TGM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGM1_HUMAN
• UniProt AC: P22735
• Protein Name: Protein-glutamine gamma-glutamyltransferase K
• Gene Name: TGM1
• Organism: Homo sapiens (Human).
• Sequence Length: 817
• Subcellular Localization: Membrane; Lipid-anchor.
• Protein Description: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation. [PubMed: 26220141]
• Protein Sequence: MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GNPLQPPTTPSPEPE CCCCCCCCCCCCCCC	59.01	20639409
22	Phosphorylation	NPLQPPTTPSPEPEP CCCCCCCCCCCCCCC	27.78	28355574
24	Phosphorylation	LQPPTTPSPEPEPEP CCCCCCCCCCCCCCC	39.54	28355574
35	Phosphorylation	EPEPDGRSRRGGGRS CCCCCCCCCCCCCCC	31.68	28355574
68	Phosphorylation	WGPEPSDSRGRGSSS CCCCCCCCCCCCCCC	40.76	21082442
82	Phosphorylation	SGTRRPGSRGSDSRR CCCCCCCCCCCCCCC	35.83	22817900
85	Phosphorylation	RRPGSRGSDSRRPVS CCCCCCCCCCCCCCC	31.16	22817900
92	Phosphorylation	SDSRRPVSRGSGVNA CCCCCCCCCCCCCCC	33.34	28355574
95	Phosphorylation	RRPVSRGSGVNAAGD CCCCCCCCCCCCCCC	38.16	30243723
104	Phosphorylation	VNAAGDGTIREGMLV CCCCCCCCCCCCEEE	22.92	28355574
119	Phosphorylation	VNGVDLLSSRSDQNR EECEEECCCCCCCCC	30.88	24719451
120	Phosphorylation	NGVDLLSSRSDQNRR ECEEECCCCCCCCCH	35.45	24719451
134	Phosphorylation	REHHTDEYEYDELIV HHHCCCCHHHHHHHH	23.69	27642862
136	Phosphorylation	HHTDEYEYDELIVRR HCCCCHHHHHHHHHC	17.51	27642862
179	Phosphorylation	NPEVGKGTHVIIPVG CCCCCCCEEEEEECC	19.22	30257219
190	Phosphorylation	IPVGKGGSGGWKAQV EECCCCCCCCCEEEE	42.68	30257219
267	Phosphorylation	HEDWRQEYVLNESGR CHHHHHHEEECCCCC	11.25	-
312	Phosphorylation	LDRRGMPYGGRGDPV HHHCCCCCCCCCCCC	24.26	-
364	Phosphorylation	GSVEILLSYLRTGYS HHHHHHHHHHHHCCC	20.76	22210691
365	Phosphorylation	SVEILLSYLRTGYSV HHHHHHHHHHHCCCC	10.52	-
370	Phosphorylation	LSYLRTGYSVPYGQC HHHHHHCCCCCCCCC	13.09	-
525	Phosphorylation	VEEKAIGTLIVTKAI EEEEECEEEEHHHHH	13.75	21406692
529	Phosphorylation	AIGTLIVTKAISSNM ECEEEEHHHHHHCCC	14.04	21406692
545	Ubiquitination	EDITYLYKHPEGSDA CCEEEEECCCCCCHH	50.52	29967540
559	Phosphorylation	AERKAVETAAAHGSK HHHHHHHHHHHCCCC	18.26	22817900
565	Phosphorylation	ETAAAHGSKPNVYAN HHHHHCCCCCCEEEC	34.76	22817900
570	Phosphorylation	HGSKPNVYANRGSAE CCCCCCEEECCCCHH	12.56	22817900
615	Phosphorylation	RTVKLHLYLSVTFYT CEEEEEEEEEEEEEC	6.03	30576142
622	Phosphorylation	YLSVTFYTGVSGTIF EEEEEEECCCCCEEE	27.24	30576142
627	Phosphorylation	FYTGVSGTIFKETKK EECCCCCEEEECCCC	18.74	30576142
751	Phosphorylation	IGGNETVTLRQSFVP CCCCCEEEEEECEEE	24.52	24719451
755	Phosphorylation	ETVTLRQSFVPVRPG CEEEEEECEEECCCC	23.06	18491316

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	19651786

Drug and Disease Associations

• Kegg Disease
• H00734: Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
• OMIM Disease
• 242300: Ichthyosis, congenital, autosomal recessive 1 (ARCI1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00130: L-Glutamine