dbPTM

VIME_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VIME_RAT
UniProt AC	P31000
Protein Name	Vimentin
Gene Name	Vim
Organism	Rattus norvegicus (Rat).
Sequence Length	466
Subcellular Localization	Cytoplasm . Cytoplasm, cytoskeleton . Nucleus matrix .
Protein Description	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2..
Protein Sequence	MSTRSVSSSSYRRMFGGSGTSSRPSSNRSYVTTSTRTYSLGSALRPSTSRSLYSSSPGGAYVTRSSAVRLRSSMPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAESTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREMEENFALEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLESLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTRSVSSS ------CCCCCCCCH	32.31	-
5	Phosphorylation	---MSTRSVSSSSYR ---CCCCCCCCHHCH	26.83	22668510
7	Phosphorylation	-MSTRSVSSSSYRRM -CCCCCCCCHHCHHH	26.25	27097102
7	O-linked_Glycosylation	-MSTRSVSSSSYRRM -CCCCCCCCHHCHHH	26.25	-
8	Phosphorylation	MSTRSVSSSSYRRMF CCCCCCCCHHCHHHC	22.58	27097102
9	Phosphorylation	STRSVSSSSYRRMFG CCCCCCCHHCHHHCC	24.71	27097102
10	Phosphorylation	TRSVSSSSYRRMFGG CCCCCCHHCHHHCCC	25.30	27097102
11	Nitrated tyrosine	RSVSSSSYRRMFGGS CCCCCHHCHHHCCCC	12.27	-
11	Phosphorylation	RSVSSSSYRRMFGGS CCCCCHHCHHHCCCC	12.27	22668510
18	Phosphorylation	YRRMFGGSGTSSRPS CHHHCCCCCCCCCCC	39.00	27097102
20	Phosphorylation	RMFGGSGTSSRPSSN HHCCCCCCCCCCCCC	25.81	27097102
21	Phosphorylation	MFGGSGTSSRPSSNR HCCCCCCCCCCCCCC	28.07	27097102
22	Phosphorylation	FGGSGTSSRPSSNRS CCCCCCCCCCCCCCC	48.31	27097102
25	Phosphorylation	SGTSSRPSSNRSYVT CCCCCCCCCCCCEEE	38.85	27097102
26	Phosphorylation	GTSSRPSSNRSYVTT CCCCCCCCCCCEEEE	38.66	27097102
29	Phosphorylation	SRPSSNRSYVTTSTR CCCCCCCCEEEEECC	28.36	27097102
30	Phosphorylation	RPSSNRSYVTTSTRT CCCCCCCEEEEECCE	9.89	27097102
32	Phosphorylation	SSNRSYVTTSTRTYS CCCCCEEEEECCEEE	13.54	27097102
33	Phosphorylation	SNRSYVTTSTRTYSL CCCCEEEEECCEEEC	20.32	27097102
33	O-linked_Glycosylation	SNRSYVTTSTRTYSL CCCCEEEEECCEEEC	20.32	-
34	Phosphorylation	NRSYVTTSTRTYSLG CCCEEEEECCEEECC	13.41	27097102
34	O-linked_Glycosylation	NRSYVTTSTRTYSLG CCCEEEEECCEEECC	13.41	-
35	Phosphorylation	RSYVTTSTRTYSLGS CCEEEEECCEEECCC	25.57	27097102
37	Phosphorylation	YVTTSTRTYSLGSAL EEEEECCEEECCCCC	19.97	27097102
38	Phosphorylation	VTTSTRTYSLGSALR EEEECCEEECCCCCC	9.90	23984901
39	Phosphorylation	TTSTRTYSLGSALRP EEECCEEECCCCCCC	26.16	16629905
42	Phosphorylation	TRTYSLGSALRPSTS CCEEECCCCCCCCCC	29.44	27097102
47	Phosphorylation	LGSALRPSTSRSLYS CCCCCCCCCCCCCCC	32.36	27097102
48	Phosphorylation	GSALRPSTSRSLYSS CCCCCCCCCCCCCCC	30.73	27097102
49	Phosphorylation	SALRPSTSRSLYSSS CCCCCCCCCCCCCCC	24.98	23984901
51	Phosphorylation	LRPSTSRSLYSSSPG CCCCCCCCCCCCCCC	31.27	27097102
53	Phosphorylation	PSTSRSLYSSSPGGA CCCCCCCCCCCCCCE	14.04	27097102
54	Phosphorylation	STSRSLYSSSPGGAY CCCCCCCCCCCCCEE	29.63	27097102
55	Phosphorylation	TSRSLYSSSPGGAYV CCCCCCCCCCCCEEE	27.31	23712012
56	Phosphorylation	SRSLYSSSPGGAYVT CCCCCCCCCCCEEEE	22.94	27097102
61	Phosphorylation	SSSPGGAYVTRSSAV CCCCCCEEEECCCCH	12.96	27097102
63	Phosphorylation	SPGGAYVTRSSAVRL CCCCEEEECCCCHHH	16.50	25403869
64	Methylation	PGGAYVTRSSAVRLR CCCEEEECCCCHHHH	20.69	24390823
65	Phosphorylation	GGAYVTRSSAVRLRS CCEEEECCCCHHHHC	17.18	23984901
66	Phosphorylation	GAYVTRSSAVRLRSS CEEEECCCCHHHHCC	27.74	27097102
72	Phosphorylation	SSAVRLRSSMPGVRL CCCHHHHCCCCCCHH	35.26	27097102
73	Phosphorylation	SAVRLRSSMPGVRLL CCHHHHCCCCCCHHH	23.67	27097102
83	Phosphorylation	GVRLLQDSVDFSLAD CCHHHCHHCCHHHHH	15.60	16629905
87	Phosphorylation	LQDSVDFSLADAINT HCHHCCHHHHHHHCC	20.41	27097102
97	Acetylation	DAINTEFKNTRTNEK HHHCCCCCCCCCCCC	51.70	25786129
104	Acetylation	KNTRTNEKVELQELN CCCCCCCCEEHHHHH	42.98	25786129
117	Phosphorylation	LNDRFANYIDKVRFL HHHHHHHHHHHHHHH	13.68	-
120	Acetylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	22902405
120	Succinylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	-
120	Succinylation	RFANYIDKVRFLEQQ HHHHHHHHHHHHHHH	26.25	-
129	Acetylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	-
129	Succinylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	-
129	Succinylation	RFLEQQNKILLAELE HHHHHHCHHHHHHHH	30.32	-
139	Acetylation	LAELEQLKGQGKSRL HHHHHHHCCCCCCCH	49.21	25786129
143	"N6,N6-dimethyllysine"	EQLKGQGKSRLGDLY HHHCCCCCCCHHHHH	25.23	-
143	Methylation	EQLKGQGKSRLGDLY HHHCCCCCCCHHHHH	25.23	12692561
144	Phosphorylation	QLKGQGKSRLGDLYE HHCCCCCCCHHHHHH	39.29	22673903
145	Dimethylation	LKGQGKSRLGDLYEE HCCCCCCCHHHHHHH	46.29	-
145	Methylation	LKGQGKSRLGDLYEE HCCCCCCCHHHHHHH	46.29	4204377
168	Acetylation	VDQLTNDKARVEVER HHHHHCCHHHHHHCC	39.91	25786129
168	Ubiquitination	VDQLTNDKARVEVER HHHHHCCHHHHHHCC	39.91	-
188	Acetylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	22902405
188	Succinylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	-
188	Ubiquitination	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	-
188	Succinylation	DIMRLREKLQEEMLQ HHHHHHHHHHHHHHH	49.38	-
201	Phosphorylation	LQREEAESTLQSFRQ HHHHHHHHHHHHHHH	41.27	27097102
202	Phosphorylation	QREEAESTLQSFRQD HHHHHHHHHHHHHHH	21.96	27097102
205	Phosphorylation	EAESTLQSFRQDVDN HHHHHHHHHHHHHCH	26.05	27097102
214	Phosphorylation	RQDVDNASLARLDLE HHHHCHHHHHHHHHH	28.90	27097102
223	Acetylation	ARLDLERKVESLQEE HHHHHHHHHHHHHHH	40.76	22902405
226	Phosphorylation	DLERKVESLQEEIAF HHHHHHHHHHHHHHH	38.04	23984901
235	Acetylation	QEEIAFLKKLHDEEI HHHHHHHHHHCHHHH	47.00	25786129
282	Acetylation	QYESVAAKNLQEAEE HHHHHHHHCHHHHHH	48.75	22902405
292	Acetylation	QEAEEWYKSKFADLS HHHHHHHHHHHHHHH	48.52	134671
293	Phosphorylation	EAEEWYKSKFADLSE HHHHHHHHHHHHHHH	19.80	27097102
294	Acetylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	25786129
294	Succinylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	-
294	Succinylation	AEEWYKSKFADLSEA HHHHHHHHHHHHHHH	40.18	-
299	Phosphorylation	KSKFADLSEAANRNN HHHHHHHHHHHHHCH	26.24	23984901
313	Acetylation	NDALRQAKQESNEYR HHHHHHHHHHHHHHH	46.38	22902405
325	Phosphorylation	EYRRQVQSLTCEVDA HHHHHHHHHHHHHHH	27.13	27097102
327	Phosphorylation	RRQVQSLTCEVDALK HHHHHHHHHHHHHHH	16.33	23984901
334	Acetylation	TCEVDALKGTNESLE HHHHHHHHCCCHHHH	66.46	22902405
336	Phosphorylation	EVDALKGTNESLERQ HHHHHHCCCHHHHHH	33.94	28432305
339	Phosphorylation	ALKGTNESLERQMRE HHHCCCHHHHHHHHH	37.29	25403869
358	Phosphorylation	FALEAANYQDTIGRL HHHHHHHHHHHHHHH	11.75	27097102
361	Phosphorylation	EAANYQDTIGRLQDE HHHHHHHHHHHHHHH	15.14	27097102
373	Acetylation	QDEIQNMKEEMARHL HHHHHHHHHHHHHHH	59.06	22902405
383	Nitrated tyrosine	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	-
383	Phosphorylation	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	-
402	Acetylation	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	22631377
402	Ubiquitination	IEIATYRKLLEGEES HHHHHHHHHHCCCCC	47.19	-
409	Phosphorylation	KLLEGEESRISLPLP HHHCCCCCCCCCCCC	30.52	23984901
412	Phosphorylation	EGEESRISLPLPNFS CCCCCCCCCCCCCCC	23.87	27097102
419	Phosphorylation	SLPLPNFSSLNLRET CCCCCCCCCCCCCCC	40.32	27097102
420	Phosphorylation	LPLPNFSSLNLRETN CCCCCCCCCCCCCCC	19.69	27097102
426	Phosphorylation	SSLNLRETNLESLPL CCCCCCCCCCHHCCC	38.37	27097102
430	Phosphorylation	LRETNLESLPLVDTH CCCCCCHHCCCCCCC	38.15	27097102
436	Phosphorylation	ESLPLVDTHSKRTLL HHCCCCCCCCCCEEE	22.14	22673903
438	Phosphorylation	LPLVDTHSKRTLLIK CCCCCCCCCCEEEEE	26.40	27097102
439	Acetylation	PLVDTHSKRTLLIKT CCCCCCCCCEEEEEE	41.62	22902405
439	Ubiquitination	PLVDTHSKRTLLIKT CCCCCCCCCEEEEEE	41.62	-
445	Acetylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	22902405
445	Succinylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	-
445	Ubiquitination	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	-
445	Succinylation	SKRTLLIKTVETRDG CCCEEEEEEEECCCC	46.62	-
446	Phosphorylation	KRTLLIKTVETRDGQ CCEEEEEEEECCCCC	19.31	-
458	Phosphorylation	DGQVINETSQHHDDL CCCEECCCCCCCCCC	29.24	27097102
459	Phosphorylation	GQVINETSQHHDDLE CCEECCCCCCCCCCC	22.72	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	S	Phosphorylation	Kinase	PKA	-	Uniprot
7	S	Phosphorylation	Kinase	PKC	-	Uniprot
9	S	Phosphorylation	Kinase	PKC	-	Uniprot
10	S	Phosphorylation	Kinase	PKC	-	Uniprot
34	S	Phosphorylation	Kinase	PKC	-	Uniprot
39	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
39	S	Phosphorylation	Kinase	ROCK2	Q62868	Uniprot
39	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
39	S	Phosphorylation	Kinase	PKA	-	Uniprot
39	S	Phosphorylation	Kinase	PKC	-	Uniprot
42	S	Phosphorylation	Kinase	PKC	-	Uniprot
47	S	Phosphorylation	Kinase	PKA	-	Uniprot
66	S	Phosphorylation	Kinase	PKC	-	Uniprot
66	S	Phosphorylation	Kinase	PKA	-	Uniprot
72	S	Phosphorylation	Kinase	ROCK2	Q62868	Uniprot
72	S	Phosphorylation	Kinase	AURKB	O55099	Uniprot
412	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
55	S	Phosphorylation	12686602
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin.
56	S	Phosphorylation	22673903
Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VIME_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VIME_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VIME_RAT

Related Literatures of Post-Translational Modification

show

show