PRKDC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRKDC_HUMAN
• UniProt AC: P78527
• Protein Name: DNA-dependent protein kinase catalytic subunit
• Gene Name: PRKDC
• Organism: Homo sapiens (Human).
• Sequence Length: 4128
• Subcellular Localization: Nucleus . Nucleus, nucleolus .
• Protein Description: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway..
• Protein Sequence: MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSGAGVR ------CCCCCHHHH	31.96	-
14	Methylation	GVRCSLLRLQETLSA HHHHHHHHHHHHHCH	39.35	-
20	Phosphorylation	LRLQETLSAADRCGA HHHHHHHCHHHHHHH	28.91	-
24	Methylation	ETLSAADRCGAALAG HHHCHHHHHHHHHHH	18.95	-
25	S-nitrosocysteine	TLSAADRCGAALAGH HHCHHHHHHHHHHHH	4.47	-
25	S-nitrosylation	TLSAADRCGAALAGH HHCHHHHHHHHHHHH	4.47	19483679
46	Phosphorylation	GQECVLSSSPAVLAL CCCHHHCCCHHHHHH	35.86	21601212
56	Phosphorylation	AVLALQTSLVFSRDF HHHHHHHHHHHCCCC	15.02	21601212
60	Phosphorylation	LQTSLVFSRDFGLLV HHHHHHHCCCCCHHH	24.38	21601212
71	2-Hydroxyisobutyrylation	GLLVFVRKSLNSIEF CHHHEHHCCCCCCCH	54.73	-
71	Ubiquitination	GLLVFVRKSLNSIEF CHHHEHHCCCCCCCH	54.73	24816145
95	Acetylation	FLCIFLEKMGQKIAP HHHHHHHHCCCCCCC	50.94	26051181
95	Ubiquitination	FLCIFLEKMGQKIAP HHHHHHHHCCCCCCC	50.94	22817900
99	Acetylation	FLEKMGQKIAPYSVE HHHHCCCCCCCEEEE	34.80	26051181
99	Malonylation	FLEKMGQKIAPYSVE HHHHCCCCCCCEEEE	34.80	26320211
99	Ubiquitination	FLEKMGQKIAPYSVE HHHHCCCCCCCEEEE	34.80	27667366
99 (in isoform 1)	Ubiquitination	-	34.80	21890473
99 (in isoform 2)	Ubiquitination	-	34.80	21890473
103	Phosphorylation	MGQKIAPYSVEIKNT CCCCCCCEEEEEECC	19.14	24719451
104	Phosphorylation	GQKIAPYSVEIKNTC CCCCCCEEEEEECCC	16.53	24719451
108	Acetylation	APYSVEIKNTCTSVY CCEEEEEECCCEEEE	32.47	26051181
108	Ubiquitination	APYSVEIKNTCTSVY CCEEEEEECCCEEEE	32.47	21963094
110	Phosphorylation	YSVEIKNTCTSVYTK EEEEEECCCEEEECC	16.50	29759185
115	Phosphorylation	KNTCTSVYTKDRAAK ECCCEEEECCCHHHC	14.08	29759185
116	Phosphorylation	NTCTSVYTKDRAAKC CCCEEEECCCHHHCC	25.06	29759185
117	Acetylation	TCTSVYTKDRAAKCK CCEEEECCCHHHCCC	27.77	19608861
117	Malonylation	TCTSVYTKDRAAKCK CCEEEECCCHHHCCC	27.77	32601280
117	Ubiquitination	TCTSVYTKDRAAKCK CCEEEECCCHHHCCC	27.77	27667366
117 (in isoform 1)	Ubiquitination	-	27.77	21890473
117 (in isoform 2)	Acetylation	-	27.77	-
117 (in isoform 2)	Ubiquitination	-	27.77	21890473
122	Ubiquitination	YTKDRAAKCKIPALD ECCCHHHCCCCCHHH	34.77	22817900
124	Ubiquitination	KDRAAKCKIPALDLL CCHHHCCCCCHHHHH	51.52	-
137	Phosphorylation	LLIKLLQTFRSSRLM HHHHHHHHHHHHCCH	22.45	20068231
137 (in isoform 2)	Phosphorylation	-	22.45	-
140	Phosphorylation	KLLQTFRSSRLMDEF HHHHHHHHHCCHHHH	18.67	20068231
141	Phosphorylation	LLQTFRSSRLMDEFK HHHHHHHHCCHHHHH	25.77	20068231
148	2-Hydroxyisobutyrylation	SRLMDEFKIGELFSK HCCHHHHHHHHHHHH	47.99	-
148	Acetylation	SRLMDEFKIGELFSK HCCHHHHHHHHHHHH	47.99	25953088
148	Ubiquitination	SRLMDEFKIGELFSK HCCHHHHHHHHHHHH	47.99	21963094
148 (in isoform 1)	Ubiquitination	-	47.99	21890473
148 (in isoform 2)	Ubiquitination	-	47.99	21890473
154	Phosphorylation	FKIGELFSKFYGELA HHHHHHHHHHHHHHH	34.18	24719451
155	Ubiquitination	KIGELFSKFYGELAL HHHHHHHHHHHHHHH	34.96	21963094
155 (in isoform 1)	Ubiquitination	-	34.96	21890473
155 (in isoform 2)	Ubiquitination	-	34.96	21890473
157	Phosphorylation	GELFSKFYGELALKK HHHHHHHHHHHHHHC	17.27	28152594
163	2-Hydroxyisobutyrylation	FYGELALKKKIPDTV HHHHHHHHCCCCHHH	46.54	-
163	Acetylation	FYGELALKKKIPDTV HHHHHHHHCCCCHHH	46.54	25953088
163	Ubiquitination	FYGELALKKKIPDTV HHHHHHHHCCCCHHH	46.54	27667366
163 (in isoform 1)	Ubiquitination	-	46.54	21890473
163 (in isoform 2)	Ubiquitination	-	46.54	21890473
164	Ubiquitination	YGELALKKKIPDTVL HHHHHHHCCCCHHHH	57.70	22817900
165	Ubiquitination	GELALKKKIPDTVLE HHHHHHCCCCHHHHH	58.86	22817900
169	Phosphorylation	LKKKIPDTVLEKVYE HHCCCCHHHHHHHHH	22.95	23403867
205	Acetylation	RAFLGELKTQMTSAV HHHHHHHHHHHHHHH	32.20	25953088
205	Ubiquitination	RAFLGELKTQMTSAV HHHHHHHHHHHHHHH	32.20	21963094
205 (in isoform 1)	Ubiquitination	-	32.20	21890473
205 (in isoform 2)	Ubiquitination	-	32.20	21890473
209	Phosphorylation	GELKTQMTSAVREPK HHHHHHHHHHHCCCC	12.06	29083192
210	Phosphorylation	ELKTQMTSAVREPKL HHHHHHHHHHCCCCH	21.30	29083192
216	2-Hydroxyisobutyrylation	TSAVREPKLPVLAGC HHHHCCCCHHHHHHH	61.75	-
216	Acetylation	TSAVREPKLPVLAGC HHHHCCCCHHHHHHH	61.75	26051181
216	Ubiquitination	TSAVREPKLPVLAGC HHHHCCCCHHHHHHH	61.75	29967540
223	Glutathionylation	KLPVLAGCLKGLSSL CHHHHHHHHHHHHHH	2.70	22555962
223	S-palmitoylation	KLPVLAGCLKGLSSL CHHHHHHHHHHHHHH	2.70	29575903
225	Ubiquitination	PVLAGCLKGLSSLLC HHHHHHHHHHHHHHH	62.98	22817900
225 (in isoform 1)	Ubiquitination	-	62.98	21890473
225 (in isoform 2)	Ubiquitination	-	62.98	21890473
228	Phosphorylation	AGCLKGLSSLLCNFT HHHHHHHHHHHHHHH	27.84	21712546
229	Phosphorylation	GCLKGLSSLLCNFTK HHHHHHHHHHHHHHH	30.33	20068231
229 (in isoform 2)	Phosphorylation	-	30.33	-
232	Glutathionylation	KGLSSLLCNFTKSME HHHHHHHHHHHHCCC	4.83	22555962
232	S-palmitoylation	KGLSSLLCNFTKSME HHHHHHHHHHHHCCC	4.83	29575903
235	Phosphorylation	SSLLCNFTKSMEEDP HHHHHHHHHCCCCCC	14.28	20068231
236	Acetylation	SLLCNFTKSMEEDPQ HHHHHHHHCCCCCCH	43.60	26051181
236	Ubiquitination	SLLCNFTKSMEEDPQ HHHHHHHHCCCCCCH	43.60	21963094
237	Phosphorylation	LLCNFTKSMEEDPQT HHHHHHHCCCCCCHH	28.50	28060719
238	Sulfoxidation	LCNFTKSMEEDPQTS HHHHHHCCCCCCHHH	7.53	28183972
244	Phosphorylation	SMEEDPQTSREIFNF CCCCCCHHHHHHHHH	34.83	28060719
245	Phosphorylation	MEEDPQTSREIFNFV CCCCCHHHHHHHHHH	23.75	28060719
254	Acetylation	EIFNFVLKAIRPQID HHHHHHHHHHHCCCC	36.14	23236377
254	Ubiquitination	EIFNFVLKAIRPQID HHHHHHHHHHHCCCC	36.14	21963094
254 (in isoform 1)	Ubiquitination	-	36.14	21890473
254 (in isoform 2)	Acetylation	-	36.14	-
254 (in isoform 2)	Ubiquitination	-	36.14	21890473
263	2-Hydroxyisobutyrylation	IRPQIDLKRYAVPSA HHCCCCCCCCCCCCH	39.35	-
263	Acetylation	IRPQIDLKRYAVPSA HHCCCCCCCCCCCCH	39.35	25953088
263	Malonylation	IRPQIDLKRYAVPSA HHCCCCCCCCCCCCH	39.35	26320211
263	Ubiquitination	IRPQIDLKRYAVPSA HHCCCCCCCCCCCCH	39.35	21963094
263 (in isoform 1)	Ubiquitination	-	39.35	21890473
263 (in isoform 2)	Ubiquitination	-	39.35	21890473
265	Phosphorylation	PQIDLKRYAVPSAGL CCCCCCCCCCCCHHH	15.46	28152594
309	2-Hydroxyisobutyrylation	AHTNVELKKAALSAL HHCCHHHHHHHHHHH	27.19	-
309	Acetylation	AHTNVELKKAALSAL HHCCHHHHHHHHHHH	27.19	25953088
309	Ubiquitination	AHTNVELKKAALSAL HHCCHHHHHHHHHHH	27.19	22817900
310	Ubiquitination	HTNVELKKAALSALE HCCHHHHHHHHHHHH	52.06	22817900
310 (in isoform 1)	Ubiquitination	-	52.06	21890473
310 (in isoform 2)	Ubiquitination	-	52.06	21890473
314	Phosphorylation	ELKKAALSALESFLK HHHHHHHHHHHHHHH	26.53	25850435
318	O-linked_Glycosylation	AALSALESFLKQVSN HHHHHHHHHHHHHHH	36.41	23301498
318	Phosphorylation	AALSALESFLKQVSN HHHHHHHHHHHHHHH	36.41	21712546
321	Ubiquitination	SALESFLKQVSNMVA HHHHHHHHHHHHHHH	46.79	-
329	Ubiquitination	QVSNMVAKNAEMHKN HHHHHHHHHHHHHHH	45.33	27667366
329 (in isoform 1)	Ubiquitination	-	45.33	21890473
329 (in isoform 2)	Ubiquitination	-	45.33	21890473
337	Ubiquitination	NAEMHKNKLQYFMEQ HHHHHHHHHHHHHHH	41.59	-
340	Phosphorylation	MHKNKLQYFMEQFYG HHHHHHHHHHHHHHH	18.48	26552605
342	Sulfoxidation	KNKLQYFMEQFYGII HHHHHHHHHHHHHHH	3.17	28183972
346	Phosphorylation	QYFMEQFYGIIRNVD HHHHHHHHHHHHCCC	13.70	26552605
354	Phosphorylation	GIIRNVDSNNKELSI HHHHCCCCCCCEEEE	37.71	20860994
357	2-Hydroxyisobutyrylation	RNVDSNNKELSIAIR HCCCCCCCEEEEEEE	65.37	-
357	Acetylation	RNVDSNNKELSIAIR HCCCCCCCEEEEEEE	65.37	23236377
357	Malonylation	RNVDSNNKELSIAIR HCCCCCCCEEEEEEE	65.37	26320211
357	Ubiquitination	RNVDSNNKELSIAIR HCCCCCCCEEEEEEE	65.37	23000965
357 (in isoform 1)	Ubiquitination	-	65.37	21890473
357 (in isoform 2)	Ubiquitination	-	65.37	21890473
360	Phosphorylation	DSNNKELSIAIRGYG CCCCCEEEEEEECCE	15.86	23312004
374	Acetylation	GLFAGPCKVINAKDV EECCCCEEEECCCCC	49.65	26051181
374	Ubiquitination	GLFAGPCKVINAKDV EECCCCEEEECCCCC	49.65	27667366
379	Ubiquitination	PCKVINAKDVDFMYV CEEEECCCCCCCHHH	54.52	22817900
379 (in isoform 1)	Ubiquitination	-	54.52	21890473
379 (in isoform 2)	Ubiquitination	-	54.52	21890473
393	Ubiquitination	VELIQRCKQMFLTQT HHHHHHHHHHHCCCC	47.16	21963094
395	Sulfoxidation	LIQRCKQMFLTQTDT HHHHHHHHHCCCCCC	1.49	21406390
398	Phosphorylation	RCKQMFLTQTDTGDD HHHHHHCCCCCCCCC	20.39	-
400	Phosphorylation	KQMFLTQTDTGDDRV HHHHCCCCCCCCCCC	30.23	-
471	Ubiquitination	VFLALAAKGPVLRNC HHHHHHHCCHHHHHH	59.13	21963094
478	S-nitrosocysteine	KGPVLRNCISTVVHQ CCHHHHHHHHHHHHH	1.78	-
478	S-nitrosylation	KGPVLRNCISTVVHQ CCHHHHHHHHHHHHH	1.78	19483679
492	Phosphorylation	QGLIRICSKPVVLPK HCHHHHCCCCEECCC	37.31	-
493	Acetylation	GLIRICSKPVVLPKG CHHHHCCCCEECCCC	37.10	25825284
493	Ubiquitination	GLIRICSKPVVLPKG CHHHHCCCCEECCCC	37.10	27667366
499	Ubiquitination	SKPVVLPKGPESESE CCCEECCCCCCCCCC	80.89	33845483
503	Phosphorylation	VLPKGPESESEDHRA ECCCCCCCCCCCCCC	49.94	23403867
505	Phosphorylation	PKGPESESEDHRASG CCCCCCCCCCCCCCC	58.57	29255136
511	Phosphorylation	ESEDHRASGEVRTGK CCCCCCCCCCCCCCC	35.13	23401153
516	Phosphorylation	RASGEVRTGKWKVPT CCCCCCCCCCCCCCC	48.57	-
518	Ubiquitination	SGEVRTGKWKVPTYK CCCCCCCCCCCCCHH	43.14	29967540
520	Acetylation	EVRTGKWKVPTYKDY CCCCCCCCCCCHHHH	41.65	26051181
520	Ubiquitination	EVRTGKWKVPTYKDY CCCCCCCCCCCHHHH	41.65	23000965
525	2-Hydroxyisobutyrylation	KWKVPTYKDYVDLFR CCCCCCHHHHHHHHH	45.09	-
525	Acetylation	KWKVPTYKDYVDLFR CCCCCCHHHHHHHHH	45.09	25953088
525	Ubiquitination	KWKVPTYKDYVDLFR CCCCCCHHHHHHHHH	45.09	23000965
525 (in isoform 1)	Ubiquitination	-	45.09	21890473
525 (in isoform 2)	Ubiquitination	-	45.09	21890473
527	Phosphorylation	KVPTYKDYVDLFRHL CCCCHHHHHHHHHHH	7.54	-
552	Phosphorylation	LADEAFFSVNSSSES HHCCCCCCCCCCCHH	17.59	-
570	Ubiquitination	LLYDEFVKSVLKIVE HHHHHHHHHHHHHHH	39.92	22817900
574	Ubiquitination	EFVKSVLKIVEKLDL HHHHHHHHHHHHCCC	42.42	22817900
574 (in isoform 1)	Ubiquitination	-	42.42	21890473
574 (in isoform 2)	Ubiquitination	-	42.42	21890473
578	Ubiquitination	SVLKIVEKLDLTLEI HHHHHHHHCCCEEEE	36.09	22817900
667	Phosphorylation	LPLISGFYKLLSITV CCCCCHHHHHHHHHC	12.30	-
668	Ubiquitination	PLISGFYKLLSITVR CCCCHHHHHHHHHCC	40.46	-
678	Ubiquitination	SITVRNAKKIKYFEG HHHCCCCCCCCEECC	59.59	22817900
679	Ubiquitination	ITVRNAKKIKYFEGV HHCCCCCCCCEECCC	41.86	22817900
681	2-Hydroxyisobutyrylation	VRNAKKIKYFEGVSP CCCCCCCCEECCCCH	53.41	-
681	Acetylation	VRNAKKIKYFEGVSP CCCCCCCCEECCCCH	53.41	25953088
681	Ubiquitination	VRNAKKIKYFEGVSP CCCCCCCCEECCCCH	53.41	22817900
681 (in isoform 1)	Ubiquitination	-	53.41	21890473
681 (in isoform 2)	Ubiquitination	-	53.41	21890473
682	Phosphorylation	RNAKKIKYFEGVSPK CCCCCCCEECCCCHH	15.44	-
687	Phosphorylation	IKYFEGVSPKSLKHS CCEECCCCHHHCCCC	37.15	25850435
689	Acetylation	YFEGVSPKSLKHSPE EECCCCHHHCCCCCC	62.00	25953088
689	Ubiquitination	YFEGVSPKSLKHSPE EECCCCHHHCCCCCC	62.00	27667366
689 (in isoform 1)	Ubiquitination	-	62.00	21890473
689 (in isoform 2)	Ubiquitination	-	62.00	21890473
690	Phosphorylation	FEGVSPKSLKHSPED ECCCCHHHCCCCCCC	46.14	23312004
692	Acetylation	GVSPKSLKHSPEDPE CCCHHHCCCCCCCHH	49.48	27452117
692	Ubiquitination	GVSPKSLKHSPEDPE CCCHHHCCCCCCCHH	49.48	21963094
692 (in isoform 1)	Ubiquitination	-	49.48	21890473
692 (in isoform 2)	Ubiquitination	-	49.48	21890473
694	Phosphorylation	SPKSLKHSPEDPEKY CHHHCCCCCCCHHHC	28.53	29214152
700	Acetylation	HSPEDPEKYSCFALF CCCCCHHHCCEEEHH	48.10	26051181
700	Ubiquitination	HSPEDPEKYSCFALF CCCCCHHHCCEEEHH	48.10	29967540
702	Phosphorylation	PEDPEKYSCFALFVK CCCHHHCCEEEHHHH	17.52	30631047
709	Ubiquitination	SCFALFVKFGKEVAV CEEEHHHHHCHHHHH	40.85	22817900
712	2-Hydroxyisobutyrylation	ALFVKFGKEVAVKMK EHHHHHCHHHHHHHH	52.74	-
712	Acetylation	ALFVKFGKEVAVKMK EHHHHHCHHHHHHHH	52.74	26051181
712	Ubiquitination	ALFVKFGKEVAVKMK EHHHHHCHHHHHHHH	52.74	27667366
712 (in isoform 1)	Ubiquitination	-	52.74	21890473
712 (in isoform 2)	Ubiquitination	-	52.74	21890473
717	Acetylation	FGKEVAVKMKQYKDE HCHHHHHHHHHHHHH	30.55	7304063
717	Ubiquitination	FGKEVAVKMKQYKDE HCHHHHHHHHHHHHH	30.55	22817900
721	Phosphorylation	VAVKMKQYKDELLAS HHHHHHHHHHHHHHH	18.19	-
728	Phosphorylation	YKDELLASCLTFLLS HHHHHHHHHHHHHHH	15.05	21601212
779	Phosphorylation	ALEEWSIYIDRHVMQ HHHHHHHEECHHHCC	7.40	22817900
785	Sulfoxidation	IYIDRHVMQPYYKDI HEECHHHCCHHHHHH	2.44	30846556
790	Acetylation	HVMQPYYKDILPCLD HHCCHHHHHHHHHHC	32.23	26051181
790	Ubiquitination	HVMQPYYKDILPCLD HHCCHHHHHHHHHHC	32.23	21963094
795	S-nitrosocysteine	YYKDILPCLDGYLKT HHHHHHHHHCHHHHH	4.92	-
795	S-nitrosylation	YYKDILPCLDGYLKT HHHHHHHHHCHHHHH	4.92	19483679
799	Phosphorylation	ILPCLDGYLKTSALS HHHHHCHHHHHCCCC	12.51	28152594
801	2-Hydroxyisobutyrylation	PCLDGYLKTSALSDE HHHCHHHHHCCCCHH	31.76	-
801	Acetylation	PCLDGYLKTSALSDE HHHCHHHHHCCCCHH	31.76	26051181
801	Ubiquitination	PCLDGYLKTSALSDE HHHCHHHHHCCCCHH	31.76	21963094
810	Acetylation	SALSDETKNNWEVSA CCCCHHCCCCHHHHH	46.35	23236377
810	Ubiquitination	SALSDETKNNWEVSA CCCCHHCCCCHHHHH	46.35	23000965
810 (in isoform 1)	Ubiquitination	-	46.35	21890473
810 (in isoform 2)	Ubiquitination	-	46.35	21890473
820	Methylation	WEVSALSRAAQKGFN HHHHHHHHHHHCCCH	34.49	-
824	2-Hydroxyisobutyrylation	ALSRAAQKGFNKVVL HHHHHHHCCCHHHHH	61.82	-
824	Neddylation	ALSRAAQKGFNKVVL HHHHHHHCCCHHHHH	61.82	32015554
824	Ubiquitination	ALSRAAQKGFNKVVL HHHHHHHCCCHHHHH	61.82	27667366
828	2-Hydroxyisobutyrylation	AAQKGFNKVVLKHLK HHHCCCHHHHHHHHH	31.31	-
828	Acetylation	AAQKGFNKVVLKHLK HHHCCCHHHHHHHHH	31.31	19608861
828	Malonylation	AAQKGFNKVVLKHLK HHHCCCHHHHHHHHH	31.31	26320211
828	Ubiquitination	AAQKGFNKVVLKHLK HHHCCCHHHHHHHHH	31.31	33845483
828 (in isoform 2)	Acetylation	-	31.31	-
832	Acetylation	GFNKVVLKHLKKTKN CCHHHHHHHHHHCCC	34.97	25825284
832	Ubiquitination	GFNKVVLKHLKKTKN CCHHHHHHHHHHCCC	34.97	23000965
832 (in isoform 2)	Acetylation	-	34.97	-
835	Ubiquitination	KVVLKHLKKTKNLSS HHHHHHHHHCCCCCC	59.10	23000965
836	Ubiquitination	VVLKHLKKTKNLSSN HHHHHHHHCCCCCCC	71.71	23000965
838	Malonylation	LKHLKKTKNLSSNEA HHHHHHCCCCCCCCC	65.85	26320211
838	Ubiquitination	LKHLKKTKNLSSNEA HHHHHHCCCCCCCCC	65.85	23000965
838 (in isoform 1)	Ubiquitination	-	65.85	21890473
838 (in isoform 2)	Ubiquitination	-	65.85	21890473
841	Phosphorylation	LKKTKNLSSNEAISL HHHCCCCCCCCCCCH	40.28	25850435
842	Phosphorylation	KKTKNLSSNEAISLE HHCCCCCCCCCCCHH	41.68	25850435
847	Phosphorylation	LSSNEAISLEEIRIR CCCCCCCCHHHHHHH	36.45	25850435
858	Sulfoxidation	IRIRVVQMLGSLGGQ HHHHHHHHHHHCCCC	2.86	28183972
861	Phosphorylation	RVVQMLGSLGGQINK HHHHHHHHCCCCCCC	21.63	20873877
868	Ubiquitination	SLGGQINKNLLTVTS HCCCCCCCCCEEECC	51.07	21963094
868 (in isoform 1)	Ubiquitination	-	51.07	21890473
868 (in isoform 2)	Ubiquitination	-	51.07	21890473
874	Phosphorylation	NKNLLTVTSSDEMMK CCCCEEECCCHHHHH	19.78	23186163
875	Phosphorylation	KNLLTVTSSDEMMKS CCCEEECCCHHHHHH	31.30	23917254
876	Phosphorylation	NLLTVTSSDEMMKSY CCEEECCCHHHHHHH	28.37	21712546
881	Ubiquitination	TSSDEMMKSYVAWDR CCCHHHHHHHHCCCC	37.01	21963094
881 (in isoform 1)	Ubiquitination	-	37.01	21890473
881 (in isoform 2)	Ubiquitination	-	37.01	21890473
882	Phosphorylation	SSDEMMKSYVAWDRE CCHHHHHHHHCCCCC	13.62	25884760
883	Phosphorylation	SDEMMKSYVAWDREK CHHHHHHHHCCCCCC	6.67	25839225
890	Ubiquitination	YVAWDREKRLSFAVP HHCCCCCCCHHCEEE	60.58	-
893	Phosphorylation	WDREKRLSFAVPFRE CCCCCCHHCEEEHHH	18.39	29255136
893 (in isoform 2)	Phosphorylation	-	18.39	-
902	Ubiquitination	AVPFREMKPVIFLDV EEEHHHCCCEEEEEE	31.23	22817900
902 (in isoform 1)	Ubiquitination	-	31.23	21890473
902 (in isoform 2)	Ubiquitination	-	31.23	21890473
922	Phosphorylation	TELALTASDRQTKVA HHHHCCCCHHHHHHH	28.26	21712546
926	Phosphorylation	LTASDRQTKVAACEL CCCCHHHHHHHHHHH	28.51	24043423
927	Ubiquitination	TASDRQTKVAACELL CCCHHHHHHHHHHHH	22.87	-
936	Phosphorylation	AACELLHSMVMFMLG HHHHHHHHHHHHHHH	17.03	24043423
946	Phosphorylation	MFMLGKATQMPEGGQ HHHHHCHHCCCCCCC	28.96	24043423
959	Phosphorylation	GQGAPPMYQLYKRTF CCCCCCHHHHHHHHH	10.92	24043423
962	Phosphorylation	APPMYQLYKRTFPVL CCCHHHHHHHHHHHH	5.27	24043423
963	Acetylation	PPMYQLYKRTFPVLL CCHHHHHHHHHHHHH	54.26	26051181
963	Ubiquitination	PPMYQLYKRTFPVLL CCHHHHHHHHHHHHH	54.26	21963094
963 (in isoform 1)	Ubiquitination	-	54.26	21890473
963 (in isoform 2)	Ubiquitination	-	54.26	21890473
974	Glutathionylation	PVLLRLACDVDQVTR HHHHHHHCCHHHHHH	6.57	22555962
974	S-palmitoylation	PVLLRLACDVDQVTR HHHHHHHCCHHHHHH	6.57	29575903
1038	Acetylation	RCIREFLKWSIKQIT HHHHHHHHHHHHHCC	44.19	26051181
1038	Ubiquitination	RCIREFLKWSIKQIT HHHHHHHHHHHHHCC	44.19	21890473
1042	Ubiquitination	EFLKWSIKQITPQQQ HHHHHHHHHCCCCHH	30.08	21963094
1042 (in isoform 1)	Ubiquitination	-	30.08	21890473
1042 (in isoform 2)	Ubiquitination	-	30.08	21890473
1051	2-Hydroxyisobutyrylation	ITPQQQEKSPVNTKS CCCCHHCCCCCCHHH	56.58	-
1051	Acetylation	ITPQQQEKSPVNTKS CCCCHHCCCCCCHHH	56.58	25953088
1051	Ubiquitination	ITPQQQEKSPVNTKS CCCCHHCCCCCCHHH	56.58	27667366
1051 (in isoform 1)	Ubiquitination	-	56.58	21890473
1051 (in isoform 2)	Ubiquitination	-	56.58	21890473
1052	Phosphorylation	TPQQQEKSPVNTKSL CCCHHCCCCCCHHHH	33.07	17192257
1052 (in isoform 2)	Phosphorylation	-	33.07	-
1057	Acetylation	EKSPVNTKSLFKRLY CCCCCCHHHHHHHHH	39.70	23954790
1057	Malonylation	EKSPVNTKSLFKRLY CCCCCCHHHHHHHHH	39.70	26320211
1057	Ubiquitination	EKSPVNTKSLFKRLY CCCCCCHHHHHHHHH	39.70	21963094
1057 (in isoform 1)	Ubiquitination	-	39.70	21890473
1057 (in isoform 2)	Acetylation	-	39.70	-
1057 (in isoform 2)	Ubiquitination	-	39.70	21890473
1058	Phosphorylation	KSPVNTKSLFKRLYS CCCCCHHHHHHHHHH	36.68	24719451
1061	Ubiquitination	VNTKSLFKRLYSLAL CCHHHHHHHHHHHHH	46.95	22817900
1064	Phosphorylation	KSLFKRLYSLALHPN HHHHHHHHHHHHCHH	12.98	28152594
1065	Phosphorylation	SLFKRLYSLALHPNA HHHHHHHHHHHCHHH	16.26	28152594
1074	Acetylation	ALHPNAFKRLGASLA HHCHHHHHHHCHHHH	44.28	25953088
1074	Ubiquitination	ALHPNAFKRLGASLA HHCHHHHHHHCHHHH	44.28	23000965
1086	Phosphorylation	SLAFNNIYREFREEE HHHHHHHHHHHHHHH	13.25	-
1140	Ubiquitination	HLCRIIEKKHVSLNK HHHHHHHHHCCCCCH	37.46	29967540
1141	Acetylation	LCRIIEKKHVSLNKA HHHHHHHHCCCCCHH	36.13	26210075
1141	Ubiquitination	LCRIIEKKHVSLNKA HHHHHHHHCCCCCHH	36.13	29967540
1144	Phosphorylation	IIEKKHVSLNKAKKR HHHHHCCCCCHHHHC	26.41	29449344
1147	2-Hydroxyisobutyrylation	KKHVSLNKAKKRRLP HHCCCCCHHHHCCCC	67.86	-
1147	Acetylation	KKHVSLNKAKKRRLP HHCCCCCHHHHCCCC	67.86	25953088
1147	Ubiquitination	KKHVSLNKAKKRRLP HHCCCCCHHHHCCCC	67.86	21963094
1149	Ubiquitination	HVSLNKAKKRRLPRG CCCCCHHHHCCCCCC	48.71	22817900
1150	Methylation	VSLNKAKKRRLPRGF CCCCHHHHCCCCCCC	47.84	23748837
1150	Ubiquitination	VSLNKAKKRRLPRGF CCCCHHHHCCCCCCC	47.84	22817900
1162	Phosphorylation	RGFPPSASLCLLDLV CCCCCCHHHHHHHHH	24.77	25599653
1186	Acetylation	PQTECRHKSIELFYK CCCHHCHHCHHHHHH	33.50	26051181
1186	Ubiquitination	PQTECRHKSIELFYK CCCHHCHHCHHHHHH	33.50	21963094
1186 (in isoform 1)	Ubiquitination	-	33.50	21890473
1186 (in isoform 2)	Ubiquitination	-	33.50	21890473
1187	Phosphorylation	QTECRHKSIELFYKF CCHHCHHCHHHHHHH	18.37	20873877
1193	Ubiquitination	KSIELFYKFVPLLPG HCHHHHHHHHHCCCC	32.33	21963094
1193 (in isoform 1)	Ubiquitination	-	32.33	21890473
1193 (in isoform 2)	Ubiquitination	-	32.33	21890473
1203	Phosphorylation	PLLPGNRSPNLWLKD HCCCCCCCCCCCHHH	23.34	28348404
1209	Acetylation	RSPNLWLKDVLKEEG CCCCCCHHHHHHHHC	33.92	19608861
1209	Ubiquitination	RSPNLWLKDVLKEEG CCCCCCHHHHHHHHC	33.92	23000965
1209 (in isoform 1)	Ubiquitination	-	33.92	21890473
1209 (in isoform 2)	Acetylation	-	33.92	-
1209 (in isoform 2)	Ubiquitination	-	33.92	21890473
1213	Ubiquitination	LWLKDVLKEEGVSFL CCHHHHHHHHCCEEE	54.27	23000965
1240	O-linked_Glycosylation	SGILAQPTLLYLRGP CCCCCCCEEEHHCCC	19.81	23301498
1275	Phosphorylation	NTFIGERTVGALQVL HHHCCCCCHHHHHHH	20.99	20068231
1275 (in isoform 2)	Phosphorylation	-	20.99	-
1284	Phosphorylation	GALQVLGTEAQSSLL HHHHHHCHHHHHHHH	24.80	20068231
1288	Phosphorylation	VLGTEAQSSLLKAVA HHCHHHHHHHHHHHH	29.96	20068231
1289	Phosphorylation	LGTEAQSSLLKAVAF HCHHHHHHHHHHHHH	26.16	24719451
1292	Ubiquitination	EAQSSLLKAVAFFLE HHHHHHHHHHHHHHH	46.22	16196087
1300	O-linked_Glycosylation	AVAFFLESIAMHDII HHHHHHHHHHHHHHH	20.14	23301498
1311	Ubiquitination	HDIIAAEKCFGTGAA HHHHHHHHHCCCCCC	30.09	-
1311 (in isoform 1)	Ubiquitination	-	30.09	21890473
1311 (in isoform 2)	Ubiquitination	-	30.09	21890473
1334	2-Hydroxyisobutyrylation	GERYNYSKCTVVVRI CCCCCCCCCEEEEEE	24.46	-
1334	Acetylation	GERYNYSKCTVVVRI CCCCCCCCCEEEEEE	24.46	26051181
1334	Ubiquitination	GERYNYSKCTVVVRI CCCCCCCCCEEEEEE	24.46	21963094
1334 (in isoform 1)	Ubiquitination	-	24.46	21890473
1334 (in isoform 2)	Ubiquitination	-	24.46	21890473
1336	Phosphorylation	RYNYSKCTVVVRIME CCCCCCCEEEEEEEE	21.77	20068231
1342	Sulfoxidation	CTVVVRIMEFTTTLL CEEEEEEEECHHHHH	2.13	28183972
1345	Phosphorylation	VVRIMEFTTTLLNTS EEEEEECHHHHHCCC	12.93	20068231
1346	Phosphorylation	VRIMEFTTTLLNTSP EEEEECHHHHHCCCH	22.29	20068231
1347	Phosphorylation	RIMEFTTTLLNTSPE EEEECHHHHHCCCHH	26.62	20068231
1351	Phosphorylation	FTTTLLNTSPEGWKL CHHHHHCCCHHHHHH	45.70	20068231
1352	Phosphorylation	TTTLLNTSPEGWKLL HHHHHCCCHHHHHHH	21.63	20068231
1352 (in isoform 2)	Phosphorylation	-	21.63	-
1357	Ubiquitination	NTSPEGWKLLKKDLC CCCHHHHHHHHHHCC	55.59	22817900
1357 (in isoform 1)	Ubiquitination	-	55.59	21890473
1357 (in isoform 2)	Ubiquitination	-	55.59	21890473
1360	Ubiquitination	PEGWKLLKKDLCNTH HHHHHHHHHHCCCHH	55.46	22817900
1361	2-Hydroxyisobutyrylation	EGWKLLKKDLCNTHL HHHHHHHHHCCCHHH	56.77	-
1361	Malonylation	EGWKLLKKDLCNTHL HHHHHHHHHCCCHHH	56.77	26320211
1361	Ubiquitination	EGWKLLKKDLCNTHL HHHHHHHHHCCCHHH	56.77	22817900
1404	Ubiquitination	DVCVNLMKALKMSPY HHHHHHHHHHCCCCH	54.45	23503661
1407	2-Hydroxyisobutyrylation	VNLMKALKMSPYKDI HHHHHHHCCCCHHHH	42.04	-
1407	Acetylation	VNLMKALKMSPYKDI HHHHHHHCCCCHHHH	42.04	25953088
1407	Malonylation	VNLMKALKMSPYKDI HHHHHHHCCCCHHHH	42.04	26320211
1407	Ubiquitination	VNLMKALKMSPYKDI HHHHHHHCCCCHHHH	42.04	27667366
1407 (in isoform 1)	Ubiquitination	-	42.04	21890473
1407 (in isoform 2)	Ubiquitination	-	42.04	21890473
1412	2-Hydroxyisobutyrylation	ALKMSPYKDILETHL HHCCCCHHHHHHHHH	41.50	-
1412	Acetylation	ALKMSPYKDILETHL HHCCCCHHHHHHHHH	41.50	25953088
1412	Ubiquitination	ALKMSPYKDILETHL HHCCCCHHHHHHHHH	41.50	21963094
1412 (in isoform 1)	Ubiquitination	-	41.50	21890473
1412 (in isoform 2)	Ubiquitination	-	41.50	21890473
1422	Ubiquitination	LETHLREKITAQSIE HHHHHHHHCCHHHHH	38.63	21963094
1424	Phosphorylation	THLREKITAQSIEEL HHHHHHCCHHHHHHH	29.70	29449344
1427	Phosphorylation	REKITAQSIEELCAV HHHCCHHHHHHHHCC	29.51	29449344
1432	Glutathionylation	AQSIEELCAVNLYGP HHHHHHHHCCCCCCC	4.49	22555962
1453	Phosphorylation	SRLAAVVSACKQLHR HHHHHHHHHHHHHHH	22.73	23403867
1455	Glutathionylation	LAAVVSACKQLHRAG HHHHHHHHHHHHHHC	1.94	22555962
1456	Acetylation	AAVVSACKQLHRAGL HHHHHHHHHHHHHCC	56.46	25953088
1456	Ubiquitination	AAVVSACKQLHRAGL HHHHHHHHHHHHHCC	56.46	23000965
1456 (in isoform 1)	Ubiquitination	-	56.46	21890473
1456 (in isoform 2)	Ubiquitination	-	56.46	21890473
1470	Phosphorylation	LLHNILPSQSTDLHH CHHHCCCCCCCCCCH	33.06	-
1481	Phosphorylation	DLHHSVGTELLSLVY CCCHHHHHHHHHHHH	22.70	-
1489	Ubiquitination	ELLSLVYKGIAPGDE HHHHHHHCCCCCCCH	36.04	21963094
1489 (in isoform 1)	Ubiquitination	-	36.04	21890473
1489 (in isoform 2)	Ubiquitination	-	36.04	21890473
1499	S-nitrosocysteine	APGDERQCLPSLDLS CCCCHHHHHCCCCHH	8.27	-
1499	S-nitrosylation	APGDERQCLPSLDLS CCCCHHHHHCCCCHH	8.27	19483679
1507	S-nitrosocysteine	LPSLDLSCKQLASGL HCCCCHHHHHHHHHH	4.18	-
1507	S-nitrosylation	LPSLDLSCKQLASGL HCCCCHHHHHHHHHH	4.18	19483679
1545	Phosphorylation	LSTASLGSSQGSVIH HHHCCCCCCCCCEEE	25.44	-
1546	Phosphorylation	STASLGSSQGSVIHF HHCCCCCCCCCEEEE	36.44	-
1594	Phosphorylation	VDNTKMVSAVLNGML CCCHHHHHHHHHHHH	14.79	-
1612	2-Hydroxyisobutyrylation	FRERANQKHQGLKLA HHHHHHHHHHHHHHH	37.39	-
1612	Ubiquitination	FRERANQKHQGLKLA HHHHHHHHHHHHHHH	37.39	27667366
1612 (in isoform 1)	Ubiquitination	-	37.39	21890473
1612 (in isoform 2)	Ubiquitination	-	37.39	21890473
1617	Acetylation	NQKHQGLKLATTILQ HHHHHHHHHHHHHHH	42.79	25953088
1617	Malonylation	NQKHQGLKLATTILQ HHHHHHHHHHHHHHH	42.79	26320211
1617	Ubiquitination	NQKHQGLKLATTILQ HHHHHHHHHHHHHHH	42.79	21963094
1620	Phosphorylation	HQGLKLATTILQHWK HHHHHHHHHHHHHHH	25.46	21406692
1621	Phosphorylation	QGLKLATTILQHWKK HHHHHHHHHHHHHHH	17.68	21406692
1627	2-Hydroxyisobutyrylation	TTILQHWKKCDSWWA HHHHHHHHHCCCCCC	41.20	-
1627	Ubiquitination	TTILQHWKKCDSWWA HHHHHHHHHCCCCCC	41.20	22817900
1627 (in isoform 1)	Ubiquitination	-	41.20	21890473
1627 (in isoform 2)	Ubiquitination	-	41.20	21890473
1628	Ubiquitination	TILQHWKKCDSWWAK HHHHHHHHCCCCCCC	37.78	22817900
1635	Acetylation	KCDSWWAKDSPLETK HCCCCCCCCCHHHHH	45.04	26051181
1635	Ubiquitination	KCDSWWAKDSPLETK HCCCCCCCCCHHHHH	45.04	29967540
1642	Ubiquitination	KDSPLETKMAVLALL CCCHHHHHHHHHHHH	18.58	21963094
1642 (in isoform 1)	Ubiquitination	-	18.58	21890473
1642 (in isoform 2)	Ubiquitination	-	18.58	21890473
1658	O-linked_Glycosylation	KILQIDSSVSFNTSH HHHCCCCCCCCCCCC	20.31	23301498
1677	O-linked_Glycosylation	EVFTTYISLLADTKL HHHHHHHHHHHCCCC	13.60	23301498
1694	Phosphorylation	HLKGQAVTLLPFFTS HHCCCHHHHHHHHHH	26.12	20068231
1694 (in isoform 2)	Phosphorylation	-	26.12	-
1700	Phosphorylation	VTLLPFFTSLTGGSL HHHHHHHHHCCCCCH	24.17	20068231
1700 (in isoform 2)	Phosphorylation	-	24.17	-
1701	Phosphorylation	TLLPFFTSLTGGSLE HHHHHHHHCCCCCHH	20.83	20068231
1701 (in isoform 2)	Phosphorylation	-	20.83	-
1703	Phosphorylation	LPFFTSLTGGSLEEL HHHHHHCCCCCHHHH	38.98	20068231
1703 (in isoform 2)	Phosphorylation	-	38.98	-
1706	Phosphorylation	FTSLTGGSLEELRRV HHHCCCCCHHHHHHH	33.67	20068231
1726	Phosphorylation	VAHFPMQSREFPPGT HHHCCCCCCCCCCCC	27.76	24117733
1733	Phosphorylation	SREFPPGTPRFNNYV CCCCCCCCCCCCHHH	19.64	23312004
1744	2-Hydroxyisobutyrylation	NNYVDCMKKFLDALE CHHHHHHHHHHHHHH	46.86	-
1744	Acetylation	NNYVDCMKKFLDALE CHHHHHHHHHHHHHH	46.86	25953088
1744	Ubiquitination	NNYVDCMKKFLDALE CHHHHHHHHHHHHHH	46.86	21963094
1745	Ubiquitination	NYVDCMKKFLDALEL HHHHHHHHHHHHHHH	25.03	22817900
1774	Sulfoxidation	CREQQHVMEELFQSS HHHHHHHHHHHHHHH	2.88	28183972
1790	Phosphorylation	RRIARRGSCVTQVGL HHHHHHCCCHHHHHH	12.00	28450419
1793	Phosphorylation	ARRGSCVTQVGLLES HHHCCCHHHHHHHHH	23.12	28450419
1800	Phosphorylation	TQVGLLESVYEMFRK HHHHHHHHHHHHHHC	29.93	23898821
1802	Phosphorylation	VGLLESVYEMFRKDD HHHHHHHHHHHHCCC	15.79	23898821
1807	Ubiquitination	SVYEMFRKDDPRLSF HHHHHHHCCCCCCCC	56.04	-
1841	Phosphorylation	DALREFFSTIVVDAI HHHHHHHHHHHHHHH	23.65	18452278
1841 (in isoform 2)	Phosphorylation	-	23.65	-
1842	Phosphorylation	ALREFFSTIVVDAID HHHHHHHHHHHHHHH	16.79	18452278
1842 (in isoform 2)	Phosphorylation	-	16.79	-
1852	Ubiquitination	VDAIDVLKSRFTKLN HHHHHHHHHHHHCCC	39.16	22817900
1856	Phosphorylation	DVLKSRFTKLNESTF HHHHHHHHCCCHHHC	33.25	25367160
1857	2-Hydroxyisobutyrylation	VLKSRFTKLNESTFD HHHHHHHCCCHHHCC	46.75	-
1857	Acetylation	VLKSRFTKLNESTFD HHHHHHHCCCHHHCC	46.75	26051181
1857	Ubiquitination	VLKSRFTKLNESTFD HHHHHHHCCCHHHCC	46.75	27667366
1857 (in isoform 1)	Ubiquitination	-	46.75	21890473
1857 (in isoform 2)	Ubiquitination	-	46.75	21890473
1861	Phosphorylation	RFTKLNESTFDTQIT HHHCCCHHHCCHHHH	33.04	25159151
1862	Phosphorylation	FTKLNESTFDTQITK HHCCCHHHCCHHHHH	21.25	27050516
1865	Phosphorylation	LNESTFDTQITKKMG CCHHHCCHHHHHHHC	20.06	25367160
1869	2-Hydroxyisobutyrylation	TFDTQITKKMGYYKI HCCHHHHHHHCCHHH	42.25	-
1869	Acetylation	TFDTQITKKMGYYKI HCCHHHHHHHCCHHH	42.25	26051181
1869	Ubiquitination	TFDTQITKKMGYYKI HCCHHHHHHHCCHHH	42.25	27667366
1869 (in isoform 1)	Ubiquitination	-	42.25	21890473
1869 (in isoform 2)	Ubiquitination	-	42.25	21890473
1870	Ubiquitination	FDTQITKKMGYYKIL CCHHHHHHHCCHHHH	28.98	22817900
1875	Ubiquitination	TKKMGYYKILDVMYS HHHHCCHHHHHHHHH	28.45	21963094
1875 (in isoform 1)	Ubiquitination	-	28.45	21890473
1875 (in isoform 2)	Ubiquitination	-	28.45	21890473
1886	Ubiquitination	VMYSRLPKDDVHAKE HHHHCCCCCCCCCCH	71.76	29967540
1892	Ubiquitination	PKDDVHAKESKINQV CCCCCCCCHHHCCCE	47.87	21963094
1892 (in isoform 1)	Ubiquitination	-	47.87	21890473
1892 (in isoform 2)	Ubiquitination	-	47.87	21890473
1895	2-Hydroxyisobutyrylation	DVHAKESKINQVFHG CCCCCHHHCCCEECC	46.93	-
1895	Acetylation	DVHAKESKINQVFHG CCCCCHHHCCCEECC	46.93	26051181
1895	Ubiquitination	DVHAKESKINQVFHG CCCCCHHHCCCEECC	46.93	21963094
1903	Phosphorylation	INQVFHGSCITEGNE CCCEECCCCCCCCCH	8.19	30622161
1904	Glutathionylation	NQVFHGSCITEGNEL CCEECCCCCCCCCHH	5.44	22555962
1906	Phosphorylation	VFHGSCITEGNELTK EECCCCCCCCCHHHH	42.01	30622161
1912	Phosphorylation	ITEGNELTKTLIKLC CCCCCHHHHHHHHHH	18.79	30622161
1913	Acetylation	TEGNELTKTLIKLCY CCCCHHHHHHHHHHH	54.69	25953088
1913	Ubiquitination	TEGNELTKTLIKLCY CCCCHHHHHHHHHHH	54.69	21963094
1913 (in isoform 1)	Ubiquitination	-	54.69	21890473
1913 (in isoform 2)	Ubiquitination	-	54.69	21890473
1914	Phosphorylation	EGNELTKTLIKLCYD CCCHHHHHHHHHHHH	28.60	30622161
1917	Ubiquitination	ELTKTLIKLCYDAFT HHHHHHHHHHHHHHH	35.30	21963094
1970	Acetylation	QGFLFSEKPEKNLLI CCCCCCCCCCCCEEE	58.22	19608861
1970	Malonylation	QGFLFSEKPEKNLLI CCCCCCCCCCCCEEE	58.22	32601280
1970	Ubiquitination	QGFLFSEKPEKNLLI CCCCCCCCCCCCEEE	58.22	27667366
1970 (in isoform 1)	Ubiquitination	-	58.22	21890473
1970 (in isoform 2)	Acetylation	-	58.22	-
1970 (in isoform 2)	Ubiquitination	-	58.22	21890473
1973	Ubiquitination	LFSEKPEKNLLIFEN CCCCCCCCCEEEEEC	62.51	29967540
1985	Acetylation	FENLIDLKRRYNFPV EECHHCHHHHHCCCC	30.95	19809637
1985	Neddylation	FENLIDLKRRYNFPV EECHHCHHHHHCCCC	30.95	32015554
1985	Ubiquitination	FENLIDLKRRYNFPV EECHHCHHHHHCCCC	30.95	23000965
1985 (in isoform 1)	Ubiquitination	-	30.95	21890473
1985 (in isoform 2)	Ubiquitination	-	30.95	21890473
1998	Sulfoxidation	PVEVEVPMERKKKYI CCEEEECHHHHHHHH	10.58	21406390
2002	Ubiquitination	EVPMERKKKYIEIRK EECHHHHHHHHHHHH	57.96	-
2003	Ubiquitination	VPMERKKKYIEIRKE ECHHHHHHHHHHHHH	55.27	24816145
2023	Phosphorylation	NGDSDGPSYMSSLSY CCCCCCCCHHHHHHH	38.71	-
2029	Phosphorylation	PSYMSSLSYLADSTL CCHHHHHHHHHCCCC	21.76	-
2034	Phosphorylation	SLSYLADSTLSEEMS HHHHHHCCCCCHHHH	26.16	-
2041	Phosphorylation	STLSEEMSQFDFSTG CCCCHHHHCCCCCCC	30.86	-
2051	Phosphorylation	DFSTGVQSYSYSSQD CCCCCCCEECCCCCC	17.40	-
2053	Phosphorylation	STGVQSYSYSSQDPR CCCCCEECCCCCCCC	24.64	-
2056	Phosphorylation	VQSYSYSSQDPRPAT CCEECCCCCCCCCCC	30.30	20711232
2102	Ubiquitination	APLTALVKHMHRSLG HHHHHHHHHHHHHHC	35.74	21963094
2107	Phosphorylation	LVKHMHRSLGPPQGE HHHHHHHHHCCCCCC	24.01	21712546
2117	Phosphorylation	PPQGEEDSVPRDLPS CCCCCCCCCCCCHHH	36.98	17192257
2117 (in isoform 2)	Phosphorylation	-	36.98	-
2127	Acetylation	RDLPSWMKFLHGKLG CCHHHHHHHHHCCCC	38.22	25953088
2127	Ubiquitination	RDLPSWMKFLHGKLG CCHHHHHHHHHCCCC	38.22	21963094
2132	Acetylation	WMKFLHGKLGNPIVP HHHHHHCCCCCCCCC	42.34	26051181
2132	Ubiquitination	WMKFLHGKLGNPIVP HHHHHHCCCCCCCCC	42.34	21963094
2132 (in isoform 2)	Ubiquitination	-	42.34	21890473
2153	Phosphorylation	LAKLVINTEEVFRPY HHHHHCCHHHHHHHH	23.54	28152594
2160	Phosphorylation	TEEVFRPYAKHWLSP HHHHHHHHHHHHHHH	24.83	28152594
2227	2-Hydroxyisobutyrylation	MKHVFHPKRAVFRHN HHHCCCHHHHHHHHC	44.40	-
2227	Ubiquitination	MKHVFHPKRAVFRHN HHHCCCHHHHHHHHC	44.40	21963094
2239	Acetylation	RHNLEIIKTLVECWK HHCHHHHHHHHHHHH	41.28	26051181
2239	Methylation	RHNLEIIKTLVECWK HHCHHHHHHHHHHHH	41.28	-
2239	Ubiquitination	RHNLEIIKTLVECWK HHCHHHHHHHHHHHH	41.28	-
2246	Acetylation	KTLVECWKDCLSIPY HHHHHHHHHHHCCCH	50.66	26051181
2246	Ubiquitination	KTLVECWKDCLSIPY HHHHHHHHHHHCCCH	50.66	21963094
2250	Phosphorylation	ECWKDCLSIPYRLIF HHHHHHHCCCHHHHH	28.05	21712546
2259	2-Hydroxyisobutyrylation	PYRLIFEKFSGKDPN CHHHHHHHHCCCCCC	33.80	-
2259	Acetylation	PYRLIFEKFSGKDPN CHHHHHHHHCCCCCC	33.80	19608861
2259	Ubiquitination	PYRLIFEKFSGKDPN CHHHHHHHHCCCCCC	33.80	33845483
2259 (in isoform 1)	Ubiquitination	-	33.80	21890473
2259 (in isoform 2)	Acetylation	-	33.80	-
2259 (in isoform 2)	Ubiquitination	-	33.80	21890473
2263	2-Hydroxyisobutyrylation	IFEKFSGKDPNSKDN HHHHHCCCCCCCCCC	69.67	-
2263	Ubiquitination	IFEKFSGKDPNSKDN HHHHHCCCCCCCCCC	69.67	27667366
2263 (in isoform 1)	Ubiquitination	-	69.67	21890473
2263 (in isoform 2)	Ubiquitination	-	69.67	21890473
2313	Ubiquitination	NMSFVRYKEVYAAAA CCCHHCHHHHHHHHH	30.09	33845483
2329	Phosphorylation	VLGLILRYVMERKNI HHHHHHHHHHHHCCH	10.74	-
2334	Ubiquitination	LRYVMERKNILEESL HHHHHHHCCHHHHHH	34.73	29901268
2342	S-nitrosocysteine	NILEESLCELVAKQL CHHHHHHHHHHHHHH	5.45	-
2342	Glutathionylation	NILEESLCELVAKQL CHHHHHHHHHHHHHH	5.45	22555962
2342	S-nitrosylation	NILEESLCELVAKQL CHHHHHHHHHHHHHH	5.45	19483679
2347	2-Hydroxyisobutyrylation	SLCELVAKQLKQHQN HHHHHHHHHHHHCCC	49.00	-
2347	Acetylation	SLCELVAKQLKQHQN HHHHHHHHHHHHCCC	49.00	26051181
2347	Neddylation	SLCELVAKQLKQHQN HHHHHHHHHHHHCCC	49.00	32015554
2347	Ubiquitination	SLCELVAKQLKQHQN HHHHHHHHHHHHCCC	49.00	21963094
2347 (in isoform 1)	Ubiquitination	-	49.00	21890473
2347 (in isoform 2)	Ubiquitination	-	49.00	21890473
2350	Ubiquitination	ELVAKQLKQHQNTME HHHHHHHHHCCCCCC	43.15	27667366
2350 (in isoform 1)	Ubiquitination	-	43.15	21890473
2350 (in isoform 2)	Ubiquitination	-	43.15	21890473
2359	2-Hydroxyisobutyrylation	HQNTMEDKFIVCLNK CCCCCCCCEEHHHHH	24.55	-
2359	Acetylation	HQNTMEDKFIVCLNK CCCCCCCCEEHHHHH	24.55	25953088
2359	Malonylation	HQNTMEDKFIVCLNK CCCCCCCCEEHHHHH	24.55	32601280
2359	Ubiquitination	HQNTMEDKFIVCLNK CCCCCCCCEEHHHHH	24.55	29967540
2366	Acetylation	KFIVCLNKVTKSFPP CEEHHHHHHHCCCCC	38.03	25953088
2366	Malonylation	KFIVCLNKVTKSFPP CEEHHHHHHHCCCCC	38.03	32601280
2366	Ubiquitination	KFIVCLNKVTKSFPP CEEHHHHHHHCCCCC	38.03	23000965
2369	Ubiquitination	VCLNKVTKSFPPLAD HHHHHHHCCCCCHHH	53.76	23000965
2369 (in isoform 1)	Ubiquitination	-	53.76	21890473
2369 (in isoform 2)	Ubiquitination	-	53.76	21890473
2416	Ubiquitination	TELYFQLKSKDFVQV HHEEEEECCCCHHHH	44.68	22817900
2418	2-Hydroxyisobutyrylation	LYFQLKSKDFVQVMR EEEEECCCCHHHHHC	54.31	-
2418	Malonylation	LYFQLKSKDFVQVMR EEEEECCCCHHHHHC	54.31	32601280
2418	Ubiquitination	LYFQLKSKDFVQVMR EEEEECCCCHHHHHC	54.31	21963094
2418 (in isoform 1)	Ubiquitination	-	54.31	21890473
2418 (in isoform 2)	Ubiquitination	-	54.31	21890473
2433	Ubiquitination	HRDDERQKVCLDIIY CCCHHHHHHHHHHHH	40.93	21963094
2440	Phosphorylation	KVCLDIIYKMMPKLK HHHHHHHHHHCCCCC	7.99	25147952
2441	Acetylation	VCLDIIYKMMPKLKP HHHHHHHHHCCCCCC	20.50	26051181
2441	Ubiquitination	VCLDIIYKMMPKLKP HHHHHHHHHCCCCCC	20.50	21963094
2445	Acetylation	IIYKMMPKLKPVELR HHHHHCCCCCCHHHH	51.77	7481395
2445	Ubiquitination	IIYKMMPKLKPVELR HHHHHCCCCCCHHHH	51.77	22817900
2447	Ubiquitination	YKMMPKLKPVELREL HHHCCCCCCHHHHHH	53.82	27667366
2447 (in isoform 1)	Ubiquitination	-	53.82	21890473
2447 (in isoform 2)	Ubiquitination	-	53.82	21890473
2463	Phosphorylation	NPVVEFVSHPSTTCR CHHHHHHCCCCCHHH	34.69	28348404
2489	Phosphorylation	DNYRDPESETDNDSQ CCCCCCCCCCCCCHH	51.70	20873877
2491	Phosphorylation	YRDPESETDNDSQEI CCCCCCCCCCCHHHH	49.75	20873877
2500	Ubiquitination	NDSQEIFKLAKDVLI CCHHHHHHHHHHHHH	53.87	23503661
2503	Ubiquitination	QEIFKLAKDVLIQGL HHHHHHHHHHHHHHH	59.82	33845483
2503 (in isoform 1)	Ubiquitination	-	59.82	21890473
2503 (in isoform 2)	Ubiquitination	-	59.82	21890473
2535	Phosphorylation	ETRLPSNTLDRLLAL CCCCCCCHHHHHHHH	34.08	20071362
2544	Phosphorylation	DRLLALNSLYSPKIE HHHHHHHHCCCCCCC	29.54	23186163
2546	Phosphorylation	LLALNSLYSPKIEVH HHHHHHCCCCCCCHH	23.81	28152594
2546 (in isoform 2)	Phosphorylation	-	23.81	-
2547	Phosphorylation	LALNSLYSPKIEVHF HHHHHCCCCCCCHHH	25.63	28152594
2549	Ubiquitination	LNSLYSPKIEVHFLS HHHCCCCCCCHHHHH	45.63	-
2599	Phosphorylation	DSDWRFRSTVLTPMF CCCCCEEHHCEECEE	21.84	29255136
2599 (in isoform 2)	Phosphorylation	-	21.84	-
2600	Phosphorylation	SDWRFRSTVLTPMFV CCCCEEHHCEECEEE	18.45	29255136
2603	Phosphorylation	RFRSTVLTPMFVETQ CEEHHCEECEEEEEE	14.36	29255136
2603 (in isoform 2)	Phosphorylation	-	14.36	-
2609	Phosphorylation	LTPMFVETQASQGTL EECEEEEEECCCCCE	24.92	29255136
2609 (in isoform 2)	Phosphorylation	-	24.92	-
2612	Phosphorylation	MFVETQASQGTLQTR EEEEEECCCCCEEEE	21.23	29255136
2612 (in isoform 2)	Phosphorylation	-	21.23	-
2615	Phosphorylation	ETQASQGTLQTRTQE EEECCCCCEEEECCC	14.20	30266825
2618	Phosphorylation	ASQGTLQTRTQEGSL CCCCCEEEECCCCCC	38.50	30266825
2620	Phosphorylation	QGTLQTRTQEGSLSA CCCEEEECCCCCCCE	34.07	17158925
2624	O-linked_Glycosylation	QTRTQEGSLSARWPV EEECCCCCCCEECCC	20.56	23301498
2624	Phosphorylation	QTRTQEGSLSARWPV EEECCCCCCCEECCC	20.56	17158925
2626	Phosphorylation	RTQEGSLSARWPVAG ECCCCCCCEECCCCC	19.93	23663014
2638	Phosphorylation	VAGQIRATQQQHDFT CCCEEEEECCCCCEE	19.64	17525332
2638 (in isoform 2)	Phosphorylation	-	19.64	-
2645	Phosphorylation	TQQQHDFTLTQTADG ECCCCCEEEEEECCC	34.65	30266825
2645 (in isoform 2)	Phosphorylation	-	34.65	-
2647	Phosphorylation	QQHDFTLTQTADGRS CCCCEEEEEECCCCC	22.33	17525332
2647 (in isoform 2)	Phosphorylation	-	22.33	-
2649	Phosphorylation	HDFTLTQTADGRSSF CCEEEEEECCCCCCC	22.83	30266825
2654	Phosphorylation	TQTADGRSSFDWLTG EEECCCCCCCCCCCC	40.67	21712546
2655	Phosphorylation	QTADGRSSFDWLTGS EECCCCCCCCCCCCC	26.34	21712546
2660	Phosphorylation	RSSFDWLTGSSTDPL CCCCCCCCCCCCCCC	30.66	24732914
2662	Phosphorylation	SFDWLTGSSTDPLVD CCCCCCCCCCCCCCC	25.48	30183078
2663	Phosphorylation	FDWLTGSSTDPLVDH CCCCCCCCCCCCCCC	37.87	30183078
2664	Phosphorylation	DWLTGSSTDPLVDHT CCCCCCCCCCCCCCC	43.25	30175587
2671	Phosphorylation	TDPLVDHTSPSSDSL CCCCCCCCCCCCCCC	37.56	23401153
2671 (in isoform 2)	Phosphorylation	-	37.56	-
2672	Phosphorylation	DPLVDHTSPSSDSLL CCCCCCCCCCCCCCH	21.26	25159151
2672 (in isoform 2)	Phosphorylation	-	21.26	-
2674	Phosphorylation	LVDHTSPSSDSLLFA CCCCCCCCCCCCHHH	46.69	25159151
2674 (in isoform 2)	Phosphorylation	-	46.69	-
2675	Phosphorylation	VDHTSPSSDSLLFAH CCCCCCCCCCCHHHH	34.30	25159151
2675 (in isoform 2)	Phosphorylation	-	34.30	-
2677	Phosphorylation	HTSPSSDSLLFAHKR CCCCCCCCCHHHHHH	28.99	21712546
2677 (in isoform 2)	Phosphorylation	-	28.99	-
2683	Acetylation	DSLLFAHKRSERLQR CCCHHHHHHHHHHHC	54.94	25953088
2683	Ubiquitination	DSLLFAHKRSERLQR CCCHHHHHHHHHHHC	54.94	21963094
2683 (in isoform 1)	Ubiquitination	-	54.94	21890473
2683 (in isoform 2)	Ubiquitination	-	54.94	21890473
2694	Acetylation	RLQRAPLKSVGPDFG HHHCCCCCCCCCCCC	41.87	25953088
2694	Methylation	RLQRAPLKSVGPDFG HHHCCCCCCCCCCCC	41.87	-
2694	Ubiquitination	RLQRAPLKSVGPDFG HHHCCCCCCCCCCCC	41.87	33845483
2694 (in isoform 1)	Ubiquitination	-	41.87	21890473
2694 (in isoform 2)	Ubiquitination	-	41.87	21890473
2695	Phosphorylation	LQRAPLKSVGPDFGK HHCCCCCCCCCCCCC	39.73	25159151
2702	2-Hydroxyisobutyrylation	SVGPDFGKKRLGLPG CCCCCCCCCCCCCCC	34.41	-
2702	Acetylation	SVGPDFGKKRLGLPG CCCCCCCCCCCCCCC	34.41	19608861
2702	Malonylation	SVGPDFGKKRLGLPG CCCCCCCCCCCCCCC	34.41	26320211
2702	Methylation	SVGPDFGKKRLGLPG CCCCCCCCCCCCCCC	34.41	-
2702	Ubiquitination	SVGPDFGKKRLGLPG CCCCCCCCCCCCCCC	34.41	27667366
2702 (in isoform 1)	Ubiquitination	-	34.41	21890473
2702 (in isoform 2)	Acetylation	-	34.41	-
2702 (in isoform 2)	Ubiquitination	-	34.41	21890473
2703	Methylation	VGPDFGKKRLGLPGD CCCCCCCCCCCCCCH	53.91	-
2703	Ubiquitination	VGPDFGKKRLGLPGD CCCCCCCCCCCCCCH	53.91	22817900
2704	Methylation	GPDFGKKRLGLPGDE CCCCCCCCCCCCCHH	37.16	-
2715	Acetylation	PGDEVDNKVKGAAGR CCHHHCHHHCCCCCC	40.64	25953088
2715	Malonylation	PGDEVDNKVKGAAGR CCHHHCHHHCCCCCC	40.64	26320211
2715	Ubiquitination	PGDEVDNKVKGAAGR CCHHHCHHHCCCCCC	40.64	27667366
2715 (in isoform 1)	Ubiquitination	-	40.64	21890473
2715 (in isoform 2)	Ubiquitination	-	40.64	21890473
2717	Ubiquitination	DEVDNKVKGAAGRTD HHHCHHHCCCCCCHH	44.43	22817900
2738	2-Hydroxyisobutyrylation	RFMRDQEKLSLMYAR HHHHHHHHHHHHHHH	37.43	-
2738	Acetylation	RFMRDQEKLSLMYAR HHHHHHHHHHHHHHH	37.43	23954790
2738	Malonylation	RFMRDQEKLSLMYAR HHHHHHHHHHHHHHH	37.43	26320211
2738	Ubiquitination	RFMRDQEKLSLMYAR HHHHHHHHHHHHHHH	37.43	23000965
2740	Phosphorylation	MRDQEKLSLMYARKG HHHHHHHHHHHHHHC	23.35	28857561
2743	Phosphorylation	QEKLSLMYARKGVAE HHHHHHHHHHHCHHH	14.46	19060867
2743 (in isoform 2)	Phosphorylation	-	14.46	-
2746	Acetylation	LSLMYARKGVAEQKR HHHHHHHHCHHHHHH	49.95	26051181
2746	Methylation	LSLMYARKGVAEQKR HHHHHHHHCHHHHHH	49.95	23748837
2746	Ubiquitination	LSLMYARKGVAEQKR HHHHHHHHCHHHHHH	49.95	29967540
2752	2-Hydroxyisobutyrylation	RKGVAEQKREKEIKS HHCHHHHHHHHHHHH	54.77	-
2752	Acetylation	RKGVAEQKREKEIKS HHCHHHHHHHHHHHH	54.77	26051181
2752	Ubiquitination	RKGVAEQKREKEIKS HHCHHHHHHHHHHHH	54.77	24816145
2755	Ubiquitination	VAEQKREKEIKSELK HHHHHHHHHHHHHHC	69.63	-
2758	Sumoylation	QKREKEIKSELKMKQ HHHHHHHHHHHCHHC	38.68	-
2758	Acetylation	QKREKEIKSELKMKQ HHHHHHHHHHHCHHC	38.68	25953088
2758	Malonylation	QKREKEIKSELKMKQ HHHHHHHHHHHCHHC	38.68	26320211
2758	Ubiquitination	QKREKEIKSELKMKQ HHHHHHHHHHHCHHC	38.68	27667366
2762	Ubiquitination	KEIKSELKMKQDAQV HHHHHHHCHHCCCEE	39.74	22817900
2763	Sulfoxidation	EIKSELKMKQDAQVV HHHHHHCHHCCCEEE	8.03	28183972
2764	Malonylation	IKSELKMKQDAQVVL HHHHHCHHCCCEEEE	43.36	26320211
2764	Ubiquitination	IKSELKMKQDAQVVL HHHHHCHHCCCEEEE	43.36	21963094
2764 (in isoform 1)	Ubiquitination	-	43.36	21890473
2764 (in isoform 2)	Ubiquitination	-	43.36	21890473
2786	2-Hydroxyisobutyrylation	DLPDIQIKHSSLITP CCCCCEEECHHHCCH	22.51	-
2786	Acetylation	DLPDIQIKHSSLITP CCCCCEEECHHHCCH	22.51	25953088
2786	Ubiquitination	DLPDIQIKHSSLITP CCCCCEEECHHHCCH	22.51	21963094
2786 (in isoform 1)	Ubiquitination	-	22.51	21890473
2786 (in isoform 2)	Ubiquitination	-	22.51	21890473
2788	Phosphorylation	PDIQIKHSSLITPLQ CCCEEECHHHCCHHH	23.10	28450419
2789	Phosphorylation	DIQIKHSSLITPLQA CCEEECHHHCCHHHH	24.42	25159151
2789 (in isoform 2)	Phosphorylation	-	24.42	-
2792	Phosphorylation	IKHSSLITPLQAVAQ EECHHHCCHHHHHHH	24.20	28450419
2792 (in isoform 2)	Phosphorylation	-	24.20	-
2806	Ubiquitination	QRDPIIAKQLFSSLF HCCHHHHHHHHHHHH	36.81	21963094
2806 (in isoform 1)	Ubiquitination	-	36.81	21890473
2806 (in isoform 2)	Ubiquitination	-	36.81	21890473
2814	Phosphorylation	QLFSSLFSGILKEMD HHHHHHHHHHHHHHH	30.16	-
2818	Ubiquitination	SLFSGILKEMDKFKT HHHHHHHHHHHHHCC	49.42	32015554
2824	Ubiquitination	LKEMDKFKTLSEKNN HHHHHHHCCHHHHCC	55.06	29967540
2827	Phosphorylation	MDKFKTLSEKNNITQ HHHHCCHHHHCCHHH	52.32	23312004
2829	Acetylation	KFKTLSEKNNITQKL HHCCHHHHCCHHHHH	52.50	25953088
2829	Ubiquitination	KFKTLSEKNNITQKL HHCCHHHHCCHHHHH	52.50	23000965
2829 (in isoform 1)	Ubiquitination	-	52.50	21890473
2829 (in isoform 2)	Ubiquitination	-	52.50	21890473
2835	Acetylation	EKNNITQKLLQDFNR HHCCHHHHHHHHHHH	42.38	25953088
2835	Ubiquitination	EKNNITQKLLQDFNR HHCCHHHHHHHHHHH	42.38	23000965
2835 (in isoform 1)	Ubiquitination	-	42.38	21890473
2835 (in isoform 2)	Ubiquitination	-	42.38	21890473
2908	2-Hydroxyisobutyrylation	LPAELPAKRVRGKAR CCCCCCCCHHCCCCC	49.87	-
2908	Acetylation	LPAELPAKRVRGKAR CCCCCCCCHHCCCCC	49.87	25953088
2908	Malonylation	LPAELPAKRVRGKAR CCCCCCCCHHCCCCC	49.87	26320211
2908	Ubiquitination	LPAELPAKRVRGKAR CCCCCCCCHHCCCCC	49.87	23000965
2908 (in isoform 1)	Ubiquitination	-	49.87	21890473
2908 (in isoform 2)	Ubiquitination	-	49.87	21890473
2913	Ubiquitination	PAKRVRGKARLPPDV CCCHHCCCCCCCHHH	21.55	23000965
2928	2-Hydroxyisobutyrylation	LRWVELAKLYRSIGE HHHHHHHHHHHHHCC	59.69	-
2928	Acetylation	LRWVELAKLYRSIGE HHHHHHHHHHHHHCC	59.69	26051181
2928	Ubiquitination	LRWVELAKLYRSIGE HHHHHHHHHHHHHCC	59.69	23000965
2928 (in isoform 1)	Ubiquitination	-	59.69	21890473
2928 (in isoform 2)	Ubiquitination	-	59.69	21890473
2932	Phosphorylation	ELAKLYRSIGEYDVL HHHHHHHHHCCHHHH	22.76	28796482
2936	Phosphorylation	LYRSIGEYDVLRGIF HHHHHCCHHHHHCHH	13.21	28796482
2940	Methylation	IGEYDVLRGIFTSEI HCCHHHHHCHHHCCC	35.69	-
2944	Phosphorylation	DVLRGIFTSEIGTKQ HHHHCHHHCCCCCHH	24.43	28674419
2945	Phosphorylation	VLRGIFTSEIGTKQI HHHCHHHCCCCCHHH	19.23	20860994
2950	Ubiquitination	FTSEIGTKQITQSAL HHCCCCCHHHHHHHH	34.19	27667366
2950 (in isoform 1)	Ubiquitination	-	34.19	21890473
2950 (in isoform 2)	Ubiquitination	-	34.19	21890473
2953	Phosphorylation	EIGTKQITQSALLAE CCCCHHHHHHHHHHH	17.61	21406692
2955	Phosphorylation	GTKQITQSALLAEAR CCHHHHHHHHHHHHH	16.54	21406692
2963	Phosphorylation	ALLAEARSDYSEAAK HHHHHHHCCHHHHHH	48.20	27642862
2965	Phosphorylation	LAEARSDYSEAAKQY HHHHHCCHHHHHHHH	15.06	28796482
2966	Phosphorylation	AEARSDYSEAAKQYD HHHHCCHHHHHHHHH	26.25	28796482
2970	Acetylation	SDYSEAAKQYDEALN CCHHHHHHHHHHHHH	57.34	23236377
2970	Ubiquitination	SDYSEAAKQYDEALN CCHHHHHHHHHHHHH	57.34	21963094
2970 (in isoform 1)	Ubiquitination	-	57.34	21890473
2970 (in isoform 2)	Ubiquitination	-	57.34	21890473
2972	Phosphorylation	YSEAAKQYDEALNKQ HHHHHHHHHHHHHCC	18.29	27642862
2978	Ubiquitination	QYDEALNKQDWVDGE HHHHHHHCCCCCCCC	50.95	27667366
2978 (in isoform 1)	Ubiquitination	-	50.95	21890473
2978 (in isoform 2)	Ubiquitination	-	50.95	21890473
2987	Phosphorylation	DWVDGEPTEAEKDFW CCCCCCCCHHHHHHH	43.45	-
2991	Ubiquitination	GEPTEAEKDFWELAS CCCCHHHHHHHHHHH	66.33	29967540
2998	Phosphorylation	KDFWELASLDCYNHL HHHHHHHHHHHHHHH	37.05	28450419
3010	Phosphorylation	NHLAEWKSLEYCSTA HHHHHCCCCCHHCCC	27.75	29507054
3013	Phosphorylation	AEWKSLEYCSTASID HHCCCCCHHCCCCCC	9.29	29449344
3014	Glutathionylation	EWKSLEYCSTASIDS HCCCCCHHCCCCCCC	1.81	22555962
3015	Phosphorylation	WKSLEYCSTASIDSE CCCCCHHCCCCCCCC	26.55	25159151
3016	Phosphorylation	KSLEYCSTASIDSEN CCCCHHCCCCCCCCC	22.36	25159151
3018	Phosphorylation	LEYCSTASIDSENPP CCHHCCCCCCCCCCC	27.32	25159151
3021	Phosphorylation	CSTASIDSENPPDLN HCCCCCCCCCCCCHH	37.29	26657352
3050	Ubiquitination	YMIRSKLKLLLQGEA HHHHHHHHHHHCCCC	40.60	-
3050 (in isoform 1)	Ubiquitination	-	40.60	21890473
3050 (in isoform 2)	Ubiquitination	-	40.60	21890473
3067	Neddylation	SLLTFIDKAMHGELQ HHHHHHHHHHCHHHH	42.67	32015554
3067	Ubiquitination	SLLTFIDKAMHGELQ HHHHHHHHHHCHHHH	42.67	23503661
3067 (in isoform 1)	Ubiquitination	-	42.67	21890473
3067 (in isoform 2)	Ubiquitination	-	42.67	21890473
3069	Sulfoxidation	LTFIDKAMHGELQKA HHHHHHHHCHHHHHH	5.27	30846556
3075	Ubiquitination	AMHGELQKAILELHY HHCHHHHHHHHHHHH	50.44	-
3101	Phosphorylation	DDVDRAKYYIQNGIQ CCHHHHHHHHHHHHH	12.57	25002506
3102	Phosphorylation	DVDRAKYYIQNGIQS CHHHHHHHHHHHHHH	8.70	25002506
3109	Phosphorylation	YIQNGIQSFMQNYSS HHHHHHHHHHHCHHH	22.29	25002506
3114	Phosphorylation	IQSFMQNYSSIDVLL HHHHHHCHHHHHHHH	6.21	25002506
3115	Phosphorylation	QSFMQNYSSIDVLLH HHHHHCHHHHHHHHH	28.50	25002506
3116	Phosphorylation	SFMQNYSSIDVLLHQ HHHHCHHHHHHHHHH	16.67	25002506
3124	Phosphorylation	IDVLLHQSRLTKLQS HHHHHHHHHHHHHHH	20.64	25002506
3127	Phosphorylation	LLHQSRLTKLQSVQA HHHHHHHHHHHHHHH	28.71	25002506
3128	Ubiquitination	LHQSRLTKLQSVQAL HHHHHHHHHHHHHHH	49.47	33845483
3147	Ubiquitination	EFISFISKQGNLSSQ HHHHHHHHCCCCCCC	58.36	-
3158	Acetylation	LSSQVPLKRLLNTWT CCCCCCHHHHHHHHH	34.62	26051181
3158	Ubiquitination	LSSQVPLKRLLNTWT CCCCCCHHHHHHHHH	34.62	27667366
3158 (in isoform 1)	Ubiquitination	-	34.62	21890473
3158 (in isoform 2)	Ubiquitination	-	34.62	21890473
3163	Phosphorylation	PLKRLLNTWTNRYPD CHHHHHHHHHHCCCC	33.37	27067055
3165	Phosphorylation	KRLLNTWTNRYPDAK HHHHHHHHHCCCCCC	14.05	28152594
3167	Methylation	LLNTWTNRYPDAKMD HHHHHHHCCCCCCCC	36.67	-
3168	Phosphorylation	LNTWTNRYPDAKMDP HHHHHHCCCCCCCCC	13.92	28152594
3172	Ubiquitination	TNRYPDAKMDPMNIW HHCCCCCCCCCCCHH	51.74	21963094
3172 (in isoform 1)	Ubiquitination	-	51.74	21890473
3172 (in isoform 2)	Ubiquitination	-	51.74	21890473
3173	Sulfoxidation	NRYPDAKMDPMNIWD HCCCCCCCCCCCHHH	8.19	28183972
3176	Sulfoxidation	PDAKMDPMNIWDDII CCCCCCCCCHHHHHH	5.04	28183972
3187	S-nitrosocysteine	DDIITNRCFFLSKIE HHHHHHCCHHHHHHH	2.83	-
3187	Glutathionylation	DDIITNRCFFLSKIE HHHHHHCCHHHHHHH	2.83	22555962
3187	S-nitrosylation	DDIITNRCFFLSKIE HHHHHHCCHHHHHHH	2.83	19483679
3191	Phosphorylation	TNRCFFLSKIEEKLT HHCCHHHHHHHHHCC	26.82	29083192
3192	Acetylation	NRCFFLSKIEEKLTP HCCHHHHHHHHHCCC	57.17	26051181
3192	Ubiquitination	NRCFFLSKIEEKLTP HCCHHHHHHHHHCCC	57.17	21963094
3192 (in isoform 1)	Ubiquitination	-	57.17	21890473
3192 (in isoform 2)	Ubiquitination	-	57.17	21890473
3196	Ubiquitination	FLSKIEEKLTPLPED HHHHHHHHCCCCCCC	44.89	21963094
3196 (in isoform 1)	Ubiquitination	-	44.89	21890473
3196 (in isoform 2)	Ubiquitination	-	44.89	21890473
3198	Phosphorylation	SKIEEKLTPLPEDNS HHHHHHCCCCCCCCC	33.57	22167270
3205	Phosphorylation	TPLPEDNSMNVDQDG CCCCCCCCCCCCCCC	24.85	29255136
3205 (in isoform 2)	Phosphorylation	-	24.85	-
3206	Sulfoxidation	PLPEDNSMNVDQDGD CCCCCCCCCCCCCCC	7.70	21406390
3215	Phosphorylation	VDQDGDPSDRMEVQE CCCCCCHHHHHHHHH	42.46	22167270
3217	Methylation	QDGDPSDRMEVQEQE CCCCHHHHHHHHHHH	27.74	-
3228	Phosphorylation	QEQEEDISSLIRSCK HHHHHHHHHHHHHCH	31.26	20639409
3229	Phosphorylation	EQEEDISSLIRSCKF HHHHHHHHHHHHCHH	28.31	20639409
3233	Phosphorylation	DISSLIRSCKFSMKM HHHHHHHHCHHHHHH	18.05	20068230
3233 (in isoform 2)	Phosphorylation	-	18.05	-
3235	Acetylation	SSLIRSCKFSMKMKM HHHHHHCHHHHHHHH	41.54	25953088
3235	Ubiquitination	SSLIRSCKFSMKMKM HHHHHHCHHHHHHHH	41.54	23000965
3237	Phosphorylation	LIRSCKFSMKMKMID HHHHCHHHHHHHHHH	11.73	24719451
3239	Acetylation	RSCKFSMKMKMIDSA HHCHHHHHHHHHHHH	33.88	18527209
3239	Ubiquitination	RSCKFSMKMKMIDSA HHCHHHHHHHHHHHH	33.88	23000965
3241	Acetylation	CKFSMKMKMIDSARK CHHHHHHHHHHHHHH	27.47	19608861
3241	Malonylation	CKFSMKMKMIDSARK CHHHHHHHHHHHHHH	27.47	26320211
3241	Ubiquitination	CKFSMKMKMIDSARK CHHHHHHHHHHHHHH	27.47	23000965
3241 (in isoform 2)	Acetylation	-	27.47	-
3248	Acetylation	KMIDSARKQNNFSLA HHHHHHHHCCCHHHH	58.03	26051181
3248	Malonylation	KMIDSARKQNNFSLA HHHHHHHHCCCHHHH	58.03	26320211
3248	Methylation	KMIDSARKQNNFSLA HHHHHHHHCCCHHHH	58.03	23748837
3248	Ubiquitination	KMIDSARKQNNFSLA HHHHHHHHCCCHHHH	58.03	16196087
3248 (in isoform 1)	Ubiquitination	-	58.03	21890473
3248 (in isoform 2)	Ubiquitination	-	58.03	21890473
3253	Phosphorylation	ARKQNNFSLAMKLLK HHHCCCHHHHHHHHH	19.83	25159151
3257	Acetylation	NNFSLAMKLLKELHK CCHHHHHHHHHHHHH	45.09	26051181
3257	Ubiquitination	NNFSLAMKLLKELHK CCHHHHHHHHHHHHH	45.09	23000965
3257 (in isoform 1)	Ubiquitination	-	45.09	21890473
3257 (in isoform 2)	Ubiquitination	-	45.09	21890473
3260	2-Hydroxyisobutyrylation	SLAMKLLKELHKESK HHHHHHHHHHHHHCC	69.53	-
3260	Acetylation	SLAMKLLKELHKESK HHHHHHHHHHHHHCC	69.53	19608861
3260	Malonylation	SLAMKLLKELHKESK HHHHHHHHHHHHHCC	69.53	26320211
3260	Ubiquitination	SLAMKLLKELHKESK HHHHHHHHHHHHHCC	69.53	23000965
3260 (in isoform 2)	Acetylation	-	69.53	-
3264	2-Hydroxyisobutyrylation	KLLKELHKESKTRDD HHHHHHHHHCCCCHH	76.06	-
3264	Ubiquitination	KLLKELHKESKTRDD HHHHHHHHHCCCCHH	76.06	29967540
3264 (in isoform 1)	Ubiquitination	-	76.06	21890473
3264 (in isoform 2)	Ubiquitination	-	76.06	21890473
3267	Acetylation	KELHKESKTRDDWLV HHHHHHCCCCHHHHH	48.98	26051181
3288	Phosphorylation	CRLSHCRSRSQGCSE HHHHHHHHHCCCCHH	41.50	28450419
3290	Phosphorylation	LSHCRSRSQGCSEQV HHHHHHHCCCCHHHH	31.97	28450419
3293	Glutathionylation	CRSRSQGCSEQVLTV HHHHCCCCHHHHHHH	2.91	22555962
3293	S-nitrosylation	CRSRSQGCSEQVLTV HHHHCCCCHHHHHHH	2.91	2212679
3294	Phosphorylation	RSRSQGCSEQVLTVL HHHCCCCHHHHHHHH	37.58	28450419
3299	Phosphorylation	GCSEQVLTVLKTVSL CCHHHHHHHHHHHHH	25.57	25072903
3302	Ubiquitination	EQVLTVLKTVSLLDE HHHHHHHHHHHHCCC	42.41	-
3303	Phosphorylation	QVLTVLKTVSLLDEN HHHHHHHHHHHCCCC	15.92	21601212
3313	O-linked_Glycosylation	LLDENNVSSYLSKNI HCCCCCHHHHHHHCC	18.52	23301498
3313	Phosphorylation	LLDENNVSSYLSKNI HCCCCCHHHHHHHCC	18.52	28152594
3314	Phosphorylation	LDENNVSSYLSKNIL CCCCCHHHHHHHCCH	26.30	28152594
3315	Phosphorylation	DENNVSSYLSKNILA CCCCHHHHHHHCCHH	13.90	28152594
3317	Phosphorylation	NNVSSYLSKNILAFR CCHHHHHHHCCHHHC	18.54	28152594
3318	Ubiquitination	NVSSYLSKNILAFRD CHHHHHHHCCHHHCC	45.47	21963094
3318 (in isoform 1)	Ubiquitination	-	45.47	21890473
3318 (in isoform 2)	Ubiquitination	-	45.47	21890473
3347	S-nitrosocysteine	ALSSEPACLAEIEED HHCCCCCHHHHCCHH	5.60	-
3347	Glutathionylation	ALSSEPACLAEIEED HHCCCCCHHHHCCHH	5.60	22555962
3347	S-nitrosylation	ALSSEPACLAEIEED HHCCCCCHHHHCCHH	5.60	19483679
3355	Acetylation	LAEIEEDKARRILEL HHHCCHHHHHHHHHH	47.26	23749302
3355	Malonylation	LAEIEEDKARRILEL HHHCCHHHHHHHHHH	47.26	26320211
3355	Ubiquitination	LAEIEEDKARRILEL HHHCCHHHHHHHHHH	47.26	21963094
3363	Phosphorylation	ARRILELSGSSSEDS HHHHHHHCCCCCCCH	27.53	20068231
3365	Phosphorylation	RILELSGSSSEDSEK HHHHHCCCCCCCHHH	27.58	20068231
3365 (in isoform 2)	Phosphorylation	-	27.58	-
3366	Phosphorylation	ILELSGSSSEDSEKV HHHHCCCCCCCHHHH	41.07	25159151
3367	Phosphorylation	LELSGSSSEDSEKVI HHHCCCCCCCHHHHH	47.31	25159151
3370	Phosphorylation	SGSSSEDSEKVIAGL CCCCCCCHHHHHHHH	34.95	20068231
3372	2-Hydroxyisobutyrylation	SSSEDSEKVIAGLYQ CCCCCHHHHHHHHHH	42.78	-
3372	Acetylation	SSSEDSEKVIAGLYQ CCCCCHHHHHHHHHH	42.78	26051181
3372	Methylation	SSSEDSEKVIAGLYQ CCCCCHHHHHHHHHH	42.78	-
3372	Ubiquitination	SSSEDSEKVIAGLYQ CCCCCHHHHHHHHHH	42.78	21963094
3372 (in isoform 1)	Ubiquitination	-	42.78	21890473
3372 (in isoform 2)	Ubiquitination	-	42.78	21890473
3378	Phosphorylation	EKVIAGLYQRAFQHL HHHHHHHHHHHHHHH	8.60	28152594
3426	Ubiquitination	FCDQQLRKEEENASV HHHHHHHHHHHCCCC	77.42	29967540
3426 (in isoform 1)	Ubiquitination	-	77.42	21890473
3426 (in isoform 2)	Ubiquitination	-	77.42	21890473
3432	Phosphorylation	RKEEENASVIDSAEL HHHHHCCCCCCHHHH	31.05	25159151
3436	Phosphorylation	ENASVIDSAELQAYP HCCCCCCHHHHHHHH	16.72	29449344
3449	Ubiquitination	YPALVVEKMLKALKL HHHHHHHHHHHHHCC	37.61	21963094
3449 (in isoform 1)	Ubiquitination	-	37.61	21890473
3449 (in isoform 2)	Ubiquitination	-	37.61	21890473
3452	Ubiquitination	LVVEKMLKALKLNSN HHHHHHHHHHCCCCC	48.45	22817900
3455	2-Hydroxyisobutyrylation	EKMLKALKLNSNEAR HHHHHHHCCCCCHHH	50.94	-
3455	Acetylation	EKMLKALKLNSNEAR HHHHHHHCCCCCHHH	50.94	26822725
3455	Malonylation	EKMLKALKLNSNEAR HHHHHHHCCCCCHHH	50.94	26320211
3455	Ubiquitination	EKMLKALKLNSNEAR HHHHHHHCCCCCHHH	50.94	27667366
3455 (in isoform 1)	Ubiquitination	-	50.94	21890473
3455 (in isoform 2)	Ubiquitination	-	50.94	21890473
3475	Phosphorylation	LLQIIERYPEETLSL HHHHHHHCCHHHHHH	11.38	20860994
3479	Phosphorylation	IERYPEETLSLMTKE HHHCCHHHHHHHHHH	21.71	20860994
3483	Sulfoxidation	PEETLSLMTKEISSV CHHHHHHHHHHCCCC	4.52	21406390
3489	Phosphorylation	LMTKEISSVPCWQFI HHHHHCCCCCHHHHH	35.42	-
3497	Phosphorylation	VPCWQFISWISHMVA CCHHHHHHHHHHHHH	21.46	-
3500	Phosphorylation	WQFISWISHMVALLD HHHHHHHHHHHHHCC	10.16	-
3543	Ubiquitination	SSESYSFKDTSTGHK ECCCCCCCCCCCCCC	54.90	29967540
3550	Ubiquitination	KDTSTGHKNKEFVAR CCCCCCCCCHHHHHH	71.68	23000965
3552	Acetylation	TSTGHKNKEFVARIK CCCCCCCHHHHHHHH	58.28	25825284
3552	Malonylation	TSTGHKNKEFVARIK CCCCCCCHHHHHHHH	58.28	26320211
3552	Ubiquitination	TSTGHKNKEFVARIK CCCCCCCHHHHHHHH	58.28	23000965
3552 (in isoform 1)	Ubiquitination	-	58.28	21890473
3552 (in isoform 2)	Ubiquitination	-	58.28	21890473
3593	Methylation	KDWSNDVRAELAKTP CCCCHHHHHHHHCCC	25.80	-
3598	2-Hydroxyisobutyrylation	DVRAELAKTPVNKKN HHHHHHHCCCCCHHH	67.02	-
3598	Ubiquitination	DVRAELAKTPVNKKN HHHHHHHCCCCCHHH	67.02	24816145
3599	Phosphorylation	VRAELAKTPVNKKNI HHHHHHCCCCCHHHH	27.19	23312004
3608	Acetylation	VNKKNIEKMYERMYA CCHHHHHHHHHHHHH	42.88	19608861
3608	Malonylation	VNKKNIEKMYERMYA CCHHHHHHHHHHHHH	42.88	26320211
3608	Ubiquitination	VNKKNIEKMYERMYA CCHHHHHHHHHHHHH	42.88	29967540
3608 (in isoform 2)	Acetylation	-	42.88	-
3614	Phosphorylation	EKMYERMYAALGDPK HHHHHHHHHHHCCCC	8.57	27642862
3621	2-Hydroxyisobutyrylation	YAALGDPKAPGLGAF HHHHCCCCCCCCHHH	72.46	-
3621	Acetylation	YAALGDPKAPGLGAF HHHHCCCCCCCCHHH	72.46	19608861
3621	Ubiquitination	YAALGDPKAPGLGAF HHHHCCCCCCCCHHH	72.46	29967540
3621 (in isoform 1)	Ubiquitination	-	72.46	21890473
3621 (in isoform 2)	Acetylation	-	72.46	-
3621 (in isoform 2)	Ubiquitination	-	72.46	21890473
3631	Acetylation	GLGAFRRKFIQTFGK CCHHHHHHHHHHHHH	42.43	25953088
3631	Malonylation	GLGAFRRKFIQTFGK CCHHHHHHHHHHHHH	42.43	26320211
3631	Ubiquitination	GLGAFRRKFIQTFGK CCHHHHHHHHHHHHH	42.43	27667366
3638	Acetylation	KFIQTFGKEFDKHFG HHHHHHHHHHHHHCC	51.52	19608861
3638	Malonylation	KFIQTFGKEFDKHFG HHHHHHHHHHHHHCC	51.52	26320211
3638	Ubiquitination	KFIQTFGKEFDKHFG HHHHHHHHHHHHHCC	51.52	33845483
3638 (in isoform 2)	Acetylation	-	51.52	-
3642	Acetylation	TFGKEFDKHFGKGGS HHHHHHHHHCCCCCH	46.27	19608861
3642	Ubiquitination	TFGKEFDKHFGKGGS HHHHHHHHHCCCCCH	46.27	29967540
3642 (in isoform 2)	Acetylation	-	46.27	-
3646	Ubiquitination	EFDKHFGKGGSKLLR HHHHHCCCCCHHHHH	60.19	29967540
3650	Acetylation	HFGKGGSKLLRMKLS HCCCCCHHHHHCCCC	55.61	25953088
3650	Malonylation	HFGKGGSKLLRMKLS HCCCCCHHHHHCCCC	55.61	26320211
3650	Ubiquitination	HFGKGGSKLLRMKLS HCCCCCHHHHHCCCC	55.61	27667366
3655	Ubiquitination	GSKLLRMKLSDFNDI CHHHHHCCCCCCCHH	38.10	22505724
3657	Phosphorylation	KLLRMKLSDFNDITN HHHHCCCCCCCHHHH	34.34	21406692
3663	Phosphorylation	LSDFNDITNMLLLKM CCCCCHHHHHHHHHH	19.89	21406692
3665	Sulfoxidation	DFNDITNMLLLKMNK CCCHHHHHHHHHHCC	1.77	21406390
3669	Acetylation	ITNMLLLKMNKDSKP HHHHHHHHHCCCCCC	40.16	23236377
3669	Ubiquitination	ITNMLLLKMNKDSKP HHHHHHHHHCCCCCC	40.16	21963094
3669 (in isoform 1)	Ubiquitination	-	40.16	21890473
3669 (in isoform 2)	Ubiquitination	-	40.16	21890473
3672	Ubiquitination	MLLLKMNKDSKPPGN HHHHHHCCCCCCCCC	60.94	22817900
3675	Acetylation	LKMNKDSKPPGNLKE HHHCCCCCCCCCHHH	66.42	26051181
3675	Ubiquitination	LKMNKDSKPPGNLKE HHHCCCCCCCCCHHH	66.42	23503661
3681	Acetylation	SKPPGNLKECSPWMS CCCCCCHHHCCCCHH	61.75	26051181
3681	Malonylation	SKPPGNLKECSPWMS CCCCCCHHHCCCCHH	61.75	26320211
3681	Ubiquitination	SKPPGNLKECSPWMS CCCCCCHHHCCCCHH	61.75	29967540
3691	Acetylation	SPWMSDFKVEFLRNE CCCHHHHHHHHHHHC	45.93	23954790
3691	Ubiquitination	SPWMSDFKVEFLRNE CCCHHHHHHHHHHHC	45.93	21963094
3696	Methylation	DFKVEFLRNELEIPG HHHHHHHHHCCCCCC	39.64	-
3705	Phosphorylation	ELEIPGQYDGRGKPL CCCCCCCCCCCCCCC	26.70	28152594
3710	Ubiquitination	GQYDGRGKPLPEYHV CCCCCCCCCCCCEEE	41.86	27667366
3710 (in isoform 1)	Ubiquitination	-	41.86	21890473
3710 (in isoform 2)	Ubiquitination	-	41.86	21890473
3715	Phosphorylation	RGKPLPEYHVRIAGF CCCCCCCEEEEECCC	12.04	28152594
3727	Phosphorylation	AGFDERVTVMASLRR CCCCCCEEHHHHCCC	15.70	21406692
3731	Phosphorylation	ERVTVMASLRRPKRI CCEEHHHHCCCCCEE	12.33	21406692
3753	2-Hydroxyisobutyrylation	REHPFLVKGGEDLRQ CCCCCEEECCHHHCH	64.44	-
3753	Ubiquitination	REHPFLVKGGEDLRQ CCCCCEEECCHHHCH	64.44	27667366
3753 (in isoform 1)	Ubiquitination	-	64.44	21890473
3753 (in isoform 2)	Ubiquitination	-	64.44	21890473
3779	Phosphorylation	NGILAQDSACSQRAL HHHHHCCCHHHHHHH	21.06	-
3781	Glutathionylation	ILAQDSACSQRALQL HHHCCCHHHHHHHHH	4.05	22555962
3784 (in isoform 2)	Dimethylation	-	22.44	-
3791	Phosphorylation	RALQLRTYSVVPMTS HHHHHHCCCCCCCCC	7.95	-
3792	Phosphorylation	ALQLRTYSVVPMTSR HHHHHCCCCCCCCCH	18.94	20860994
3797	Phosphorylation	TYSVVPMTSRLGLIE CCCCCCCCCHHCHHH	12.48	-
3798	Phosphorylation	YSVVPMTSRLGLIEW CCCCCCCCHHCHHHH	21.18	20860994
3802 (in isoform 2)	Dimethylation	-	3.67	-
3809	Ubiquitination	LIEWLENTVTLKDLL HHHHHHHCCCHHHHH	12.90	23000965
3811	Phosphorylation	EWLENTVTLKDLLLN HHHHHCCCHHHHHHH	26.50	-
3814	Ubiquitination	ENTVTLKDLLLNTMS HHCCCHHHHHHHCCC	45.74	23000965
3814 (in isoform 2)	Ubiquitination	-	45.74	21890473
3818	Ubiquitination	TLKDLLLNTMSQEEK CHHHHHHHCCCHHHH	33.43	23000965
3819	Phosphorylation	LKDLLLNTMSQEEKA HHHHHHHCCCHHHHH	20.40	28450419
3821	Phosphorylation	DLLLNTMSQEEKAAY HHHHHCCCHHHHHHH	32.19	25159151
3825	Acetylation	NTMSQEEKAAYLSDP HCCCHHHHHHHHCCC	37.25	26051181
3825	Ubiquitination	NTMSQEEKAAYLSDP HCCCHHHHHHHHCCC	37.25	21963094
3825 (in isoform 1)	Ubiquitination	-	37.25	21890473
3828	Phosphorylation	SQEEKAAYLSDPRAP CHHHHHHHHCCCCCC	16.17	18083107
3829	Ubiquitination	QEEKAAYLSDPRAPP HHHHHHHHCCCCCCC	3.92	23000965
3829 (in isoform 2)	Ubiquitination	-	3.92	21890473
3837	Glutathionylation	SDPRAPPCEYKDWLT CCCCCCCCCCHHHHH	9.69	22555962
3840	2-Hydroxyisobutyrylation	RAPPCEYKDWLTKMS CCCCCCCHHHHHHHC	21.82	-
3840	Acetylation	RAPPCEYKDWLTKMS CCCCCCCHHHHHHHC	21.82	25825284
3840	Ubiquitination	RAPPCEYKDWLTKMS CCCCCCCHHHHHHHC	21.82	23000965
3845	Acetylation	EYKDWLTKMSGKHDV CCHHHHHHHCCCCCH	28.97	25953088
3845	Ubiquitination	EYKDWLTKMSGKHDV CCHHHHHHHCCCCCH	28.97	23000965
3845 (in isoform 1)	Ubiquitination	-	28.97	21890473
3846	Ubiquitination	YKDWLTKMSGKHDVG CHHHHHHHCCCCCHH	5.56	27667366
3849	Ubiquitination	WLTKMSGKHDVGAYM HHHHHCCCCCHHHEE	29.35	23000965
3853	Ubiquitination	MSGKHDVGAYMLMYK HCCCCCHHHEEEEEC	19.63	21963094
3853 (in isoform 2)	Ubiquitination	-	19.63	21890473
3855	Phosphorylation	GKHDVGAYMLMYKGA CCCCHHHEEEEECCC	5.71	-
3859	Phosphorylation	VGAYMLMYKGANRTE HHHEEEEECCCCCCC	11.43	-
3860	Acetylation	GAYMLMYKGANRTET HHEEEEECCCCCCCC	37.27	26051181
3860	Ubiquitination	GAYMLMYKGANRTET HHEEEEECCCCCCCC	37.27	23000965
3860 (in isoform 1)	Ubiquitination	-	37.27	21890473
3865	Phosphorylation	MYKGANRTETVTSFR EECCCCCCCCCCHHH	35.50	23312004
3867	Phosphorylation	KGANRTETVTSFRKR CCCCCCCCCCHHHHC	28.59	23186163
3869	O-linked_Glycosylation	ANRTETVTSFRKRES CCCCCCCCHHHHCCC	29.57	23301498
3869	Phosphorylation	ANRTETVTSFRKRES CCCCCCCCHHHHCCC	29.57	23186163
3870	O-linked_Glycosylation	NRTETVTSFRKRESK CCCCCCCHHHHCCCC	20.79	23301498
3870	Phosphorylation	NRTETVTSFRKRESK CCCCCCCHHHHCCCC	20.79	23401153
3877	Acetylation	SFRKRESKVPADLLK HHHHCCCCCCHHHHH	47.70	25953088
3877	Ubiquitination	SFRKRESKVPADLLK HHHHCCCCCCHHHHH	47.70	27667366
3884	2-Hydroxyisobutyrylation	KVPADLLKRAFVRMS CCCHHHHHHHHHHCC	49.31	-
3884	Acetylation	KVPADLLKRAFVRMS CCCHHHHHHHHHHCC	49.31	26051181
3884	Ubiquitination	KVPADLLKRAFVRMS CCCHHHHHHHHHHCC	49.31	21963094
3884 (in isoform 1)	Ubiquitination	-	49.31	21890473
3890	Sulfoxidation	LKRAFVRMSTSPEAF HHHHHHHCCCCHHHH	4.27	21406390
3891	Phosphorylation	KRAFVRMSTSPEAFL HHHHHHCCCCHHHHH	18.37	24117733
3892	Phosphorylation	RAFVRMSTSPEAFLA HHHHHCCCCHHHHHH	38.67	24117733
3893	Phosphorylation	AFVRMSTSPEAFLAL HHHHCCCCHHHHHHH	17.28	24117733
3950	Phosphorylation	GHAFGSATQFLPVPE CHHCCCCCCCCCCCC	22.88	17158925
3951 (in isoform 2)	Phosphorylation	-	37.28	-
3976	Ubiquitination	NLMLPMKETGLMYSI HHHCCCCHHCHHHHH	41.68	21963094
3976 (in isoform 2)	Ubiquitination	-	41.68	21890473
3977	Phosphorylation	LMLPMKETGLMYSIM HHCCCCHHCHHHHHH	30.05	27050516
3981	Phosphorylation	MKETGLMYSIMVHAL CCHHCHHHHHHHHHH	10.49	20068231
3982	Phosphorylation	KETGLMYSIMVHALR CHHCHHHHHHHHHHH	7.11	20068231
3983	Ubiquitination	ETGLMYSIMVHALRA HHCHHHHHHHHHHHH	1.52	21963094
3988	Ubiquitination	YSIMVHALRAFRSDP HHHHHHHHHHHHCCC	2.15	22817900
3988 (in isoform 2)	Ubiquitination	-	2.15	21890473
3991	Ubiquitination	MVHALRAFRSDPGLL HHHHHHHHHCCCCCC	6.58	23503661
3992	Ubiquitination	VHALRAFRSDPGLLT HHHHHHHHCCCCCCC	38.88	22505724
3992 (in isoform 2)	Ubiquitination	-	38.88	21890473
3993	Phosphorylation	HALRAFRSDPGLLTN HHHHHHHCCCCCCCC	41.52	28192239
3995	Phosphorylation	LRAFRSDPGLLTNTM HHHHHCCCCCCCCCC	36.26	32142685
3995 (in isoform 2)	Phosphorylation	-	36.26	-
3999	Phosphorylation	RSDPGLLTNTMDVFV HCCCCCCCCCCEEEE	33.41	28450419
4002	Sulfoxidation	PGLLTNTMDVFVKEP CCCCCCCCEEEECCC	4.48	21406390
4005	Ubiquitination	LTNTMDVFVKEPSFD CCCCCEEEECCCCCC	5.91	32015554
4005 (in isoform 2)	Ubiquitination	-	5.91	21890473
4007	Acetylation	NTMDVFVKEPSFDWK CCCEEEECCCCCCCC	53.06	26051181
4007	Ubiquitination	NTMDVFVKEPSFDWK CCCEEEECCCCCCCC	53.06	21963094
4007 (in isoform 1)	Ubiquitination	-	53.06	21890473
4012	Ubiquitination	FVKEPSFDWKNFEQK EECCCCCCCCHHHHH	60.83	24816145
4014	Acetylation	KEPSFDWKNFEQKML CCCCCCCCHHHHHHH	54.31	26051181
4014	Ubiquitination	KEPSFDWKNFEQKML CCCCCCCCHHHHHHH	54.31	21963094
4019	2-Hydroxyisobutyrylation	DWKNFEQKMLKKGGS CCCHHHHHHHHHCCC	38.72	-
4019	Ubiquitination	DWKNFEQKMLKKGGS CCCHHHHHHHHHCCC	38.72	22817900
4019 (in isoform 1)	Ubiquitination	-	38.72	21890473
4022	Ubiquitination	NFEQKMLKKGGSWIQ HHHHHHHHHCCCHHH	45.96	23503661
4023	Ubiquitination	FEQKMLKKGGSWIQE HHHHHHHHCCCHHHH	65.62	29967540
4023 (in isoform 1)	Ubiquitination	-	65.62	21890473
4026	Phosphorylation	KMLKKGGSWIQEINV HHHHHCCCHHHHEEC	29.67	19664994
4036	Ubiquitination	QEINVAEKNWYPRQK HHEECCCCCCCCHHH	42.94	29967540
4036 (in isoform 1)	Ubiquitination	-	42.94	21890473
4039	Ubiquitination	NVAEKNWYPRQKICY ECCCCCCCCHHHHHH	9.64	21963094
4043	Ubiquitination	KNWYPRQKICYAKRK CCCCCHHHHHHHHHH	35.70	24816145
4045	S-nitrosocysteine	WYPRQKICYAKRKLA CCCHHHHHHHHHHHC	3.30	-
4045	S-nitrosylation	WYPRQKICYAKRKLA CCCHHHHHHHHHHHC	3.30	19483679
4048	Acetylation	RQKICYAKRKLAGAN HHHHHHHHHHHCCCC	24.48	26051181
4048	Ubiquitination	RQKICYAKRKLAGAN HHHHHHHHHHHCCCC	24.48	-
4050	Ubiquitination	KICYAKRKLAGANPA HHHHHHHHHCCCCCE	41.82	24816145
4054	Ubiquitination	AKRKLAGANPAVITC HHHHHCCCCCEEEEC	17.15	29967540
4061	Glutathionylation	ANPAVITCDELLLGH CCCEEEECHHHHCCC	2.35	22555962
4070	2-Hydroxyisobutyrylation	ELLLGHEKAPAFRDY HHHCCCCCCHHHHHH	54.73	-
4070	Acetylation	ELLLGHEKAPAFRDY HHHCCCCCCHHHHHH	54.73	25953088
4070	Ubiquitination	ELLLGHEKAPAFRDY HHHCCCCCCHHHHHH	54.73	21963094
4074	Ubiquitination	GHEKAPAFRDYVAVA CCCCCHHHHHHHHHH	6.26	21963094
4075	Methylation	HEKAPAFRDYVAVAR CCCCHHHHHHHHHHC	36.13	-
4077	Phosphorylation	KAPAFRDYVAVARGS CCHHHHHHHHHHCCC	6.00	28152594
4082	Methylation	RDYVAVARGSKDHNI HHHHHHHCCCCCCCC	43.23	-
4084	Phosphorylation	YVAVARGSKDHNIRA HHHHHCCCCCCCCCC	29.38	21601212
4085	2-Hydroxyisobutyrylation	VAVARGSKDHNIRAQ HHHHCCCCCCCCCCC	66.87	-
4085	Ubiquitination	VAVARGSKDHNIRAQ HHHHCCCCCCCCCCC	66.87	29967540
4096	Phosphorylation	IRAQEPESGLSEETQ CCCCCCCCCCCHHHH	56.61	21712546
4099	Phosphorylation	QEPESGLSEETQVKC CCCCCCCCHHHHHHH	36.59	21815630
4102	Phosphorylation	ESGLSEETQVKCLMD CCCCCHHHHHHHHHH	34.31	22210691
4105	Ubiquitination	LSEETQVKCLMDQAT CCHHHHHHHHHHCCC	16.31	21963094
4106	Glutathionylation	SEETQVKCLMDQATD CHHHHHHHHHHCCCC	3.90	22555962
4128	Sulfoxidation	WEGWEPWM------- CCCCCCCC-------	6.03	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
511	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
2053	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
2056	S	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
2609	T	Phosphorylation	Kinase	ATM	Q13315	PSP
2609	T	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
2609	T	Phosphorylation	Kinase	ATR	Q13535	PSP
2612	S	Phosphorylation	Kinase	ATR	Q13535	PSP
2612	S	Phosphorylation	Kinase	ATM	Q13315	PSP
2612	S	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
2620	T	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
2638	T	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
2638	T	Phosphorylation	Kinase	ATM	Q13315	PSP
2647	T	Phosphorylation	Kinase	ATR	Q13535	PSP
2647	T	Phosphorylation	Kinase	ATM	Q13315	PSP
2647	T	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
3205	S	Phosphorylation	Kinase	PLK1	P53350	PSP
3205	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
3950	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	RNF144A	P50876	PMID:24979766
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2056	S	Phosphorylation	Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647.	14734805
2056	S	Phosphorylation	Ser-2056 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C.	14734805
2609	T	Phosphorylation	Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647.	12186630
2609	T	Phosphorylation	Ser-2056 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C.	12186630
2638	T	Phosphorylation	Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647.	12186630
2647	T	Phosphorylation	Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647.	12186630

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRKDC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	15640154
AP1B1_HUMAN	AP1B1	physical	10608806
ATM_HUMAN	ATM	physical	10608806
BRCA1_HUMAN	BRCA1	physical	10608806
CHK1_HUMAN	CHEK1	physical	10608806
E4F1_HUMAN	E4F1	physical	10608806
DNLI4_HUMAN	LIG4	physical	10608806
MRE11_HUMAN	MRE11A	physical	10608806
RAD17_HUMAN	RAD17	physical	10608806
CTIP_HUMAN	RBBP8	physical	10608806
P53_HUMAN	TP53	physical	10608806
WRN_HUMAN	WRN	physical	10608806
P53_HUMAN	TP53	physical	12756247
NCOA6_HUMAN	NCOA6	physical	10823961
KAT2A_HUMAN	KAT2A	physical	9488450
RFA2_HUMAN	RPA2	physical	10064605
XRCC6_HUMAN	XRCC6	physical	10064605
RFA1_HUMAN	RPA1	physical	10064605
C1D_HUMAN	C1D	physical	9679063
P53_HUMAN	TP53	physical	9679063
WRN_HUMAN	WRN	physical	11889123
IKKB_HUMAN	IKBKB	physical	9632806
IKKA_HUMAN	CHUK	physical	9632806
AKT2_HUMAN	AKT2	physical	16221682
ILF3_HUMAN	ILF3	physical	9442054
ILF2_HUMAN	ILF2	physical	9442054
IF2B_HUMAN	EIF2S2	physical	9442054
NCF1_HUMAN	NCF1	physical	9914162
NCF2_HUMAN	NCF2	physical	9914162
NCF4_HUMAN	NCF4	physical	9914162
MK08_HUMAN	MAPK8	physical	11749722
MK09_HUMAN	MAPK9	physical	11749722
CIB1_HUMAN	CIB1	physical	9372844
ATM_HUMAN	ATM	physical	10464290
DCR1C_HUMAN	DCLRE1C	physical	11955432
SIR6_HUMAN	SIRT6	physical	20157594
AIRE_HUMAN	AIRE	physical	20085707
PO2F1_HUMAN	POU2F1	physical	17213819
KAT5_HUMAN	KAT5	physical	16603769
H2AX_HUMAN	H2AFX	physical	14627815
PO2F1_HUMAN	POU2F1	physical	14612514
PDX1_HUMAN	PDX1	physical	16166097
H11_BOVIN	HIST1H1A	physical	15671175
AICDA_HUMAN	AICDA	physical	15634916
H2AX_HUMAN	H2AFX	physical	15613478
DHX9_HUMAN	DHX9	physical	15613478
HDAC3_HUMAN	HDAC3	physical	17242407
BIRC5_HUMAN	BIRC5	physical	20394854
H2AX_HUMAN	H2AFX	physical	20356835
H11_HUMAN	HIST1H1A	physical	20356835
PP2AA_HUMAN	PPP2CA	physical	20065038
PPP6_HUMAN	PPP6C	physical	20065038
PP6R1_HUMAN	PPP6R1	physical	20065038
PP6R2_HUMAN	PPP6R2	physical	20065038
PP6R3_HUMAN	PPP6R3	physical	20065038
PRKDC_HUMAN	PRKDC	physical	20065038
SP1_HUMAN	SP1	physical	8422676
HXB7_HUMAN	HOXB7	physical	17308091
XRCC5_HUMAN	XRCC5	physical	15758953
CTDP1_HUMAN	CTDP1	physical	21450944
TAT_HV1H2	tat	physical	21450944
ILF3_HUMAN	ILF3	physical	21969602
XRCC6_HUMAN	XRCC6	physical	21969602
XRCC5_HUMAN	XRCC5	physical	22404984
CSK21_HUMAN	CSNK2A1	physical	22404984
H31_HUMAN	HIST1H3A	physical	22404984
ROA1_HUMAN	HNRNPA1	physical	14704337
HNRPC_HUMAN	HNRNPC	physical	14704337
P53_HUMAN	TP53	physical	19918261
ARHG6_HUMAN	ARHGEF6	physical	19918261
P53_HUMAN	TP53	physical	9363941
DCAF1_HUMAN	VPRBP	physical	22184063
H2AX_HUMAN	H2AFX	physical	22184063
DCR1C_HUMAN	DCLRE1C	physical	15456891
MBP_HUMAN	MBP	physical	15147269
XPA_HUMAN	XPA	physical	16540648
RFA2_HUMAN	RPA2	physical	16540648
RFA2_HUMAN	RPA2	physical	9295339
GCR_HUMAN	NR3C1	physical	9038175
XRCC4_HUMAN	XRCC4	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
PRP8_HUMAN	PRPF8	physical	22939629
CWC27_HUMAN	CWC27	physical	22939629
THOC6_HUMAN	THOC6	physical	22939629
YBOX1_HUMAN	YBX1	physical	22939629
TRA2B_HUMAN	TRA2B	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
RBM25_HUMAN	RBM25	physical	22939629
PRP16_HUMAN	DHX38	physical	22939629
RAD21_HUMAN	RAD21	physical	22939629
SRP14_HUMAN	SRP14	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
SMCA5_HUMAN	SMARCA5	physical	22939629
SRS10_HUMAN	SRSF10	physical	22939629
SRP54_HUMAN	SRP54	physical	22939629
SERA_HUMAN	PHGDH	physical	22939629
RBP2_HUMAN	RANBP2	physical	22939629
PTER_HUMAN	PTER	physical	22939629
THYN1_HUMAN	THYN1	physical	22939629
TPR_HUMAN	TPR	physical	22939629
PRGR_HUMAN	PGR	physical	10750018
XRCC6_HUMAN	XRCC6	physical	10750018
XRCC5_HUMAN	XRCC5	physical	10750018
PRKDC_HUMAN	PRKDC	physical	10750018
AKT1_HUMAN	AKT1	physical	15262962
DNLI4_HUMAN	LIG4	physical	15194694
GSK3A_HUMAN	GSK3A	physical	15678105
GSK3B_HUMAN	GSK3B	physical	15678105
AKT2_HUMAN	AKT2	physical	15678105
AKT1_HUMAN	AKT1	physical	15678105
SRF_HUMAN	SRF	physical	8407951
JUN_HUMAN	JUN	physical	8464713
DCR1C_HUMAN	DCLRE1C	physical	16857680
XRCC5_HUMAN	XRCC5	physical	16857680
4EBP1_HUMAN	EIF4EBP1	physical	10713094
P53_HUMAN	TP53	physical	10713094
CHK2_HUMAN	CHEK2	physical	10713094
RFA2_HUMAN	RPA2	physical	10713094
XRCC5_HUMAN	XRCC5	physical	20023628
CIB1_HUMAN	CIB1	physical	15190070
PYRG2_HUMAN	CTPS2	physical	22863883
GTF2I_HUMAN	GTF2I	physical	22863883
PRDX1_HUMAN	PRDX1	physical	22863883
P53_HUMAN	TP53	physical	9744860
P53_HUMAN	TP53	physical	25362358
RASF1_HUMAN	RASSF1	physical	10608806
ANC2_HUMAN	ANAPC2	physical	26221070
FZR1_HUMAN	FZR1	physical	26221070
LOX15_HUMAN	ALOX15	physical	18785202
RFA2_HUMAN	RPA2	physical	8943020
XRCC1_HUMAN	XRCC1	physical	18678286
RIR2_HUMAN	RRM2	genetic	28319113
VHL_HUMAN	VHL	genetic	28319113
FACD2_HUMAN	FANCD2	genetic	24036544

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615966: Immunodeficiency 26 with or without neurologic abnormalities (IMD26)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00201: Caffeine

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-117; LYS-254; LYS-828;LYS-832; LYS-1057; LYS-1209; LYS-1970; LYS-2259; LYS-3241; LYS-3260;LYS-3608; LYS-3621; LYS-3638 AND LYS-3642, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3205, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511; SER-841; SER-893;SER-2612; THR-2671; SER-2672; SER-3205 AND SER-4026, AND MASSSPECTROMETRY.
PubMed: 19369195

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893; SER-3205 ANDSER-4026, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1052; SER-2117; SER-3205AND SER-4026, AND MASS SPECTROMETRY.
PubMed: 18691976

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2612; THR-2638 ANDTHR-2647, AND MASS SPECTROMETRY.
PubMed: 17525332

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2603; THR-2609;SER-2612; THR-2638; THR-2647 AND THR-2649, AND MASS SPECTROMETRY.
PubMed: 16565220

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3205, AND MASSSPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3205, AND MASSSPECTROMETRY.
PubMed: 15302935

"Identification of in vitro and in vivo phosphorylation sites in thecatalytic subunit of the DNA-dependent protein kinase.";
Douglas P., Sapkota G.P., Morrice N., Yu Y., Goodarzi A.A., Merkle D.,Meek K., Alessi D.R., Lees-Miller S.P.;
Biochem. J. 368:243-251(2002).
Cited for: PHOSPHORYLATION AT THR-2609; SER-2612; THR-2638 AND THR-2647.
PubMed: 12186630

"Autophosphorylation of the DNA-dependent protein kinase catalyticsubunit is required for rejoining of DNA double-strand breaks.";
Chan D.W., Chen B.P., Prithivirajsingh S., Kurimasa A., Story M.D.,Qin J., Chen D.J.;
Genes Dev. 16:2333-2338(2002).
Cited for: MASS SPECTROMETRY, PHOSPHORYLATION AT THR-2609, MUTAGENESIS OFTHR-2609, AND SUBCELLULAR LOCATION.
PubMed: 12231622

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2743, AND MASSSPECTROMETRY.
PubMed: 18083107