H11_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H11_BOVIN
• UniProt AC: G3N131
• Protein Name: Histone H1.1
• Gene Name: HIST1H1A
• Organism: Bos taurus (Bovine).
• Sequence Length: 218
• Subcellular Localization: Nucleus . Chromosome . Mainly localizes in euchromatin..
• Protein Description: H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity)..
• Protein Sequence: MSEVALPAPAASTSPEKPSAGKKAKKPAKAAAAAKKKPAGPSVSELIVQAVSSSKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVGKGTLVQTKGTGASGSFKLNKKVASVDAKPTATKVATKTKVTSASKKPKKASGAAAAKKSVKTPKKARKSVLTKKSSKSPKKPKAVKPKKVAKSPAKAKAVKPKGAKVKVTKPKTAAKPKKAAPKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEVALPAP ------CCCCCCCCC	61.93	-
2	Phosphorylation	------MSEVALPAP ------CCCCCCCCC	61.93	-
12	Phosphorylation	ALPAPAASTSPEKPS CCCCCCCCCCCCCCC	24.73	-
17	Acetylation	AASTSPEKPSAGKKA CCCCCCCCCCCCCCC	25.48	-
37	Other	AAAAAKKKPAGPSVS HHHHHHCCCCCCCHH	24.51	-
44	Phosphorylation	KPAGPSVSELIVQAV CCCCCCHHHHHHHHH	26.10	-
55	Other	VQAVSSSKERSGVSL HHHHHCCCCCCCCCH	21.18	-
57	Citrullination	AVSSSKERSGVSLAA HHHCCCCCCCCCHHH	18.80	-
57	Citrullination	AVSSSKERSGVSLAA HHHCCCCCCCCCHHH	18.80	-
67	Other	VSLAALKKALAAAGY CCHHHHHHHHHHCCC	11.41	-
78	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCEEE	31.98	-
88	Other	SRIKLGLKSLVGKGT CCEEECHHHHHCCCE	30.57	-
93	Other	GLKSLVGKGTLVQTK CHHHHHCCCEEEEEC	7.34	-
93	Acetylation	GLKSLVGKGTLVQTK CHHHHHCCCEEEEEC	7.34	-
107	Phosphorylation	KGTGASGSFKLNKKV CCCCCCCCEECCCEE		3134256
109	Other	TGASGSFKLNKKVAS CCCCCCEECCCEEEE		-
125	Acetylation	DAKPTATKVATKTKV CCCCCCCEECCCCCC		-
206	Phosphorylation	VKVTKPKTAAKPKKA EEECCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
107	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H11_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H11_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UHRF1_MOUSE	Uhrf1	physical	14993289

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"The amino acid sequence of residues 1-104 of CTL-1, a bovine H1histone.";
Liao L.W., Cole R.D.;
J. Biol. Chem. 256:3024-3029(1981).
Cited for: PROTEIN SEQUENCE.
PubMed: 7204387

Phosphorylation

"Identification of the phosphoserine residue in histone H1phosphorylated by protein kinase C.";
Jakes S., Hastings T.G., Reimann E.M., Schlender K.K.;
FEBS Lett. 234:31-34(1988).
Cited for: PHOSPHORYLATION AT SER-103.
PubMed: 3134256