dbPTM

CH033_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CH033_HUMAN
UniProt AC	Q9H7E9
Protein Name	UPF0488 protein C8orf33
Gene Name	C8orf33
Organism	Homo sapiens (Human).
Sequence Length	229
Subcellular Localization
Protein Description
Protein Sequence	MAALGHLAGEAAAAPGPGTPCASRGARLPGPVSSARNPSTVCLCPEQPTCSNADSRAHPLGDEGGTASKKQKNKKKTRNRASVANGGEKASEKLAPEEVPLSAEAQAQQLAQELAWCVEQLELGLKRQKPTPKQKEQAIGAIRTLRSKRTPLPRKRQLMHSLFGDYRAQMEAEWREALRALRAAAYSAQVQPVDGATRKKSQRVCRPRSIWRAKATLDMPDEEFRFNFF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALGHLAG ------CCCHHHHHH	16.05	19413330
19	Phosphorylation	AAAPGPGTPCASRGA HCCCCCCCCCCCCCC	20.51	29255136
23	Phosphorylation	GPGTPCASRGARLPG CCCCCCCCCCCCCCC	37.65	29255136
24	Methylation	PGTPCASRGARLPGP CCCCCCCCCCCCCCC	25.02	-
27	Methylation	PCASRGARLPGPVSS CCCCCCCCCCCCCCC	44.21	24129315
33	Phosphorylation	ARLPGPVSSARNPST CCCCCCCCCCCCCCC	22.78	24732914
34	Phosphorylation	RLPGPVSSARNPSTV CCCCCCCCCCCCCCE	31.33	24732914
39	Phosphorylation	VSSARNPSTVCLCPE CCCCCCCCCEEECCC	36.70	21712546
40	Phosphorylation	SSARNPSTVCLCPEQ CCCCCCCCEEECCCC	19.25	30576142
66	Phosphorylation	PLGDEGGTASKKQKN CCCCCCCCCCHHHHC	38.32	25159151
68	Phosphorylation	GDEGGTASKKQKNKK CCCCCCCCHHHHCCC	39.98	23312004
69	Acetylation	DEGGTASKKQKNKKK CCCCCCCHHHHCCCH	57.68	25953088
70	Ubiquitination	EGGTASKKQKNKKKT CCCCCCHHHHCCCHH	65.10	24816145
82	Phosphorylation	KKTRNRASVANGGEK CHHCCHHHHHCCCCH	20.65	22496350
82	O-linked_Glycosylation	KKTRNRASVANGGEK CHHCCHHHHHCCCCH	20.65	28510447
129	Ubiquitination	ELGLKRQKPTPKQKE HHHHCCCCCCHHHHH	55.69	24816145
135	Ubiquitination	QKPTPKQKEQAIGAI CCCCHHHHHHHHHHH	58.90	29967540
144	Phosphorylation	QAIGAIRTLRSKRTP HHHHHHHHHHHCCCC	22.02	28555341
161	Phosphorylation	RKRQLMHSLFGDYRA CHHHHHHHHHHCHHH	16.07	28857561
166	Phosphorylation	MHSLFGDYRAQMEAE HHHHHHCHHHHHHHH	14.29	24719451
186	Phosphorylation	RALRAAAYSAQVQPV HHHHHHHHHCCCCCC	10.38	21945579
187	Phosphorylation	ALRAAAYSAQVQPVD HHHHHHHHCCCCCCC	13.90	21945579
209	Phosphorylation	QRVCRPRSIWRAKAT CCCCCCHHHHEEEEE	29.23	24719451
214	Ubiquitination	PRSIWRAKATLDMPD CHHHHEEEEECCCCC	33.07	24816145
216	Phosphorylation	SIWRAKATLDMPDEE HHHEEEEECCCCCHH	23.68	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CH033_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CH033_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CH033_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GASP1_HUMAN	GPRASP1	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
MOFA1_HUMAN	MRFAP1	physical	21900206
MIC60_HUMAN	IMMT	physical	21900206
BRD4_HUMAN	BRD4	physical	21900206
CEP70_HUMAN	CEP70	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
EPS8_HUMAN	EPS8	physical	21900206
TAOK1_HUMAN	TAOK1	physical	21900206
RASF1_HUMAN	RASSF1	physical	21900206
FEZ1_HUMAN	FEZ1	physical	21900206
DVL3_HUMAN	DVL3	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
HAP1_HUMAN	HAP1	physical	21900206
EDRF1_HUMAN	EDRF1	physical	21900206
NOL7_HUMAN	NOL7	physical	21900206
ZN331_HUMAN	ZNF331	physical	21900206
ZN205_HUMAN	ZNF205	physical	21900206
SF3B2_HUMAN	SF3B2	physical	21900206
BL1S2_HUMAN	BLOC1S2	physical	21900206
CREL2_HUMAN	CRELD2	physical	21900206
ZC3HF_HUMAN	ZC3H15	physical	21900206
ZFP28_HUMAN	ZFP28	physical	21900206
FYN_HUMAN	FYN	physical	21900206
KBTB7_HUMAN	KBTBD7	physical	21900206
HEM1_HUMAN	ALAS1	physical	21900206
AAMP_HUMAN	AAMP	physical	21900206
WIZ_HUMAN	WIZ	physical	21900206
TBB2B_HUMAN	TUBB2B	physical	21900206
FST_HUMAN	FST	physical	21900206
NGEF_HUMAN	NGEF	physical	21900206
A4_HUMAN	APP	physical	21832049
MDFI_HUMAN	MDFI	physical	19060904
HMBX1_HUMAN	HMBOX1	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
KCTD6_HUMAN	KCTD6	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CH033_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]