dbPTM

PEPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PEPL_HUMAN
UniProt AC	O60437
Protein Name	Periplakin
Gene Name	PPL
Organism	Homo sapiens (Human).
Sequence Length	1756
Subcellular Localization	Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.
Protein Description	Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling..
Protein Sequence	MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRRSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MNSLFRKRNK -----CCCCCCCCCC	40.52	24719451
12	Acetylation	FRKRNKGKYSPTVQT CCCCCCCCCCCCCCC	44.13	21339330
13	Phosphorylation	RKRNKGKYSPTVQTR CCCCCCCCCCCCCCC	28.66	22167270
14	Phosphorylation	KRNKGKYSPTVQTRS CCCCCCCCCCCCCCC	19.99	22167270
16	Phosphorylation	NKGKYSPTVQTRSIS CCCCCCCCCCCCCCC	21.21	22167270
19	Phosphorylation	KYSPTVQTRSISNKE CCCCCCCCCCCCHHH	23.27	19691289
21	Phosphorylation	SPTVQTRSISNKELS CCCCCCCCCCHHHHH	33.48	24719451
23	Phosphorylation	TVQTRSISNKELSEL CCCCCCCCHHHHHHH	42.99	28857561
28	Phosphorylation	SISNKELSELIEQLQ CCCHHHHHHHHHHHH	31.30	21406692
74	Ubiquitination	HRDVTLQKVLDSEKL CCCCCHHHHHCHHHH	48.13	29967540
130	Acetylation	QIYRLAVKEVDPQVN HHHHHHHEECCCCCC	46.54	23954790
153	Phosphorylation	LDKLNNQSFGTDLPL HHHHHCCCCCCCCCC	27.97	25056879
218	Phosphorylation	HLSSLQDYMQRCTNE HHHHHHHHHHHHHHH	5.12	-
227	Phosphorylation	QRCTNELYWLDQQAK HHHHHHHHHHCHHCC	9.57	-
239	Phosphorylation	QAKGRMQYDWSDRNL HCCCCCCCCCCCCCC	15.27	-
248	Phosphorylation	WSDRNLDYPSRRRQY CCCCCCCCCHHHHHH	13.28	-
255	Phosphorylation	YPSRRRQYENFINRN CCHHHHHHHHHHHHC	15.84	25690035
275	Phosphorylation	ERINKLHSEGDQLLA HHHHHHHHHHHHHHH	54.43	-
322	Phosphorylation	HLKYMEDYHQFHEDV HHHHHHHHHHHHHHH	5.56	-
338	Ubiquitination	DAQELLRKVDSDLNQ HHHHHHHHHCHHHHH	50.81	-
341	Phosphorylation	ELLRKVDSDLNQKYG HHHHHHCHHHHHHHC	47.16	28348404
369	Ubiquitination	RELDDQEKVLDKYED HHCCCHHHHHHHHHH	42.33	22817900
373	Ubiquitination	DQEKVLDKYEDVVQG CHHHHHHHHHHHHHH	46.51	22817900
374	Phosphorylation	QEKVLDKYEDVVQGL HHHHHHHHHHHHHHH	19.61	-
382	Ubiquitination	EDVVQGLQKRGQQVV HHHHHHHHHCCCEEC	39.98	22817900
383	Ubiquitination	DVVQGLQKRGQQVVP HHHHHHHHCCCEECC	64.64	21906983
386	Ubiquitination	QGLQKRGQQVVPLKY HHHHHCCCEECCCEE	36.61	22817900
396	Ubiquitination	VPLKYRRETPLKPIP CCCEECCCCCCCCCC	45.86	22817900
400	Ubiquitination	YRRETPLKPIPVEAL ECCCCCCCCCCHHHC	41.95	29967540
422	Phosphorylation	GLISRGYSYTLQKNN CCEECCEEEEEECCC	17.92	27499020
432	Phosphorylation	LQKNNGESWELMDSA EECCCCCCEEEECCC	27.52	20068231
465	Phosphorylation	EALALADSLGSQYRS HHHHHHHHHHHHHHH	29.08	24275569
488	Phosphorylation	KRTLQQRYEVLKTEN HHHHHHHHHHHHCCC	13.17	-
492	Ubiquitination	QQRYEVLKTENPGDA HHHHHHHHCCCCCCH	59.99	21906983
505	Ubiquitination	DASDLQGRQLLAGLD CHHHHHHHHHHHHHH	15.83	22817900
508	Ubiquitination	DLQGRQLLAGLDKVA HHHHHHHHHHHHHHH	2.41	22817900
513	Ubiquitination	QLLAGLDKVASDLDR HHHHHHHHHHHHCHH	44.75	29967540
521	Ubiquitination	VASDLDRQEKAITGI HHHHCHHHHHHHHCC	57.09	22817900
547	Ubiquitination	QDSAERAKDLKNITN HCHHHHHHHHHHHHH	70.57	22817900
550	Ubiquitination	AERAKDLKNITNELL HHHHHHHHHHHHHHH	57.34	21906983
560	Ubiquitination	TNELLRIEPEKTRST HHHHHCCCCCCCCCC	40.76	22817900
563	Ubiquitination	LLRIEPEKTRSTAEG HHCCCCCCCCCCHHH	61.01	22817900
566	Ubiquitination	IEPEKTRSTAEGEAF CCCCCCCCCHHHHHH	36.88	22817900
576	Ubiquitination	EGEAFIQALPGSGTT HHHHHHHHCCCCCCC	15.77	22817900
579	Ubiquitination	AFIQALPGSGTTPLL HHHHHCCCCCCCCCE	39.29	22817900
583	Phosphorylation	ALPGSGTTPLLRTRV HCCCCCCCCCEEEHH	18.57	-
596	Ubiquitination	RVEDTNRKYEHLLQL HHHHCCHHHHHHHHH	57.99	29967540
644	Phosphorylation	QDDTVPESSRVLDSK CCCCCCHHHHHHCCH	19.85	-
667	Phosphorylation	CELQAQKSLLGEVEQ HHHHHHHHHHHHHHH	19.42	22617229
732	Phosphorylation	LQSAKAAYEHFHRGH HHHHHHHHHHHHCCC	18.13	-
779	Phosphorylation	NLLDEIASREQEVQK HHHHHHHHHHHHHHH	41.85	19664995
801	Phosphorylation	YQQAVKDYELEAEKL HHHHHHHHHHHHHHH	19.39	25599653
807	Ubiquitination	DYELEAEKLRSLLDL HHHHHHHHHHHHHCC	57.14	23503661
820	Ubiquitination	DLENGRRSHVSKRAR CCCCCCCCCCCHHHH	27.21	23503661
823	Ubiquitination	NGRRSHVSKRARLQS CCCCCCCCHHHHCCC	15.82	23503661
830	Phosphorylation	SKRARLQSPATKVKE CHHHHCCCCCCCCHH	22.54	25849741
833	Phosphorylation	ARLQSPATKVKEEEA HHCCCCCCCCHHHHH	39.49	27794612
836	Ubiquitination	QSPATKVKEEEAALA CCCCCCCHHHHHHHH	62.05	23503661
850	Phosphorylation	AAKFTEVYAINRQRL HHHHHHHHEECHHHH	8.77	-
887	Phosphorylation	LQRNRPDSGVEEAWK HHHCCCCCCHHHHHH	47.63	28355574
931	Phosphorylation	RNQGPQESVVRKEVL HHCCCCHHHHCHHHH	22.21	28355574
949	Phosphorylation	PDPVLEESFQQLQRT CCHHHHHHHHHHHHH	20.98	25159151
992	Phosphorylation	TRDGGQEYVVKEVLR HCCCCCEEEEEEEEE	11.58	28152594
1070	Phosphorylation	DPQLEAEYQQLQEDH CHHHHHHHHHHHHHH	14.49	25394399
1126	Phosphorylation	KVEKDAATEREVSDL HHHCCCCCHHHHHHH	36.98	28674151
1143	Ubiquitination	QYEDEAAKARASQRE HHHHHHHHHHHHHHH	45.51	22817900
1156	Ubiquitination	REKTELLRKIWALEE HHHHHHHHHHHHHCH	40.83	22817900
1159	Ubiquitination	TELLRKIWALEEENA HHHHHHHHHHCHHCC	9.60	22817900
1172	Ubiquitination	NAKVVVQEKVREIVR CCEEEEEHHHHHHHC	41.74	22817900
1173	2-Hydroxyisobutyrylation	AKVVVQEKVREIVRP CEEEEEHHHHHHHCC	29.51	-
1214	Phosphorylation	EQLRSYQSELEALRR HHHHHHHHHHHHHHH	35.60	-
1229	Acetylation	RGPQVEVKEVTKEVI HCCCEEHHHHHHHHH	32.72	23954790
1258	Ubiquitination	LREEIVDKTRLIERC HHHHHHHHHHHHHHC	25.34	29967540
1270	Phosphorylation	ERCDLEIYQLKKEIQ HHCCHHHHHHHHHHH	9.83	28152594
1273	Acetylation	DLEIYQLKKEIQALK CHHHHHHHHHHHHHH	32.60	7964155
1274	Acetylation	LEIYQLKKEIQALKD HHHHHHHHHHHHHHC	69.51	7964167
1280	Acetylation	KKEIQALKDTKPQVQ HHHHHHHHCCCCCCC	67.38	7964179
1304	Phosphorylation	QFQEDPQTKEEVASL HHCCCCCCHHHHHHH	45.90	27251275
1310	Phosphorylation	QTKEEVASLRAKLSE CCHHHHHHHHHHCCH	24.46	28355574
1331	Phosphorylation	DLERERASQEEQIAR HHHHHHHHHHHHHHH	44.33	22817900
1358	Phosphorylation	VQQEVVRYEEEPGLR HHHHHHCCCCCCCCH	18.97	26356563
1397	Phosphorylation	RRLQRRRTELERQLE HHHHHHHHHHHHHHH	43.01	-
1521	Phosphorylation	QEIQRLKSSLEEESR HHHHHHHHHHHHHHH	44.76	27251275
1538	Phosphorylation	RELDVEVSRLEARLS HHHHHHHHHHHHHHH	20.03	-
1552	Phosphorylation	SELEFHNSKSSKELD HHHHCCCCCCHHHHH	25.91	28348404
1579	Phosphorylation	RQNLQLETRRLQSEI HHHHHHHHHHHHHHH	29.67	22817900
1584	Phosphorylation	LETRRLQSEINMAAT HHHHHHHHHHHHHHH	45.06	28464451
1591	Phosphorylation	SEINMAATETRDLRN HHHHHHHHCCHHHHC	28.49	28464451
1610	Phosphorylation	DSGTNHDSRLWSLER CCCCCHHHHHHHHHH	23.01	22499768
1614	Phosphorylation	NHDSRLWSLERELDD CHHHHHHHHHHHHHH	25.58	28355574
1642	Phosphorylation	ELQKRLGSVAVKREQ HHHHHHCHHHHHHHH	16.11	-
1657	Phosphorylation	RENHLRRSIVVIHPD HHHCCCCEEEEECCC	17.19	25159151
1665	Phosphorylation	IVVIHPDTGRELSPE EEEECCCCCCCCCHH	42.46	23312004
1670	Phosphorylation	PDTGRELSPEEAHRA CCCCCCCCHHHHHHC	26.05	23312004
1727	Phosphorylation	SIEEALQSGRLTPAQ CHHHHHHCCCCCHHH	27.08	27251275
1731	Phosphorylation	ALQSGRLTPAQYDRY HHHCCCCCHHHHHHH	18.41	27251275
1744	Phosphorylation	RYVNKDMSIQELAVL HHCCCCCCHHHHHHH	31.11	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PEPL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PEPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PEPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAZRN_HUMAN	KAZN	physical	15337775
PPHLN_HUMAN	PPHLN1	physical	12853457
EVPL_HUMAN	EVPL	physical	12432088
EVPL_HUMAN	EVPL	physical	9412476
K2C8_HUMAN	KRT8	physical	12366696
VIME_HUMAN	VIM	physical	12366696
AKT1_HUMAN	AKT1	physical	12244133
VIME_HUMAN	VIM	physical	12244133
VIME_RAT	Vim	physical	12244133
TRI27_HUMAN	TRIM27	physical	25416956
TRAF2_HUMAN	TRAF2	physical	25416956
VIME_HUMAN	VIM	physical	25416956
SAHH2_HUMAN	AHCYL1	physical	25416956
RBP1_HUMAN	RALBP1	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
RAB3I_HUMAN	RAB3IP	physical	25416956
ZSCA1_HUMAN	ZSCAN1	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
PSB6_HUMAN	PSMB6	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PEPL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1331, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1579, AND MASSSPECTROMETRY.	16565220 [Abstract]