dbPTM

APC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	APC1_HUMAN
UniProt AC	Q9H1A4
Protein Name	Anaphase-promoting complex subunit 1
Gene Name	ANAPC1
Organism	Homo sapiens (Human).
Sequence Length	1944
Subcellular Localization
Protein Description	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains..
Protein Sequence	MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGSLQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVVDHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSSLTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGVHSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNIREKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQLKMPVRALLRLAPLLLGNPQPMVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSNFYEERTTMI ---CCCHHHHHHHHH	22.56	27642862
24	Ubiquitination	LQEFVPFGRDHCKHH HHHHCCCCCHHHHCC	28.21	21987572
29	Ubiquitination	PFGRDHCKHHPNALN CCCCHHHHCCCCHHH	41.34	29967540
39	Ubiquitination	PNALNLQLRQLQPAS CCHHHHHHHHHCCHH	4.20	21963094
42	Ubiquitination	LNLQLRQLQPASELW HHHHHHHHCCHHHHH	5.49	21963094
46	Phosphorylation	LRQLQPASELWSSDG HHHHCCHHHHHCCCC	39.65	28102081
50	Phosphorylation	QPASELWSSDGAAGL CCHHHHHCCCCCHHH	31.04	22617229
51	Phosphorylation	PASELWSSDGAAGLV CHHHHHCCCCCHHHH	28.60	21712546
60	Phosphorylation	GAAGLVGSLQEVTIH CCHHHHCCEEEEEEC	21.28	22617229
65	Phosphorylation	VGSLQEVTIHEKQKE HCCEEEEEECHHHHH	18.83	21082442
69	Ubiquitination	QEVTIHEKQKESWQL EEEEECHHHHHHHHH	53.13	21906983
71	Ubiquitination	VTIHEKQKESWQLRK EEECHHHHHHHHHHC	65.86	22817900
86	Ubiquitination	GVSEIGEDVDYDEEL CHHHCCCCCCCCCCE	33.12	21987572
107	Ubiquitination	VIWSKGSKSQALAVY EEEECCCHHHHEEEE	56.08	29967540
115	Ubiquitination	SQALAVYKAFTVDSP HHHEEEEEEEECCCH	30.35	22817900
118	Phosphorylation	LAVYKAFTVDSPVQQ EEEEEEEECCCHHHH	28.41	22817900
124	Ubiquitination	FTVDSPVQQALWCDF EECCCHHHHHHHHCE	26.64	21963094
137	Ubiquitination	DFIISQDKSEKAYSS CEEECCCCCCCCCCC	53.53	21963094
140	Ubiquitination	ISQDKSEKAYSSNEV ECCCCCCCCCCCCHH	60.77	21906983
150	Ubiquitination	SSNEVEKCICILQSS CCCHHHHHHHHHHHH	1.62	21890473
177	Ubiquitination	IASLPFQVANVWPTK EEECCEEEECCCCCC	4.24	22817900
184	Ubiquitination	VANVWPTKYGLLFER EECCCCCCEEEEEEC	32.99	21987572
186	Ubiquitination	NVWPTKYGLLFERSA CCCCCCEEEEEECCC	19.91	21963094
192	Phosphorylation	YGLLFERSASSHEVP EEEEEECCCCCCCCC	25.88	28634298
194	Phosphorylation	LLFERSASSHEVPPG EEEECCCCCCCCCCC	33.21	28634298
195	Phosphorylation	LFERSASSHEVPPGS EEECCCCCCCCCCCC	24.31	28634298
202	Phosphorylation	SHEVPPGSPREPLPT CCCCCCCCCCCCCCC	26.93	25159151
209	Phosphorylation	SPREPLPTMFSMLHP CCCCCCCCCHHHCCC	38.23	26434776
212	Phosphorylation	EPLPTMFSMLHPLDE CCCCCCHHHCCCHHH	15.04	26434776
212	Ubiquitination	EPLPTMFSMLHPLDE CCCCCCHHHCCCHHH	15.04	21890473
221	Phosphorylation	LHPLDEITPLVCKSG CCCHHHCCCEEECCC	14.44	28634298
233	Phosphorylation	KSGSLFGSSRVQYVV CCCCCCCCHHHHHHH	13.98	22817900
234	Phosphorylation	SGSLFGSSRVQYVVD CCCCCCCHHHHHHHC	36.53	23312004
245	Ubiquitination	YVVDHAMKIVFLNTD HHHCCCEEEEEECCC	36.18	-
269	Ubiquitination	VQNVHSVWTLRRVKS HCCCHHHEEEEECCC	7.85	21963094
275	Ubiquitination	VWTLRRVKSEEENVV HEEEEECCCCCCCEE	50.79	22817900
284	Ubiquitination	EEENVVLKFSEQGGT CCCCEEEEEECCCCC	34.92	21963094
286	Phosphorylation	ENVVLKFSEQGGTPQ CCEEEEEECCCCCCC	27.67	21712546
291	Phosphorylation	KFSEQGGTPQNVATS EEECCCCCCCCEECC	28.64	22167270
297	Phosphorylation	GTPQNVATSSSLTAH CCCCCEECCHHHHHH	25.51	20068231
298	O-linked_Glycosylation	TPQNVATSSSLTAHL CCCCEECCHHHHHHH	14.27	30059200
298	Phosphorylation	TPQNVATSSSLTAHL CCCCEECCHHHHHHH	14.27	25159151
299	Phosphorylation	PQNVATSSSLTAHLR CCCEECCHHHHHHHH	25.64	25159151
300	Phosphorylation	QNVATSSSLTAHLRS CCEECCHHHHHHHHH	29.52	25159151
302	Phosphorylation	VATSSSLTAHLRSLS EECCHHHHHHHHHHC	17.61	20068231
307	Phosphorylation	SLTAHLRSLSKGDSP HHHHHHHHHCCCCCC	43.27	18669648
309	Phosphorylation	TAHLRSLSKGDSPVT HHHHHHHCCCCCCCC	35.52	28464451
310	Ubiquitination	AHLRSLSKGDSPVTS HHHHHHCCCCCCCCC	72.53	21906983
313	Phosphorylation	RSLSKGDSPVTSPFQ HHHCCCCCCCCCCCC	29.91	23401153
316	Phosphorylation	SKGDSPVTSPFQNYS CCCCCCCCCCCCCCH	33.78	25159151
317	Phosphorylation	KGDSPVTSPFQNYSS CCCCCCCCCCCCCHH	24.77	25159151
317	Ubiquitination	KGDSPVTSPFQNYSS CCCCCCCCCCCCCHH	24.77	22817900
322	Phosphorylation	VTSPFQNYSSIHSQS CCCCCCCCHHHCCCC	7.94	28857561
323	Phosphorylation	TSPFQNYSSIHSQSR CCCCCCCHHHCCCCC	30.30	23401153
324	Phosphorylation	SPFQNYSSIHSQSRS CCCCCCHHHCCCCCC	17.60	28857561
327	Phosphorylation	QNYSSIHSQSRSTSS CCCHHHCCCCCCCCC	28.34	23090842
329	Phosphorylation	YSSIHSQSRSTSSPS CHHHCCCCCCCCCCC	31.08	23090842
331	Phosphorylation	SIHSQSRSTSSPSLH HHCCCCCCCCCCCHH	37.58	22199227
331	Ubiquitination	SIHSQSRSTSSPSLH HHCCCCCCCCCCCHH	37.58	21963094
332	Phosphorylation	IHSQSRSTSSPSLHS HCCCCCCCCCCCHHC	31.92	22199227
333	Phosphorylation	HSQSRSTSSPSLHSR CCCCCCCCCCCHHCC	41.31	25159151
334	Phosphorylation	SQSRSTSSPSLHSRS CCCCCCCCCCHHCCC	20.70	25159151
336	Phosphorylation	SRSTSSPSLHSRSPS CCCCCCCCHHCCCCC	40.43	22199227
339	Phosphorylation	TSSPSLHSRSPSISN CCCCCHHCCCCCHHH	39.48	30576142
341	Phosphorylation	SPSLHSRSPSISNMA CCCHHCCCCCHHHHH	26.47	25159151
343	Phosphorylation	SLHSRSPSISNMAAL CHHCCCCCHHHHHHH	39.64	23401153
345	Phosphorylation	HSRSPSISNMAALSR HCCCCCHHHHHHHHH	25.53	26055452
351	Phosphorylation	ISNMAALSRAHSPAL HHHHHHHHHCCCCCC	23.77	25159151
352	Methylation	SNMAALSRAHSPALG HHHHHHHHCCCCCCC	36.85	-
355	Phosphorylation	AALSRAHSPALGVHS HHHHHCCCCCCCCCC	15.75	29255136
362	Phosphorylation	SPALGVHSFSGVQRF CCCCCCCCCCCCCCE	20.78	22167270
364	Phosphorylation	ALGVHSFSGVQRFNI CCCCCCCCCCCCEEC	40.86	22167270
372	Phosphorylation	GVQRFNISSHNQSPK CCCCEECCCCCCCCC	27.01	22167270
373	Phosphorylation	VQRFNISSHNQSPKR CCCEECCCCCCCCCC	23.74	22167270
377	Phosphorylation	NISSHNQSPKRHSIS ECCCCCCCCCCCCCC	37.39	29255136
379	Ubiquitination	SSHNQSPKRHSISHS CCCCCCCCCCCCCCC	68.91	22817900
386	Phosphorylation	KRHSISHSPNSNSNG CCCCCCCCCCCCCCC	20.98	22067460
389	Phosphorylation	SISHSPNSNSNGSFL CCCCCCCCCCCCCCC	45.05	23836654
405	Ubiquitination	PETEPIVPELCIDHL CCCCCCCCHHHHHHH	29.57	21963094
429	Ubiquitination	EKNSQASKVFITSDL HHCCCCCEEEEECCC	44.15	21906983
433	Phosphorylation	QASKVFITSDLCGQK CCCEEEEECCCCCCH	12.53	30624053
434	Phosphorylation	ASKVFITSDLCGQKF CCEEEEECCCCCCHH	24.62	30624053
448	Phosphorylation	FLCFLVESQLQLRCV HHHHHHHHHHHHEEE	28.81	30624053
463	Ubiquitination	KFQESNDKTQLIFGS EEECCCCCEEEEEEE	42.28	29967540
467	Ubiquitination	SNDKTQLIFGSVTNI CCCCEEEEEEEEECC	2.36	21963094
477	Ubiquitination	SVTNIPAKDAAPVEK EEECCCCCCCCCHHH	42.41	21906983
518	Phosphorylation	IPGLPAPSLTMSNTM CCCCCCCCCCCCCCC	38.28	22115753
520	Phosphorylation	GLPAPSLTMSNTMPR CCCCCCCCCCCCCCC	23.92	21712546
522	Phosphorylation	PAPSLTMSNTMPRPS CCCCCCCCCCCCCCC	24.74	22115753
524	Phosphorylation	PSLTMSNTMPRPSTP CCCCCCCCCCCCCCC	22.65	22115753
529	Phosphorylation	SNTMPRPSTPLDGVS CCCCCCCCCCCCCCC	43.89	22167270
530	Phosphorylation	NTMPRPSTPLDGVST CCCCCCCCCCCCCCC	30.47	22167270
534	Ubiquitination	RPSTPLDGVSTPKPL CCCCCCCCCCCCHHH	23.98	22817900
535	Ubiquitination	PSTPLDGVSTPKPLS CCCCCCCCCCCHHHH	6.02	22817900
536	Phosphorylation	STPLDGVSTPKPLSK CCCCCCCCCCHHHHH	44.51	25159151
537	Phosphorylation	TPLDGVSTPKPLSKL CCCCCCCCCHHHHHH	32.69	25159151
539	Ubiquitination	LDGVSTPKPLSKLLG CCCCCCCHHHHHHHC	59.69	29967540
542	Phosphorylation	VSTPKPLSKLLGSLD CCCCHHHHHHHCCCC	29.77	29978859
547	Phosphorylation	PLSKLLGSLDEVVLL HHHHHHCCCCEEEEE	32.39	22167270
555	Phosphorylation	LDEVVLLSPVPELRD CCEEEEEECCCHHCC	21.49	17001009
563	Phosphorylation	PVPELRDSSKLHDSL CCCHHCCCCCCCHHH	23.96	22167270
564	Phosphorylation	VPELRDSSKLHDSLY CCHHCCCCCCCHHHC	43.45	22167270
565	Ubiquitination	PELRDSSKLHDSLYN CHHCCCCCCCHHHCC	54.51	21963094
569	Phosphorylation	DSSKLHDSLYNEDCT CCCCCCHHHCCCCCC	23.23	14657031
571	Phosphorylation	SKLHDSLYNEDCTFQ CCCCHHHCCCCCCHH	22.06	22817900
576	Phosphorylation	SLYNEDCTFQQLGTY HHCCCCCCHHHHHHH	36.48	27080861
586	Phosphorylation	QLGTYIHSIRDPVHN HHHHHHHHCCCCCCC	15.12	24719451
596	Phosphorylation	DPVHNRVTLELSNGS CCCCCCEEEEECCCC	15.98	-
596	Ubiquitination	DPVHNRVTLELSNGS CCCCCCEEEEECCCC	15.98	22817900
597	Ubiquitination	PVHNRVTLELSNGSM CCCCCEEEEECCCCE	5.96	22817900
600	Phosphorylation	NRVTLELSNGSMVRI CCEEEEECCCCEEEE	29.75	22817900
686	Phosphorylation	RNFDFEGSLSPVIAP CCCCCCCCCCCEECC	20.62	22167270
688	Phosphorylation	FDFEGSLSPVIAPKK CCCCCCCCCEECCCC	20.86	19664994
694	Ubiquitination	LSPVIAPKKARPSET CCCEECCCCCCCCCC	50.47	21906983
695	Ubiquitination	SPVIAPKKARPSETG CCEECCCCCCCCCCC	48.87	29967540
699	Phosphorylation	APKKARPSETGSDDD CCCCCCCCCCCCCCC	42.09	25159151
701	Phosphorylation	KKARPSETGSDDDWE CCCCCCCCCCCCCHH	46.45	14657031
703	Phosphorylation	ARPSETGSDDDWEYL CCCCCCCCCCCHHHH	45.33	25159151
709	Phosphorylation	GSDDDWEYLLNSDYH CCCCCHHHHHCCCHH	16.54	28450419
713	Phosphorylation	DWEYLLNSDYHQNVE CHHHHHCCCHHHHHH	39.24	27251275
721	Phosphorylation	DYHQNVESHLLNRSL CHHHHHHHHHCCCHH	18.36	26074081
727	Phosphorylation	ESHLLNRSLCLSPSE HHHHCCCHHCCCHHH	23.51	30266825
731	Phosphorylation	LNRSLCLSPSEASQM CCCHHCCCHHHHHHC	25.94	30266825
733	Phosphorylation	RSLCLSPSEASQMKD CHHCCCHHHHHHCCC	42.28	30266825
736	Phosphorylation	CLSPSEASQMKDEDF CCCHHHHHHCCCCCC	27.10	30266825
745	Ubiquitination	MKDEDFSQNLSLDSS CCCCCCCCCCCCCHH	55.68	21963094
807	Ubiquitination	GPYVDHYYRDYPTLV CHHCCHHCCCCCCEE	8.12	21963094
825	Ubiquitination	GQVCTIDPGQTGFMH CCEEEECCCCCCCCC	32.70	21963094
834	Ubiquitination	QTGFMHHPSFFTSEP CCCCCCCCHHCCCCC	20.39	22817900
836	Ubiquitination	GFMHHPSFFTSEPPS CCCCCCHHCCCCCCC	10.24	21963094
876	Phosphorylation	RSRLVVLSIALYILG HHHHHHHHHHHHHHC	8.33	-
886	Phosphorylation	LYILGDESLVSDESS HHHHCCHHHCCCCHH	38.52	-
887	Ubiquitination	YILGDESLVSDESSQ HHHCCHHHCCCCHHH	3.93	21963094
892	Phosphorylation	ESLVSDESSQYLTRI HHHCCCCHHHHHEEE	27.94	19690332
893	Phosphorylation	SLVSDESSQYLTRIT HHCCCCHHHHHEEEE	22.31	19690332
895	Phosphorylation	VSDESSQYLTRITIA CCCCHHHHHEEEEEC	16.40	19690332
896	Ubiquitination	SDESSQYLTRITIAP CCCHHHHHEEEEECC	1.69	22817900
898	Ubiquitination	ESSQYLTRITIAPQK CHHHHHEEEEECCCC	22.81	21963094
905	Ubiquitination	RITIAPQKLQVEQEE EEEECCCCCCHHCCC	39.57	21906983
906	Ubiquitination	ITIAPQKLQVEQEEN EEECCCCCCHHCCCC	6.09	21963094
910	Ubiquitination	PQKLQVEQEENRFSF CCCCCHHCCCCCCCC	65.53	21963094
916	Phosphorylation	EQEENRFSFRHSTSV HCCCCCCCCCCCCCH	20.38	28122231
920	Phosphorylation	NRFSFRHSTSVSSLA CCCCCCCCCCHHHHH	20.37	29214152
921	Phosphorylation	RFSFRHSTSVSSLAE CCCCCCCCCHHHHHH	27.33	23312004
922	Phosphorylation	FSFRHSTSVSSLAER CCCCCCCCHHHHHHH	24.02	28555341
940	Phosphorylation	WMTNVGFTLRDLETL HHHHCCCCHHHHHCC	18.24	24719451
968	Ubiquitination	HCREQPASDWPEAVC HHCCCCCCCCCHHHH	47.06	21963094
972	Ubiquitination	QPASDWPEAVCLLIG CCCCCCCHHHHHHHC	49.86	21963094
984	Phosphorylation	LIGRQDLSKQACEGN HHCCCCHHHHHHCCC	30.89	24667141
985	Acetylation	IGRQDLSKQACEGNL HCCCCHHHHHHCCCC	49.57	26051181
985	Ubiquitination	IGRQDLSKQACEGNL HCCCCHHHHHHCCCC	49.57	27667366
994	Ubiquitination	ACEGNLPKGKSVLSS HHCCCCCCCCCCCCC	80.35	22817900
996	Ubiquitination	EGNLPKGKSVLSSDV CCCCCCCCCCCCCCC	43.44	21963094
1058	Phosphorylation	VVQYPELSDHEFIEE EEECCCCCCHHHHHH	34.95	30266825
1066	Ubiquitination	DHEFIEEKENRLLQL CHHHHHHHHHHHHHH	47.72	21906983
1070	Ubiquitination	IEEKENRLLQLCQRT HHHHHHHHHHHHHHH	5.57	21963094
1108	Phosphorylation	PIPKLNLTGRAPPRN CCCCCCCCCCCCCCC	24.45	25599653
1162	Ubiquitination	SAWIVYNKPKHAELA EEEEEECCCCHHHHH	37.44	29967540
1311	Phosphorylation	MVCLGHGSNLIGMSD HHHHCCCCCCCCCCC	23.84	24043423
1317	Phosphorylation	GSNLIGMSDLNVPEQ CCCCCCCCCCCCCHH	33.46	24043423
1326	Phosphorylation	LNVPEQLYQYMVGGH CCCCHHHHHHHHHCC	9.40	24043423
1328	Phosphorylation	VPEQLYQYMVGGHRR CCHHHHHHHHHCCCC	4.72	24043423
1346	Ubiquitination	GMHREKHKSPSYQIK CCCCCCCCCCCCCCC	75.12	29967540
1347	Phosphorylation	MHREKHKSPSYQIKE CCCCCCCCCCCCCCC	20.85	25159151
1349	Phosphorylation	REKHKSPSYQIKEGD CCCCCCCCCCCCCCC	36.44	20363803
1350	Phosphorylation	EKHKSPSYQIKEGDT CCCCCCCCCCCCCCE	20.03	28176443
1488	Ubiquitination	NLSAFNCLHKFAKDF CHHHHHHHHHHHHHH	5.30	21963094
1492	Ubiquitination	FNCLHKFAKDFMTYL HHHHHHHHHHHHHHH	18.47	21963094
1549	Ubiquitination	LHMKTGGEMNYGFHL HCCCCCCCCCHHHHH	26.12	21963094
1550	Ubiquitination	HMKTGGEMNYGFHLA CCCCCCCCCHHHHHH	5.46	21963094
1552	Phosphorylation	KTGGEMNYGFHLAHH CCCCCCCHHHHHHHH	21.62	22817900
1553	Ubiquitination	TGGEMNYGFHLAHHM CCCCCCHHHHHHHHH	9.86	21963094
1554	Ubiquitination	GGEMNYGFHLAHHMA CCCCCHHHHHHHHHH	2.77	21963094
1610	Phosphorylation	LQALRHLYVLAAEPR HHHHHHHHHHHCCCC	6.31	-
1611	Ubiquitination	QALRHLYVLAAEPRL HHHHHHHHHHCCCCE	3.54	21963094
1615	Ubiquitination	HLYVLAAEPRLLVPV HHHHHHCCCCEEEEE	25.91	21963094
1617	Methylation	YVLAAEPRLLVPVDV HHHHCCCCEEEEECC	31.96	-
1638	Phosphorylation	YALLEVTYKGTQWYE EEEEEEEECCCCHHH	16.76	-
1648	Ubiquitination	TQWYEQTKEELMAPT CCHHHHCHHHHHHCC	49.22	21963094
1652	Ubiquitination	EQTKEELMAPTLLPE HHCHHHHHHCCCHHH	4.80	21963094
1664	Ubiquitination	LPELHLLKQIKVKGP HHHHHHHHHCCCCCC	57.23	29967540
1673	Phosphorylation	IKVKGPRYWELLIDL CCCCCCCHHHEEEEH	13.33	22210691
1688	Ubiquitination	SKGTQHLKSILSKDG HHCCHHHHHHHHCCC	33.07	29967540
1689	Phosphorylation	KGTQHLKSILSKDGV HCCHHHHHHHHCCCE	34.81	24719451
1693	Ubiquitination	HLKSILSKDGVLYVK HHHHHHHCCCEEEEE	55.87	29967540
1698	Phosphorylation	LSKDGVLYVKLRAGQ HHCCCEEEEEEECCC	7.98	-
1700	Ubiquitination	KDGVLYVKLRAGQLS CCCEEEEEEECCCCC	20.78	-
1707	Phosphorylation	KLRAGQLSYKEDPMG EEECCCCCCCCCCCC	26.69	22817900
1709	Ubiquitination	RAGQLSYKEDPMGWQ ECCCCCCCCCCCCHH	52.87	21906983
1713	Ubiquitination	LSYKEDPMGWQSLLA CCCCCCCCCHHHHHH	15.31	21963094
1717	Phosphorylation	EDPMGWQSLLAQTVA CCCCCHHHHHHHHHH	20.88	27732954
1722	Phosphorylation	WQSLLAQTVANRNSE HHHHHHHHHHHCCHH	18.91	27732954
1772	Phosphorylation	QEILDLFSSVLYECV HHHHHHHHHHHHHHH	27.17	24043423
1773	Phosphorylation	EILDLFSSVLYECVT HHHHHHHHHHHHHHC	14.60	24043423
1776	Phosphorylation	DLFSSVLYECVTQET HHHHHHHHHHHCCCC	12.72	24043423
1780	Phosphorylation	SVLYECVTQETPEML HHHHHHHCCCCCCHH	32.14	24043423
1783	Phosphorylation	YECVTQETPEMLPAY HHHHCCCCCCHHHHH	18.09	24043423
1790	Phosphorylation	TPEMLPAYIAMDQAI CCCHHHHHHHHHHHH	6.30	24043423
1835	2-Hydroxyisobutyrylation	ERLQNHPKRGLFMNS HHHHHCCCCCCCCCC	52.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
291	T	Phosphorylation	Kinase	PLK1	P53350	PSP
291	T	Phosphorylation	Kinase	CDK1	P06493	PSP
355	S	Phosphorylation	Kinase	PLK1	P53350	PSP
355	S	Phosphorylation	Kinase	CDK1	P06493	PSP
373	S	Phosphorylation	Kinase	CDK1	P06493	PSP
373	S	Phosphorylation	Kinase	PLK1	P53350	PSP
377	S	Phosphorylation	Kinase	CDK1	P06493	PSP
377	S	Phosphorylation	Kinase	PLK1	P53350	PSP
520	T	Phosphorylation	Kinase	PLK1	P53350	PSP
530	T	Phosphorylation	Kinase	CDK1	P06493	PSP
530	T	Phosphorylation	Kinase	PLK1	P53350	PSP
537	T	Phosphorylation	Kinase	CDK1	P06493	PSP
547	S	Phosphorylation	Kinase	PLK1	P53350	PSP
547	S	Phosphorylation	Kinase	CDK1	P06493	PSP
555	S	Phosphorylation	Kinase	CDK1	P06493	PSP
686	S	Phosphorylation	Kinase	PLK1	P53350	PhosphoELM
688	S	Phosphorylation	Kinase	PLK1	P53350	PSP
688	S	Phosphorylation	Kinase	CDK1	P06493	PSP
701	T	Phosphorylation	Kinase	CDK1	P06493	PSP
701	T	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
355	S	Phosphorylation		14657031
Phosphorylation on Ser-355 occurs specifically during mitosis.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of APC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC27_HUMAN	CDC27	physical	11076961
APC4_HUMAN	ANAPC4	physical	11076961
APC5_HUMAN	ANAPC5	physical	11076961
CDC16_HUMAN	CDC16	physical	11076961
CDC23_HUMAN	CDC23	physical	11076961
ANC2_HUMAN	ANAPC2	physical	11076961
APC7_HUMAN	ANAPC7	physical	11076961
MDC1_HUMAN	MDC1	physical	19826003
CSN2_HUMAN	COPS2	physical	19535905
CDC23_HUMAN	CDC23	physical	22939629
CDC27_HUMAN	CDC27	physical	22939629
APC5_HUMAN	ANAPC5	physical	22939629
CDC16_HUMAN	CDC16	physical	22939629
APC4_HUMAN	ANAPC4	physical	22939629
APC7_HUMAN	ANAPC7	physical	22939629
CDC26_HUMAN	CDC26	physical	22939629
TRI33_HUMAN	TRIM33	physical	23160376
UBP1_HUMAN	USP1	physical	21768287
APC16_HUMAN	ANAPC16	physical	26344197
APC4_HUMAN	ANAPC4	physical	26344197
APC7_HUMAN	ANAPC7	physical	26344197
CDC16_HUMAN	CDC16	physical	26344197
CDC26_HUMAN	CDC26	physical	26344197
CDC27_HUMAN	CDC27	physical	26344197
NP1L4_HUMAN	NAP1L4	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of APC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-547; SER-555;SER-686 AND SER-688, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-688, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-699, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; SER-60; THR-65;THR-291; SER-341; SER-355; SER-362; SER-547; SER-563; SER-686 ANDSER-688, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; SER-377; SER-547;SER-555; SER-686 AND SER-688, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-362; SER-377AND SER-569, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-688, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688 AND SER-731, ANDMASS SPECTROMETRY.	15302935 [Abstract]
"Mitotic regulation of the human anaphase-promoting complex byphosphorylation."; Kraft C., Herzog F., Gieffers C., Mechtler K., Hagting A., Pines J.,Peters J.-M.; EMBO J. 22:6598-6609(2003). Cited for: PHOSPHORYLATION AT SER-202; SER-286; THR-291; SER-355; SER-373;SER-377; THR-537; TYR-571 AND SER-688.	14657031 [Abstract]

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