dbPTM

IER5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IER5_HUMAN
UniProt AC	Q5VY09
Protein Name	Immediate early response gene 5 protein
Gene Name	IER5
Organism	Homo sapiens (Human).
Sequence Length	327
Subcellular Localization	Nucleus . Cytoplasm . Predominantly cytoplasmic (PubMed:25816751). Translocated in the nucleus during heat shock (PubMed:25816751).
Protein Description	Plays a role as a transcription factor. [PubMed: 22132193]
Protein Sequence	MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPAPPPQQQPGEPAAGPPAGWGEPPPPAARASWPETEPQPERSSVSDAPRVGDEVPVATVTGVGDVFQGGEADATEAAWSRVEGPRQAAAREAEGTAGGWGVFPEVSRAARRPCGCPLGGEDPPGTPAATPRAACCCAPQPAEDEPPAPPAVCPRKRCAAGVGGGPAGCPAPGSTPLKKPRRNLEQPPSGGEDDDAEEMETGNVANLISIFGSSFSGLLRKSPGGGREEEEGEESGPEAAEPGQICCDKPVLRDMNPWSTAIVAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MEFKLEAHRIV ----CCCCEEEEEEE	31.92	-
19	Phosphorylation	SISLGKIYNSRVQRG EEECHHHHHCCCCCC	15.57	23532336
21	Phosphorylation	SLGKIYNSRVQRGGI ECHHHHHCCCCCCCC	19.50	23532336
123	Phosphorylation	EVPVATVTGVGDVFQ CCCEEEEEECCCCCC	23.07	24275569
188	Phosphorylation	GGEDPPGTPAATPRA CCCCCCCCCCCCCCC	18.61	-
192	Phosphorylation	PPGTPAATPRAACCC CCCCCCCCCCCCCCC	18.53	-
240	Ubiquitination	APGSTPLKKPRRNLE CCCCCCCCCCCCCCC	63.03	29967540
311	Ubiquitination	PGQICCDKPVLRDMN CCCCCCCCCCCCCCC	24.10	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IER5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IER5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IER5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IER5_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IER5_HUMAN

Related Literatures of Post-Translational Modification