dbPTM

DD19B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DD19B_HUMAN
UniProt AC	Q9UMR2
Protein Name	ATP-dependent RNA helicase DDX19B
Gene Name	DDX19B
Organism	Homo sapiens (Human).
Sequence Length	479
Subcellular Localization	Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Nuclear pore complex cytoplasmic fibrils.
Protein Description	ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins..
Protein Sequence	MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATDSWALA ------CCCCCCEEE	21.80	22223895
3	Phosphorylation	-----MATDSWALAV -----CCCCCCEEEH	29.30	28634298
5	Phosphorylation	---MATDSWALAVDE ---CCCCCCEEEHHH	15.19	28634298
19	Phosphorylation	EQEAAAESLSNLHLK HHHHHHHHHHCCCCC	32.16	27251275
41	Phosphorylation	TNGAVVKTNANAEKT CCCCEEECCCCCCCC	28.14	23312004
48	Phosphorylation	TNANAEKTDEEEKED CCCCCCCCCHHHHHH	39.90	28985074
60	Phosphorylation	KEDRAAQSLLNKLIR HHHHHHHHHHHHHHH	30.05	24275569
64	Ubiquitination	AAQSLLNKLIRSNLV HHHHHHHHHHHCCCC	45.31	21890473
64 (in isoform 2)	Ubiquitination	-	45.31	21890473
64	Ubiquitination	AAQSLLNKLIRSNLV HHHHHHHHHHHCCCC	45.31	21890473
64 (in isoform 1)	Ubiquitination	-	45.31	21890473
69	Ubiquitination	LNKLIRSNLVDNTNQ HHHHHHCCCCCCCCC	33.95	21890473
74	Phosphorylation	RSNLVDNTNQVEVLQ HCCCCCCCCCEEEEC	23.67	23186163
78	Ubiquitination	VDNTNQVEVLQRDPN CCCCCCEEEECCCCC	27.96	21890473
86	Phosphorylation	VLQRDPNSPLYSVKS EECCCCCCCCCCCCC	22.97	25159151
89	Phosphorylation	RDPNSPLYSVKSFEE CCCCCCCCCCCCHHH	18.14	28450419
90	Phosphorylation	DPNSPLYSVKSFEEL CCCCCCCCCCCHHHH	30.65	28450419
92	Ubiquitination	NSPLYSVKSFEELRL CCCCCCCCCHHHHCC	43.41	21890473
92 (in isoform 1)	Ubiquitination	-	43.41	21890473
92 (in isoform 2)	Ubiquitination	-	43.41	21890473
92	Ubiquitination	NSPLYSVKSFEELRL CCCCCCCCCHHHHCC	43.41	21890473
93 (in isoform 2)	Phosphorylation	-	35.42	24275569
93	Phosphorylation	SPLYSVKSFEELRLK CCCCCCCCHHHHCCC	35.42	28857561
97	Ubiquitination	SVKSFEELRLKPQLL CCCCHHHHCCCHHHH	6.47	21890473
98 (in isoform 4)	Phosphorylation	-	43.90	24275569
108	Phosphorylation	PQLLQGVYAMGFNRP HHHHHHHHHCCCCCC	9.55	28842319
145	Phosphorylation	SQSGTGKTAAFVLAM CCCCCCHHHHHHHHH	25.27	-
154	Phosphorylation	AFVLAMLSQVEPANK HHHHHHHHCCCCCCC	21.06	24850871
156 (in isoform 2)	Ubiquitination	-	9.51	21890473
161	Ubiquitination	SQVEPANKYPQCLCL HCCCCCCCCCCCEEE	61.49	21890473
169	Phosphorylation	YPQCLCLSPTYELAL CCCCEEECCCHHHHH	17.75	28258704
172	Phosphorylation	CLCLSPTYELALQTG CEEECCCHHHHHHHC	16.60	28258704
187	Ubiquitination	KVIEQMGKFYPELKL HHHHHHHHHCHHHHH	36.06	21890473
187	Ubiquitination	KVIEQMGKFYPELKL HHHHHHHHHCHHHHH	36.06	21890473
187 (in isoform 1)	Ubiquitination	-	36.06	21890473
193	Ubiquitination	GKFYPELKLAYAVRG HHHCHHHHHHHHHHC	29.43	-
198	Acetylation	ELKLAYAVRGNKLER HHHHHHHHHCCCCCC	5.40	19608861
199	Methylation	LKLAYAVRGNKLERG HHHHHHHHCCCCCCC	34.49	-
202	Acetylation	AYAVRGNKLERGQKI HHHHHCCCCCCCCCC	55.33	7670197
203	Acetylation	YAVRGNKLERGQKIS HHHHCCCCCCCCCCC	6.69	19608861
217	Phosphorylation	SEQIVIGTPGTVLDW CCEEECCCCCCHHHH	13.86	28348404
220	Phosphorylation	IVIGTPGTVLDWCSK EECCCCCCHHHHHHC	21.06	28348404
229	Acetylation	LDWCSKLKFIDPKKI HHHHHCCCCCCHHHC	43.97	19608861
287	Acetylation	SVWKFAQKVVPDPNV HHHHHHHHHCCCCCE	41.59	24780969
287	Ubiquitination	SVWKFAQKVVPDPNV HHHHHHHHHCCCCCE	41.59	-
308	Ubiquitination	EETLDTIKQYYVLCS HHHHHHHHHHHHHHC	34.05	-
345	Phosphorylation	IFCHTRKTASWLAAE HHHCCHHHHHHHHHH	23.72	20068231
347	Phosphorylation	CHTRKTASWLAAELS HCCHHHHHHHHHHHC	28.05	20068231
354	Phosphorylation	SWLAAELSKEGHQVA HHHHHHHCCCCCCEE	21.84	20068231
422	Phosphorylation	DGNPDNETYLHRIGR CCCCCCCCCHHHCCC	37.32	-
423	Phosphorylation	GNPDNETYLHRIGRT CCCCCCCCHHHCCCC	8.37	-
445	Phosphorylation	LAVNMVDSKHSMNIL EEEEECCCHHHHHHH	22.36	20860994
448	Phosphorylation	NMVDSKHSMNILNRI EECCCHHHHHHHHHH	19.77	22798277
468	Phosphorylation	KKIERLDTDDLDEIE HHHHCCCCCCHHHHH	35.68	27273156
476	Ubiquitination	DDLDEIEKIAN---- CCHHHHHHHHC----	53.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
93	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DD19B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DD19B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCK_HUMAN	DCK	physical	16169070
RACK1_HUMAN	GNB2L1	physical	16169070
XPO7_HUMAN	XPO7	physical	16169070
A4_HUMAN	APP	physical	21832049
CTBP2_HUMAN	CTBP2	physical	22863883
MI4GD_HUMAN	MIF4GD	physical	25416956
TRFE_HUMAN	TF	physical	26186194
PLEC_HUMAN	PLEC	physical	26186194
EPIPL_HUMAN	EPPK1	physical	26186194
EVPL_HUMAN	EVPL	physical	26186194
CO3_HUMAN	C3	physical	26186194
ANXA1_HUMAN	ANXA1	physical	26186194
AACT_HUMAN	SERPINA3	physical	26186194
TRI29_HUMAN	TRIM29	physical	26186194
CALL5_HUMAN	CALML5	physical	26186194
GELS_HUMAN	GSN	physical	26186194
FIBB_HUMAN	FGB	physical	26186194
TGM1_HUMAN	TGM1	physical	26186194
FIBG_HUMAN	FGG	physical	26186194
PEPL_HUMAN	PPL	physical	26186194
APOA1_HUMAN	APOA1	physical	26186194
AK1BA_HUMAN	AKR1B10	physical	26186194
TRI25_HUMAN	TRIM25	physical	26186194
PLSL_HUMAN	LCP1	physical	26186194
DRA_HUMAN	HLA-DRA	physical	26186194
PSME1_HUMAN	PSME1	physical	26186194
TREX2_HUMAN	TREX2	physical	26186194
IQGA1_HUMAN	IQGAP1	physical	26186194
SPB5_HUMAN	SERPINB5	physical	26186194
CALL3_HUMAN	CALML3	physical	26186194
MVP_HUMAN	MVP	physical	26186194
SPB4_HUMAN	SERPINB4	physical	26186194
SPB3_HUMAN	SERPINB3	physical	26186194
ST2B1_HUMAN	SULT2B1	physical	26186194
FIBA_HUMAN	FGA	physical	26186194
RNAS7_HUMAN	RNASE7	physical	26186194
POF1B_HUMAN	POF1B	physical	26186194
CAPG_HUMAN	CAPG	physical	26186194
NGAL_HUMAN	LCN2	physical	26186194
SYNC_HUMAN	NARS	physical	26186194
INVO_HUMAN	IVL	physical	26186194
HMOX1_HUMAN	HMOX1	physical	26186194
SAP3_HUMAN	GM2A	physical	26186194
ILEU_HUMAN	SERPINB1	physical	26186194
RAB5A_HUMAN	RAB5A	physical	26186194
TYPH_HUMAN	TYMP	physical	26186194
STAT3_HUMAN	STAT3	physical	26186194
PPAP_HUMAN	ACPP	physical	26186194
TRFL_HUMAN	LTF	physical	26186194
ANXA8_HUMAN	ANXA8	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
NAGK_HUMAN	NAGK	physical	26186194
A1AT_HUMAN	SERPINA1	physical	26186194
PAI2_HUMAN	SERPINB2	physical	26186194
LOX15_HUMAN	ALOX15	physical	26186194
LEG1_HUMAN	LGALS1	physical	26186194
FCGBP_HUMAN	FCGBP	physical	26186194
HUTH_HUMAN	HAL	physical	26186194
HPT_HUMAN	HP	physical	26186194
NDRG2_HUMAN	NDRG2	physical	26186194
A1AG1_HUMAN	ORM1	physical	26186194
RABP2_HUMAN	CRABP2	physical	26186194
CFAB_HUMAN	CFB	physical	26186194
IGLL5_HUMAN	IGLL5	physical	26186194
ACOX1_HUMAN	ACOX1	physical	26186194
SPB7_HUMAN	SERPINB7	physical	26186194
EHD4_HUMAN	EHD4	physical	26186194
RIR2_HUMAN	RRM2	physical	26344197
FCGBP_HUMAN	FCGBP	physical	28514442
FIBB_HUMAN	FGB	physical	28514442
DRA_HUMAN	HLA-DRA	physical	28514442
CO3_HUMAN	C3	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
MVP_HUMAN	MVP	physical	28514442
ANXA8_HUMAN	ANXA8	physical	28514442
FIBG_HUMAN	FGG	physical	28514442
ST2B1_HUMAN	SULT2B1	physical	28514442
FIBA_HUMAN	FGA	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
LOX15_HUMAN	ALOX15	physical	28514442
A1AT_HUMAN	SERPINA1	physical	28514442
A1AG1_HUMAN	ORM1	physical	28514442
NDRG2_HUMAN	NDRG2	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
APOA1_HUMAN	APOA1	physical	28514442
TREX2_HUMAN	TREX2	physical	28514442
INVO_HUMAN	IVL	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
ILEU_HUMAN	SERPINB1	physical	28514442
AACT_HUMAN	SERPINA3	physical	28514442
SPB7_HUMAN	SERPINB7	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
TRI25_HUMAN	TRIM25	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
AK1BA_HUMAN	AKR1B10	physical	28514442
PLSL_HUMAN	LCP1	physical	28514442
HPT_HUMAN	HP	physical	28514442
CAPG_HUMAN	CAPG	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
RABP2_HUMAN	CRABP2	physical	28514442
TRFE_HUMAN	TF	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
EPIPL_HUMAN	EPPK1	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
PSME1_HUMAN	PSME1	physical	28514442
TRFL_HUMAN	LTF	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
LEG1_HUMAN	LGALS1	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
CFAB_HUMAN	CFB	physical	28514442
S10A9_HUMAN	S100A9	physical	28514442
GSDMA_HUMAN	GSDMA	physical	28514442
I36RA_HUMAN	IL36RN	physical	28514442
SAP3_HUMAN	GM2A	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
HMOX1_HUMAN	HMOX1	physical	28514442
PLEC_HUMAN	PLEC	physical	28514442
CATL2_HUMAN	CTSV	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
ABC3A_HUMAN	APOBEC3A	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442
ANXA1_HUMAN	ANXA1	physical	28514442
KPYM_HUMAN	PKM	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DD19B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-229, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.	18669648 [Abstract]