TYPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYPH_HUMAN
• UniProt AC: P19971
• Protein Name: Thymidine phosphorylase
• Gene Name: TYMP
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Protein Description: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis..
• Protein Sequence: MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAALMTPGTGAPP --CCCCCCCCCCCCC	21.29	25159151
9	Phosphorylation	AALMTPGTGAPPAPG CCCCCCCCCCCCCCC	31.23	20068231
19	Phosphorylation	PPAPGDFSGEGSQGL CCCCCCCCCCCCCCC	40.45	28857561
23	Phosphorylation	GDFSGEGSQGLPDPS CCCCCCCCCCCCCCC	19.44	26657352
30	Phosphorylation	SQGLPDPSPEPKQLP CCCCCCCCCCHHHHH	49.64	28857561
50	Phosphorylation	KRDGGRLSEADIRGF CCCCCCCCHHHHHHH	29.40	28857561
115	Acetylation	WRQQLVDKHSTGGVG HHHHHHHHHCCCCCC	31.79	27452117
151	Phosphorylation	SGRGLGHTGGTLDKL CCCCCCCCCCHHHHH	35.19	22985185
154	Phosphorylation	GLGHTGGTLDKLESI CCCCCCCHHHHHHCC	32.88	22985185
205	Phosphorylation	LYAARDVTATVDSLP EEEECCCCCCCCCHH	22.39	18785766
217	Phosphorylation	SLPLITASILSKKLV CHHHHHHHHHCHHHH	18.53	24719451
271	Phosphorylation	LRVAAALTAMDKPLG HHHHHHHHHCCCCCH	18.40	20068231
275	Acetylation	AALTAMDKPLGRCVG HHHHHCCCCCHHHHH	29.11	7679233
409	Phosphorylation	HELGAGRSRAGEPLR HHHCCCCCCCCCCCC	26.09	27251275
414	Phosphorylation	GRSRAGEPLRLGVGA CCCCCCCCCCCCCCC	23.12	27251275
435	Phosphorylation	GQRLRRGTPWLRVHR HHHHHCCCCCEEEEC	14.96	-
471	Phosphorylation	RAPFAAPSPFAELVL CCCCCCCCCCHHHCC	28.11	28348404
476	Phosphorylation	APSPFAELVLPPQQ- CCCCCHHHCCCCCC-	4.26	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	22480737
EF2_HUMAN	EEF2	physical	22863883
G3P_HUMAN	GAPDH	physical	22863883
TYPH_HUMAN	TYMP	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603041: Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01101: Capecitabine
• DB00369: Cidofovir
• DB00322: Floxuridine
• DB00544: Fluorouracil
• DB00432: Trifluridine