ABC3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABC3A_HUMAN
• UniProt AC: P31941
• Protein Name: DNA dC->dU-editing enzyme APOBEC-3A
• Gene Name: APOBEC3A
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation..
• Protein Sequence: MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	RIFAARIYDYDPLYK EEEEEEECCCCHHHH	11.69	-
132	Phosphorylation	FAARIYDYDPLYKEA EEEEECCCCHHHHHH	11.50	-
136	Phosphorylation	IYDYDPLYKEALQML ECCCCHHHHHHHHHH	16.51	-
137	Ubiquitination	YDYDPLYKEALQMLR CCCCHHHHHHHHHHH	44.16	21906983
151	Phosphorylation	RDAGAQVSIMTYDEF HHCCCCEEEEEHHHH	8.44	-
164	Phosphorylation	EFKHCWDTFVDHQGC HHHHHHHHCCCCCCC	10.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABC3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABC3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABC3A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ABC3A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.