FCGBP_HUMAN - dbPTM
FCGBP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FCGBP_HUMAN
UniProt AC Q9Y6R7
Protein Name IgGFc-binding protein
Gene Name FCGBP
Organism Homo sapiens (Human).
Sequence Length 5405
Subcellular Localization Secreted .
Protein Description May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa..
Protein Sequence MGALWSWWILWAGATLLWGLTQEASVDLKNTGREEFLTAFLQNYQLAYSKAYPRLLISSLSESPASVSILSQADNTSKKVTVRPGESVMVNISAKAEMIGSKIFQHAVVIHSDYAISVQALNAKPDTAELTLLRPIQALGTEYFVLTPPGTSARNVKEFAVVAGAAGASVSVTLKGSVTFNGKFYPAGDVLRVTLQPYNVAQLQSSVDLSGSKVTASSPVAVLSGHSCAQKHTTCNHVVEQLLPTSAWGTHYVVPTLASQSRYDLAFVVASQATKLTYNHGGITGSRGLQAGDVVEFEVRPSWPLYLSANVGIQVLLFGTGAIRNEVTYDPYLVLIPDVAAYCPAYVVKSVPGCEGVALVVAQTKAISGLTIDGHAVGAKLTWEAVPGSEFSYAEVELGTADMIHTAEATTNLGLLTFGLAKAIGYATAADCGRTVLSPVEPSCEGMQCAAGQRCQVVGGKAGCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMVELCSEDDTLPAFSVEAKNEHRGSRRVSYVGLVTVRAYSHSVSLTRGEVGFVLVDNQRSRLPVSLSEGRLRVYQSGPRAVVELVFGLVVTYDWDCQLALSLPARFQDQVCGLCGNYNGDPADDFLTPDGALAPDAVEFASSWKLDDGDYLCEDGCQNNCPACTPGQAQHYEGDRLCGMLTKLDGPFAVCHDTLDPRPFLEQCVYDLCVVGGERLSLCRGLSAYAQACLELGISVGDWRSPANCPLSCPANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLPGFVASGGACVPASSCGCTFQGLQLAPGQEVWADELCQRRCTCNGATHQVTCRDKQSCPAGERCSVQNGLLGCYPDRFGTCQGSGDPHYVSFDGRRFDFMGTCTYLLVGSCGQNAALPAFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGQVLVDDVLQYLPFQAADGQVQVFRQGRDAVVRTDFGLTVTYDWNARVTAKVPSSYAEALCGLCGNFNGDPADDLALRGGGQAANALAFGNSWQEETRPGCGATEPGDCPKLDSLVAQQLQSKNECGILADPKGPFRECHSKLDPQGAVRDCVYDRCLLPGQSGPLCDALATYAAACQAAGATVHPWRSEELCPLSCPPHSHYEACSYGCPLSCGDLPVPGGCGSECHEGCVCDEGFALSGESCLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGLVSCESSSCGPHEACQPSGGSLGCVAVGSSTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQQMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPTPCPPGSEDCIPSHKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRTETFCPMECPPNSHYELCADTCSLGCSALSAPPQCQDGCAEGCQCDSGFLYNGQACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKGMVCQEHSCKPGQVCQPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGSPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSCPGSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGRRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCPPGSEGCIPSEECPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGQVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQCDSGFLYNGQACVPIQQCGCYHNGAYYEPEQTVLIDNCRQQCTCHVGKVVVCQEHSCKPGQVCQPSGGILSCVNKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVTQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLAPGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLREWRRPDFCPFQCPAHSHYELCGDSCPGSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVSCEPSSCGPHETCRPSGGSLGCVAVGSTTCQASGDPHYTTFDGHRFDFMGTCVYVLAQTCGTRPGLHRFAVLQENVAWGNGRVSVTRVITVQVANFTLRLEQRQWKVTVNGVDMKLPVVLANGQIRASQHGSDVVIETDFGLRVAYDLVYYVRVTVPGNYYQLMCGLCGNYNGDPKDDFQKPNGSQAGNANEFGNSWEEVVPDSPCLPPPTCPPGSAGCIPSDKCPPELEKKYQKEEFCGLLSSPTGPLSSCHKLVDPQGPLKDCIFDLCLGGGNLSILCSNIHAYVSACQAAGGHVEPWRNETFCPMECPQNSHYELCADTCSLGCSALSAPLQCPDGCAEGCQCDSGFLYNGQACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHVGKVVVCQEHSCKPGQVCQPSGGILSCVTKDPCHGVTCRPQETCKEQGGQGVCLPNYEATCWLWGDPHYHSFDGRKFDFQGTCNYVLATTGCPGVSTQGLTPFTVTTKNQNRGNPAVSYVRVVTVAALGTNISIHKDEIGKVRVNGVLTALPVSVADGRISVAQGASKALLVADFGLQVSYDWNWRVDVTLPSSYHGAVCGLCGNMDRNPNNDQVFPNGTLAPSIPIWGGSWRAPGWDPLCWDECRGSCPTCPEDRLEQYEGPGFCGPLSSGTGGPFTTCHAHVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVCGPPCPASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCGCWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGLGEVCGLLPSGQHGCQPVSTAECQAWGDPHYVTLDGHRFDFQGTCEYLLSAPCHGPPLGAENFTVTVANEHRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVALPFQLDSLLHAHLSGADVVVTTTSGLSLAFDGDSFVRLRVPAAYAASLCGLCGNYNQDPADDLKAVGGKPAGWQVGGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQVQGHPGGLCPAVATYVAACQAAGAQLGEWRRPDFCPLQCPAHSHYELCGDSCPVSCPSLSAPEGCESACREGCVCDAGFVLSGDTCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPGGHVTCQEGAACGPHEECRLEDGVQACHATGCGRCLANGGIHYITLDGRVYDLHGSCSYVLAQVCHPKPGDEDFSIVLEKNAAGDLQRLLVTVAGQVVSLAQGQQVTVDGEAVALPVAVGRVRVTAEGRNMVLQTTKGLRLLFDGDAHLLMSIPSPFRGRLCGLCGNFNGNWSDDFVLPNGSAASSVETFGAAWRAPGSSKGCGEGCGPQGCPVCLAEETAPYESNEACGQLRNPQGPFATCQAVLSPSEYFRQCVYDLCAQKGDKAFLCRSLAAYTAACQAAGVAVKPWRTDSFCPLHCPAHSHYSICTRTCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTCQAAGCPPGRVCEVKAEARNCWATRGLCVLSVGANLTTFDGARGATTSPGVYELSSRCPGLQNTIPWYRVVAEVQICHGKTEAVGQVHIFFQDGMVTLTPNKGVWVNGLRVDLPAEKLASVSVSRTPDGSLLVRQKAGVQVWLGANGKVAVIVSNDHAGKLCGACGNFDGDQTNDWHDSQEKPAMEKWRAQDFSPCYG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68PhosphorylationSESPASVSILSQADN
CCCCCCEEEEECCCC		18.4722210691
75N-linked_GlycosylationSILSQADNTSKKVTV
EEEECCCCCCCCEEE		49.6316335952
76PhosphorylationILSQADNTSKKVTVR
EEECCCCCCCCEEEC		42.3322210691
81PhosphorylationDNTSKKVTVRPGESV
CCCCCCEEECCCCEE		21.4822210691
91N-linked_GlycosylationPGESVMVNISAKAEM
CCCEEEEEEECCHHH		12.3716335952
212PhosphorylationSSVDLSGSKVTASSP
ECEECCCCCCCCCCC		22.1524260401
368PhosphorylationVAQTKAISGLTIDGH
EEEECCCCCCEECCE		32.3925404012
371PhosphorylationTKAISGLTIDGHAVG
ECCCCCCEECCEEEE		22.1325404012
426PhosphorylationGLAKAIGYATAADCG
HHHHHHCCHHHHHCC		8.48-
428PhosphorylationAKAIGYATAADCGRT
HHHHCCHHHHHCCCE		17.56-
472S-nitrosylationVAESTAVCRAQGDPH
EEEEHHHHHCCCCCC		2.5025040305
488PhosphorylationTTFDGRRYDMMGTCS
ECCCCCCCCCCCCCE		13.5630576142
493PhosphorylationRRYDMMGTCSYTMVE
CCCCCCCCCEEEEEE		4.7530576142
512PhosphorylationDDTLPAFSVEAKNEH
CCCCCCEEEEECCCC		22.5830576142
526PhosphorylationHRGSRRVSYVGLVTV
CCCCCCEEEEEEEEE		16.5823312004
527PhosphorylationRGSRRVSYVGLVTVR
CCCCCEEEEEEEEEE		8.8323312004
598PhosphorylationWDCQLALSLPARFQD
CCCCHHHCCCHHHCH		27.0524719451
973PhosphorylationGRDAVVRTDFGLTVT
CCCEEEEECCCCEEE		24.8729759185
978PhosphorylationVRTDFGLTVTYDWNA
EEECCCCEEEEECCC		15.9229759185
980PhosphorylationTDFGLTVTYDWNARV
ECCCCEEEEECCCEE		15.5525907765
981PhosphorylationDFGLTVTYDWNARVT
CCCCEEEEECCCEEE		18.0229759185
988PhosphorylationYDWNARVTAKVPSSY
EECCCEEEEECCHHH		18.4029759185
1306PhosphorylationAWGNGRVSVTRVITV
EECCCCEEEEEEEEE		19.1930257219
1308PhosphorylationGNGRVSVTRVITVQV
CCCCEEEEEEEEEEE		16.2322210691
1312PhosphorylationVSVTRVITVQVANFT
EEEEEEEEEEEEEEE		11.3022210691
1317N-linked_GlycosylationVITVQVANFTLRLEQ
EEEEEEEEEEEEEEE		31.4215084671
1319PhosphorylationTVQVANFTLRLEQRQ
EEEEEEEEEEEEECE		15.6924719451
1368PhosphorylationDFGLRVAYDLVYYVR
CCCCCCEEEEEEEEE		13.6221060948
1372PhosphorylationRVAYDLVYYVRVTVP
CCEEEEEEEEEEECC		11.9821060948
1432O-linked_GlycosylationDSPCLPPTPCPPGSE
CCCCCCCCCCCCCCC		35.27OGP
1730PhosphorylationNRGNPAVSYVRVVTV
CCCCCCCEEEEEEEE		21.7330266825
1731PhosphorylationRGNPAVSYVRVVTVA
CCCCCCEEEEEEEEE		5.9130266825
1743N-linked_GlycosylationTVAALGTNISIHKDE
EEEEECCCEEECHHC		24.9816335952
1775PhosphorylationADGRISVTQGASKAL
CCCCEEECCCCCCEE		17.94-
1779PhosphorylationISVTQGASKALLVAD
EEECCCCCCEEEEEE		25.86-
2138N-linked_GlycosylationSVTLQIYNHSLTLSA
EEEEEEEECCCEEEE		21.6516335952
2442PhosphorylationTCRPSGGSLGCVAVG
CCCCCCCCCEEEEEC		25.7222210691
2452PhosphorylationCVAVGSTTCQASGDP
EEEECCCEEECCCCC		12.3422210691
2507PhosphorylationAWGNGRVSVTRVITV
EECCCCEEEEEEEEE		19.1930257219
2509PhosphorylationGNGRVSVTRVITVQV
CCCCEEEEEEEEEEE		16.2322210691
2513PhosphorylationVSVTRVITVQVANFT
EEEEEEEEEEEEEEE		11.3022210691
2518N-linked_GlycosylationVITVQVANFTLRLEQ
EEEEEEEEEEEEEEE		31.4215084671
2520PhosphorylationTVQVANFTLRLEQRQ
EEEEEEEEEEEEECE		15.6924719451
2569PhosphorylationDFGLRVAYDLVYYVR
CCCCCCEEEEEEEEE		13.6221060948
2573PhosphorylationRVAYDLVYYVRVTVP
CCEEEEEEEEEEECC		11.9821060948
2634O-linked_GlycosylationSPCLPPPTCPPGSEG
CCCCCCCCCCCCCCC		43.34OGP
2839PhosphorylationQPSGGILSCVNKDPC
CCCCCEEEECCCCCC		17.6925627689
2931PhosphorylationNRGNPAVSYVRVVTV
CCCCCCCEEEEEEEE		21.7330266825
2932PhosphorylationRGNPAVSYVRVVTVA
CCCCCCEEEEEEEEE		5.9130266825
2944N-linked_GlycosylationTVAALGTNISIHKDE
EEEEECCCEEECHHC		24.9816335952
2976PhosphorylationADGRISVTQGASKAL
CCCCEEECCCCCCEE		17.94-
2980PhosphorylationISVTQGASKALLVAD
EEECCCCCCEEEEEE		25.86-
3339N-linked_GlycosylationSVTLQIYNHSLTLSA
EEEEEEEECCCEEEE		21.6516335952
3708PhosphorylationAWGNGRVSVTRVITV
EECCCCEEEEEEEEE		19.1930257219
3710PhosphorylationGNGRVSVTRVITVQV
CCCCEEEEEEEEEEE		16.2322210691
3714PhosphorylationVSVTRVITVQVANFT
EEEEEEEEEEEEEEE		11.3022210691
3719N-linked_GlycosylationVITVQVANFTLRLEQ
EEEEEEEEEEEEEEE		31.4215084671
3721PhosphorylationTVQVANFTLRLEQRQ
EEEEEEEEEEEEECE		15.6924719451
3770PhosphorylationDFGLRVAYDLVYYVR
CCCCCCEEEEEEEEE		13.6221060948
3774PhosphorylationRVAYDLVYYVRVTVP
CCEEEEEEEEEEECC		11.9821060948
3835O-linked_GlycosylationSPCLPPPTCPPGSAG
CCCCCCCCCCCCCCC		43.34OGP
4132PhosphorylationNRGNPAVSYVRVVTV
CCCCCCCEEEEEEEE		21.7330266825
4133PhosphorylationRGNPAVSYVRVVTVA
CCCCCCEEEEEEEEE		5.9130266825
4145N-linked_GlycosylationTVAALGTNISIHKDE
EEEEECCCEEECHHC		24.9816335952
4540N-linked_GlycosylationSVTLQIYNHSLTLSA
EEEEEEEECCCEEEE		21.6516335952
4743PhosphorylationPLQCPAHSHYELCGD
CCCCCCCCCCCCCCC		29.8522210691
4745PhosphorylationQCPAHSHYELCGDSC
CCCCCCCCCCCCCCC		17.3822210691
4767PhosphorylationSAPEGCESACREGCV
CCCCCHHHHHHCCCE		36.4222210691
5186N-linked_GlycosylationNGRYLPVNSSLLTSD
CCEEEECCHHHCCCC		24.7617623646
5186N-linked_GlycosylationNGRYLPVNSSLLTSD
CCEEEECCHHHCCCC		24.76-
5245PhosphorylationSVGANLTTFDGARGA
EECCCCEECCCCCCC		23.9322468782
5254PhosphorylationDGARGATTSPGVYEL
CCCCCCCCCCCCHHH		32.1822468782
5259PhosphorylationATTSPGVYELSSRCP
CCCCCCCHHHHHCCC		19.6422468782
5331PhosphorylationKLASVSVSRTPDGSL
HCEEEEEEECCCCCE		23.9524114839
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FCGBP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FCGBP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FCGBP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FCGBP_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FCGBP_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2518, AND MASSSPECTROMETRY.
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-75; ASN-91; ASN-1743;ASN-2138 AND ASN-2518, AND MASS SPECTROMETRY.
"A proteomic analysis of human bile.";
Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H.,Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.;
Mol. Cell. Proteomics 3:715-728(2004).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3719, AND MASSSPECTROMETRY.

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