ANXA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA8_HUMAN
• UniProt AC: P13928
• Protein Name: Annexin A8 {ECO:0000312|HGNC:HGNC:546}
• Gene Name: ANXA8 {ECO:0000312|HGNC:HGNC:546}
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Protein Description: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade..
• Protein Sequence: MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	QEGVTVKSSSHFNPD HCCCEEECCCCCCCC	32.51	23090842
18	Phosphorylation	EGVTVKSSSHFNPDP CCCEEECCCCCCCCC	23.32	23090842
19	Phosphorylation	GVTVKSSSHFNPDPD CCEEECCCCCCCCCC	38.91	23090842
29	Phosphorylation	NPDPDAETLYKAMKG CCCCCHHHHHHHHHC	36.79	26356563
31	Phosphorylation	DPDAETLYKAMKGIG CCCHHHHHHHHHCCC	12.24	27259358
32	Acetylation	PDAETLYKAMKGIGT CCHHHHHHHHHCCCC	45.15	23954790
32	Ubiquitination	PDAETLYKAMKGIGT CCHHHHHHHHHCCCC	45.15	29967540
35	Ubiquitination	ETLYKAMKGIGTNEQ HHHHHHHHCCCCCHH	52.84	29967540
61	Ubiquitination	TQRQQIAKSFKAQFG HHHHHHHHHHHHHHC	59.04	29967540
61	Succinylation	TQRQQIAKSFKAQFG HHHHHHHHHHHHHHC	59.04	23954790
74	Phosphorylation	FGKDLTETLKSELSG HCCHHHHHHHHHHCC	33.96	21082442
76	Acetylation	KDLTETLKSELSGKF CHHHHHHHHHHCCHH	49.67	66728611
82	Ubiquitination	LKSELSGKFERLIVA HHHHHCCHHHHHHHH	40.45	29901268
99	Ubiquitination	YPPYRYEAKELHDAM CCCCHHHHHHHHHHH	11.16	29967540
107	Ubiquitination	KELHDAMKGLGTKEG HHHHHHHCCCCCCCC	53.34	29967540
112	Ubiquitination	AMKGLGTKEGVIIEI HHCCCCCCCCHHHHH	51.15	33845483
120	Ubiquitination	EGVIIEILASRTKNQ CCHHHHHHHHCCHHH	1.99	29901268
135	Ubiquitination	LREIMKAYEEDYGSS HHHHHHHHHHHHCCC	17.84	29967540
161	S-palmitoylation	YLERILVCLLQGSRD HHHHHHHHHHHCCCC	2.55	29575903
173	Ubiquitination	SRDDVSSFVDPGLAL CCCHHHHHCCCCCHH	5.86	29967540
192	Ubiquitination	DLYAAGEKIRGTDEM HHHHCCCCCCCCCCC	36.46	29967540
222	Acetylation	RVFEEYEKIANKSIE HHHHHHHHHHCCCHH	46.33	-
263	Phosphorylation	SYFAERLYYAMKGAG HHHHHHHHHHHCCCC	8.73	23663014
264	Phosphorylation	YFAERLYYAMKGAGT HHHHHHHHHHCCCCC	12.57	23663014
267	Acetylation	ERLYYAMKGAGTRDG HHHHHHHCCCCCCCC	37.12	-
299	Phosphorylation	KCHFKKMYGKTLSSM HHHHHHHHCCCHHHH	25.09	18669648
304	Phosphorylation	KMYGKTLSSMIMEDT HHHCCCHHHHHHHCC	24.08	18669648
312	Phosphorylation	SMIMEDTSGDYKNAL HHHHHCCCCHHHHHH	41.82	18669648
315	Phosphorylation	MEDTSGDYKNALLSL HHCCCCHHHHHHHHH	15.07	18669648
321	Phosphorylation	DYKNALLSLVGSDP- HHHHHHHHHHCCCC-	23.12	21601212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ACTS_HUMAN	ACTA1	physical	26186194
ACTS_HUMAN	ACTA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.