MDC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MDC1_HUMAN
• UniProt AC: Q14676
• Protein Name: Mediator of DNA damage checkpoint protein 1
• Gene Name: MDC1
• Organism: Homo sapiens (Human).
• Sequence Length: 2089
• Subcellular Localization: Nucleus . Chromosome. Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks.
• Protein Description: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1..
• Protein Sequence: MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQLPAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQAFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEDTQAIDWDV ----CCCCCCCCCCC	24.16	30108239
17	Phosphorylation	DVEEEEETEQSSESL CCCCHHHHHHCCHHH	42.47	26552605
20	Phosphorylation	EEEETEQSSESLRCN CHHHHHHCCHHHCCC	29.82	26552605
21	Phosphorylation	EEETEQSSESLRCNV HHHHHHCCHHHCCCC	30.79	26552605
23	Phosphorylation	ETEQSSESLRCNVEP HHHHCCHHHCCCCCC	24.06	27251275
45	"N6,N6-dimethyllysine"	SGAHGPEKDFPLHLG CCCCCCCCCCCCCCC	68.73	-
45	Acetylation	SGAHGPEKDFPLHLG CCCCCCCCCCCCCCC	68.73	26051181
45	Methylation	SGAHGPEKDFPLHLG CCCCCCCCCCCCCCC	68.73	-
45	Ubiquitination	SGAHGPEKDFPLHLG CCCCCCCCCCCCCCC	68.73	21890473
45 (in isoform 1)	Ubiquitination	-	68.73	21890473
45 (in isoform 2)	Ubiquitination	-	68.73	21890473
45 (in isoform 3)	Ubiquitination	-	68.73	21890473
45 (in isoform 4)	Ubiquitination	-	68.73	21890473
94	Phosphorylation	PILRDCGSLNGTQIL CCCCCCCCCCCCEEC	25.62	24719451
98	Phosphorylation	DCGSLNGTQILRPPK CCCCCCCCEECCCCC	16.03	22234877
108	Phosphorylation	LRPPKVLSPGVSHRL CCCCCCCCCCCCCCC	23.69	30266825
112	Phosphorylation	KVLSPGVSHRLRDQE CCCCCCCCCCCCHHH	14.59	23927012
136	Phosphorylation	QYHRLDVSLPFVSRG HHHCCCCCCCEEECC	29.96	20068231
141	Phosphorylation	DVSLPFVSRGPLTVE CCCCCEEECCCCCCC	31.72	20068231
146	Phosphorylation	FVSRGPLTVEETPRV EEECCCCCCCCCCCC	29.07	20068231
150	Phosphorylation	GPLTVEETPRVQGET CCCCCCCCCCCCCCC	11.68	29255136
157	Phosphorylation	TPRVQGETQPQRLLL CCCCCCCCCCCEEEE	52.99	22817900
168	Phosphorylation	RLLLAEDSEEEVDFL EEEECCCCHHHHHHH	38.11	19664994
176	Phosphorylation	EEEVDFLSERRMVKK HHHHHHHHHHCCCCC	29.11	23927012
189	Phosphorylation	KKSRTTSSSVIVPES CCCCCCCCCEECCCC	26.91	28464451
190	Phosphorylation	KSRTTSSSVIVPESD CCCCCCCCEECCCCC	18.68	28464451
196	Phosphorylation	SSVIVPESDEEGHSP CCEECCCCCCCCCCC	44.23	25137130
202	Phosphorylation	ESDEEGHSPVLGGLG CCCCCCCCCCCCCCC	27.79	25137130
218	Phosphorylation	PFAFNLNSDTDVEEG CCCCCCCCCCCCCCC	45.08	18678890
220	Phosphorylation	AFNLNSDTDVEEGQQ CCCCCCCCCCCCCCC	41.59	18678890
276	Methylation	DNDTKVKRGAGNGVV CCCCCCCCCCCCCCC	43.09	115483053
292	Phosphorylation	AGVILERSQPPGEDS CEEEEECCCCCCCCC	37.35	29255136
299	Phosphorylation	SQPPGEDSDTDVDDD CCCCCCCCCCCCCCC	37.80	29255136
301	Phosphorylation	PPGEDSDTDVDDDSR CCCCCCCCCCCCCCC	41.70	29255136
307	Phosphorylation	DTDVDDDSRPPGRPA CCCCCCCCCCCCCCC	54.39	28176443
329	Phosphorylation	QPFGFIDSDTDAEEE CCCCCCCCCCCHHHH	37.28	29255136
331	Phosphorylation	FGFIDSDTDAEEERI CCCCCCCCCHHHHCC	40.85	29255136
341	Phosphorylation	EEERIPATPVVIPMK HHHCCCCCCEEEECC	15.97	28176443
358	Phosphorylation	KIFHGVGTRGPGAPG CCCCCCCCCCCCCCC	30.01	21406692
372	Phosphorylation	GLAHLQESQAGSDTD CHHHHHHHHCCCCCC	16.63	29255136
376	Phosphorylation	LQESQAGSDTDVEEG HHHHHCCCCCCCCCC	40.11	29255136
378	Phosphorylation	ESQAGSDTDVEEGKA HHHCCCCCCCCCCCC	43.58	29255136
394	Phosphorylation	QAVPLEKSQASMVIN CCCCCCHHHCCEEEC	22.92	30278072
397	Phosphorylation	PLEKSQASMVINSDT CCCHHHCCEEECCCC	13.12	30278072
402	Phosphorylation	QASMVINSDTDDEEE HCCEEECCCCCCHHH	30.66	25159151
404	Phosphorylation	SMVINSDTDDEEEVS CEEECCCCCCHHHHH	45.21	25159151
411	Phosphorylation	TDDEEEVSAALTLAH CCCHHHHHHHHHHHH	15.88	30278072
415	Phosphorylation	EEVSAALTLAHLKES HHHHHHHHHHHHHHH	19.71	30278072
422	Phosphorylation	TLAHLKESQPAIWNR HHHHHHHHCCCCCCC	39.62	17525332
429	Methylation	SQPAIWNRDAEEDMP HCCCCCCCCCCCCCC	29.53	115483045
445	Phosphorylation	RVVLLQRSQTTTERD EEEEEECCCCCCCCC	20.93	22167270
447	Phosphorylation	VLLQRSQTTTERDSD EEEECCCCCCCCCCC	36.61	22167270
448	Phosphorylation	LLQRSQTTTERDSDT EEECCCCCCCCCCCC	21.01	22167270
449	Phosphorylation	LQRSQTTTERDSDTD EECCCCCCCCCCCCC	32.20	22167270
453	Phosphorylation	QTTTERDSDTDVEEE CCCCCCCCCCCCCHH	48.94	29255136
455	Phosphorylation	TTERDSDTDVEEEEL CCCCCCCCCCCHHCC	45.99	29255136
472	Ubiquitination	ENREAVLKDHTKIRA CCHHHHHCHHHHHHH	40.65	-
476	Ubiquitination	AVLKDHTKIRALVRA HHHCHHHHHHHHHHH	27.12	-
485	Phosphorylation	RALVRAHSEKDQPPF HHHHHHHCCCCCCCC	45.41	23927012
487	Acetylation	LVRAHSEKDQPPFGD HHHHHCCCCCCCCCC	65.75	23236377
495	Phosphorylation	DQPPFGDSDDSVEAD CCCCCCCCCCCCCCC	43.63	29255136
498	Phosphorylation	PFGDSDDSVEADKSS CCCCCCCCCCCCCCC	27.18	29255136
504	Phosphorylation	DSVEADKSSPGIHLE CCCCCCCCCCCCEEE	42.17	29255136
505	Phosphorylation	SVEADKSSPGIHLER CCCCCCCCCCCEEEE	32.65	29255136
513	Phosphorylation	PGIHLERSQASTTVD CCCEEEECCCEEEEE	22.26	17525332
516	Phosphorylation	HLERSQASTTVDINT EEEECCCEEEEECCC	19.58	17525332
517	Phosphorylation	LERSQASTTVDINTQ EEECCCEEEEECCCC	33.58	30266825
518	Phosphorylation	ERSQASTTVDINTQV EECCCEEEEECCCCE	17.43	30266825
523	Phosphorylation	STTVDINTQVEKEVP EEEEECCCCEEEECC	34.03	17525332
533	Phosphorylation	EKEVPPGSAIIHIKK EEECCCCCEEEEEEE	23.28	28555341
540	Ubiquitination	SAIIHIKKHQVSVEG CEEEEEEEEEEEEEC	38.37	-
544	Phosphorylation	HIKKHQVSVEGTNQT EEEEEEEEEECCCHH	14.10	25159151
548	Phosphorylation	HQVSVEGTNQTDVKA EEEEEECCCHHHCEE	15.62	28857561
551	Phosphorylation	SVEGTNQTDVKAVGG EEECCCHHHCEECCC	44.84	28387310
579	Phosphorylation	PLHGDCETDAEEGTS CCCCCCCCCCCCCCC	47.01	26074081
590	Phosphorylation	EGTSLTASVVADVRK CCCCEEEEEEEEHHH	16.34	-
598	Phosphorylation	VVADVRKSQLPAEGD EEEEHHHHHCCCCCC	26.78	25850435
616	Acetylation	EWAAAVLKQERAHEV HHHHHHHHHHHHHHH	43.44	26051181
616	Sumoylation	EWAAAVLKQERAHEV HHHHHHHHHHHHHHH	43.44	25114211
616	Ubiquitination	EWAAAVLKQERAHEV HHHHHHHHHHHHHHH	43.44	-
641	Phosphorylation	VEQDLPISRENLTDL EEECCCCCHHHCCEE	31.44	25849741
646	Phosphorylation	PISRENLTDLVVDTD CCCHHHCCEEEEECC	38.58	30108239
652	Phosphorylation	LTDLVVDTDTLGEST CCEEEEECCCCCCCC	21.19	17525332
654	Phosphorylation	DLVVDTDTLGESTQP EEEEECCCCCCCCCC	38.46	30175587
658	Phosphorylation	DTDTLGESTQPQREG ECCCCCCCCCCCCCC	30.46	30108239
659	Phosphorylation	TDTLGESTQPQREGA CCCCCCCCCCCCCCC	39.71	17525332
719	Phosphorylation	QSMEDEPTQAFMLTP HCCCCCCCCEEEECC	30.40	26074081
725	Phosphorylation	PTQAFMLTPPQELGP CCCEEEECCCHHHCC	22.57	26074081
733	Phosphorylation	PPQELGPSHCSFQTT CCHHHCCCCCCCCCC	35.01	26074081
736	Phosphorylation	ELGPSHCSFQTTGTL HHCCCCCCCCCCCCC	18.24	26074081
739	Phosphorylation	PSHCSFQTTGTLDEP CCCCCCCCCCCCCCC	25.78	26074081
740	Phosphorylation	SHCSFQTTGTLDEPW CCCCCCCCCCCCCCC	19.86	26074081
742	Phosphorylation	CSFQTTGTLDEPWEV CCCCCCCCCCCCCEE	29.01	26074081
752	Phosphorylation	EPWEVLATQPFCLRE CCCEEEECCCEEECC	32.39	26074081
760	Phosphorylation	QPFCLRESEDSETQP CCEEECCCCCCCCCC	40.03	30266825
763	Phosphorylation	CLRESEDSETQPFDT EECCCCCCCCCCCCC	38.19	17525332
765	Phosphorylation	RESEDSETQPFDTHL CCCCCCCCCCCCCCH	45.56	17525332
770	Phosphorylation	SETQPFDTHLEAYGP CCCCCCCCCHHHHCC	28.83	30266825
775	Phosphorylation	FDTHLEAYGPCLSPP CCCCHHHHCCCCCCC	16.54	30266825
780	Phosphorylation	EAYGPCLSPPRAIPG HHHCCCCCCCCCCCC	39.31	29255136
793	Phosphorylation	PGDQHPESPVHTEPM CCCCCCCCCCCCCCC	36.35	29255136
797	Phosphorylation	HPESPVHTEPMGIQG CCCCCCCCCCCCCCC	41.86	30266825
809	Phosphorylation	IQGRGRQTVDKVMGI CCCCCCCHHHHHCCC	29.34	26074081
812	Acetylation	RGRQTVDKVMGIPKE CCCCHHHHHCCCCHH	29.77	19608861
837	Acetylation	PLERETEKLLPERQT CCHHHHHHHCCCCCC	63.84	26051181
844	Phosphorylation	KLLPERQTDVTGEEE HHCCCCCCCCCCHHH	38.36	21406692
847	Phosphorylation	PERQTDVTGEEELTK CCCCCCCCCHHHHHC	41.51	20068231
853	Phosphorylation	VTGEEELTKGKQDRE CCCHHHHHCCCCHHH	40.82	21406692
854	Acetylation	TGEEELTKGKQDREQ CCHHHHHCCCCHHHH	76.39	26051181
874	Phosphorylation	RDTQRQESDKNGESA HHHHHHHHHCCCCCC	45.61	28122231
880	Phosphorylation	ESDKNGESASPERDR HHHCCCCCCCHHHHH	35.13	21955146
882	Phosphorylation	DKNGESASPERDRES HCCCCCCCHHHHHHH	36.25	29255136
889	Phosphorylation	SPERDRESLKVEIET CHHHHHHHHEEEEEC	34.09	29514088
896	Phosphorylation	SLKVEIETSEEIQEK HHEEEEECHHHHHHH	47.28	25404012
907	Acetylation	IQEKQVQKQTLPSKA HHHHHHHHCCCCHHH	46.52	25953088
912	Phosphorylation	VQKQTLPSKAFEREV HHHCCCCHHHHHHHC	39.46	24719451
936	Acetylation	DPAELEEKVPKVILE CHHHHHHHCCEEEEE	55.23	26051181
946	Phosphorylation	KVILERDTQRGEPEG EEEEECCCCCCCCCC	26.79	23312004
955	Phosphorylation	RGEPEGGSQDQKGQA CCCCCCCCCCCCCCC	41.25	17525332
963	Phosphorylation	QDQKGQASSPTPEPG CCCCCCCCCCCCCCC	29.03	30278072
964	Phosphorylation	DQKGQASSPTPEPGV CCCCCCCCCCCCCCC	35.49	17525332
966	Phosphorylation	KGQASSPTPEPGVGA CCCCCCCCCCCCCCC	42.08	30278072
980	Phosphorylation	AGDLPGPTSAPVPSG CCCCCCCCCCCCCCC	43.36	30278072
981	Phosphorylation	GDLPGPTSAPVPSGS CCCCCCCCCCCCCCC	33.44	30278072
986	Phosphorylation	PTSAPVPSGSQSGGR CCCCCCCCCCCCCCC	51.84	23401153
988	Phosphorylation	SAPVPSGSQSGGRGS CCCCCCCCCCCCCCC	26.05	23401153
990	Phosphorylation	PVPSGSQSGGRGSPV CCCCCCCCCCCCCCC	44.93	30278072
995	Phosphorylation	SQSGGRGSPVSPRRH CCCCCCCCCCCCCCC	22.29	30266825
998	Phosphorylation	GGRGSPVSPRRHQKG CCCCCCCCCCCCCCC	24.34	30266825
1016	Acetylation	CKMPPAEKASRIRAA CCCCHHHHHHHHHHH	54.49	23749302
1025	Acetylation	SRIRAAEKVSRGDQE HHHHHHHHHCCCCCC	40.56	25953088
1027	Phosphorylation	IRAAEKVSRGDQESP HHHHHHHCCCCCCCC	41.43	30576142
1033	Phosphorylation	VSRGDQESPDACLPP HCCCCCCCCCCCCCC	23.58	25159151
1041	Phosphorylation	PDACLPPTVPEAPAP CCCCCCCCCCCCCCC	46.91	18669648
1051	Acetylation	EAPAPPQKPLNSQSQ CCCCCCCCCCCCCCC	58.19	26051181
1052 (in isoform 4)	Ubiquitination	-	31.37	21890473
1055	Phosphorylation	PPQKPLNSQSQKHLA CCCCCCCCCCCCCCC	38.60	23312004
1057	Phosphorylation	QKPLNSQSQKHLAPP CCCCCCCCCCCCCCC	40.80	25159151
1068	Phosphorylation	LAPPPLLSPLLPSIK CCCCCCHHCCCCCCC	22.61	29255136
1073	Phosphorylation	LLSPLLPSIKPTVRK CHHCCCCCCCCCCCC	43.12	24732914
1075	"N6,N6-dimethyllysine"	SPLLPSIKPTVRKTR HCCCCCCCCCCCCCC	38.69	-
1075	Acetylation	SPLLPSIKPTVRKTR HCCCCCCCCCCCCCC	38.69	25953088
1075	Methylation	SPLLPSIKPTVRKTR HCCCCCCCCCCCCCC	38.69	-
1077	Phosphorylation	LLPSIKPTVRKTRQD CCCCCCCCCCCCCCC	28.13	24732914
1081	Phosphorylation	IKPTVRKTRQDGSQE CCCCCCCCCCCCCCC	24.01	23898821
1086	Phosphorylation	RKTRQDGSQEAPEAP CCCCCCCCCCCCCCC	32.89	17525332
1095	Phosphorylation	EAPEAPLSSELEPFH CCCCCCCCCCCCCCC	22.25	17525332
1096	Phosphorylation	APEAPLSSELEPFHP CCCCCCCCCCCCCCC	54.61	20068231
1104	"N6,N6-dimethyllysine"	ELEPFHPKPKIRTRK CCCCCCCCCCCCCCC	50.83	-
1104	Acetylation	ELEPFHPKPKIRTRK CCCCCCCCCCCCCCC	50.83	26051181
1104	Methylation	ELEPFHPKPKIRTRK CCCCCCCCCCCCCCC	50.83	-
1116	Phosphorylation	TRKSSRMTPFPATSA CCCCCCCCCCCCCCC	22.22	26074081
1121	Phosphorylation	RMTPFPATSAAPEPH CCCCCCCCCCCCCCC	21.09	26074081
1122	Phosphorylation	MTPFPATSAAPEPHP CCCCCCCCCCCCCCC	25.25	30576142
1130	Phosphorylation	AAPEPHPSTSTAQPV CCCCCCCCCCCCCCC	31.77	25159151
1131	Phosphorylation	APEPHPSTSTAQPVT CCCCCCCCCCCCCCC	34.25	30576142
1132	Phosphorylation	PEPHPSTSTAQPVTP CCCCCCCCCCCCCCC	26.53	29978859
1133	Phosphorylation	EPHPSTSTAQPVTPK CCCCCCCCCCCCCCC	29.42	29978859
1138	Phosphorylation	TSTAQPVTPKPTSQA CCCCCCCCCCCCCHH	32.07	25159151
1140	"N6,N6-dimethyllysine"	TAQPVTPKPTSQATR CCCCCCCCCCCHHCC	52.11	-
1140	Methylation	TAQPVTPKPTSQATR CCCCCCCCCCCHHCC	52.11	-
1142	Phosphorylation	QPVTPKPTSQATRSR CCCCCCCCCHHCCCC	39.33	29978859
1143	Phosphorylation	PVTPKPTSQATRSRT CCCCCCCCHHCCCCC	26.75	29978859
1146	Phosphorylation	PKPTSQATRSRTNRS CCCCCHHCCCCCCCC	22.88	29978859
1150	Phosphorylation	SQATRSRTNRSSVKT CHHCCCCCCCCCCCC	35.91	30576142
1153	Phosphorylation	TRSRTNRSSVKTPEP CCCCCCCCCCCCCCC	41.37	23401153
1154	Phosphorylation	RSRTNRSSVKTPEPV CCCCCCCCCCCCCCC	25.13	30278072
1157	Phosphorylation	TNRSSVKTPEPVVPT CCCCCCCCCCCCCCC	30.63	23401153
1164	Phosphorylation	TPEPVVPTAPELQPS CCCCCCCCCCCCCCC	43.14	30278072
1171	Phosphorylation	TAPELQPSTSTDQPV CCCCCCCCCCCCCCC	23.25	23927012
1172	Phosphorylation	APELQPSTSTDQPVT CCCCCCCCCCCCCCC	42.18	23403867
1173	Phosphorylation	PELQPSTSTDQPVTS CCCCCCCCCCCCCCC	34.03	23403867
1174	Phosphorylation	ELQPSTSTDQPVTSE CCCCCCCCCCCCCCC	38.45	23403867
1179	Phosphorylation	TSTDQPVTSEPTSQV CCCCCCCCCCCCCCC	33.77	23403867
1180	Phosphorylation	STDQPVTSEPTSQVT CCCCCCCCCCCCCCC	41.64	23403867
1183	Phosphorylation	QPVTSEPTSQVTRGR CCCCCCCCCCCCCCC	27.95	23403867
1184	Phosphorylation	PVTSEPTSQVTRGRK CCCCCCCCCCCCCCC	33.11	23403867
1187	Phosphorylation	SEPTSQVTRGRKSRS CCCCCCCCCCCCCCC	21.55	23403867
1192	Phosphorylation	QVTRGRKSRSSVKTP CCCCCCCCCCCCCCC	35.71	30576142
1194	Phosphorylation	TRGRKSRSSVKTPET CCCCCCCCCCCCCCC	46.72	23401153
1195	Phosphorylation	RGRKSRSSVKTPETV CCCCCCCCCCCCCCC	26.90	25159151
1198	Phosphorylation	KSRSSVKTPETVVPT CCCCCCCCCCCCCCC	24.97	29255136
1201	Phosphorylation	SSVKTPETVVPTALE CCCCCCCCCCCCEEE	28.18	29255136
1205	Phosphorylation	TPETVVPTALELQPS CCCCCCCCEEECCCC	32.06	29255136
1212	Phosphorylation	TALELQPSTSTDRPV CEEECCCCCCCCCCC	23.25	28122231
1213	Phosphorylation	ALELQPSTSTDRPVT EEECCCCCCCCCCCC	42.18	24732914
1214	Phosphorylation	LELQPSTSTDRPVTS EECCCCCCCCCCCCC	32.42	24732914
1215	Phosphorylation	ELQPSTSTDRPVTSE ECCCCCCCCCCCCCC	35.80	24732914
1220	Phosphorylation	TSTDRPVTSEPTSQA CCCCCCCCCCCCCHH	30.01	24732914
1221	Phosphorylation	STDRPVTSEPTSQAT CCCCCCCCCCCCHHC	41.64	24732914
1224	Phosphorylation	RPVTSEPTSQATRGR CCCCCCCCCHHCCCC	29.44	24732914
1225	Phosphorylation	PVTSEPTSQATRGRK CCCCCCCCHHCCCCC	28.65	24732914
1228	Phosphorylation	SEPTSQATRGRKNRS CCCCCHHCCCCCCCC	26.48	24732914
1235	Phosphorylation	TRGRKNRSSVKTPEP CCCCCCCCCCCCCCC	49.21	23401153
1236	Phosphorylation	RGRKNRSSVKTPEPV CCCCCCCCCCCCCCC	25.13	23927012
1239	Phosphorylation	KNRSSVKTPEPVVPT CCCCCCCCCCCCCCC	30.63	23401153
1246	Phosphorylation	TPEPVVPTAPELQPS CCCCCCCCCCCCCCC	43.14	23927012
1253	Phosphorylation	TAPELQPSTSTDQPV CCCCCCCCCCCCCCC	23.25	23927012
1254	Phosphorylation	APELQPSTSTDQPVT CCCCCCCCCCCCCCC	42.18	23403867
1255	Phosphorylation	PELQPSTSTDQPVTS CCCCCCCCCCCCCCC	34.03	23403867
1256	Phosphorylation	ELQPSTSTDQPVTSE CCCCCCCCCCCCCCC	38.45	23403867
1261	Phosphorylation	TSTDQPVTSEPTYQA CCCCCCCCCCCCCCC	33.77	23403867
1262	Phosphorylation	STDQPVTSEPTYQAT CCCCCCCCCCCCCCC	41.64	23403867
1265	Phosphorylation	QPVTSEPTYQATRGR CCCCCCCCCCCCCCC	24.98	23403867
1266	Phosphorylation	PVTSEPTYQATRGRK CCCCCCCCCCCCCCC	13.58	23403867
1269	Phosphorylation	SEPTYQATRGRKNRS CCCCCCCCCCCCCCC	20.38	23403867
1276	Phosphorylation	TRGRKNRSSVKTPEP CCCCCCCCCCCCCCC	49.21	24732914
1277	Phosphorylation	RGRKNRSSVKTPEPV CCCCCCCCCCCCCCC	25.13	26657352
1280	Phosphorylation	KNRSSVKTPEPVVPT CCCCCCCCCCCCCCC	30.63	25159151
1287	Phosphorylation	TPEPVVPTAPELRPS CCCCCCCCCCCCCCC	43.14	21712546
1294	Phosphorylation	TAPELRPSTSTDRPV CCCCCCCCCCCCCCC	28.67	21712546
1295	Phosphorylation	APELRPSTSTDRPVT CCCCCCCCCCCCCCC	38.03	21712546
1296	Phosphorylation	PELRPSTSTDRPVTP CCCCCCCCCCCCCCC	32.42	21712546
1297	Phosphorylation	ELRPSTSTDRPVTPK CCCCCCCCCCCCCCC	35.80	21712546
1302	Phosphorylation	TSTDRPVTPKPTSRT CCCCCCCCCCCCCCC	28.42	25159151
1306	Phosphorylation	RPVTPKPTSRTTRSR CCCCCCCCCCCCCCC	36.65	21082442
1307	Phosphorylation	PVTPKPTSRTTRSRT CCCCCCCCCCCCCCC	35.84	27794612
1310	Phosphorylation	PKPTSRTTRSRTNMS CCCCCCCCCCCCCCC	26.07	-
1314	Phosphorylation	SRTTRSRTNMSSVKT CCCCCCCCCCCCCCC	36.20	29978859
1317	Phosphorylation	TRSRTNMSSVKTPET CCCCCCCCCCCCCCC	33.77	29978859
1318	Phosphorylation	RSRTNMSSVKTPETV CCCCCCCCCCCCCCC	19.50	29978859
1321	Phosphorylation	TNMSSVKTPETVVPT CCCCCCCCCCCCCCC	24.97	25159151
1324	Phosphorylation	SSVKTPETVVPTAPE CCCCCCCCCCCCCCC	28.18	25159151
1328	Phosphorylation	TPETVVPTAPELQIS CCCCCCCCCCCCEEE	43.14	28464451
1335	Phosphorylation	TAPELQISTSTDQPV CCCCCEEECCCCCCC	11.89	30266825
1336	Phosphorylation	APELQISTSTDQPVT CCCCEEECCCCCCCC	36.96	30266825
1337	Phosphorylation	PELQISTSTDQPVTP CCCEEECCCCCCCCC	24.16	30266825
1338	Phosphorylation	ELQISTSTDQPVTPK CCEEECCCCCCCCCC	38.45	30266825
1343	Phosphorylation	TSTDQPVTPKPTSRT CCCCCCCCCCCCCCC	32.07	30266825
1345	"N6,N6-dimethyllysine"	TDQPVTPKPTSRTTR CCCCCCCCCCCCCCC	52.11	-
1345	Methylation	TDQPVTPKPTSRTTR CCCCCCCCCCCCCCC	52.11	-
1347	Phosphorylation	QPVTPKPTSRTTRSR CCCCCCCCCCCCCCC	36.65	30266825
1348	Phosphorylation	PVTPKPTSRTTRSRT CCCCCCCCCCCCCCC	35.84	30266825
1351	Phosphorylation	PKPTSRTTRSRTNMS CCCCCCCCCCCCCCH	26.07	-
1366	Phosphorylation	SVKNPESTVPIAPEL HCCCCCCCCCCCCCC	28.74	18669648
1376	Phosphorylation	IAPELPPSTSTEQPV CCCCCCCCCCCCCCC	32.81	25850435
1377	Phosphorylation	APELPPSTSTEQPVT CCCCCCCCCCCCCCC	45.50	25850435
1378	Phosphorylation	PELPPSTSTEQPVTP CCCCCCCCCCCCCCC	33.99	22199227
1379	Phosphorylation	ELPPSTSTEQPVTPE CCCCCCCCCCCCCCC	38.43	22199227
1384	Phosphorylation	TSTEQPVTPEPTSRA CCCCCCCCCCCCCCC	28.72	25159151
1388	Phosphorylation	QPVTPEPTSRATRGR CCCCCCCCCCCCCCC	29.23	25850435
1389	Phosphorylation	PVTPEPTSRATRGRK CCCCCCCCCCCCCCC	30.54	22199227
1399	Phosphorylation	TRGRKNRSSGKTPET CCCCCCCCCCCCCCC	53.49	30266825
1400	Phosphorylation	RGRKNRSSGKTPETL CCCCCCCCCCCCCCC	40.86	30266825
1402	Acetylation	RKNRSSGKTPETLVP CCCCCCCCCCCCCCC	63.96	19608861
1403	Phosphorylation	KNRSSGKTPETLVPT CCCCCCCCCCCCCCC	29.86	25159151
1406	Phosphorylation	SSGKTPETLVPTAPK CCCCCCCCCCCCCCC	33.97	30266825
1410	Phosphorylation	TPETLVPTAPKLEPS CCCCCCCCCCCCCCC	48.38	21712546
1413	Acetylation	TLVPTAPKLEPSTST CCCCCCCCCCCCCCC	64.12	26051181
1413	Sumoylation	TLVPTAPKLEPSTST CCCCCCCCCCCCCCC	64.12	25114211
1417	Phosphorylation	TAPKLEPSTSTDQPV CCCCCCCCCCCCCCC	26.14	25159151
1418	Phosphorylation	APKLEPSTSTDQPVT CCCCCCCCCCCCCCC	46.49	29255136
1419	Phosphorylation	PKLEPSTSTDQPVTP CCCCCCCCCCCCCCC	34.03	30266825
1420	Phosphorylation	KLEPSTSTDQPVTPE CCCCCCCCCCCCCCC	38.45	30266825
1425	Phosphorylation	TSTDQPVTPEPTSQA CCCCCCCCCCCCCCC	28.72	29255136
1429	Phosphorylation	QPVTPEPTSQATRGR CCCCCCCCCCCCCCC	31.63	30175587
1430	Phosphorylation	PVTPEPTSQATRGRT CCCCCCCCCCCCCCC	28.65	17525332
1433	Phosphorylation	PEPTSQATRGRTNRS CCCCCCCCCCCCCCC	26.48	24732914
1437	Phosphorylation	SQATRGRTNRSSVKT CCCCCCCCCCCCCCC	37.50	18669648
1440	Phosphorylation	TRGRTNRSSVKTPET CCCCCCCCCCCCCCC	41.37	23401153
1441	Phosphorylation	RGRTNRSSVKTPETV CCCCCCCCCCCCCCC	25.13	30278072
1444	Phosphorylation	TNRSSVKTPETVVPT CCCCCCCCCCCCCCC	24.97	27273156
1447	Phosphorylation	SSVKTPETVVPTAPE CCCCCCCCCCCCCCC	28.18	25159151
1451	Phosphorylation	TPETVVPTAPELQPS CCCCCCCCCCCCCCC	43.14	30175587
1458	Phosphorylation	TAPELQPSTSTDQPV CCCCCCCCCCCCCCC	23.25	30278072
1459	Phosphorylation	APELQPSTSTDQPVT CCCCCCCCCCCCCCC	42.18	22115753
1460	Phosphorylation	PELQPSTSTDQPVTP CCCCCCCCCCCCCCC	34.03	30175587
1461	Phosphorylation	ELQPSTSTDQPVTPE CCCCCCCCCCCCCCC	38.45	22115753
1466	Phosphorylation	TSTDQPVTPEPTSQA CCCCCCCCCCCCCCC	28.72	27273156
1470	Phosphorylation	QPVTPEPTSQATRGR CCCCCCCCCCCCCCC	31.63	22115753
1471	Phosphorylation	PVTPEPTSQATRGRT CCCCCCCCCCCCCCC	28.65	17525332
1474	Phosphorylation	PEPTSQATRGRTDRS CCCCCCCCCCCCCHH	26.48	21955146
1478	Phosphorylation	SQATRGRTDRSSVKT CCCCCCCCCHHCCCC	38.29	30576142
1481	Phosphorylation	TRGRTDRSSVKTPET CCCCCCHHCCCCCCC	42.15	23401153
1482	Phosphorylation	RGRTDRSSVKTPETV CCCCCHHCCCCCCCC	28.64	30278072
1485	Phosphorylation	TDRSSVKTPETVVPT CCHHCCCCCCCCCCC	24.97	30278072
1488	Phosphorylation	SSVKTPETVVPTAPE HCCCCCCCCCCCCHH	28.18	23401153
1492	Phosphorylation	TPETVVPTAPELQAS CCCCCCCCCHHHHHC	43.14	23927012
1499	Phosphorylation	TAPELQASASTDQPV CCHHHHHCCCCCCCC	15.14	24732914
1501	Phosphorylation	PELQASASTDQPVTS HHHHHCCCCCCCCCC	29.98	24732914
1502	Phosphorylation	ELQASASTDQPVTSE HHHHCCCCCCCCCCC	38.07	24732914
1507	Phosphorylation	ASTDQPVTSEPTSRT CCCCCCCCCCCCCCC	33.77	24732914
1508	Phosphorylation	STDQPVTSEPTSRTT CCCCCCCCCCCCCCC	41.64	24732914
1511	Phosphorylation	QPVTSEPTSRTTRGR CCCCCCCCCCCCCCC	27.13	24732914
1512	Phosphorylation	PVTSEPTSRTTRGRK CCCCCCCCCCCCCCC	38.04	24732914
1522	Phosphorylation	TRGRKNRSSVKTPET CCCCCCCCCCCCCCC	49.21	23401153
1523	Phosphorylation	RGRKNRSSVKTPETV CCCCCCCCCCCCCCC	25.13	23927012
1526	Phosphorylation	KNRSSVKTPETVVPA CCCCCCCCCCCCCCC	24.97	23927012
1529	Phosphorylation	SSVKTPETVVPAAPE CCCCCCCCCCCCCCC	28.18	23927012
1540	Phosphorylation	AAPELQPSTSTDQPV CCCCCCCCCCCCCCC	23.25	29255136
1541	Phosphorylation	APELQPSTSTDQPVT CCCCCCCCCCCCCCC	42.18	29255136
1542	Phosphorylation	PELQPSTSTDQPVTP CCCCCCCCCCCCCCC	34.03	29255136
1543	Phosphorylation	ELQPSTSTDQPVTPE CCCCCCCCCCCCCCC	38.45	29255136
1548	Phosphorylation	TSTDQPVTPEPTSRA CCCCCCCCCCCCCCC	28.72	29255136
1552	Phosphorylation	QPVTPEPTSRATRGR CCCCCCCCCCCCCCC	29.23	29255136
1553	Phosphorylation	PVTPEPTSRATRGRT CCCCCCCCCCCCCCC	30.54	29255136
1560	Phosphorylation	SRATRGRTNRSSVKT CCCCCCCCCCCCCCC	37.50	26434776
1563	Phosphorylation	TRGRTNRSSVKTPES CCCCCCCCCCCCCHH	41.37	23401153
1564	Phosphorylation	RGRTNRSSVKTPESI CCCCCCCCCCCCHHH	25.13	30266825
1567	Phosphorylation	TNRSSVKTPESIVPI CCCCCCCCCHHHCCC	30.08	23927012
1570	Phosphorylation	SSVKTPESIVPIAPE CCCCCCHHHCCCCCC	30.04	30266825
1581	Phosphorylation	IAPELQPSTSRNQLV CCCCCCCCCCCCCCC	26.50	23927012
1582	Phosphorylation	APELQPSTSRNQLVT CCCCCCCCCCCCCCC	38.09	23927012
1583	Phosphorylation	PELQPSTSRNQLVTP CCCCCCCCCCCCCCC	33.30	24732914
1589	Phosphorylation	TSRNQLVTPEPTSRA CCCCCCCCCCCCCCC	30.44	30266825
1593	Phosphorylation	QLVTPEPTSRATRCR CCCCCCCCCCCCCCC	29.23	30266825
1594	Phosphorylation	LVTPEPTSRATRCRT CCCCCCCCCCCCCCC	30.54	30266825
1597	Phosphorylation	PEPTSRATRCRTNRS CCCCCCCCCCCCCCC	29.23	30631047
1601	Phosphorylation	SRATRCRTNRSSVKT CCCCCCCCCCCCCCC	38.31	28450419
1604	Phosphorylation	TRCRTNRSSVKTPEP CCCCCCCCCCCCCCC	41.37	23401153
1605	Phosphorylation	RCRTNRSSVKTPEPV CCCCCCCCCCCCCCC	25.13	23927012
1608	Phosphorylation	TNRSSVKTPEPVVPT CCCCCCCCCCCCCCC	30.63	29255136
1615	Phosphorylation	TPEPVVPTAPEPHPT CCCCCCCCCCCCCCC	43.14	23927012
1622	Phosphorylation	TAPEPHPTTSTDQPV CCCCCCCCCCCCCCC	30.28	29255136
1623	Phosphorylation	APEPHPTTSTDQPVT CCCCCCCCCCCCCCC	33.80	29255136
1624	Phosphorylation	PEPHPTTSTDQPVTP CCCCCCCCCCCCCCH	32.25	29255136
1625	Phosphorylation	EPHPTTSTDQPVTPK CCCCCCCCCCCCCHH	36.24	29255136
1630	Phosphorylation	TSTDQPVTPKLTSRA CCCCCCCCHHHCCHH	22.76	29255136
1648	Acetylation	KTNRSSVKTPKPVEP CCCCCCCCCCCCCCC	62.14	12654515
1649	Phosphorylation	TNRSSVKTPKPVEPA CCCCCCCCCCCCCCC	34.10	25159151
1658	Phosphorylation	KPVEPAASDLEPFTP CCCCCCHHCCCCCCC	44.85	25159151
1664	Phosphorylation	ASDLEPFTPTDQSVT HHCCCCCCCCCCCCC	35.67	27273156
1666	Phosphorylation	DLEPFTPTDQSVTPE CCCCCCCCCCCCCHH	43.54	25159151
1669	Phosphorylation	PFTPTDQSVTPEAIA CCCCCCCCCCHHHHH	30.67	25159151
1671	Phosphorylation	TPTDQSVTPEAIAQG CCCCCCCCHHHHHCC	22.21	23401153
1681	Phosphorylation	AIAQGGQSKTLRSST HHHCCCCCCCCCCCC	30.77	25159151
1682	Acetylation	IAQGGQSKTLRSSTV HHCCCCCCCCCCCCE	43.63	26051181
1686	Phosphorylation	GQSKTLRSSTVRAMP CCCCCCCCCCEEEEC	33.21	25159151
1687	Phosphorylation	QSKTLRSSTVRAMPV CCCCCCCCCEEEECC	25.20	25159151
1688	Phosphorylation	SKTLRSSTVRAMPVP CCCCCCCCEEEECCC	18.43	26699800
1696	Phosphorylation	VRAMPVPTTPEFQSP EEEECCCCCCCCCCC	56.04	25159151
1697	Phosphorylation	RAMPVPTTPEFQSPV EEECCCCCCCCCCCC	18.10	25159151
1702	Phosphorylation	PTTPEFQSPVTTDQP CCCCCCCCCCCCCCC	27.02	25159151
1705	Phosphorylation	PEFQSPVTTDQPISP CCCCCCCCCCCCCCC	28.21	21712546
1706	Phosphorylation	EFQSPVTTDQPISPE CCCCCCCCCCCCCCC	32.63	21712546
1711	Phosphorylation	VTTDQPISPEPITQP CCCCCCCCCCCCCCH	29.87	25159151
1716	Phosphorylation	PISPEPITQPSCIKR CCCCCCCCCHHHHHH	45.18	22199227
1719	Phosphorylation	PEPITQPSCIKRQRA CCCCCCHHHHHHHHH	20.75	22199227
1732	Phosphorylation	RAAGNPGSLAAPIDH HHCCCCCCCCCCCCC	18.98	28555341
1740	"N6,N6-dimethyllysine"	LAAPIDHKPCSAPLE CCCCCCCCCCCCCCC	43.93	-
1740	Acetylation	LAAPIDHKPCSAPLE CCCCCCCCCCCCCCC	43.93	23954790
1740	Methylation	LAAPIDHKPCSAPLE CCCCCCCCCCCCCCC	43.93	-
1740	Sumoylation	LAAPIDHKPCSAPLE CCCCCCCCCCCCCCC	43.93	28112733
1743	Phosphorylation	PIDHKPCSAPLEPKS CCCCCCCCCCCCCCC	41.26	23312004
1766	Phosphorylation	GAVRAAESLTAIPEP HHHHHHHHHCCCCCC	26.71	28176443
1768	Phosphorylation	VRAAESLTAIPEPAS HHHHHHHCCCCCCCC	31.64	28176443
1775	Phosphorylation	TAIPEPASPQLLETP CCCCCCCCCCHHCCC	24.72	29255136
1781	Phosphorylation	ASPQLLETPIHASQI CCCCHHCCCCCHHHC	27.75	30266825
1786	Phosphorylation	LETPIHASQIQKVEP HCCCCCHHHCEEECC	17.41	28176443
1788 (in isoform 3)	Ubiquitination	-	3.86	21890473
1790	Sumoylation	IHASQIQKVEPAGRS CCHHHCEEECCCCCC	50.63	28112733
1797	Phosphorylation	KVEPAGRSRFTPELQ EECCCCCCCCCHHHC	30.72	30266825
1800	Phosphorylation	PAGRSRFTPELQPKA CCCCCCCCHHHCCCC	18.10	25159151
1810	Phosphorylation	LQPKASQSRKRSLAT HCCCCCHHHCCHHHC	36.96	-
1811 (in isoform 2)	Ubiquitination	-	30.67	21890473
1812	Acetylation	PKASQSRKRSLATMD CCCCHHHCCHHHCCC	52.14	20167786
1814	Phosphorylation	ASQSRKRSLATMDSP CCHHHCCHHHCCCCC	25.95	25159151
1817	Phosphorylation	SRKRSLATMDSPPHQ HHCCHHHCCCCCCCC	27.14	28176443
1820	Phosphorylation	RSLATMDSPPHQKQP CHHHCCCCCCCCCCC	29.52	25159151
1825	Acetylation	MDSPPHQKQPQRGEV CCCCCCCCCCCCCCC	61.99	25953088
1833	Phosphorylation	QPQRGEVSQKTVIIK CCCCCCCCCCEEEEE	22.97	26074081
1840	Sumoylation	SQKTVIIKEEEEDTA CCCEEEEECCCCCCC	48.20	-
1840	Sumoylation	SQKTVIIKEEEEDTA CCCEEEEECCCCCCC	48.20	22635276
1840	Ubiquitination	SQKTVIIKEEEEDTA CCCEEEEECCCCCCC	48.20	PubMed
1852	Acetylation	DTAEKPGKEEDVVTP CCCCCCCCCCCCCCC	67.47	20167786
1858	Phosphorylation	GKEEDVVTPKPGKRK CCCCCCCCCCCCCCC	25.99	25159151
1878	Phosphorylation	EEPNRIPSRSLRRTK HCCCCCCCHHHHHCC	31.93	26434776
1880	Phosphorylation	PNRIPSRSLRRTKLN CCCCCCHHHHHCCCC	30.48	26434776
1885	Acetylation	SRSLRRTKLNQESTA CHHHHHCCCCCCCCC	43.56	25953088
1885	Ubiquitination	SRSLRRTKLNQESTA CHHHHHCCCCCCCCC	43.56	-
1904	Methylation	FTGVVDARGERAVLA EEEEECCCCCEEEEE	42.94	115483061
1915	Phosphorylation	AVLALGGSLAGSAAE EEEECCCCHHHHHHH	17.16	18767875
1924	Phosphorylation	AGSAAEASHLVTDRI HHHHHHHHHHHHHHH	14.62	18767875
1936	Acetylation	DRIRRTVKFLCALGR HHHHHHHHHHHHHCC	31.82	26051181
1943	Methylation	KFLCALGRGIPILSL HHHHHHCCCCCEEEH	40.49	24129315
1949	Phosphorylation	GRGIPILSLDWLHQS CCCCCEEEHHHHHHC	25.63	27499020
1956	Phosphorylation	SLDWLHQSRKAGFFL EHHHHHHCCCCCCCC	25.63	20860994
1971	Phosphorylation	PPDEYVVTDPEQEKN CCHHCEECCHHHHHH	35.47	-
1977	Ubiquitination	VTDPEQEKNFGFSLQ ECCHHHHHHCCCCHH	58.22	21857162
2050	Phosphorylation	PQDFPHCSIPLRVGL CCCCCCCCCCEECCC	24.98	24719451
2071	Sumoylation	FLLTGVLKQEAKPEA HHHHCCCCCCCCCCC	43.62	-
2075	Ubiquitination	GVLKQEAKPEAFVLS CCCCCCCCCCCEEEC	42.51	2190698
2075 (in isoform 1)	Ubiquitination	-	42.51	21890473
2087	Phosphorylation	VLSPLEMSST----- EECCCCCCCC-----	22.81	21712546
2088	Phosphorylation	LSPLEMSST------ ECCCCCCCC------	36.50	21712546
2089	Phosphorylation	SPLEMSST------- CCCCCCCC-------	35.01	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	T	Phosphorylation	Kinase	PLK1	P53350	PSP
4	T	Phosphorylation	Kinase	ATM	Q13315	Uniprot
20	S	Phosphorylation	Kinase	PLK1	P53350	PSP
98	T	Phosphorylation	Kinase	ATM	Q13315	PSP
218	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
220	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
299	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
301	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
329	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
331	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
341	T	Phosphorylation	Kinase	CDK2	P24941	PSP
376	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
378	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
402	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
404	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
453	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
455	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
513	S	Phosphorylation	Kinase	ATR	Q13535	PSP
523	T	Phosphorylation	Kinase	CHEK1	O14757	GPS
847	T	Phosphorylation	Kinase	PLK1	P53350	PSP
1068	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1630	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
4	T	Phosphorylation	Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain.	12607003
1840	K	Sumoylation	Sumoylation at Lys-1840 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.	22635276
1840	K	ubiquitylation	Sumoylation at Lys-1840 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.	22635276

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MDC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2AX_HUMAN	H2AFX	physical	12607005
CENPC_HUMAN	CENPC	physical	14578343
GATA4_HUMAN	GATA4	physical	14578343
HDA10_HUMAN	HDAC10	physical	14578343
HDAC8_HUMAN	HDAC8	physical	14578343
MDM2_HUMAN	MDM2	physical	14578343
RPB1_HUMAN	POLR2A	physical	14578343
WRN_HUMAN	WRN	physical	14578343
MRE11_HUMAN	MRE11A	physical	14519663
NBN_HUMAN	NBN	physical	14519663
RAD50_HUMAN	RAD50	physical	14519663
P53_HUMAN	TP53	physical	14519663
H2AX_HUMAN	H2AFX	physical	14519663
ATM_HUMAN	ATM	physical	14519663
CHK2_HUMAN	CHEK2	physical	12607004
BRCA1_HUMAN	BRCA1	physical	17525332
TP53B_HUMAN	TP53BP1	physical	18986980
RAD51_HUMAN	RAD51	physical	16186822
RAD50_HUMAN	RAD50	physical	12607003
MRE11_HUMAN	MRE11A	physical	12607003
NBN_HUMAN	NBN	physical	12607003
NBN_HUMAN	NBN	physical	15201865
RNF8_HUMAN	RNF8	physical	18001824
APC1_HUMAN	ANAPC1	physical	17827148
APC5_HUMAN	ANAPC5	physical	17827148
CDC16_HUMAN	CDC16	physical	17827148
CDC27_HUMAN	CDC27	physical	17827148
NBN_HUMAN	NBN	physical	20460517
BIRC5_HUMAN	BIRC5	physical	20394854
RNF8_HUMAN	RNF8	physical	18006705
UIMC1_HUMAN	UIMC1	physical	21622030
BRCA1_HUMAN	BRCA1	physical	21622030
H2AX_HUMAN	H2AFX	physical	21622030
HERC2_HUMAN	HERC2	physical	20023648
PRKDC_HUMAN	PRKDC	physical	15377652
XRCC5_HUMAN	XRCC5	physical	15377652
SMC1A_HUMAN	SMC1A	physical	12607005
TP53B_HUMAN	TP53BP1	physical	12607005
FACD2_HUMAN	FANCD2	physical	12607005
MRE11_HUMAN	MRE11A	physical	12607005
NBN_HUMAN	NBN	physical	12607005
RAD50_HUMAN	RAD50	physical	12607005
ATM_HUMAN	ATM	physical	12607005
NBN_HUMAN	NBN	physical	15377652
APC7_HUMAN	ANAPC7	physical	19826003
CDC27_HUMAN	CDC27	physical	19826003
CDC16_HUMAN	CDC16	physical	19826003
CDC20_HUMAN	CDC20	physical	19826003
CBP_HUMAN	CREBBP	physical	19826003
BRCA1_HUMAN	BRCA1	physical	12611903
BARD1_HUMAN	BARD1	physical	12611903
NSD2_HUMAN	WHSC1	physical	21293379
H2AX_HUMAN	H2AFX	physical	21293379
MDM2_HUMAN	MDM2	physical	18471438
H2AX_HUMAN	H2AFX	physical	20159462
NBN_HUMAN	NBN	physical	20224574
AMFR_HUMAN	AMFR	physical	22990118
AUP1_HUMAN	AUP1	physical	22990118
CLUS_HUMAN	CLU	physical	22990118
PRI1_HUMAN	PRIM1	physical	22990118
RL29_HUMAN	RPL29	physical	22990118
VAMP5_HUMAN	VAMP5	physical	22990118
CSN5_HUMAN	COPS5	physical	22990118
ZN251_HUMAN	ZNF251	physical	22990118
DTX2_HUMAN	DTX2	physical	22990118
AT2A2_HUMAN	ATP2A2	physical	22990118
CAZA1_HUMAN	CAPZA1	physical	22990118
CAPZB_HUMAN	CAPZB	physical	22990118
CDC5L_HUMAN	CDC5L	physical	22990118
CDC20_HUMAN	CDC20	physical	22990118
CSRP2_HUMAN	CSRP2	physical	22990118
EMD_HUMAN	EMD	physical	22990118
ENOA_HUMAN	ENO1	physical	22990118
EPS8_HUMAN	EPS8	physical	22990118
FLNA_HUMAN	FLNA	physical	22990118
FLNB_HUMAN	FLNB	physical	22990118
HNRPC_HUMAN	HNRNPC	physical	22990118
IMB1_HUMAN	KPNB1	physical	22990118
KI67_HUMAN	MKI67	physical	22990118
3MG_HUMAN	MPG	physical	22990118
MYO1D_HUMAN	MYO1D	physical	22990118
NDUAA_HUMAN	NDUFA10	physical	22990118
NUMA1_HUMAN	NUMA1	physical	22990118
ODPB_HUMAN	PDHB	physical	22990118
PLRG1_HUMAN	PLRG1	physical	22990118
RPB1_HUMAN	POLR2A	physical	22990118
RPB2_HUMAN	POLR2B	physical	22990118
RPB3_HUMAN	POLR2C	physical	22990118
RPAB1_HUMAN	POLR2E	physical	22990118
PP1A_HUMAN	PPP1CA	physical	22990118
PP2AA_HUMAN	PPP2CA	physical	22990118
ABCD3_HUMAN	ABCD3	physical	22990118
P5CR1_HUMAN	PYCR1	physical	22990118
RFC2_HUMAN	RFC2	physical	22990118
RFC4_HUMAN	RFC4	physical	22990118
RFC5_HUMAN	RFC5	physical	22990118
ATX2_HUMAN	ATXN2	physical	22990118
SRSF1_HUMAN	SRSF1	physical	22990118
SMN_HUMAN	SMN1	physical	22990118
RSMB_HUMAN	SNRPB	physical	22990118
SSRA_HUMAN	SSR1	physical	22990118
STAU1_HUMAN	STAU1	physical	22990118
SPT6H_HUMAN	SUPT6H	physical	22990118
TPM1_HUMAN	TPM1	physical	22990118
TPM3_HUMAN	TPM3	physical	22990118
VDAC1_HUMAN	VDAC1	physical	22990118
VDAC2_HUMAN	VDAC2	physical	22990118
1433Z_HUMAN	YWHAZ	physical	22990118
M2OM_HUMAN	SLC25A11	physical	22990118
TAGL2_HUMAN	TAGLN2	physical	22990118
PRKRA_HUMAN	PRKRA	physical	22990118
SRSF9_HUMAN	SRSF9	physical	22990118
CDC23_HUMAN	CDC23	physical	22990118
CDC16_HUMAN	CDC16	physical	22990118
PCH2_HUMAN	TRIP13	physical	22990118
RECQ5_HUMAN	RECQL5	physical	22990118
SNR40_HUMAN	SNRNP40	physical	22990118
BABA2_HUMAN	BRE	physical	22990118
RBM39_HUMAN	RBM39	physical	22990118
TR150_HUMAN	THRAP3	physical	22990118
SF3A1_HUMAN	SF3A1	physical	22990118
APC10_HUMAN	ANAPC10	physical	22990118
RACK1_HUMAN	GNB2L1	physical	22990118
ML12A_HUMAN	MYL12A	physical	22990118
CPSF4_HUMAN	CPSF4	physical	22990118
MIC60_HUMAN	IMMT	physical	22990118
CPSF6_HUMAN	CPSF6	physical	22990118
COPE_HUMAN	COPE	physical	22990118
PHB2_HUMAN	PHB2	physical	22990118
CBX3_HUMAN	CBX3	physical	22990118
EXOS8_HUMAN	EXOSC8	physical	22990118
POGZ_HUMAN	POGZ	physical	22990118
SR140_HUMAN	U2SURP	physical	22990118
EXOS2_HUMAN	EXOSC2	physical	22990118
RAI14_HUMAN	RAI14	physical	22990118
PAIRB_HUMAN	SERBP1	physical	22990118
SERA_HUMAN	PHGDH	physical	22990118
BABA1_HUMAN	BABAM1	physical	22990118
ANC2_HUMAN	ANAPC2	physical	22990118
P5CR2_HUMAN	PYCR2	physical	22990118
S61A1_HUMAN	SEC61A1	physical	22990118
APC4_HUMAN	ANAPC4	physical	22990118
PDZ11_HUMAN	PDZD11	physical	22990118
FZR1_HUMAN	FZR1	physical	22990118
APC5_HUMAN	ANAPC5	physical	22990118
APC7_HUMAN	ANAPC7	physical	22990118
CPSF3_HUMAN	CPSF3	physical	22990118
UIMC1_HUMAN	UIMC1	physical	22990118
PELO_HUMAN	PELO	physical	22990118
CPSF2_HUMAN	CPSF2	physical	22990118
PAF1_HUMAN	PAF1	physical	22990118
MIC19_HUMAN	CHCHD3	physical	22990118
CX057_HUMAN	CXorf57	physical	22990118
RMD3_HUMAN	RMDN3	physical	22990118
WDR33_HUMAN	WDR33	physical	22990118
CARF_HUMAN	CDKN2AIP	physical	22990118
LYAR_HUMAN	LYAR	physical	22990118
DEP1B_HUMAN	DEPDC1B	physical	22990118
WDR18_HUMAN	WDR18	physical	22990118
MICA3_HUMAN	MICAL3	physical	22990118
APC1_HUMAN	ANAPC1	physical	22990118
MET17_HUMAN	METTL17	physical	22990118
COA7_HUMAN	COA7	physical	22990118
ASHWN_HUMAN	C2orf49	physical	22990118
BRCC3_HUMAN	BRCC3	physical	22990118
HMBX1_HUMAN	HMBOX1	physical	22990118
ZN768_HUMAN	ZNF768	physical	22990118
GHC1_HUMAN	SLC25A22	physical	22990118
MYH14_HUMAN	MYH14	physical	22990118
PCAT1_HUMAN	LPCAT1	physical	22990118
LAS1L_HUMAN	LAS1L	physical	22990118
ABRX1_HUMAN	FAM175A	physical	22990118
SPF45_HUMAN	RBM17	physical	22990118
OSBL8_HUMAN	OSBPL8	physical	22990118
APC16_HUMAN	ANAPC16	physical	22990118
LSM12_HUMAN	LSM12	physical	22990118
PGAM5_HUMAN	PGAM5	physical	22990118
HNRL2_HUMAN	HNRNPUL2	physical	22990118
CHAP1_HUMAN	CHAMP1	physical	22990118
NUCL_HUMAN	NCL	physical	23145133
MRE11_HUMAN	MRE11A	physical	18583988
RAD50_HUMAN	RAD50	physical	18583988
NBN_HUMAN	NBN	physical	18583988
RAG1_HUMAN	RAG1	physical	22942284
CDC27_HUMAN	CDC27	physical	22942284
RNF8_HUMAN	RNF8	physical	25512560
HNRPU_HUMAN	HNRNPU	physical	26344197
SMRC1_HUMAN	SMARCC1	physical	26344197
SMRD2_HUMAN	SMARCD2	physical	26344197
SSBP3_HUMAN	SSBP3	physical	26344197
H2AX_HUMAN	H2AFX	physical	26734725
RNF8_HUMAN	RNF8	physical	26734725
ATM_HUMAN	ATM	physical	26734725
ATX3_HUMAN	ATXN3	physical	28275011
UBP13_HUMAN	USP13	physical	28569838

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-812 AND LYS-1402, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-176; SER-329;THR-331; SER-372; SER-376; THR-378; SER-402; THR-404; SER-411;THR-449; SER-453; THR-455; THR-654; SER-780; THR-1157; THR-1425;THR-1466 AND SER-1775, AND MASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-176; SER-299;THR-301; SER-329; THR-331; THR-341; SER-394; SER-397; SER-402;THR-404; THR-449; SER-453; THR-455; SER-495; SER-498; SER-504;SER-513; SER-780; SER-793; SER-1033; SER-1068; THR-1198; SER-1212;SER-1399; SER-1400; THR-1403; THR-1425; THR-1444; THR-1466; THR-1589;THR-1601; SER-1604; THR-1608; THR-1630; THR-1649; THR-1664; THR-1671;SER-1681; THR-1696; THR-1697; SER-1702; SER-1711; SER-1775 ANDTHR-1858, AND MASS SPECTROMETRY.
PubMed: 18669648

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1399; THR-1403 ANDTHR-1425, AND MASS SPECTROMETRY.
PubMed: 18220336

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.
PubMed: 18187866

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372; SER-376; THR-378;SER-422; SER-513; SER-516; THR-523; THR-652; THR-659; SER-763;THR-765; SER-780; SER-955; SER-964; SER-986; SER-1086; SER-1095 ANDSER-1430, AND MASS SPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1623; SER-1814 ANDSER-1820, AND MASS SPECTROMETRY.
PubMed: 17287340

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.
PubMed: 17693683

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1068 AND SER-1797, ANDMASS SPECTROMETRY.
PubMed: 17924679

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-329; THR-331;SER-402; THR-404; SER-495; SER-498; SER-882 AND SER-1797, AND MASSSPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-329; SER-964;SER-988; SER-995; THR-1425 AND THR-1461, AND MASS SPECTROMETRY.
PubMed: 15302935

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1589, AND MASSSPECTROMETRY.
PubMed: 19007248