| UniProt ID | SPB7_HUMAN | |
|---|---|---|
| UniProt AC | O75635 | |
| Protein Name | Serpin B7 | |
| Gene Name | SERPINB7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 380 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.. | |
| Protein Sequence | MASLAAANAEFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLSVIEDPSMKILELRYNGGINMYVLLPENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNIVEKQLPQSTLFRADHPFLFVIRKDDIILFSGKVSCP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 132 | Phosphorylation | KVERVDFTNHLEDTR CCEECCCCCHHHHHH | 19.77 | 27794612 | |
| 138 | Phosphorylation | FTNHLEDTRRNINKW CCCHHHHHHHHHHHH | 23.35 | 27794612 | |
| 176 | Phosphorylation | MVLVNAVYFKGKWQS HHHHHHHEECCCHHH | 9.36 | 27259358 | |
| 183 | Phosphorylation | YFKGKWQSAFTKSET EECCCHHHCCCCCCE | 25.00 | 28731282 | |
| 196 | Methylation | ETINCHFKSPKCSGK CEEEEEECCCCCCCC | 42.03 | 115981487 | |
| 217 | Phosphorylation | QERKFNLSVIEDPSM CHHCCCCEEECCCCC | 23.35 | 20068231 | |
| 223 | Phosphorylation | LSVIEDPSMKILELR CEEECCCCCEEEEEE | 45.06 | 20068231 | |
| 262 | Phosphorylation | FQNLMEWTNPRRMTS HHHHHHHCCCCCCCC | 23.26 | - | |
| 337 | Phosphorylation | TEEGTEATAATGSNI ECCCCCCEECCCCCH | 15.59 | - | |
| 340 | Phosphorylation | GTEATAATGSNIVEK CCCCEECCCCCHHHC | 38.38 | - | |
| 342 | Phosphorylation | EATAATGSNIVEKQL CCEECCCCCHHHCCC | 21.01 | - | |
| 367 | Ubiquitination | PFLFVIRKDDIILFS CEEEEEECCCEEEEC | 48.94 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPB7_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615598 | Keratoderma, palmoplantar, Nagashima type (PPKN) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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