	115920677
12 (in isoform 6)	Phosphorylation	-	21.94	24719451
12	Phosphorylation	ECFKCGRSGHWAREC CCCCCCCCCCCCCCC	21.94	26657352
25	Dimethylation	ECPTGGGRGRGMRSR CCCCCCCCCCCCCCC	34.60	-
25	Methylation	ECPTGGGRGRGMRSR CCCCCCCCCCCCCCC	34.60	24726729
27	Methylation	PTGGGRGRGMRSRGR CCCCCCCCCCCCCCC	34.08	24726729
27	Dimethylation	PTGGGRGRGMRSRGR CCCCCCCCCCCCCCC	34.08	-
30	Methylation	GGRGRGMRSRGRGGF CCCCCCCCCCCCCCC	26.48	54560907
32 (in isoform 5)	Methylation	-	28.59	24129315
32 (in isoform 2)	Methylation	-	28.59	24129315
32 (in isoform 8)	Methylation	-	28.59	24129315
32	Dimethylation	RGRGMRSRGRGGFTS CCCCCCCCCCCCCCC	28.59	-
32	Methylation	RGRGMRSRGRGGFTS CCCCCCCCCCCCCCC	28.59	24394347
34 (in isoform 5)	Methylation	-	40.74	24129315
34 (in isoform 2)	Methylation	-	40.74	24129315
34	Dimethylation	RGMRSRGRGGFTSDR CCCCCCCCCCCCCHH	40.74	-
34	Methylation	RGMRSRGRGGFTSDR CCCCCCCCCCCCCHH	40.74	12018949
34 (in isoform 8)	Methylation	-	40.74	24129315
41 (in isoform 8)	Phosphorylation	-	47.82	29116813
41 (in isoform 2)	Phosphorylation	-	47.82	29116813
41 (in isoform 5)	Phosphorylation	-	47.82	29116813
47	Phosphorylation	DRGFQFVSSSLPDIC HHCCHHHHCCCCHHH	18.59	22617229
47 (in isoform 6)	Phosphorylation	-	18.59	27251275
48	Acetylation	RGFQFVSSSLPDICY HCCHHHHCCCCHHHH	30.50	-
48	Phosphorylation	RGFQFVSSSLPDICY HCCHHHHCCCCHHHH	30.50	28348404
48	Ubiquitination	RGFQFVSSSLPDICY HCCHHHHCCCCHHHH	30.50	-
48 (in isoform 6)	Phosphorylation	-	30.50	27251275
49	Phosphorylation	GFQFVSSSLPDICYR CCHHHHCCCCHHHHH	36.09	22617229
49 (in isoform 6)	Phosphorylation	-	36.09	24719451
54	Glutathionylation	SSSLPDICYRCGESG HCCCCHHHHHCCCCC	1.98	22555962
55	Phosphorylation	SSLPDICYRCGESGH CCCCHHHHHCCCCCC	14.85	20068231
65	Ubiquitination	GESGHLAKDCDLQED CCCCCCCCCCCCCCC	66.31	-
65	Acetylation	GESGHLAKDCDLQED CCCCCCCCCCCCCCC	66.31	23749302
68	Acetylation	GHLAKDCDLQEDACY CCCCCCCCCCCCCCH	62.61	-
73 (in isoform 8)	Methylation	-	9.28	24129315
75	Phosphorylation	DLQEDACYNCGRGGH CCCCCCCHHCCCCCC	18.40	28796482
79	Methylation	DACYNCGRGGHIAKD CCCHHCCCCCCHHCC	50.55	24129315
80 (in isoform 4)	Methylation	-	19.81	24129315
85	Acetylation	GRGGHIAKDCKEPKR CCCCCHHCCCCCCCH	64.16	23749302
86	Ubiquitination	RGGHIAKDCKEPKRE CCCCHHCCCCCCCHH	39.43	-
86	Acetylation	RGGHIAKDCKEPKRE CCCCHHCCCCCCCHH	39.43	-
97	Acetylation	PKREREQCCYNCGKP CCHHHHHHHHHCCCC	1.97	19608861
97	Ubiquitination	PKREREQCCYNCGKP CCHHHHHHHHHCCCC	1.97	19608861
97	Glutathionylation	PKREREQCCYNCGKP CCHHHHHHHHHCCCC	1.97	22555962
98	Acetylation	KREREQCCYNCGKPG CHHHHHHHHHCCCCC	2.46	19608861
98	Ubiquitination	KREREQCCYNCGKPG CHHHHHHHHHCCCCC	2.46	19608861
99	Phosphorylation	REREQCCYNCGKPGH HHHHHHHHHCCCCCC	22.55	21945579
101	Ubiquitination	REQCCYNCGKPGHLA HHHHHHHCCCCCCHH	2.75	-
103	Ubiquitination	QCCYNCGKPGHLARD HHHHHCCCCCCHHCC	50.45	-
103	Acetylation	QCCYNCGKPGHLARD HHHHHCCCCCCHHCC	50.45	23749302
104	Ubiquitination	CCYNCGKPGHLARDC HHHHCCCCCCHHCCC	22.26	19608861
104	Acetylation	CCYNCGKPGHLARDC HHHHCCCCCCHHCCC	22.26	19608861
105	Acetylation	CYNCGKPGHLARDCD HHHCCCCCCHHCCCC	31.74	19608861
105	Ubiquitination	CYNCGKPGHLARDCD HHHCCCCCCHHCCCC	31.74	19608861
113	Ubiquitination	HLARDCDHADEQKCY CHHCCCCCCCCHHCC	41.22	-
117	Ubiquitination	DCDHADEQKCYSCGE CCCCCCCHHCCCCCC	41.49	-
118	Acetylation	CDHADEQKCYSCGEF CCCCCCHHCCCCCCC	32.85	25953088
118	Ubiquitination	CDHADEQKCYSCGEF CCCCCCHHCCCCCCC	32.85	-
119	Glutathionylation	DHADEQKCYSCGEFG CCCCCHHCCCCCCCC	2.78	22555962
120	Phosphorylation	HADEQKCYSCGEFGH CCCCHHCCCCCCCCC	17.65	25394399
121	Phosphorylation	ADEQKCYSCGEFGHI CCCHHCCCCCCCCCC	25.72	28348404
123 (in isoform 6)	Phosphorylation	-	27.59	27251275
130	Ubiquitination	GEFGHIQKDCTKVKC CCCCCCCCCCCEEEE	54.92	-
130	Acetylation	GEFGHIQKDCTKVKC CCCCCCCCCCCEEEE	54.92	25953088
135	Ubiquitination	IQKDCTKVKCYRCGE CCCCCCEEEEEECCC	2.52	-
143	Phosphorylation	KCYRCGETGHVAINC EEEECCCCCCEEEEC	20.19	23312004
151	Phosphorylation	GHVAINCSKTSEVNC CCEEEECCCCCCEEE	34.18	20068231
152	Acetylation	HVAINCSKTSEVNCY CEEEECCCCCCEEEE	59.27	25953088
152	Ubiquitination	HVAINCSKTSEVNCY CEEEECCCCCCEEEE	59.27	-
153 (in isoform 6)	Phosphorylation	-	17.52	27251275
153	Phosphorylation	VAINCSKTSEVNCYR EEEECCCCCCEEEEE	17.52	21945579
154	Phosphorylation	AINCSKTSEVNCYRC EEECCCCCCEEEEEC	43.19	21945579
159	Phosphorylation	KTSEVNCYRCGESGH CCCCEEEEECCCCCC	12.07	21945579
164	Phosphorylation	NCYRCGESGHLAREC EEEECCCCCCEEEEE	19.45	21945579
166 (in isoform 6)	Phosphorylation	-	26.12	24719451
172	Phosphorylation	GHLARECTIEATA-- CCEEEEEEEEECC--	19.66	26437602
174 (in isoform 6)	Phosphorylation	-	23.09	24719451
176	Phosphorylation	RECTIEATA------ EEEEEEECC------	21.80	27251275
178 (in isoform 6)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CNBP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CNBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CNBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF2B1_HUMAN	IGF2BP1	physical	17353931
RL3_HUMAN	RPL3	physical	17353931
HNRPC_HUMAN	HNRNPC	physical	17353931
PURA_HUMAN	PURA	physical	17353931
RS3A_HUMAN	RPS3A	physical	17353931
DHX9_HUMAN	DHX9	physical	17353931
ROAA_HUMAN	HNRNPAB	physical	17353931
RL34_HUMAN	RPL34	physical	17353931
IF2B3_HUMAN	IGF2BP3	physical	17353931
BRX1_HUMAN	BRIX1	physical	17353931
RL23A_HUMAN	RPL23A	physical	17353931
RBMX_HUMAN	RBMX	physical	17353931
HNRPR_HUMAN	HNRNPR	physical	17353931
RL31_HUMAN	RPL31	physical	17353931
RL35A_HUMAN	RPL35A	physical	17353931
RS16_HUMAN	RPS16	physical	17353931
ABC3C_HUMAN	APOBEC3C	physical	17353931
RFA3_HUMAN	RPA3	physical	17353931
RL36_HUMAN	RPL36	physical	17353931
RS19_HUMAN	RPS19	physical	17353931
ERH_HUMAN	ERH	physical	17353931
EBP2_HUMAN	EBNA1BP2	physical	17353931
HNRL1_HUMAN	HNRNPUL1	physical	17353931
HNRPQ_HUMAN	SYNCRIP	physical	17353931
ROA3_HUMAN	HNRNPA3	physical	17353931
RL1D1_HUMAN	RSL1D1	physical	17353931
RT29_HUMAN	DAP3	physical	17353931
FKTN_HUMAN	FKTN	physical	21232131
MYH4_HUMAN	MYH4	physical	21232131
BZW2_HUMAN	BZW2	physical	22863883
PABP3_HUMAN	PABPC3	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
TRI56_HUMAN	TRIM56	physical	28514442
H11_HUMAN	HIST1H1A	physical	28514442
NLE1_HUMAN	NLE1	physical	28514442
ZN275_HUMAN	ZNF275	physical	28514442
CENPR_HUMAN	ITGB3BP	physical	28514442
RL18_HUMAN	RPL18	physical	28514442
RL36_HUMAN	RPL36	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
RLA0_HUMAN	RPLP0	physical	28514442
RL27_HUMAN	RPL27	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
RLA2_HUMAN	RPLP2	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RPF1_HUMAN	RPF1	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
ZN689_HUMAN	ZNF689	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
RS8_HUMAN	RPS8	physical	28514442
CENPN_HUMAN	CENPN	physical	28514442
RL37A_HUMAN	RPL37A	physical	28514442
PK1IP_HUMAN	PAK1IP1	physical	28514442
RL13_HUMAN	RPL13	physical	28514442
RL14_HUMAN	RPL14	physical	28514442
RRS1_HUMAN	RRS1	physical	28514442
RL15_HUMAN	RPL15	physical	28514442
CENPU_HUMAN	CENPU	physical	28514442
ZN184_HUMAN	ZNF184	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
ZN800_HUMAN	ZNF800	physical	28514442
RL12_HUMAN	RPL12	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RS6_HUMAN	RPS6	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
RL6_HUMAN	RPL6	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
ZFP62_HUMAN	ZFP62	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
REPI1_HUMAN	REPIN1	physical	28514442
RLA1_HUMAN	RPLP1	physical	28514442
ZNF48_HUMAN	ZNF48	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
RL7_HUMAN	RPL7	physical	28514442
RS13_HUMAN	RPS13	physical	28514442
RL8_HUMAN	RPL8	physical	28514442
CH033_HUMAN	C8orf33	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
ZSC25_HUMAN	ZSCAN25	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
SURF6_HUMAN	SURF6	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
NIP7_HUMAN	NIP7	physical	28514442
RL11_HUMAN	RPL11	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
RL5_HUMAN	RPL5	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
NOL12_HUMAN	NOL12	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
RL35A_HUMAN	RPL35A	physical	28514442
POP1_HUMAN	POP1	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
FCF1_HUMAN	FCF1	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
MAK16_HUMAN	MAK16	physical	28514442
RL13A_HUMAN	RPL13A	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
RL7L_HUMAN	RPL7L1	physical	28514442
LLPH_HUMAN	LLPH	physical	28514442
PAPD5_HUMAN	PAPD5	physical	28514442
ABT1_HUMAN	ABT1	physical	28514442
ZN771_HUMAN	ZNF771	physical	28514442
NOP53_HUMAN	GLTSCR2	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
602668	Dystrophia myotonica 2 (DM2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CNBP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-103, AND MASS SPECTROMETRY.	19608861 [Abstract]