| UniProt ID | CE120_HUMAN | |
|---|---|---|
| UniProt AC | Q8N960 | |
| Protein Name | Centrosomal protein of 120 kDa | |
| Gene Name | CEP120 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 986 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.. | |
| Protein Description | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity).. | |
| Protein Sequence | MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQREGIDSQSLIELKTQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPVPSHNQSPPTKDDATESEVESLQYDKDTKPNPKASSSVPASLAQLVTTSNASEVASGQKIAVPATSHHFCFSIDLRSIHALEIGFPINCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFLGSNGEQCWRQTYSESVPVIAAQGSNNRIADLSYTVTLEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAKSNASN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MVSKSDQLLIVV ---CCCHHHEEEEEE | 24.08 | - | |
| 25 | Ubiquitination | RHFPKRPKHMLVVEA CCCCCCCCCEEEEEE | 45.76 | - | |
| 76 | Ubiquitination | RLQRTPIKLQCFALD HHCCCCEEEEEEEEC | 33.44 | - | |
| 101 | Phosphorylation | YIVLDLRTAQETKQA EEEEECCCHHHHCCC | 39.73 | 20860994 | |
| 105 | Phosphorylation | DLRTAQETKQAPKWY ECCCHHHHCCCCHHH | 19.17 | 20860994 | |
| 116 | Phosphorylation | PKWYQLLSNKYTKFK CHHHHHHHCCCHHCC | 39.61 | 26657352 | |
| 119 | Phosphorylation | YQLLSNKYTKFKSEI HHHHHCCCHHCCCEE | 21.29 | 26657352 | |
| 120 | Phosphorylation | QLLSNKYTKFKSEIQ HHHHCCCHHCCCEEE | 31.45 | 26657352 | |
| 124 | Phosphorylation | NKYTKFKSEIQISIA CCCHHCCCEEEEEEE | 42.96 | - | |
| 129 | Phosphorylation | FKSEIQISIALETDT CCCEEEEEEEEECCC | 5.85 | - | |
| 262 | Phosphorylation | SVEILRVYLALQSKL HHHHHHHHHHHHCCC | 4.65 | 28258704 | |
| 320 | Ubiquitination | PPNRAKQKLAPIPVE CCCHHHHHCCCCCCC | 46.00 | - | |
| 345 | Phosphorylation | LQREGIDSQSLIELK EECCCCCCHHHEEHH | 21.54 | 28450419 | |
| 347 | Phosphorylation | REGIDSQSLIELKTQ CCCCCCHHHEEHHHC | 34.95 | 21815630 | |
| 352 | Ubiquitination | SQSLIELKTQNEHEP CHHHEEHHHCCCCCC | 34.96 | - | |
| 368 | Phosphorylation | HSKKKVLTPIKEKTL CCCCCCCCCCCCCCC | 26.42 | 22199227 | |
| 373 | Acetylation | VLTPIKEKTLTGPKS CCCCCCCCCCCCCCC | 43.78 | 15626053 | |
| 374 | Phosphorylation | LTPIKEKTLTGPKSP CCCCCCCCCCCCCCC | 30.55 | 22199227 | |
| 376 | Phosphorylation | PIKEKTLTGPKSPTV CCCCCCCCCCCCCCC | 57.58 | 22496350 | |
| 379 | Acetylation | EKTLTGPKSPTVSPV CCCCCCCCCCCCCCC | 71.11 | 19815041 | |
| 380 | Phosphorylation | KTLTGPKSPTVSPVP CCCCCCCCCCCCCCC | 29.01 | 23927012 | |
| 382 | Phosphorylation | LTGPKSPTVSPVPSH CCCCCCCCCCCCCCC | 40.48 | 23927012 | |
| 384 | Phosphorylation | GPKSPTVSPVPSHNQ CCCCCCCCCCCCCCC | 23.74 | 23927012 | |
| 388 | Phosphorylation | PTVSPVPSHNQSPPT CCCCCCCCCCCCCCC | 34.99 | 30576142 | |
| 392 | Phosphorylation | PVPSHNQSPPTKDDA CCCCCCCCCCCCCCC | 37.86 | 30576142 | |
| 395 | Phosphorylation | SHNQSPPTKDDATES CCCCCCCCCCCCCHH | 50.95 | 22199227 | |
| 400 | Phosphorylation | PPTKDDATESEVESL CCCCCCCCHHHHHHH | 47.22 | 30576142 | |
| 402 | Phosphorylation | TKDDATESEVESLQY CCCCCCHHHHHHHCC | 42.46 | 25159151 | |
| 406 | Phosphorylation | ATESEVESLQYDKDT CCHHHHHHHCCCCCC | 26.42 | 25159151 | |
| 409 | Phosphorylation | SEVESLQYDKDTKPN HHHHHHCCCCCCCCC | 30.19 | 27732954 | |
| 413 | Phosphorylation | SLQYDKDTKPNPKAS HHCCCCCCCCCCCCC | 54.89 | 27732954 | |
| 420 | Phosphorylation | TKPNPKASSSVPASL CCCCCCCCCCCCHHH | 29.31 | 27732954 | |
| 421 | Phosphorylation | KPNPKASSSVPASLA CCCCCCCCCCCHHHH | 39.97 | 27732954 | |
| 422 | Phosphorylation | PNPKASSSVPASLAQ CCCCCCCCCCHHHHH | 29.62 | 27732954 | |
| 426 | Phosphorylation | ASSSVPASLAQLVTT CCCCCCHHHHHHHHC | 20.40 | 27732954 | |
| 432 | Phosphorylation | ASLAQLVTTSNASEV HHHHHHHHCCCHHHH | 32.85 | 27732954 | |
| 433 | Phosphorylation | SLAQLVTTSNASEVA HHHHHHHCCCHHHHH | 16.71 | 27732954 | |
| 434 | Phosphorylation | LAQLVTTSNASEVAS HHHHHHCCCHHHHHC | 22.49 | 27732954 | |
| 437 | Phosphorylation | LVTTSNASEVASGQK HHHCCCHHHHHCCCE | 36.53 | 25850435 | |
| 441 | Phosphorylation | SNASEVASGQKIAVP CCHHHHHCCCEEEEE | 47.10 | 25850435 | |
| 478 | Phosphorylation | PINCILRYSYPFFGS CCEEEEECCCCCCCC | 14.76 | - | |
| 567 | Phosphorylation | EKTRFLGSNGEQCWR CCCCCCCCCHHHHHH | 43.75 | 26714015 | |
| 577 | Phosphorylation | EQCWRQTYSESVPVI HHHHHHHCCCCCCEE | 11.34 | 30576142 | |
| 580 | Phosphorylation | WRQTYSESVPVIAAQ HHHHCCCCCCEEEEC | 26.27 | 30576142 | |
| 675 | Ubiquitination | FENQLKQKELAHMQA HHHHHHHHHHHHHHH | 53.78 | - | |
| 711 | Ubiquitination | EYTILEGKLQKTLID HHHHHHCHHHHHHHH | 38.07 | - | |
| 714 | Ubiquitination | ILEGKLQKTLIDLEK HHHCHHHHHHHHHHH | 56.59 | - | |
| 721 | Ubiquitination | KTLIDLEKREQQLAS HHHHHHHHHHHHHHH | 69.41 | - | |
| 754 | Phosphorylation | NLQELQDSIRRAKED HHHHHHHHHHHHHHH | 12.67 | 23403867 | |
| 759 | Ubiquitination | QDSIRRAKEDCIHQV HHHHHHHHHHHHHHH | 52.88 | - | |
| 773 (in isoform 2) | Ubiquitination | - | 3.99 | 21890473 | |
| 799 | Ubiquitination | NKYKILEKEFQQFKD HHHHHHHHHHHHHHH | 61.45 | 21890473 | |
| 799 (in isoform 1) | Ubiquitination | - | 61.45 | 21890473 | |
| 818 | Phosphorylation | KPEIRLQSEINLLTL CCCCHHHHHHEEEHH | 45.06 | 30622161 | |
| 836 | Phosphorylation | ELERKLESATKSKLH HHHHHHHHHCHHHHH | 52.23 | 21712546 | |
| 838 | Phosphorylation | ERKLESATKSKLHYK HHHHHHHCHHHHHHH | 45.17 | 21712546 | |
| 840 | Phosphorylation | KLESATKSKLHYKQQ HHHHHCHHHHHHHHH | 35.77 | 21712546 | |
| 845 | Ubiquitination | TKSKLHYKQQWGRAL CHHHHHHHHHHHHHH | 25.84 | - | |
| 884 | Phosphorylation | LEQMRLRYLAAEEKD HHHHHHHHHHHHCCC | 12.80 | - | |
| 916 | Ubiquitination | RLRQQEQKQYQDSTE HHHHHHHHHHHCHHH | 50.66 | - | |
| 929 | Ubiquitination | TEIASGKKDGPHGSV HHHHCCCCCCCCCCH | 72.02 | - | |
| 935 | Phosphorylation | KKDGPHGSVLEEGLD CCCCCCCCHHHCCHH | 22.09 | 28450419 | |
| 981 | Ubiquitination | QIREILAKSNASN-- HHHHHHHHHCCCC-- | 40.57 | - | |
| 982 | Phosphorylation | IREILAKSNASN--- HHHHHHHHCCCC--- | 31.83 | 28258704 | |
| 985 | Phosphorylation | ILAKSNASN------ HHHHHCCCC------ | 100.00 | 28258704 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CE120_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CE120_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CE120_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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