| UniProt ID | SPB3_HUMAN | |
|---|---|---|
| UniProt AC | P29508 | |
| Protein Name | Serpin B3 | |
| Gene Name | SERPINB3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization | Cytoplasm . Seems to also be secreted in plasma by cancerous cells but at a low level. | |
| Protein Description | May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).. | |
| Protein Sequence | MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MNSLSEAN -------CCCHHHHH | 7.49 | - | |
| 3 | Phosphorylation | -----MNSLSEANTK -----CCCHHHHHHH | 31.79 | 29759185 | |
| 5 | Phosphorylation | ---MNSLSEANTKFM ---CCCHHHHHHHHH | 34.19 | 29759185 | |
| 9 | Phosphorylation | NSLSEANTKFMFDLF CCHHHHHHHHHHHHH | 32.48 | 20068231 | |
| 22 | Phosphorylation | LFQQFRKSKENNIFY HHHHHHHHCCCCCCC | 40.73 | 22210691 | |
| 29 | Phosphorylation | SKENNIFYSPISITS HCCCCCCCCCCCHHH | 15.11 | 25850435 | |
| 30 | Phosphorylation | KENNIFYSPISITSA CCCCCCCCCCCHHHH | 12.66 | 22210691 | |
| 33 | Phosphorylation | NIFYSPISITSALGM CCCCCCCCHHHHHHH | 24.17 | 25850435 | |
| 35 | Phosphorylation | FYSPISITSALGMVL CCCCCCHHHHHHHHH | 10.93 | - | |
| 35 | O-linked_Glycosylation | FYSPISITSALGMVL CCCCCCHHHHHHHHH | 10.93 | 29351928 | |
| 36 | O-linked_Glycosylation | YSPISITSALGMVLL CCCCCHHHHHHHHHH | 21.59 | 29351928 | |
| 66 | Phosphorylation | FDQVTENTTGKAATY HHCCCCCCCCCEEEE | 30.60 | 29759185 | |
| 72 | Phosphorylation | NTTGKAATYHVDRSG CCCCCEEEEEECCCC | 21.01 | 26356563 | |
| 73 | Phosphorylation | TTGKAATYHVDRSGN CCCCEEEEEECCCCC | 8.63 | 26356563 | |
| 119 | Phosphorylation | TYLFLQEYLDAIKKF HHHHHHHHHHHHHHH | 9.27 | - | |
| 129 | Phosphorylation | AIKKFYQTSVESVDF HHHHHHHHCHHHCCC | 24.30 | - | |
| 143 | Phosphorylation | FANAPEESRKKINSW CCCCCHHHHHHHHHH | 47.97 | 22468782 | |
| 149 | Phosphorylation | ESRKKINSWVESQTN HHHHHHHHHHHHHCC | 35.65 | 27966365 | |
| 153 | Phosphorylation | KINSWVESQTNEKIK HHHHHHHHHCCHHHH | 32.46 | 21406692 | |
| 155 | Phosphorylation | NSWVESQTNEKIKNL HHHHHHHCCHHHHHH | 55.41 | 21406692 | |
| 181 | Phosphorylation | LVLVNAIYFKGQWEK EEEEEEEEECCHHHH | 9.23 | 27259358 | |
| 206 | Phosphorylation | KFWPNKNTYKSIQMM CCCCCCCHHHHHHHH | 33.66 | - | |
| 208 | Acetylation | WPNKNTYKSIQMMRQ CCCCCHHHHHHHHHH | 38.76 | 7710323 | |
| 216 | Phosphorylation | SIQMMRQYTSFHFAS HHHHHHHHHCCCCCC | 8.25 | - | |
| 237 | Neddylation | KVLEIPYKGKDLSMI HEEECCCCCCCEEEE | 54.88 | 32015554 | |
| 298 | Phosphorylation | ESYDLKDTLRTMGMV CCCCHHHHHHHCCCE | 19.29 | 22210691 | |
| 301 | Phosphorylation | DLKDTLRTMGMVDIF CHHHHHHHCCCEEEC | 22.61 | 22210691 | |
| 315 | Phosphorylation | FNGDADLSGMTGSRG CCCCCCCCCCCCCHH | 27.37 | 22210691 | |
| 318 | Phosphorylation | DADLSGMTGSRGLVL CCCCCCCCCCHHHHH | 35.21 | 22210691 | |
| 320 | Phosphorylation | DLSGMTGSRGLVLSG CCCCCCCCHHHHHHC | 17.63 | 22210691 | |
| 326 | Phosphorylation | GSRGLVLSGVLHKAF CCHHHHHHCHHHHHH | 21.26 | 24719451 | |
| 378 | Phosphorylation | FFIRQNKTNSILFYG EEEECCCCCCEEEEE | 41.57 | 24719451 | |
| 384 | Phosphorylation | KTNSILFYGRFSSP- CCCCEEEEEECCCC- | 12.16 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CATK_HUMAN | CTSK | physical | 9548757 | |
| CATL1_HUMAN | CTSL | physical | 9548757 | |
| CATS_HUMAN | CTSS | physical | 9548757 | |
| MK08_HUMAN | MAPK8 | physical | 16549498 | |
| CATL1_HUMAN | CTSL | physical | 12949073 | |
| SPB4_HUMAN | SERPINB4 | physical | 26186194 | |
| VIGLN_HUMAN | HDLBP | physical | 26186194 | |
| SHLB1_HUMAN | SH3GLB1 | physical | 26186194 | |
| EI2BA_HUMAN | EIF2B1 | physical | 26344197 | |
| TPIS_HUMAN | TPI1 | physical | 26344197 | |
| SPB4_HUMAN | SERPINB4 | physical | 28514442 | |
| SHLB1_HUMAN | SH3GLB1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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