AICDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AICDA_HUMAN
• UniProt AC: Q9GZX7
• Protein Name: Single-stranded DNA cytosine deaminase
• Gene Name: AICDA
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
• Protein Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. [PubMed: 18722174]
• Protein Sequence: MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSLLMNRRK -----CCCHHCCHHH	23.31	41321001
27	Phosphorylation	WAKGRRETYLCYVVK CCCCCCCEEEEEEEE	21.71	16387847
38	Phosphorylation	YVVKRRDSATSFSLD EEEECCCCCCEEEEE	31.47	16723391
41	Phosphorylation	KRRDSATSFSLDFGY ECCCCCCEEEEEHHE	16.74	22817900
43	Phosphorylation	RDSATSFSLDFGYLR CCCCCEEEEEHHEEC	27.14	8510999
48	Phosphorylation	SFSLDFGYLRNKNGC EEEEEHHEECCCCCC	11.50	50564227
160	Acetylation	ENHERTFKAWEGLHE HCCHHHHHHHHHHHH	52.56	19810345

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
27	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
27	T	Phosphorylation	Kinase	PKA	-	Uniprot
38	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
38	S	Phosphorylation	Kinase	PKA	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	RNF126	Q9BV68	PMID:23277564

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
27	T	Phosphorylation	Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation.	16387847
38	S	Phosphorylation	Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation.	16387847

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AICDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKDC_HUMAN	PRKDC	physical	15634916
TBB4B_HUMAN	TUBB4B	physical	15634916
IMA5_HUMAN	KPNA1	physical	21385873
CTBL1_HUMAN	CTNNBL1	physical	21385873
A4_HUMAN	APP	physical	21832049
AICDA_HUMAN	AICDA	physical	19412186
XPO1_HUMAN	XPO1	physical	19412186
KAPCA_HUMAN	PRKACA	physical	16251902
EXOS6_HUMAN	EXOSC6	physical	21255825
EXOS7_HUMAN	EXOSC7	physical	21255825
EXOS3_HUMAN	EXOSC3	physical	21255825
EXOS2_HUMAN	EXOSC2	physical	21255825
PCNA_HUMAN	PCNA	physical	21255825
EXOS4_HUMAN	EXOSC4	physical	21255825
EXOS1_HUMAN	EXOSC1	physical	21255825
EXOS5_HUMAN	EXOSC5	physical	21255825
HNRPM_HUMAN	HNRNPM	physical	23277564
ROA0_HUMAN	HNRNPA0	physical	23277564
DDX21_HUMAN	DDX21	physical	23277564
DD19B_HUMAN	DDX19B	physical	23277564
EIF2D_HUMAN	EIF2D	physical	23277564
CPSF3_HUMAN	CPSF3	physical	23277564
XRN2_HUMAN	XRN2	physical	23277564
EF1A1_HUMAN	EEF1A1	physical	23277564
RBM39_HUMAN	RBM39	physical	23277564
CTBL1_HUMAN	CTNNBL1	physical	23277564
NUP93_HUMAN	NUP93	physical	23277564
IMB1_HUMAN	KPNB1	physical	23277564
RAD51_HUMAN	RAD51	physical	23277564
RIR2B_HUMAN	RRM2B	physical	23277564
IER5_HUMAN	IER5	physical	23277564
FEN1_HUMAN	FEN1	physical	23277564
ACTG_HUMAN	ACTG1	physical	23277564
PGAM1_HUMAN	PGAM1	physical	23277564
UB2L3_HUMAN	UBE2L3	physical	23277564
2AAA_HUMAN	PPP2R1A	physical	23277564
AICDA_HUMAN	AICDA	physical	23277564
RFA1_HUMAN	RPA1	physical	23277564
TCPH_HUMAN	CCT7	physical	23277564
GRP78_HUMAN	HSPA5	physical	23277564
HERP2_HUMAN	HERPUD2	physical	23277564
HAUS4_HUMAN	HAUS4	physical	23277564
RTCB_HUMAN	RTCB	physical	23277564
DAZP2_HUMAN	DAZAP2	physical	23277564
ZMIZ2_HUMAN	ZMIZ2	physical	23277564
RN126_HUMAN	RNF126	physical	23277564

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605258: Immunodeficiency with hyper-IgM 2 (HIGM2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.