ZN689_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN689_HUMAN
• UniProt AC: Q96CS4
• Protein Name: Zinc finger protein 689
• Gene Name: ZNF689
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAPPSAPLPAQGPGKARPSRKRGRRPRALKFVDVAVYFSPEEWGCLRPAQRALYRDVMRETYGHLGALGCAGPKPALISWLERNTDDWEPAALDPQEYPRGLTVQRKSRTRKKNGEKEVFPPKEAPRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPDHQALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTHTGEKPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECNRRFRQRTALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCFRQRWSLAVHKCSPKAPNCSPRSAIGGSSQRGNAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	QEYPRGLTVQRKSRT CCCCCCCCCCCCCCC	19.88	24719451
187	Phosphorylation	PDCGRRFSYPSLLVS CCCCCCCCCCHHEEE	34.03	29457462
188	Phosphorylation	DCGRRFSYPSLLVSH CCCCCCCCCHHEEEC	8.30	28555341
190	Phosphorylation	GRRFSYPSLLVSHRR CCCCCCCHHEEECCC	26.55	23312004
194	Phosphorylation	SYPSLLVSHRRAHSG CCCHHEEECCCCCCC	15.96	-
200	Phosphorylation	VSHRRAHSGECPYVC EECCCCCCCCCCCEE	34.99	21712546
205	Phosphorylation	AHSGECPYVCDQCGK CCCCCCCCEECCCCC	25.93	-
215	Phosphorylation	DQCGKRFSQRKNLSQ CCCCCHHHHCCCCCC	32.86	24719451
228	Phosphorylation	SQHQVIHTGEKPYHC CCCCEEECCCCCCCC	35.59	25159151
272	Phosphorylation	SCGRRFAYPSLLAIH CCCCCCCCHHHHHHH	7.22	27174698
274	Phosphorylation	GRRFAYPSLLAIHQR CCCCCCHHHHHHHCC	24.28	27174698
282	Phosphorylation	LLAIHQRTHTGEKPY HHHHHCCCCCCCCCE	19.74	-
284	Phosphorylation	AIHQRTHTGEKPYTC HHHCCCCCCCCCEEH	46.56	29214152
287	Acetylation	QRTHTGEKPYTCLEC CCCCCCCCCEEHHHC	44.67	7428871
312	Phosphorylation	VIHQRIHTGEKPYPC EEEEEECCCCCCCCC	44.67	29214152
336	Methylation	SSRLVSHRRVHSGER CCCCEEECEECCCCC	34.51	24388085
340	Phosphorylation	VSHRRVHSGERPYAC EEECEECCCCCCCHH	39.22	28555341
368	Phosphorylation	LQHQLLHTGEKPYPC HHHHHHHCCCCCCCC	47.18	29214152
385	Phosphorylation	CGRAFRRSGSLAIHR HHHHHHHHCCEEEEC	28.60	29449344
387	Phosphorylation	RAFRRSGSLAIHRST HHHHHHCCEEEECCC	18.84	23312004
396	Phosphorylation	AIHRSTHTEEKLHAC EEECCCCCHHHHHCC	46.02	29214152
414	Phosphorylation	GRRFAYPSLLASHRR CCCCCCHHHHHHCCC	24.28	26074081
418	Phosphorylation	AYPSLLASHRRVHSG CCHHHHHHCCCCCCC	19.93	26074081
424	Phosphorylation	ASHRRVHSGERPYAC HHCCCCCCCCCCCHH	39.22	28555341
452	Phosphorylation	AQHQLLHTGEKPFPC HHHHHHHCCCCCCCE	47.18	-
455	Sumoylation	QLLHTGEKPFPCLEC HHHHCCCCCCCEECC	53.99	28112733
478	Phosphorylation	SLAVHKCSPKAPNCS EEEEEECCCCCCCCC	33.95	27134283
496	Methylation	AIGGSSQRGNAH--- CCCCCCCCCCCC---	42.13	115920601

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN689_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN689_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN689_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPU_HUMAN	HNRNPU	physical	16568080
TIF1B_HUMAN	TRIM28	physical	16568080
NUCL_HUMAN	NCL	physical	16568080
HNRPF_HUMAN	HNRNPF	physical	16568080

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.