KAZRN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAZRN_HUMAN
• UniProt AC: Q674X7
• Protein Name: Kazrin
• Gene Name: KAZN
• Organism: Homo sapiens (Human).
• Sequence Length: 775
• Subcellular Localization: Cytoplasm, cytoskeleton.; Isoform 2: Cytoplasm. Cell junction, desmosome. Nucleus. Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Coloc
• Protein Description: Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known..
• Protein Sequence: MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAGRLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 3)	Phosphorylation	-	60.04	23927012
8 (in isoform 3)	Phosphorylation	-	5.31	28355574
8	Phosphorylation	MMEDNKQLALRIDGA CCCCCHHHHHHHHHH	5.31	24719451
24	O-linked_Glycosylation	QSASQEVTNLRAELT HCHHHHHHHHHHHHH	27.99	30059200
31	Phosphorylation	TNLRAELTATNRRLA HHHHHHHHHHHHHHH	23.96	-
55	Phosphorylation	PGPGAAASASAAGDS CCCCHHHHHHHHCCC	20.31	22210691
57	Phosphorylation	PGAAASASAAGDSAA CCHHHHHHHHCCCHH	19.02	22210691
62	Phosphorylation	SASAAGDSAATNMEN HHHHHCCCHHHCCCC	20.91	22210691
67 (in isoform 3)	Phosphorylation	-	4.59	28674419
246	O-linked_Glycosylation	ELAMAKQSLATLTKD HHHHHHHHHHHHCCC	21.18	30059200
249	O-linked_Glycosylation	MAKQSLATLTKDVPK HHHHHHHHHCCCCCC	40.01	30059200
253	Phosphorylation	SLATLTKDVPKRHSL HHHHHCCCCCCCCCC	57.63	24719451
259	Phosphorylation	KDVPKRHSLAMPGET CCCCCCCCCCCCCCE	23.12	24719451
283	Phosphorylation	VQADLPLTAAIRQSQ EECCCCHHHHHHHHH	16.47	24719451
289	Phosphorylation	LTAAIRQSQQTLYHS HHHHHHHHHHHHHHC	17.88	24719451
292	Phosphorylation	AIRQSQQTLYHSHPP HHHHHHHHHHHCCCC	22.96	26356563
293	Phosphorylation	IRQSQQTLYHSHPPH HHHHHHHHHHCCCCC	2.92	32142685
294	Phosphorylation	RQSQQTLYHSHPPHP HHHHHHHHHCCCCCC	12.50	25394399
296	Phosphorylation	SQQTLYHSHPPHPAD HHHHHHHCCCCCCCC	24.92	26356563
304	Phosphorylation	HPPHPADRQAVRVSP CCCCCCCCCCEEECC	28.59	24719451
310	Phosphorylation	DRQAVRVSPCHSRQP CCCCEEECCCCCCCC	15.96	27422710
312	Phosphorylation	QAVRVSPCHSRQPSV CCEEECCCCCCCCCC	3.38	24719451
314	Phosphorylation	VRVSPCHSRQPSVIS EEECCCCCCCCCCCC	39.05	27794612
318	Phosphorylation	PCHSRQPSVISDASA CCCCCCCCCCCCCHH	24.60	29978859
321	Phosphorylation	SRQPSVISDASAAEG CCCCCCCCCCHHCCC	25.60	29978859
324	Phosphorylation	PSVISDASAAEGDRS CCCCCCCHHCCCCCC	32.76	24719451
331	Phosphorylation	SAAEGDRSSTPSDIN HHCCCCCCCCCHHCC	43.22	28985074
332	Phosphorylation	AAEGDRSSTPSDINS HCCCCCCCCCHHCCC	45.27	28857561
333	Phosphorylation	AEGDRSSTPSDINSP CCCCCCCCCHHCCCC	28.23	28857561
335	Phosphorylation	GDRSSTPSDINSPRH CCCCCCCHHCCCCCC	51.73	28985074
339	Phosphorylation	STPSDINSPRHRTHS CCCHHCCCCCCCCCC	24.52	28985074
340	Phosphorylation	TPSDINSPRHRTHSL CCHHCCCCCCCCCCC	31.44	24719451
344	Phosphorylation	INSPRHRTHSLCNGD CCCCCCCCCCCCCCC	15.08	25850435
346	Phosphorylation	SPRHRTHSLCNGDSP CCCCCCCCCCCCCCC	33.72	23927012
352	Phosphorylation	HSLCNGDSPGPVQKN CCCCCCCCCCCCCHH	32.91	23927012
361	Phosphorylation	GPVQKNLHNPIVQSL CCCCHHCCCHHHHCH	47.62	24719451
367	Phosphorylation	LHNPIVQSLEDLEDQ CCCHHHHCHHHHHHH	23.88	22617229
381	Phosphorylation	QKRKKKKEKMGFGSI HHHHHHHHHHCCCHH	58.09	24719451
387	Phosphorylation	KEKMGFGSISRVFAR HHHHCCCHHHHHHHC	18.35	10470851
389	Phosphorylation	KMGFGSISRVFARGK HHCCCHHHHHHHCCC	24.88	22167270
440	Phosphorylation	QQVELVRTTPMSHWK HHHEEEECCCCCCCC	27.98	25003641
444	Phosphorylation	LVRTTPMSHWKAGTV EEECCCCCCCCCCHH	27.65	25003641
482	Phosphorylation	GKVLLSLSDEDLQLG CCEEEECCHHHHHHC	35.26	28258704
495	Phosphorylation	LGLGVCSSLHRRKLR HCHHHHHHHHHHHHH	24.06	28258704
500	Acetylation	CSSLHRRKLRLAIED HHHHHHHHHHHHHHH	37.61	19815035
662	Phosphorylation	ATALGIPSGKHILRR HHHHCCCCCHHHHHH	59.56	24719451
684	Phosphorylation	AVFHPANSTGIREAE HHCCCCCCCCCCHHH	30.07	24719451
685	Phosphorylation	VFHPANSTGIREAER HCCCCCCCCCCHHHH	36.11	24719451
716	Methylation	EENSSGLKYKAGRLP CCCCCCCCCCCCCCC	48.51	115971883
717	Phosphorylation	ENSSGLKYKAGRLPL CCCCCCCCCCCCCCC	15.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAZRN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAZRN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAZRN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEPL_HUMAN	PPL	physical	15337775
LZTS2_HUMAN	LZTS2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.