dbPTM

RPGF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPGF6_HUMAN
UniProt AC	Q8TEU7
Protein Name	Rap guanine nucleotide exchange factor 6
Gene Name	RAPGEF6
Organism	Homo sapiens (Human).
Sequence Length	1601
Subcellular Localization	Cytoplasm . Cell membrane . Upon binding to M-Ras, it translocates to the plasma membrane.
Protein Description	Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP..
Protein Sequence	MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSPVDPG -------CCCCCCHH	46.85	22814378
3	Phosphorylation	-----MNSPVDPGAR -----CCCCCCHHHH	37.85	12581858
27	Phosphorylation	RTPEDLNTIYSYLHG CCHHHHHHHHHHHHH	28.70	30576142
29	Phosphorylation	PEDLNTIYSYLHGME HHHHHHHHHHHHHHH	6.82	-
30	Phosphorylation	EDLNTIYSYLHGMEI HHHHHHHHHHHHHHH	19.84	-
31	Phosphorylation	DLNTIYSYLHGMEIL HHHHHHHHHHHHHHH	5.92	30576142
39	Phosphorylation	LHGMEILSNLREHQL HHHHHHHHHHHHHHH	39.21	24719451
55	Phosphorylation	LMSARARYERYSGNQ HHHHHHHHHHHCCCE	12.08	18083107
58	Phosphorylation	ARARYERYSGNQVLF HHHHHHHHCCCEEEE	14.69	18083107
127	Phosphorylation	NAKDNEDSILQREIP CCCCCCCCHHHCCCC	21.01	20873877
138	Phosphorylation	REIPARQSRRRFRKI CCCCHHHHHHHHHCC	23.38	23312004
147	Phosphorylation	RRFRKINYKGERQTI HHHHCCCCCCCCCCC	24.68	-
153	Phosphorylation	NYKGERQTITDDVEV CCCCCCCCCCCCCCH	31.87	18452278
163	Phosphorylation	DDVEVNSYLSLPADL CCCCHHHEEECCCCH	8.63	18452278
165	Phosphorylation	VEVNSYLSLPADLTK CCHHHEEECCCCHHH	24.87	27690223
171	Phosphorylation	LSLPADLTKMHLTEN EECCCCHHHCCCCCC	27.20	27690223
230	Phosphorylation	LPEGPVDSEDDEEED CCCCCCCCCCCHHHH	43.06	29255136
243	Phosphorylation	EDEEIDRTDPLQGRD HHHHCCCCCCCCHHH	37.92	30266825
294	Phosphorylation	SVRRELCSVMIFEVV HHHHHHHHHHHHHHH	27.61	28188228
319	Phosphorylation	GQELDSWYVILNGTV CCCCCEEEEEEECEE	4.99	28188228
325	Phosphorylation	WYVILNGTVEISHPD EEEEEECEEEEECCC	17.56	28188228
347	Phosphorylation	MGNSFGITPTLDKQY CCCCCCCCCCCCHHH	15.59	27067055
349	Phosphorylation	NSFGITPTLDKQYMH CCCCCCCCCCHHHHC	38.65	27067055
362	Ubiquitination	MHGIVRTKVDDCQFV HCCEEEECCCCCCEE	32.86	-
385	Ubiquitination	RILNHVEKNTHKVEE HHHHHHHHCCCCCEE	67.09	-
389	Ubiquitination	HVEKNTHKVEEEGEI HHHHCCCCCEECCEE	49.67	-
496	Phosphorylation	FEGDPAMTRFLEEFE CCCCHHHHHHHHHHH	22.00	17081983
509	Phosphorylation	FEKNLEDTKMNGHLR HHHHHHHHHCCHHHH	23.87	24719451
510	Ubiquitination	EKNLEDTKMNGHLRL HHHHHHHHCCHHHHH	42.56	-
525	Ubiquitination	LNIACAAKAKWRQVV HHHHHHHHHHHHHHH	31.79	-
535	Ubiquitination	WRQVVLQKASRESPL HHHHHHHHCCCCCCC	44.14	-
537	Phosphorylation	QVVLQKASRESPLQF HHHHHHCCCCCCCEE	43.55	28450419
540	Phosphorylation	LQKASRESPLQFSLN HHHCCCCCCCEEEEC	29.78	28450419
545	Phosphorylation	RESPLQFSLNGGSEK CCCCCEEEECCCCCC	14.15	28509920
566	Ubiquitination	EGVEPGSKAADSGLK ECCCCCCHHHHCCCC	54.21	-
573	Ubiquitination	KAADSGLKRGDQIME HHHHCCCCCCCEEEE	58.84	-
602	Phosphorylation	VEILRNNTHLALTVK HHHHHCCCCEEEEEE	23.09	20873877
626	Ubiquitination	LFRTEQEKSGVPHIP HHCCCHHHCCCCCCH	52.80	-
640	Phosphorylation	PKIAEKKSNRHSIQH HHHHCCCCCCCCCCC	50.60	23401153
644	Phosphorylation	EKKSNRHSIQHVPGD CCCCCCCCCCCCCCC	22.24	23401153
655	Phosphorylation	VPGDIEQTSQEKGSK CCCCHHHHHCCCCCC	21.42	25159151
656	Phosphorylation	PGDIEQTSQEKGSKK CCCHHHHHCCCCCCC	35.72	29978859
659	Ubiquitination	IEQTSQEKGSKKVKA HHHHHCCCCCCCCCC	61.93	-
661	Phosphorylation	QTSQEKGSKKVKANT HHHCCCCCCCCCCCE	40.13	23917254
701	Phosphorylation	SDGGLSQSQDDSIVG CCCCCCCCCCCCCCC	32.00	29214152
705	Phosphorylation	LSQSQDDSIVGTRHC CCCCCCCCCCCCCCC	27.71	28555341
715	Phosphorylation	GTRHCRHSLAIMPIP CCCCCCCEEEEEECC	10.51	27080861
724	Phosphorylation	AIMPIPGTLSSSSPD EEEECCCCCCCCCCC	20.36	28450419
726	Phosphorylation	MPIPGTLSSSSPDLL EECCCCCCCCCCCCC	28.19	28450419
727	Phosphorylation	PIPGTLSSSSPDLLQ ECCCCCCCCCCCCCC	37.64	28450419
728	Phosphorylation	IPGTLSSSSPDLLQP CCCCCCCCCCCCCCC	42.38	28450419
729	Phosphorylation	PGTLSSSSPDLLQPT CCCCCCCCCCCCCCC	25.12	28450419
736	Phosphorylation	SPDLLQPTTSMLDFS CCCCCCCCCCCCCCC	20.67	28450419
737	Phosphorylation	PDLLQPTTSMLDFSN CCCCCCCCCCCCCCC	20.87	28450419
738	Phosphorylation	DLLQPTTSMLDFSNP CCCCCCCCCCCCCCH	21.59	28450419
743	Phosphorylation	TTSMLDFSNPSDIPD CCCCCCCCCHHCCCH	47.71	27080861
817	Ubiquitination	RLPDQFSKLADRIQL CCCHHHHHHHHHHHH	49.32	-
836	Phosphorylation	YLKNNMETETLCSDE EECCCCCCCEECCHH	24.41	27251275
838	Phosphorylation	KNNMETETLCSDEDA CCCCCCCEECCHHHH	40.25	27251275
841	Phosphorylation	METETLCSDEDAQEL CCCCEECCHHHHHHH	47.34	25159151
890	Ubiquitination	EYIDDLFKLNSKTGN HHHHHHHHCCCCCCC	54.80	-
894	Ubiquitination	DLFKLNSKTGNTHLK HHHHCCCCCCCCHHH	60.42	-
932	Ubiquitination	LKRMKIIKHFIKIAL HHHHHHHHHHHHHHH	35.62	-
949	Phosphorylation	RECKNFNSMFAIISG HHCCCHHHHHHHHHC	15.90	-
968	Phosphorylation	SVARLRGTWEKLPSK HHHHHHCHHHHCCHH	24.82	24719451
974	Phosphorylation	GTWEKLPSKYEKHLQ CHHHHCCHHHHHHHH	59.30	24719451
976	Phosphorylation	WEKLPSKYEKHLQDL HHHCCHHHHHHHHHH	34.25	-
978	Ubiquitination	KLPSKYEKHLQDLQD HCCHHHHHHHHHHHH	46.67	-
1018	Ubiquitination	PLFPVVKKDMTFLHE CCCCEEECCCEEEEC	40.91	-
1039	Ubiquitination	DGLVNFEKLRMISKE CCCCCHHHHHHHHHH	36.94	-
1054	Phosphorylation	IRQVVRMTSANMDPA HHHHHHHHCCCCCHH	17.70	30206219
1055	Phosphorylation	RQVVRMTSANMDPAM HHHHHHHCCCCCHHH	14.33	30206219
1068	Phosphorylation	AMMFRQRSLSQGSTN HHHHHHHHHCCCCCC	24.84	23927012
1070	Phosphorylation	MFRQRSLSQGSTNSN HHHHHHHCCCCCCCC	33.47	17525332
1073	Phosphorylation	QRSLSQGSTNSNMLD HHHHCCCCCCCCCCC	19.44	23927012
1073 (in isoform 4)	Phosphorylation	-	19.44	27732954
1073 (in isoform 5)	Phosphorylation	-	19.44	27732954
1074	Phosphorylation	RSLSQGSTNSNMLDV HHHCCCCCCCCCCCC	49.87	23927012
1076	Phosphorylation	LSQGSTNSNMLDVQG HCCCCCCCCCCCCCC	24.57	28450419
1076 (in isoform 4)	Phosphorylation	-	24.57	27732954
1076 (in isoform 5)	Phosphorylation	-	24.57	27732954
1078 (in isoform 3)	Phosphorylation	-	3.20	27732954
1078 (in isoform 4)	Phosphorylation	-	3.20	27732954
1078 (in isoform 5)	Phosphorylation	-	3.20	27732954
1081 (in isoform 3)	Phosphorylation	-	5.12	27732954
1081 (in isoform 4)	Phosphorylation	-	5.12	27732954
1081 (in isoform 5)	Phosphorylation	-	5.12	27732954
1082 (in isoform 4)	Phosphorylation	-	44.24	27732954
1082 (in isoform 5)	Phosphorylation	-	44.24	27732954
1083 (in isoform 3)	Phosphorylation	-	34.79	27732954
1084 (in isoform 4)	Phosphorylation	-	13.86	27732954
1084 (in isoform 5)	Phosphorylation	-	13.86	27732954
1086 (in isoform 3)	Phosphorylation	-	39.17	27732954
1087 (in isoform 3)	Phosphorylation	-	43.34	27732954
1089 (in isoform 3)	Phosphorylation	-	37.82	27732954
1093	Phosphorylation	HKKRARRSSLLNAKK HHHHHHHHHHHCHHH	21.56	30266825
1094	Phosphorylation	KKRARRSSLLNAKKL HHHHHHHHHHCHHHH	34.76	22167270
1102	Phosphorylation	LLNAKKLYEDAQMAR HHCHHHHHHHHHHHH	22.20	29496907
1110	Ubiquitination	EDAQMARKVKQYLSS HHHHHHHHHHHHHHC	44.22	-
1112	Ubiquitination	AQMARKVKQYLSSLD HHHHHHHHHHHHCCC	35.94	-
1138	Phosphorylation	SLQWEPAYGTLTKNL HCEEECCCCHHCCCH	22.74	-
1140	Phosphorylation	QWEPAYGTLTKNLSE EEECCCCHHCCCHHH	20.69	27251275
1146	Phosphorylation	GTLTKNLSEKRSAKS CHHCCCHHHHHCCCC	50.93	24719451
1153	Phosphorylation	SEKRSAKSSEMSPVP HHHHCCCCCCCCCCC	31.11	29978859
1154	Phosphorylation	EKRSAKSSEMSPVPM HHHCCCCCCCCCCCC	36.29	29978859
1157	Phosphorylation	SAKSSEMSPVPMRSA CCCCCCCCCCCCCCC	20.77	23401153
1163	Phosphorylation	MSPVPMRSAGQTTKA CCCCCCCCCCCCCCC	30.42	26074081
1168	Phosphorylation	MRSAGQTTKAHLHQP CCCCCCCCCCCCCCC	20.53	26074081
1169	Ubiquitination	RSAGQTTKAHLHQPH CCCCCCCCCCCCCCC	36.88	-
1179	Phosphorylation	LHQPHRVSQVLQVPA CCCCCCCHHEEECCC	17.96	29978859
1195	Acetylation	NLHPIRKKGQTKDPA CCCCCCCCCCCCCCC	46.53	12433787
1205	Phosphorylation	TKDPALNTSLPQKVL CCCCCCCCCCCHHHC	32.27	29255136
1206	Phosphorylation	KDPALNTSLPQKVLG CCCCCCCCCCHHHCC	36.66	29255136
1221	Acetylation	TTEEISGKKHTEDTI CCCCCCCCCCCCCCC	34.29	25953088
1221	Ubiquitination	TTEEISGKKHTEDTI CCCCCCCCCCCCCCC	34.29	-
1224	Phosphorylation	EISGKKHTEDTISVA CCCCCCCCCCCCHHH	44.42	23663014
1227	Phosphorylation	GKKHTEDTISVASSL CCCCCCCCCHHHHHH	14.66	23663014
1229	Phosphorylation	KHTEDTISVASSLHS CCCCCCCHHHHHHHC	17.45	23927012
1232	Phosphorylation	EDTISVASSLHSSPP CCCCHHHHHHHCCCC	31.14	23401153
1233	Phosphorylation	DTISVASSLHSSPPA CCCHHHHHHHCCCCC	21.99	23927012
1236	Phosphorylation	SVASSLHSSPPASPQ HHHHHHHCCCCCCCC	50.24	23927012
1237	Phosphorylation	VASSLHSSPPASPQG HHHHHHCCCCCCCCC	24.93	25159151
1241	Phosphorylation	LHSSPPASPQGSPHK HHCCCCCCCCCCCCC	24.43	23927012
1245	Phosphorylation	PPASPQGSPHKGYTL CCCCCCCCCCCCEEE	20.70	23927012
1250	Phosphorylation	QGSPHKGYTLIPSAK CCCCCCCEEECCCCC	11.81	28796482
1251	Phosphorylation	GSPHKGYTLIPSAKS CCCCCCEEECCCCCC	27.21	22210691
1255	Phosphorylation	KGYTLIPSAKSDNLS CCEEECCCCCCCCCC	41.14	22210691
1258	Phosphorylation	TLIPSAKSDNLSDSS EECCCCCCCCCCCCC	31.29	25072903
1262	Phosphorylation	SAKSDNLSDSSHSEI CCCCCCCCCCCCCCH	41.52	25159151
1264	Phosphorylation	KSDNLSDSSHSEISS CCCCCCCCCCCCHHC	26.95	25072903
1265	Phosphorylation	SDNLSDSSHSEISSR CCCCCCCCCCCHHCC	35.70	25072903
1267	Phosphorylation	NLSDSSHSEISSRSS CCCCCCCCCHHCCHH	38.28	25072903
1270	Phosphorylation	DSSHSEISSRSSIVS CCCCCCHHCCHHHHC	18.69	25072903
1271	Phosphorylation	SSHSEISSRSSIVSN CCCCCHHCCHHHHCC	41.67	25072903
1273	Phosphorylation	HSEISSRSSIVSNCS CCCHHCCHHHHCCCC	26.77	27251275
1274	Phosphorylation	SEISSRSSIVSNCSV CCHHCCHHHHCCCCH	26.37	27251275
1277	Phosphorylation	SSRSSIVSNCSVDSM HCCHHHHCCCCHHHH	30.37	27251275
1280	Phosphorylation	SSIVSNCSVDSMSAA HHHHCCCCHHHHHHH	32.96	28985074
1283	Phosphorylation	VSNCSVDSMSAALQD HCCCCHHHHHHHHCC	16.69	27251275
1284 (in isoform 2)	Phosphorylation	-	2.46	20068231
1288 (in isoform 2)	Phosphorylation	-	7.06	20068231
1290 (in isoform 2)	Phosphorylation	-	46.27	20068231
1291 (in isoform 2)	Phosphorylation	-	42.50	20068231
1294	Phosphorylation	ALQDERCSSQALAVP HHCCCCCCCCCCCCC	31.54	25690035
1295 (in isoform 2)	Phosphorylation	-	24.09	20068231
1303	Phosphorylation	QALAVPESTGALEKT CCCCCCCCCCCCCCC	26.52	25690035
1330	Ubiquitination	GPGWTLLKPSLIKCL CCCCCCCCHHHHHHH	35.36	-
1332	Phosphorylation	GWTLLKPSLIKCLAV CCCCCCHHHHHHHHH	40.93	24719451
1362 (in isoform 2)	Phosphorylation	-	39.67	-
1367 (in isoform 2)	Phosphorylation	-	13.02	-
1373 (in isoform 2)	Phosphorylation	-	35.66	-
1378	Phosphorylation	SSHDNFQSLPNPKSW CCCCCCCCCCCCCCH	41.47	-
1383	Ubiquitination	FQSLPNPKSWDFLNS CCCCCCCCCHHHHHH	71.47	-
1384	Phosphorylation	QSLPNPKSWDFLNSY CCCCCCCCHHHHHHC	32.89	28450419
1391	Phosphorylation	SWDFLNSYRHTHLDD CHHHHHHCCCCCCCC	12.82	-
1406	Phosphorylation	PIAEVEPTDSEPYSC CCCCCCCCCCCCCCC	38.36	28796482
1408	Phosphorylation	AEVEPTDSEPYSCSK CCCCCCCCCCCCCCC	42.84	28796482
1411	Phosphorylation	EPTDSEPYSCSKSCS CCCCCCCCCCCCHHC	20.47	28796482
1412	Phosphorylation	PTDSEPYSCSKSCSR CCCCCCCCCCCHHCC	23.72	28796482
1414	Phosphorylation	DSEPYSCSKSCSRTC CCCCCCCCCHHCCCC	22.97	28796482
1415	Ubiquitination	SEPYSCSKSCSRTCG CCCCCCCCHHCCCCC	60.86	-
1420	Phosphorylation	CSKSCSRTCGQCKGS CCCHHCCCCCCCCCC	12.51	25002506
1425	Ubiquitination	SRTCGQCKGSLERKS CCCCCCCCCCHHCCC	43.58	-
1427	Phosphorylation	TCGQCKGSLERKSWT CCCCCCCCHHCCCCC	16.74	25849741
1431	Ubiquitination	CKGSLERKSWTSSSS CCCCHHCCCCCCCCC	40.75	-
1432	Phosphorylation	KGSLERKSWTSSSSL CCCHHCCCCCCCCCC	41.63	21945579
1434	Phosphorylation	SLERKSWTSSSSLSD CHHCCCCCCCCCCCC	26.31	21945579
1435	Phosphorylation	LERKSWTSSSSLSDT HHCCCCCCCCCCCCC	23.20	21945579
1436	Phosphorylation	ERKSWTSSSSLSDTY HCCCCCCCCCCCCCC	19.30	21945579
1437	Phosphorylation	RKSWTSSSSLSDTYE CCCCCCCCCCCCCCC	34.76	21945579
1438	Phosphorylation	KSWTSSSSLSDTYEP CCCCCCCCCCCCCCC	33.56	21945579
1440	Phosphorylation	WTSSSSLSDTYEPNY CCCCCCCCCCCCCCC	29.83	21945579
1442	Phosphorylation	SSSSLSDTYEPNYGT CCCCCCCCCCCCCCC	26.80	21945579
1443	Phosphorylation	SSSLSDTYEPNYGTV CCCCCCCCCCCCCCH	34.09	21945579
1447	Phosphorylation	SDTYEPNYGTVKQRV CCCCCCCCCCHHHHH	25.53	21945579
1449	Phosphorylation	TYEPNYGTVKQRVLE CCCCCCCCHHHHHHH	17.73	21945579
1458	Phosphorylation	KQRVLESTPAESSEG HHHHHHCCCCCCCCC	19.69	21815630
1463	O-linked_Glycosylation	ESTPAESSEGLDPKD HCCCCCCCCCCCHHC	27.47	30379171
1469	Acetylation	SSEGLDPKDATDPVY CCCCCCHHCCCCCCC	60.71	20167786
1469	Ubiquitination	SSEGLDPKDATDPVY CCCCCCHHCCCCCCC	60.71	-
1472	Phosphorylation	GLDPKDATDPVYKTV CCCHHCCCCCCCEEC	51.47	26552605
1476	Phosphorylation	KDATDPVYKTVTSST HCCCCCCCEECCCCC	13.31	25159151
1477	Ubiquitination	DATDPVYKTVTSSTE CCCCCCCEECCCCCC	36.43	-
1478	Phosphorylation	ATDPVYKTVTSSTEK CCCCCCEECCCCCCC	16.01	21712546
1480	Phosphorylation	DPVYKTVTSSTEKGL CCCCEECCCCCCCEE	23.38	22210691
1481	Phosphorylation	PVYKTVTSSTEKGLI CCCEECCCCCCCEEE	30.81	22210691
1482	Phosphorylation	VYKTVTSSTEKGLIV CCEECCCCCCCEEEE	31.08	22210691
1483	Phosphorylation	YKTVTSSTEKGLIVY CEECCCCCCCEEEEE	41.29	21712546
1488 (in isoform 5)	Phosphorylation	-	2.57	24719451
1490	Phosphorylation	TEKGLIVYCVTSPKK CCCEEEEEEECCCCC	3.68	21945579
1491 (in isoform 5)	Phosphorylation	-	1.54	24719451
1493	Phosphorylation	GLIVYCVTSPKKDDR EEEEEEECCCCCCCC	35.43	21945579
1493 (in isoform 3)	Phosphorylation	-	35.43	24719451
1494	Phosphorylation	LIVYCVTSPKKDDRY EEEEEECCCCCCCCC	17.83	23401153
1496 (in isoform 3)	Phosphorylation	-	69.47	24719451
1501	Phosphorylation	SPKKDDRYREPPPTP CCCCCCCCCCCCCCC	26.73	28796482
1507	Phosphorylation	RYREPPPTPPGYLGI CCCCCCCCCCCCCCE	48.14	25159151
1511	Phosphorylation	PPPTPPGYLGISLAD CCCCCCCCCCEEHHH	13.92	28796482
1515	Phosphorylation	PPGYLGISLADLKEG CCCCCCEEHHHCCCC	18.73	29978859
1520	Ubiquitination	GISLADLKEGPHTHL CEEHHHCCCCCCCCC	62.26	-
1525	Phosphorylation	DLKEGPHTHLKPPDY HCCCCCCCCCCCCCC	31.85	-
1528	Ubiquitination	EGPHTHLKPPDYSVA CCCCCCCCCCCCCHH	47.07	-
1533	Phosphorylation	HLKPPDYSVAVQRSK CCCCCCCCHHHHHHH	15.81	-
1540	Acetylation	SVAVQRSKMMHNSLS CHHHHHHHHCCHHHH	42.29	25953088
1540	Ubiquitination	SVAVQRSKMMHNSLS CHHHHHHHHCCHHHH	42.29	-
1545	Phosphorylation	RSKMMHNSLSRLPPA HHHHCCHHHHCCCCC	17.03	24719451
1556	O-linked_Glycosylation	LPPASLSSNLVACVP CCCCHHCCCCEEEEC	39.20	30379171
1586	Phosphorylation	HPKLGDVTDADSEAD CCCCCCCCCCCCCCC	30.15	25159151
1590	Phosphorylation	GDVTDADSEADENEQ CCCCCCCCCCCCCCC	36.08	25159151
1599	Phosphorylation	ADENEQVSAV----- CCCCCCCCCC-----	24.02	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPGF6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPGF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPGF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAP1A_HUMAN	RAP1A	physical	11524421
RAP2A_HUMAN	RAP2A	physical	11524421
RASM_HUMAN	MRAS	physical	11524421

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPGF6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230 AND SER-1590, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1590, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230 AND THR-1507, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1590, AND MASSSPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1494, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-496, AND MASSSPECTROMETRY.	17081983 [Abstract]