ST2B1_HUMAN - dbPTM
ST2B1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ST2B1_HUMAN
UniProt AC O00204
Protein Name Sulfotransferase family cytosolic 2B member 1
Gene Name SULT2B1
Organism Homo sapiens (Human).
Sequence Length 365
Subcellular Localization Cytoplasm. Microsome. Nucleus. Cytoplasm, cytosol . Phosphorylation of Ser-348 is required for translocation to the nucleus.
Protein Description Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation. [PubMed: 28575648]
Protein Sequence MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 2)Phosphorylation-23.2429507054
9 (in isoform 2)Phosphorylation-4.2329507054
15PhosphorylationQIPGLWDTYEDDISE
CCCCCHHCCCCCHHH		19.7522210691
16PhosphorylationIPGLWDTYEDDISEI
CCCCHHCCCCCHHHH		18.1922210691
31PhosphorylationSQKLPGEYFRYKGVP
HHHCCCCCCEECCCC		10.1622210691
44PhosphorylationVPFPVGLYSLESISL
CCCCCEEEEHHCCCC		12.7927174698
45PhosphorylationPFPVGLYSLESISLA
CCCCEEEEHHCCCCC		30.6127174698
48PhosphorylationVGLYSLESISLAENT
CEEEEHHCCCCCCCC		23.8327174698
50PhosphorylationLYSLESISLAENTQD
EEEHHCCCCCCCCCC		30.7027174698
55PhosphorylationSISLAENTQDVRDDD
CCCCCCCCCCCCCCC		20.0427174698
123PhosphorylationQYSPRLMSSHLPIQI
CCCHHHHHCCCCHHH		21.1420068231
124PhosphorylationYSPRLMSSHLPIQIF
CCHHHHHCCCCHHHH		18.3120068231
132PhosphorylationHLPIQIFTKAFFSSK
CCCHHHHHHHHHCCC		24.0820068231
137PhosphorylationIFTKAFFSSKAKVIY
HHHHHHHCCCCEEEE		25.1925106551
138PhosphorylationFTKAFFSSKAKVIYM
HHHHHHCCCCEEEEC		31.3228060719
155PhosphorylationNPRDVVVSLYHYSKI
CHHHHEEEEECHHHH		16.1724719451
157PhosphorylationRDVVVSLYHYSKIAG
HHHEEEEECHHHHHC		7.3924719451
159PhosphorylationVVVSLYHYSKIAGQL
HEEEEECHHHHHCCC		9.7124719451
253PhosphorylationFSAMKANTMSNYTLL
HHHHHCCCCCCCEEC		27.17-
318PhosphorylationEDPEEDGSPDPEPSP
CCCCCCCCCCCCCCC		38.1526657352
324PhosphorylationGSPDPEPSPEPEPKP
CCCCCCCCCCCCCCC		39.9925849741
347PhosphorylationEREPRPNSSPSPSPG
CCCCCCCCCCCCCCC		46.4330278072
348PhosphorylationREPRPNSSPSPSPGQ
CCCCCCCCCCCCCCC		35.7230278072
350PhosphorylationPRPNSSPSPSPGQAS
CCCCCCCCCCCCCCC		39.7030278072
352PhosphorylationPNSSPSPSPGQASET
CCCCCCCCCCCCCCC		46.1025849741
357PhosphorylationSPSPGQASETPHPRP
CCCCCCCCCCCCCCC		33.8326330541
359PhosphorylationSPGQASETPHPRPS-
CCCCCCCCCCCCCC-		25.1326330541
365PhosphorylationETPHPRPS-------
CCCCCCCC-------		54.8826330541
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ST2B1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ST2B1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ST2B1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AL2SB_HUMANALS2CR12physical
16189514
ST2B1_HUMANSULT2B1physical
25416956
ST1B1_HUMANSULT1B1physical
25416956
AL2SB_HUMANALS2CR12physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ST2B1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Site-directed mutagenesis of human cytosolic sulfotransferase (SULT)2B1b to phospho-mimetic Ser348Asp results in an isoform with increasedcatalytic activity.";
Salman E.D., He D., Runge-Morris M., Kocarek T.A., Falany C.N.;
J. Steroid Biochem. Mol. Biol. 127:315-323(2011).
Cited for: BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, PHOSPHORYLATIONAT SER-348, AND MUTAGENESIS OF SER-347; SER-348; SER-352 AND SER-357.

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