LLPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LLPH_HUMAN
• UniProt AC: Q9BRT6
• Protein Name: Protein LLP homolog
• Gene Name: LLPH
• Organism: Homo sapiens (Human).
• Sequence Length: 129
• Subcellular Localization: Nucleus, nucleolus . Chromosome . Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (By similarity). Localizes at the chromosome periphery during mitosis (PubMed:20813266).
• Protein Description: In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission..
• Protein Sequence: MAKSLRSKWKRKMRAEKRKKNAPKEASRLKSILKLDGDVLMKDVQEIATVVVPKPKHCQEKMQCEVKDEKDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKREKRKGKSKAKAVKVAKGLAW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	KEASRLKSILKLDGD HHHHHHHHHHHHCCC	37.43	24719451
41	Sulfoxidation	KLDGDVLMKDVQEIA HHCCCEEHHCHHHHH	3.32	21406390
42	Acetylation	LDGDVLMKDVQEIAT HCCCEEHHCHHHHHE	51.06	26051181
42	Ubiquitination	LDGDVLMKDVQEIAT HCCCEEHHCHHHHHE	51.06	-
61	Acetylation	KPKHCQEKMQCEVKD CCCHHHHHHCCEECC	14.37	26051181
67	Sumoylation	EKMQCEVKDEKDDMK HHHCCEECCHHHCCH	37.57	-
67	Sumoylation	EKMQCEVKDEKDDMK HHHCCEECCHHHCCH	37.57	28112733
67	Acetylation	EKMQCEVKDEKDDMK HHHCCEECCHHHCCH	37.57	21339330
70	Acetylation	QCEVKDEKDDMKMET CCEECCHHHCCHHHH	69.98	21339330
74	Sumoylation	KDEKDDMKMETDIKR CCHHHCCHHHHHHHH	40.35	-
74	Sumoylation	KDEKDDMKMETDIKR CCHHHCCHHHHHHHH	40.35	28112733
74	Acetylation	KDEKDDMKMETDIKR CCHHHCCHHHHHHHH	40.35	21339330
80	Acetylation	MKMETDIKRNKKTLL CHHHHHHHHCHHHHH	53.37	21339330
80	2-Hydroxyisobutyrylation	MKMETDIKRNKKTLL CHHHHHHHHCHHHHH	53.37	-
84	Acetylation	TDIKRNKKTLLDQHG HHHHHCHHHHHHHCC	48.21	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LLPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LLPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LLPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.