CATK_HUMAN - dbPTM
CATK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CATK_HUMAN
UniProt AC P43235
Protein Name Cathepsin K
Gene Name CTSK
Organism Homo sapiens (Human).
Sequence Length 329
Subcellular Localization Lysosome.
Protein Description Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation..
Protein Sequence MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationKKTHRKQYNNKVDEI
HHHHHHHHCCHHHHH		24.6029083192
45PhosphorylationNNKVDEISRRLIWEK
CCHHHHHHHHHHHHC		14.8629083192
94AcetylationVQKMTGLKVPLSHSR
HHHHHCCCCCCCCCC		43.0526051181
103N-linked_GlycosylationPLSHSRSNDTLYIPE
CCCCCCCCCEEEECC		45.21UniProtKB CARBOHYD
118PhosphorylationWEGRAPDSVDYRKKG
CCCCCCCCCCCCCCC		18.8126552605
121PhosphorylationRAPDSVDYRKKGYVT
CCCCCCCCCCCCCEE		23.3726552605
128PhosphorylationYRKKGYVTPVKNQGQ
CCCCCCEECCCCCCC		17.5529396449
139S-nitrosocysteineNQGQCGSCWAFSSVG
CCCCCCCCEEHHCCC		1.52-
139S-nitrosylationNQGQCGSCWAFSSVG
CCCCCCCCEEHHCCC		1.5222178444
197PhosphorylationQKNRGIDSEDAYPYV
HHCCCCCCCCCCCCC		35.1426552605
201PhosphorylationGIDSEDAYPYVGQEE
CCCCCCCCCCCCCCC		13.8626552605
203PhosphorylationDSEDAYPYVGQEESC
CCCCCCCCCCCCCCC		12.4426552605
209PhosphorylationPYVGQEESCMYNPTG
CCCCCCCCCEECCCC		11.9326552605
212PhosphorylationGQEESCMYNPTGKAA
CCCCCCEECCCCCCC		23.4726552605
215PhosphorylationESCMYNPTGKAAKCR
CCCEECCCCCCCCCC		47.9126552605
246PhosphorylationVARVGPVSVAIDASL
HHHHCCCEEEEECCC		14.68-
260PhosphorylationLTSFQFYSKGVYYDE
CCEEEEECCCCCCCC		24.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CATK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CATK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CATK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARI4B_HUMANARID4Bphysical
26186194
ERBIN_HUMANERBB2IPphysical
26186194
CATL2_HUMANCTSVphysical
26186194
CR025_HUMANC18orf25physical
26186194
ARI4B_HUMANARID4Bphysical
28514442
CATL1_HUMANCTSLphysical
28514442
CR025_HUMANC18orf25physical
28514442
CATL2_HUMANCTSVphysical
28514442
ERBIN_HUMANERBB2IPphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
265800Pycnodysostosis (PKND)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CATK_HUMAN

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Related Literatures of Post-Translational Modification

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