NOL7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOL7_HUMAN
• UniProt AC: Q9UMY1
• Protein Name: Nucleolar protein 7
• Gene Name: NOL7
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Nucleus, nucleolus .
• Protein Sequence: MVQLRPRASRAPASAEAMVDEGQLASEEEEAEHGLLLGQPSSGAAAEPLEEDEEGDDEFDDEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRREELFIEQKKRKLLPDTILEKLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKVQKVQSVSQNKSYLAVRLKDQDLRDSRQQAAQAFIHNSLYGPGTNRTTVNKFLSLANKRLPVKRAAVQFLNNAWGIQKKQNAKRFKRRWMVRKMKTKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VDEGQLASEEEEAEH HCCCCCCCHHHHHHH	54.88	26074081
71	Phosphorylation	PEELTFASAQAEARE CHHHCHHHHHHHHHH	19.40	-
109	2-Hydroxyisobutyrylation	EELFIEQKKRKLLPD HHHHHHHHHHHCCCH	41.58	-
112	Ubiquitination	FIEQKKRKLLPDTIL HHHHHHHHCCCHHHH	64.35	-
117	Phosphorylation	KRKLLPDTILEKLTT HHHCCCHHHHHHHHH	26.06	20068231
121	Ubiquitination	LPDTILEKLTTASQT CCHHHHHHHHHHHHH	47.92	-
123	Phosphorylation	DTILEKLTTASQTNI HHHHHHHHHHHHHCC	31.24	23403867
124	Phosphorylation	TILEKLTTASQTNIK HHHHHHHHHHHHCCC	34.45	23927012
126 (in isoform 2)	Phosphorylation	-	35.13	25056879
126	Phosphorylation	LEKLTTASQTNIKKS HHHHHHHHHHCCCCC	35.13	23927012
128	Phosphorylation	KLTTASQTNIKKSPG HHHHHHHHCCCCCCC	36.09	23927012
131	2-Hydroxyisobutyrylation	TASQTNIKKSPGKVK HHHHHCCCCCCCCEE	49.63	-
131	Ubiquitination	TASQTNIKKSPGKVK HHHHHCCCCCCCCEE	49.63	-
131	Sumoylation	TASQTNIKKSPGKVK HHHHHCCCCCCCCEE	49.63	28112733
131	Acetylation	TASQTNIKKSPGKVK HHHHHCCCCCCCCEE	49.63	25953088
133 (in isoform 2)	Phosphorylation	-	33.60	28842319
133	Phosphorylation	SQTNIKKSPGKVKEV HHHCCCCCCCCEEEE	33.60	23401153
138	Ubiquitination	KKSPGKVKEVNLQKK CCCCCCEEEEECCCC	60.47	-
144	Acetylation	VKEVNLQKKNEDCEK EEEEECCCCCCCCCC	61.81	25953088
151	Acetylation	KKNEDCEKGNDSKKV CCCCCCCCCCCCCCE	70.15	26051181
162	Ubiquitination	SKKVKVQKVQSVSQN CCCEEEEEEEEHHCC	45.27	-
162	Acetylation	SKKVKVQKVQSVSQN CCCEEEEEEEEHHCC	45.27	25953088
162	Sumoylation	SKKVKVQKVQSVSQN CCCEEEEEEEEHHCC	45.27	28112733
167	Phosphorylation	VQKVQSVSQNKSYLA EEEEEEHHCCCCEEE	33.03	20044836
170	Ubiquitination	VQSVSQNKSYLAVRL EEEHHCCCCEEEEEE	32.61	-
171	Phosphorylation	QSVSQNKSYLAVRLK EEHHCCCCEEEEEEC	32.69	28555341
172	Phosphorylation	SVSQNKSYLAVRLKD EHHCCCCEEEEEECC	10.57	20044836
178	Methylation	SYLAVRLKDQDLRDS CEEEEEECCCCHHHH	42.66	116253975
178	Ubiquitination	SYLAVRLKDQDLRDS CEEEEEECCCCHHHH	42.66	-
185	Phosphorylation	KDQDLRDSRQQAAQA CCCCHHHHHHHHHHH	26.09	24825855
210	Ubiquitination	TNRTTVNKFLSLANK CCHHHHHHHHHHHHC	43.26	21890473
210	Acetylation	TNRTTVNKFLSLANK CCHHHHHHHHHHHHC	43.26	25953088
210 (in isoform 1)	Ubiquitination	-	43.26	21890473
213	Phosphorylation	TTVNKFLSLANKRLP HHHHHHHHHHHCCCC	28.68	24173317
217	Ubiquitination	KFLSLANKRLPVKRA HHHHHHHCCCCHHHH	50.10	-
217	Acetylation	KFLSLANKRLPVKRA HHHHHHHCCCCHHHH	50.10	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOL7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOL7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOL7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WDR75_HUMAN	WDR75	physical	28514442
CE120_HUMAN	CEP120	physical	28514442
UTP15_HUMAN	UTP15	physical	28514442
WDR43_HUMAN	WDR43	physical	28514442
UTP4_HUMAN	CIRH1A	physical	28514442
NOL11_HUMAN	NOL11	physical	28514442
IPO5_HUMAN	IPO5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-126, AND MASSSPECTROMETRY.
PubMed: 19007248